LOCUS       NM_007410               1604 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus alcohol dehydrogenase 5 (class III), chi polypeptide
            (Adh5), transcript variant 1, mRNA.
ACCESSION   NM_007410
VERSION     NM_007410.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1604)
  AUTHORS   Su,L.Y., Jiao,L., Liu,Q., Qiao,X., Xie,T., Ma,Z., Xu,M., Ye,M.S.,
            Yang,L.X., Chen,C. and Yao,Y.G.
  TITLE     S-nitrosoglutathione reductase alleviates morphine analgesic
            tolerance by restricting PKCalpha S-nitrosation
  JOURNAL   Redox Biol 75, 103239 (2024)
   PUBMED   38901102
REFERENCE   2  (bases 1 to 1604)
  AUTHORS   Liu,Q., Jiao,L., Ye,M.S., Ma,Z., Yu,J., Su,L.Y., Zou,W.Y.,
            Yang,L.X., Chen,C. and Yao,Y.G.
  TITLE     GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation
            of MAPK14
  JOURNAL   Cell Mol Immunol 21 (6), 561-574 (2024)
   PUBMED   38570588
  REMARK    GeneRIF: GSNOR negatively regulates the NLRP3 inflammasome via
            S-nitrosation of MAPK14.
REFERENCE   3  (bases 1 to 1604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1604)
  AUTHORS   Jia,M., Chai,L., Wang,J., Wang,M., Qin,D., Song,H., Fu,Y., Zhao,C.,
            Gao,C., Jia,J. and Zhao,W.
  TITLE     S-nitrosothiol homeostasis maintained by ADH5 facilitates
            STING-dependent host defense against pathogens
  JOURNAL   Nat Commun 15 (1), 1750 (2024)
   PUBMED   38409248
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1604)
  AUTHORS   Kim,J., Qiao,F., Singh,A.K., Won,J. and Singh,I.
  TITLE     Efficacies of S-nitrosoglutathione (GSNO) and GSNO reductase
            inhibitor in SARS-CoV-2 spike protein induced acute lung disease in
            mice
  JOURNAL   Front Pharmacol 14, 1304697 (2023)
   PUBMED   38143504
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1604)
  AUTHORS   Zgombic-Knight,M., Ang,H.L., Foglio,M.H. and Duester,G.
  TITLE     Cloning of the mouse class IV alcohol dehydrogenase (retinol
            dehydrogenase) cDNA and tissue-specific expression patterns of the
            murine ADH gene family
  JOURNAL   J Biol Chem 270 (18), 10868-10877 (1995)
   PUBMED   7738026
REFERENCE   7  (bases 1 to 1604)
  AUTHORS   Hur,M.W., Ho,W.H., Brown,C.J., Goldman,D. and Edenberg,H.J.
  TITLE     Molecular cloning of mouse alcohol dehydrogenase-B2 cDNA:
            nucleotide sequences of the class III ADH genes evolve slowly even
            for silent substitutions
  JOURNAL   DNA Seq 3 (3), 167-175 (1992)
   PUBMED   1472709
REFERENCE   8  (bases 1 to 1604)
  AUTHORS   Edenberg,H.J., Brown,C.J., Carr,L.G., Ho,W.H. and Hur,M.W.
  TITLE     Alcohol dehydrogenase gene expression and cloning of the mouse
            chi-like ADH
  JOURNAL   Adv Exp Med Biol 284, 253-262 (1991)
   PUBMED   2053480
REFERENCE   9  (bases 1 to 1604)
  AUTHORS   Giri,P.R., Krug,J.F., Kozak,C., Moretti,T., O'Brien,S.J.,
            Seuanez,H.N. and Goldman,D.
  TITLE     Cloning and comparative mapping of a human class III (chi) alcohol
            dehydrogenase cDNA
  JOURNAL   Biochem Biophys Res Commun 164 (1), 453-460 (1989)
   PUBMED   2679557
REFERENCE   10 (bases 1 to 1604)
  AUTHORS   Algar,E.M. and Holmes,R.S.
  TITLE     Mouse mitochondrial aldehyde dehydrogenase isozymes: purification
            and molecular properties
  JOURNAL   Int J Biochem 17 (1), 51-60 (1985)
   PUBMED   3996732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY125542.1 and AK076507.1.
            
            On Dec 21, 2013 this sequence version replaced NM_007410.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076507.1, AK159803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BY125542.1         1-71
            72-1604             AK076507.1         1-1533
FEATURES             Location/Qualifiers
     source          1..1604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.26 cM"
     gene            1..1604
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /note="alcohol dehydrogenase 5 (class III), chi
                     polypeptide"
                     /db_xref="GeneID:11532"
                     /db_xref="MGI:MGI:87929"
     exon            1..101
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            102..203
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            204..345
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            346..433
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            434..653
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            654..914
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1050
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1189
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1604
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1403..1408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /note="hexamer: AATAAA"
     polyA_site      1421
                     /gene="Adh5"
                     /gene_synonym="Adh-5; Adh3; GSNOR"
                     /note="major polyA site"
ORIGIN      
        1 gcacagcccc tcccctcacg cacggtccag ccctcacccg ggttccgcta cactcgtgaa
       61 ccttagcgct cgatcccgaa ctagcggcca tggcgaacca ggtgatcagg tgtaaggctg
      121 cagtcgcctg ggaggcggga aagcctctct ccatagagga gatagaagtg gcccctccaa
      181 aggctcatga agttcggatt aagatccttg ccactgctgt ttgccacacc gatgcctata
      241 ccctgagcgg agctgacccc gaggggtgtt tcccagtgat cttgggacat gaaggtgctg
      301 gaattgtgga aagtgttggt gaaggggtca cgaagctgaa ggcaggtgac actgtcatcc
      361 cactctacat cccacagtgt ggagaatgca agttttgtct gaatcctaaa acaaaccttt
      421 gccagaaaat aagggtcact caggggaagg gattaatgcc agatgggact agcagattta
      481 cctgcaaagg aaagtctgtt tttcacttca tggggactag cacattttcc gagtacacag
      541 ttgtggctga catctctgtt gctaaaatcg atccttcggc ccctttggat aaagtctgcc
      601 ttctcggctg tggtatttca actggctacg gggctgctgt gaacactgcc aaggtggagc
      661 ctggttctac ttgtgccgtc tttggcctgg gaggagttgg actggcagtg atcatgggct
      721 gtaaggtggc tggtgcatcc cggatcattg gtatcgacat caataaagat aaattcgcaa
      781 aggccaaaga atttggagcc tctgaatgta ttagccccca agacttcagt aaatccatcc
      841 aggaagtcct cgttgagatg acagatgggg gcgtggatta ctcctttgag tgcattggca
      901 acgtgaaggt catgagatca gcccttgagg cagcccacaa aggctggggt gtcagtgtgg
      961 tagtgggagt agctgcttca ggggaagaaa tctccactcg tccattccag ctggtgacag
     1021 gacgcacatg gaaaggcacc gcctttggag gatggaagag tgtggagagt gtcccaaagc
     1081 tggtgtctga atatatgtcc aaaaagataa aagttgacga atttgtgacc ggcaatctct
     1141 ccttcgacca aattaaccaa gcctttgatc tgatgcactc gggagacagc attcgaactg
     1201 ttctaaagat gtaagttctg aagagaacac tgtccatcct gcactctttc ctgtgattgg
     1261 ctagaaacag acaggattta caagctaacc acgtcgtaga cttcagaaat gactagaagg
     1321 aatgtgcata atcgagactg taatcatgaa ctaggcaaat tccacataaa caattgctgc
     1381 tcattgtgca acattttaac ataataaaaa tactttctgc atgtgtgtgt gagttgaaca
     1441 tcttgtcatc ttgtaggatc ccagttcatt gacagtcaac tgtgtctaga aacagtgcta
     1501 acccaaaaat gaaggctgat cttgaattca tccacatggg tttagaatag ccgaaatcag
     1561 aatattcttt ctttctcagc aaataaattt tagaagtgta tact
//
