LOCUS       NM_011996               1312 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus alcohol dehydrogenase 4 (class II), pi polypeptide
            (Adh4), mRNA.
ACCESSION   NM_011996
VERSION     NM_011996.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1312)
  AUTHORS   Anvret,A., Ran,C., Westerlund,M., Gellhaar,S., Lindqvist,E.,
            Pernold,K., Lundstromer,K., Duester,G., Felder,M.R., Galter,D. and
            Belin,A.C.
  TITLE     Adh1 and Adh1/4 knockout mice as possible rodent models for
            presymptomatic Parkinson's disease
  JOURNAL   Behav Brain Res 227 (1), 252-257 (2012)
   PUBMED   22079585
  REMARK    GeneRIF: This study demonistrated that adh1/adh4 knockout mice as
            possible rodent models for presymptomatic Parkinson's disease.
REFERENCE   2  (bases 1 to 1312)
  AUTHORS   Belin,A.C., Westerlund,M., Anvret,A., Lindqvist,E., Pernold,K.,
            Ogren,S.O., Duester,G. and Galter,D.
  TITLE     Modeling Parkinson's disease genetics: altered function of the
            dopamine system in Adh4 knockout mice
  JOURNAL   Behav Brain Res 217 (2), 439-445 (2011)
   PUBMED   21075145
  REMARK    GeneRIF: The results suggested that lack of Adh4 gene activity
            induces changes in the function of the dopamine system, findings
            which are compatible with a role of loss-of-function mutations in
            ADH4 as possible risk factors for parkinson disease.
REFERENCE   3  (bases 1 to 1312)
  AUTHORS   Fenstermaker,A.G., Prasad,A.A., Bechara,A., Adolfs,Y., Tissir,F.,
            Goffinet,A., Zou,Y. and Pasterkamp,R.J.
  TITLE     Wnt/planar cell polarity signaling controls the anterior-posterior
            organization of monoaminergic axons in the brainstem
  JOURNAL   J Neurosci 30 (47), 16053-16064 (2010)
   PUBMED   21106844
REFERENCE   4  (bases 1 to 1312)
  AUTHORS   Hu,P., Zhang,M. and Napoli,J.L.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   5  (bases 1 to 1312)
  AUTHORS   Hellgren,M., Stromberg,P., Gallego,O., Martras,S., Farres,J.,
            Persson,B., Pares,X. and Hoog,J.O.
  TITLE     Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol
            metabolism
  JOURNAL   Cell Mol Life Sci 64 (4), 498-505 (2007)
   PUBMED   17279314
  REMARK    GeneRIF: The metabolism of all-trans- and 9-cis-retinol/
            retinaldehyde has been investigated with focus on the activities of
            human, mouse and rat alcohol dehydrogenase 2 (ADH2), an intriguing
            enzyme with apparently different functions in human and rodents.
REFERENCE   6  (bases 1 to 1312)
  AUTHORS   Ulven,S.M., Gundersen,T.E., Sakhi,A.K., Glover,J.C. and Blomhoff,R.
  TITLE     Quantitative axial profiles of retinoic acid in the embryonic mouse
            spinal cord: 9-cis retinoic acid only detected after
            all-trans-retinoic acid levels are super-elevated experimentally
  JOURNAL   Dev Dyn 222 (3), 341-353 (2001)
   PUBMED   11747070
REFERENCE   7  (bases 1 to 1312)
  AUTHORS   Svensson,S., Hoog,J.O., Schneider,G. and Sandalova,T.
  TITLE     Crystal structures of mouse class II alcohol dehydrogenase reveal
            determinants of substrate specificity and catalytic efficiency
  JOURNAL   J Mol Biol 302 (2), 441-453 (2000)
   PUBMED   10970744
REFERENCE   8  (bases 1 to 1312)
  AUTHORS   Ulven,S.M., Gundersen,T.E., Weedon,M.S., Landaas,V.O., Sakhi,A.K.,
            Fromm,S.H., Geronimo,B.A., Moskaug,J.O. and Blomhoff,R.
  TITLE     Identification of endogenous retinoids, enzymes, binding proteins,
            and receptors during early postimplantation development in mouse:
            important role of retinal dehydrogenase type 2 in synthesis of
            all-trans-retinoic acid
  JOURNAL   Dev Biol 220 (2), 379-391 (2000)
   PUBMED   10753524
REFERENCE   9  (bases 1 to 1312)
  AUTHORS   Svensson,S., Stromberg,P. and Hoog,J.O.
  TITLE     A novel subtype of class II alcohol dehydrogenase in rodents.
            Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse
            enzyme
  JOURNAL   J Biol Chem 274 (42), 29712-29719 (1999)
   PUBMED   10514444
REFERENCE   10 (bases 1 to 1312)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK132994.1.
            
            On Jan 5, 2007 this sequence version replaced NM_011996.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132994.1, BC100729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.24 cM"
     gene            1..1312
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /note="alcohol dehydrogenase 4 (class II), pi polypeptide"
                     /db_xref="GeneID:26876"
                     /db_xref="MGI:MGI:1349472"
     exon            1..53
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1169
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /EC_number="1.1.1.105"
                     /note="alcohol dehydrogenase II; alcohol dehydrogenase
                     class II; class II type ADH; alcohol dehydrogenase 2"
                     /codon_start=1
                     /product="all-trans-retinol dehydrogenase [NAD(+)] ADH4"
                     /protein_id="NP_036126.2"
                     /db_xref="CCDS:CCDS38653.1"
                     /db_xref="GeneID:26876"
                     /db_xref="MGI:MGI:1349472"
                     /translation="MGTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIAT
                     CVCPTDINATDPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCK
                     LCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEA
                     NLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPSSTCAVFGLGCVGLSAIIGCKI
                     AGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGT
                     AQTLKAAVDCTVLGWGSCTVVGAKVDKMTIPTVDVILGRSINGTFFGGWKSVDSVPNL
                     VSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTILTF"
     exon            54..155
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            156..294
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..382
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..614
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..875
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1005
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1144
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1312
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1291..1296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /note="hexamer: TATAAA"
     polyA_site      1312
                     /gene="Adh4"
                     /gene_synonym="Adh2"
                     /note="major polyA site"
ORIGIN      
        1 agaaagatac tttcaaagca agcttcccaa ggaaaatggg cacccaggga aaagttatta
       61 aatgcaaggc agccattgcc tggaaaactg gcagtcccct ttgcattgaa gaaattgagg
      121 tgtcccctcc taaagcttgt gaggttcgga ttcaggtaat cgccacgtgt gtgtgcccta
      181 ctgacatcaa tgccaccgat cctaagaaga aagctctctt cccggtagtc cttggtcatg
      241 agtgtgcagg aattgtagaa agtgttgggc cgggagtgac caacttcaaa ccaggtgaca
      301 aagtaatccc attctttgca ccacagtgca aaaggtgcaa gctctgtctg agccctctca
      361 caaacctctg tggaaaactc cgaaacttca aataccccac tattgatcag gagctcatgg
      421 aagacagaac cagcaggttt acctgcaaag gaagatcaat ttaccatttc atgggcgtca
      481 gttcattctc tcaatacact gtggtttcag aggccaatct tgccagagtc gatgatgagg
      541 caaacttgga gagagtgtgt ctgattggat gtgggttctc atcaggctac ggggctgcca
      601 tcaatactgc caaggtcacc cccagttcca cttgtgctgt ctttggcctg gggtgtgtag
      661 gtctttctgc cataattggg tgtaaaatag caggtgcttc cagaatcata gctattgaca
      721 tcaacggtga gaagttccca aaagccaagg ccctgggagc cactgactgc ctgaatccca
      781 gggagctaga caaacctgtc caggatgtca tcactgagct gacagctgga ggtgtggatt
      841 actcccttga ctgtgcagga acagctcaga ccttgaaagc agctgtggac tgcactgtat
      901 taggctgggg gtcgtgcact gtggtcggag caaaggttga caaaatgact atacccaccg
      961 tggacgttat attgggccgt tctataaatg gaacattctt tggtggttgg aaaagtgtag
     1021 actctgtccc aaacctggtt tctgactaca agaataagaa attcgatctg gacttactgg
     1081 tgacccatgc cctacctttc gagagcataa atgatgccat tgacctgatg aaggaaggaa
     1141 aaagcatccg aacaatcctg accttctgaa aatgccagga gcaacttgga atgttatctg
     1201 attggatccg agcctgtctg gatgatttat tacctcacat gatgagccaa agaaagcctg
     1261 catttacact ttgtatcagc acaaatgaac tataaattat acattcactg tt
//
