LOCUS       NM_007409               1413 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus alcohol dehydrogenase 1 (class I) (Adh1), mRNA.
ACCESSION   NM_007409
VERSION     NM_007409.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Xu,Z., Wang,W., Yang,T., Li,L., Ma,X., Chen,J., Wang,J., Huang,Y.,
            Gould,J., Lu,H., Du,W., Sahu,S.K., Yang,F., Li,Z., Hu,Q., Hua,C.,
            Hu,S., Liu,Y., Cai,J., You,L., Zhang,Y., Li,Y., Zeng,W., Chen,A.,
            Wang,B., Liu,L., Chen,F., Ma,K., Xu,X. and Wei,X.
  TITLE     STOmicsDB: a comprehensive database for spatial transcriptomics
            data sharing, analysis and visualization
  JOURNAL   Nucleic Acids Res 52 (D1), D1053-D1061 (2024)
   PUBMED   37953328
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Zheng,Y., Cai,J.J., Yang,X., Shao,Z.Q., Liu,J.Q., Yang,X.H.,
            Sun,R.H., Hu,B.C., Mo,S.J. and Li,L.J.
  TITLE     Alcohol dehydrogenase 1 is a tubular mitophagy-dependent apoptosis
            inhibitor against septic acute kidney injury
  JOURNAL   Exp Cell Res 433 (1), 113804 (2023)
   PUBMED   37806378
  REMARK    GeneRIF: Alcohol dehydrogenase 1 is a tubular mitophagy-dependent
            apoptosis inhibitor against septic acute kidney injury.
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Mackowiak,B., Xu,M., Lin,Y., Guan,Y., Seo,W., Ren,R., Feng,D.,
            Jones,J.W., Wang,H. and Gao,B.
  TITLE     Hepatic CYP2B10 is highly induced by binge ethanol and contributes
            to acute-on-chronic alcohol-induced liver injury
  JOURNAL   Alcohol Clin Exp Res 46 (12), 2163-2176 (2022)
   PUBMED   36224745
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Li,S., Yang,H., Li,W., Liu,J.Y., Ren,L.W., Yang,Y.H., Ge,B.B.,
            Zhang,Y.Z., Fu,W.Q., Zheng,X.J., Du,G.H. and Wang,J.H.
  TITLE     ADH1C inhibits progression of colorectal cancer through the
            ADH1C/PHGDH /PSAT1/serine metabolic pathway
  JOURNAL   Acta Pharmacol Sin 43 (10), 2709-2722 (2022)
   PUBMED   35354963
  REMARK    GeneRIF: ADH1C inhibits progression of colorectal cancer through
            the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
            Erratum:[Acta Pharmacol Sin. 2024 Nov;45(11):2450-2451. doi:
            10.1038/s41401-024-01319-3. PMID: 38918585]
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Petrosino,J.M., Longenecker,J.Z., Ramkumar,S., Xu,X., Dorn,L.E.,
            Bratasz,A., Yu,L., Maurya,S., Tolstikov,V., Bussberg,V.,
            Janssen,P.M., Periasamy,M., Kiebish,M.A., Duester,G., von
            Lintig,J., Ziouzenkova,O. and Accornero,F.
  TITLE     Paracardial fat remodeling affects systemic metabolism through
            alcohol dehydrogenase 1
  JOURNAL   J Clin Invest 131 (4) (2021)
   PUBMED   33586683
  REMARK    GeneRIF: Paracardial fat remodeling affects systemic metabolism
            through alcohol dehydrogenase 1.
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Fulchignoni-Lataud,M.C., Szpirer,J., Levan,G. and Weiss,M.C.
  TITLE     Assignment of the rat genes coding for alpha 1-antitrypsin (PI),
            phosphoenolpyruvate carboxykinase (PEPCK), alcohol dehydrogenase
            (ADH), and fructose-1,6-bisphosphatase (FDP)
  JOURNAL   Mamm Genome 3 (1), 42-45 (1992)
   PUBMED   1316195
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   von Deimling,O.H. and Gaa,A.
  TITLE     Biochemical and genetic characterization of esterase-27 (ES-27),
            the major plasma cholinesterase of the house mouse (Mus musculus)
  JOURNAL   Genet Res 57 (1), 61-70 (1991)
   PUBMED   2040456
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of alcohol dehydrogenase isozymes in the
            mouse: evidence for a cis-acting regulator gene (Adt-i) controlling
            C2 isozyme expression in reproductive tissues and close linkage of
            Adh-3 and Adt-i on chromosome 3
  JOURNAL   Biochem Genet 17 (5-6), 461-472 (1979)
   PUBMED   518534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD355981.1, AC079682.29, DV044803.1, AI326887.1 and AI256543.1.
            
            On Nov 10, 2017 this sequence version replaced NM_007409.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013477.1, AK146094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               CD355981.1         4-272
            270-271             AC079682.29        36239-36240         c
            272-533             CD355981.1         275-536
            534-716             DV044803.1         495-677
            717-962             AC079682.29        29677-29922         c
            963-1294            AI326887.1         112-443             c
            1295-1295           AC079682.29        26037-26037         c
            1296-1413           AI256543.1         1-118               c
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.16 cM"
     gene            1..1413
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /note="alcohol dehydrogenase 1 (class I)"
                     /db_xref="GeneID:11522"
                     /db_xref="MGI:MGI:87921"
     exon            1..152
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            153..254
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            255..393
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            394..481
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            482..701
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            702..962
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1098
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1237
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1401
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1369..1374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /note="hexamer: AATAAA"
     polyA_site      1397
                     /gene="Adh1"
                     /gene_synonym="Adh-1; Adh-1-t; Adh-1e; Adh-1t; Adh-3e;
                     ADH-A2; ADH-AA; Adh1-e; Adh1-t; Adh1tl; Adh3-e"
                     /note="major polyA site"
ORIGIN      
        1 agatcacgtg tgggatcagc tgacaacccc agcaaacaaa atatgtgtgc aactttggcc
       61 cggttcacta gaggagggaa gaagtctaca aggacccatc aatttcctgc ctgcctgcag
      121 caaggacaga cggcatgagc actgcgggaa aagtgatcaa atgcaaagct gcggtgctat
      181 gggagcttca caaacccttc accatcgagg acatagaagt cgcacccccc aaggcccatg
      241 aagttcgaat taagatggtg gccactggtg tctgccgctc agacgatcac gtggttagtg
      301 gaaccctggt cacacctctt cctgcagttt taggccatga gggagcaggc attgttgaga
      361 gcgttggaga aggggtgact tgtgtgaaac caggtgataa agtcattcca ctcttttccc
      421 ctcagtgtgg agaatgcagg atttgcaagc acccggaaag caacttttgt agccgaagcg
      481 atctgctaat gcctcggggg actttgcgcg aaggcaccag caggttctcc tgcaagggaa
      541 agcagatcca caactttatc agcaccagca ccttctccca gtacaccgtg gtagatgata
      601 tagcagtggc caaaatcgat ggagcttcac cactggacaa agtctgcctc atcggctgtg
      661 ggttctcaac tggctatggc tctgccgtca aagtcgccaa ggtgacccca ggctccacat
      721 gtgccgtgtt tggcctcgga ggtgtcggtc tgtctgtcat cattggctgt aaagcagcag
      781 gagcagccag gatcattgct gtggacatca acaaggacaa gtttgccaag gccaaagagt
      841 tgggtgcaac tgagtgcatc aaccctcaag actacagcaa acccatccag gaagttctcc
      901 aggagatgac cgacggaggg gtggactttt cgtttgaagt catcggccgc cttgacacca
      961 tgacttctgc cctgctgagc tgccatgcag catgtggtgt aagcgtcgtc gtaggagtgc
     1021 ctcccaatgc ccagaacctc tccatgaacc ccatgttgct gctgctggga cgcacctgga
     1081 agggagcaat atttggcggg tttaagagta aagattctgt ccctaaactt gtggctgact
     1141 tcatggctaa gaagtttccg ttggacccgt taattaccca tgttttacct ttcgagaaaa
     1201 taaatgaagc atttgacctg cttcgttctg gaaagagcat ccgtaccgtc ctgactttct
     1261 gagatcatgt ggatgccttc ccacgcacca gtttctgaac cctaaaccag actgattcaa
     1321 gcaccagcca catcacagcc ttaatctttg ctctttagag acacagccaa taaagtactt
     1381 gtgtaagctc tccacaagaa aaaaaaaaaa aaa
//
