LOCUS       NM_009626               2079 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus alcohol dehydrogenase 7 (class IV), mu or sigma
            polypeptide (Adh7), mRNA.
ACCESSION   NM_009626
VERSION     NM_009626.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Yi,H.S., Lee,Y.S., Byun,J.S., Seo,W., Jeong,J.M., Park,O.,
            Duester,G., Haseba,T., Kim,S.C., Park,K.G., Gao,B. and Jeong,W.I.
  TITLE     Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing
            stellate cell activation and suppressing natural killer cells in
            mice
  JOURNAL   Hepatology 60 (3), 1044-1053 (2014)
   PUBMED   24668648
  REMARK    GeneRIF: ADH3 promotes liver fibrosis by enhancing hepatic stellate
            cell activation and inhibiting natural killer cell activity
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Anvret,A., Ran,C., Westerlund,M., Gellhaar,S., Lindqvist,E.,
            Pernold,K., Lundstromer,K., Duester,G., Felder,M.R., Galter,D. and
            Belin,A.C.
  TITLE     Adh1 and Adh1/4 knockout mice as possible rodent models for
            presymptomatic Parkinson's disease
  JOURNAL   Behav Brain Res 227 (1), 252-257 (2012)
   PUBMED   22079585
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Belin,A.C., Westerlund,M., Anvret,A., Lindqvist,E., Pernold,K.,
            Ogren,S.O., Duester,G. and Galter,D.
  TITLE     Modeling Parkinson's disease genetics: altered function of the
            dopamine system in Adh4 knockout mice
  JOURNAL   Behav Brain Res 217 (2), 439-445 (2011)
   PUBMED   21075145
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Hu,P., Zhang,M. and Napoli,J.L.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Westerlund,M., Belin,A.C., Felder,M.R., Olson,L. and Galter,D.
  TITLE     High and complementary expression patterns of alcohol and aldehyde
            dehydrogenases in the gastrointestinal tract: implications for
            Parkinson's disease
  JOURNAL   FEBS J 274 (5), 1212-1223 (2007)
   PUBMED   17257171
  REMARK    GeneRIF: Cellular expression of Adh3 in the GUI tract was studied.
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Lane,P.W., Bronson,R.T. and Spencer,C.A.
  TITLE     Rostral cerebellar malformation, (rcm): a new recessive mutation on
            chromosome 3 of the mouse
  JOURNAL   J Hered 83 (4), 315-318 (1992)
   PUBMED   1401878
REFERENCE   7  (bases 1 to 2079)
  AUTHORS   Ramesh,V., Cheng,S.V., Kozak,C.A., Herron,B.J., Shih,V.E.,
            Taylor,B.A. and Gusella,J.F.
  TITLE     Mapping of ornithine aminotransferase gene sequences to mouse
            chromosomes 7, X, and 3
  JOURNAL   Mamm Genome 3 (1), 17-22 (1992)
   PUBMED   1349842
REFERENCE   8  (bases 1 to 2079)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
REFERENCE   9  (bases 1 to 2079)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
REFERENCE   10 (bases 1 to 2079)
  AUTHORS   Holmes,R.S.
  TITLE     The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase
            in the mouse: evidence for multiple gene loci and linkage between
            Hao-2 and Adh-3
  JOURNAL   Genetics 87 (4), 709-716 (1977)
   PUBMED   604164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ560660.1 and AF331802.1.
            
            On Apr 17, 2008 this sequence version replaced NM_009626.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF331802.1, AK009600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BQ560660.1         1-2
            3-2079              AF331802.1         1-2077
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.13 cM"
     gene            1..2079
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /note="alcohol dehydrogenase 7 (class IV), mu or sigma
                     polypeptide"
                     /db_xref="GeneID:11529"
                     /db_xref="MGI:MGI:87926"
     exon            1..136
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..238
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..377
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..465
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..682
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..943
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1079
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1218
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..2079
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1929..1934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /note="hexamer: AATAAA"
     polyA_site      1954
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /note="major polyA site"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2072
                     /gene="Adh7"
                     /gene_synonym="Adh-3; Adh-3e; Adh-3t; Adh3; Adh3-e;
                     Adh3-t; Adh4; Adt-1"
                     /note="major polyA site"
ORIGIN      
        1 gaacttccaa gtcacgctat ttattgaagg ccgaagatgc tggtacccat agaagagtga
       61 accgtgcctc agtcagaaga cgttcctgtt tgcaggccac acacccagga gaggcaggat
      121 gggcaccgct ggaaaagtta ttaagtgcaa agcggctgtc ctatggggag tgaaccagcc
      181 tttctccatt gaggaaatcg aggtggcccc accaaaggct aaggaagtcc gtgttaagat
      241 tttggccaca ggaatctgtc gcacagatga ccatataata aaaggatcga tggtgtctaa
      301 gtttccagtg attgtgggac atgaagcagt tggggttgtg gagagtgttg gagaaggggt
      361 cactacagtg agaccaggtg acaaagtcat ccccctcttt ctaccacagt gtagagaatg
      421 caacgcctgc ctgaacccag agggcaatct ctgcattagg agcgatctga caggccgtgg
      481 agtattggct gatggcacta ccagattcac ctgcaagggc aaaccggtcc agcacttcat
      541 gaacaccagc accttcactg agtacacggt gctggacgaa tcctccgtag cgaaggttga
      601 cggtgcggct ccgcctgaga aagcctgctt gatcggctgt ggattttcca cgggttatgg
      661 agctgctgtt aaaactgcca aggtcacccc tggctccact tgtgttgtct ttggcctggg
      721 aggagttggc ctgtcagtca tcatgggctg taaagcagct ggtgcctcca ggatcattgg
      781 aatcgacatc aacaaagaca aattccagaa agctctggcc gtaggtgcca cagagtgtat
      841 cagtcccaag gactctacca agcccatcag tgaggtgcta tccgacatga caggcaacac
      901 catacagtat acttttgaag ttattgggcg tcttgagacc atggttgatg ccctctcatc
      961 ttgccatatg aactatggga ccagtgtggt ggttggtgct cctccgtcag ccaagatgct
     1021 cacctatgac ccaatgctgc tcttcactgg gcgtacgtgg aagggctgcg tctttggagg
     1081 gtggaagagc agagatgatg tacctaaact ggtgactgag ttcctggaaa agaagtttga
     1141 cctggaccag ttgataaccc acaccttgcc ttttaataac atcaatgaag gatttgaatt
     1201 gctgtattcg gggaaaagca ttcggactgt cctgacattt tgagttccag agacctgggt
     1261 gttctgagct gggctaccgt gacctgaagc cttgctcctg acagtgttct ctgagatcac
     1321 aagtctgtct cagaagcaca cagaagcaga gctggggaaa gacagagaag ctttctagag
     1381 tctggcaaac ctttatctgc ttagtttacc gagtgcctag gcttcgcaga gaactcagca
     1441 gtaacaataa atgttctaat ttgtgttttc caaggctata attctatatt ttataagcat
     1501 gtacttaggg ttctatttgt tgaaagaggg attgttttca gaattttaca gttgttatgg
     1561 cttaaaacag atgtggcatg tagagatgta gaaaatgaat ttttcaagaa atgaccatca
     1621 aaaccaccag agctctcatt ctgttttttt ttaacagaaa cacttttaaa acatgttatg
     1681 aattaacttg aattagattg tgaaatagca cacataactt gattagatta agaaagaaat
     1741 tgggaaattt aagggaaggg cacatttttc aatgattaac ttggagaatt atcattatat
     1801 aactttgtga catgggaaaa gcacagccat gtctggagat gttagtcagt gtttatcaat
     1861 ataagacaag acatttttag aatagcaatt aaatataacc gcattgtgat atttaccata
     1921 ctaagtttaa taaagtcgaa ttacaagccc ttaagtacat agtaataact acatttaaca
     1981 tggggattat ttttttattt gctgtaattg caccagcatc tgtcagtgga gatgtacata
     2041 aatttactat gcattaaaat ttcattatgg tatgtttca
//
