LOCUS       NM_133222               4106 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor L4 (Adgrl4), mRNA.
ACCESSION   NM_133222
VERSION     NM_133222.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4106)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4106)
  AUTHORS   Huang,H., Georganaki,M., Conze,L.L., Lavina,B., van Hooren,L.,
            Vemuri,K., van de Walle,T., Ramachandran,M., Zhang,L., Ponten,F.,
            Bergqvist,M., Smits,A., Betsholtz,C., Dejana,E., Magnusson,P.U.,
            He,L., Lugano,R. and Dimberg,A.
  TITLE     ELTD1 deletion reduces vascular abnormality and improves T-cell
            recruitment after PD-1 blockade in glioma
  JOURNAL   Neuro Oncol 24 (3), 398-411 (2022)
   PUBMED   34347079
  REMARK    GeneRIF: ELTD1 deletion reduces vascular abnormality and improves
            T-cell recruitment after PD-1 blockade in glioma.
REFERENCE   3  (bases 1 to 4106)
  AUTHORS   Lu,S., Liu,S., Wietelmann,A., Kojonazarov,B., Atzberger,A.,
            Tang,C., Schermuly,R.T., Grone,H.J. and Offermanns,S.
  TITLE     Developmental vascular remodeling defects and postnatal kidney
            failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)
  JOURNAL   PLoS One 12 (8), e0183166 (2017)
   PUBMED   28806758
  REMARK    GeneRIF: loss of GPR116 and ELTD1 expressed by other cells accounts
            for the observed cardiovascular and renal defects.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4106)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   5  (bases 1 to 4106)
  AUTHORS   Xiao,J., Jiang,H., Zhang,R., Fan,G., Zhang,Y., Jiang,D. and Li,H.
  TITLE     Augmented cardiac hypertrophy in response to pressure overload in
            mice lacking ELTD1
  JOURNAL   PLoS One 7 (5), e35779 (2012)
   PUBMED   22606234
  REMARK    GeneRIF: ELTD1 deficiency exacerbates cardiac hypertrophy and
            cardiac function induced by aortic banding-induced pressure
            overload by promoting both cardiomyocyte hypertrophy and cardiac
            fibrosis.
REFERENCE   6  (bases 1 to 4106)
  AUTHORS   Wallgard,E., Larsson,E., He,L., Hellstrom,M., Armulik,A.,
            Nisancioglu,M.H., Genove,G., Lindahl,P. and Betsholtz,C.
  TITLE     Identification of a core set of 58 gene transcripts with broad and
            specific expression in the microvasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1469-1476 (2008)
   PUBMED   18483404
REFERENCE   7  (bases 1 to 4106)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   8  (bases 1 to 4106)
  AUTHORS   Kwakkenbos,M.J., Kop,E.N., Stacey,M., Matmati,M., Gordon,S.,
            Lin,H.H. and Hamann,J.
  TITLE     The EGF-TM7 family: a postgenomic view
  JOURNAL   Immunogenetics 55 (10), 655-666 (2004)
   PUBMED   14647991
  REMARK    Review article
REFERENCE   9  (bases 1 to 4106)
  AUTHORS   Terskikh,A.V., Easterday,M.C., Li,L., Hood,L., Kornblum,H.I.,
            Geschwind,D.H. and Weissman,I.L.
  TITLE     From hematopoiesis to neuropoiesis: evidence of overlapping genetic
            programs
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7934-7939 (2001)
   PUBMED   11438738
REFERENCE   10 (bases 1 to 4106)
  AUTHORS   Nechiporuk,T., Urness,L.D. and Keating,M.T.
  TITLE     ETL, a novel seven-transmembrane receptor that is developmentally
            regulated in the heart. ETL is a member of the secretin family and
            belongs to the epidermal growth factor-seven-transmembrane
            subfamily
  JOURNAL   J Biol Chem 276 (6), 4150-4157 (2001)
   PUBMED   11050079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127233.2.
            
            On Mar 21, 2008 this sequence version replaced NM_133222.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF385682.1, BC017134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC127233.2         123990-124112       c
            124-273             AC127233.2         122607-122756       c
            274-423             AC127233.2         69568-69717         c
            424-573             AC127233.2         64018-64167         c
            574-644             AC127233.2         63574-63644         c
            645-824             AC127233.2         61769-61948         c
            825-1008            AC127233.2         61482-61665         c
            1009-1125           AC127233.2         60153-60269         c
            1126-1328           AC127233.2         54443-54645         c
            1329-1505           AC127233.2         52615-52791         c
            1506-1709           AC127233.2         51205-51408         c
            1710-1930           AC127233.2         44377-44597         c
            1931-1997           AC127233.2         44187-44253         c
            1998-2089           AC127233.2         20942-21033         c
            2090-2258           AC127233.2         19145-19313         c
            2259-4106           AC127233.2         16913-18760         c
FEATURES             Location/Qualifiers
     source          1..4106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 76.76 cM"
     gene            1..4106
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /note="adhesion G protein-coupled receptor L4"
                     /db_xref="GeneID:170757"
                     /db_xref="MGI:MGI:2655562"
     exon            1..123
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..2321
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /note="EGF, latrophilin seven transmembrane
                     domain-containing protein 1; EGF-TM7 receptor; EGF,
                     latrophilin seven transmembrane domain containing 1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L4
                     precursor"
                     /protein_id="NP_573485.2"
                     /db_xref="CCDS:CCDS17910.1"
                     /db_xref="GeneID:170757"
                     /db_xref="MGI:MGI:2655562"
                     /translation="MRLLPLLVGFSTLLNCSYTQNCSKTTCLPNAKCEVHNGVEACFC
                     SQGYSGNGVTICEDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPND
                     GSYCQDIDECSESSVCGDHAVCENVNGGFSCFCREGYQTATGKSQFTPNDGSYCQESM
                     NSNCHLEHACIAANINKTLKRIGPITEQTTLLQEIYRNSEAELSLMDIVTYIEILTES
                     SSLLGHPNSTTSYKDAHFNSTLTEFGETINNFVERSTHKMWDQLPTNHRRLHLTKLMH
                     TAELVTLQIAQNTQKNSQFDMNSTDLALKVFAFDSTHMKHAHPHMNVDGGYVKISPRR
                     KAAHGTTGNVVVAFLCYKSIGPLLSSSDNFLLDTQNDNSEGKEKVISSVISASISSNP
                     PTLYELEKITFTLSHVKLSDKHRTQCAFWNYSVDAMNNGSWSTEGCELTHSNDTHTSC
                     RCSHLTHFAILMSSTSSIGIKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTR
                     TTIHKNLCCSLFLAELVFLIGININTNKLVCSIIAGLLHYFFLAAFAWMCIEGIHLYL
                     IVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSASLGYRYYGTTKVCWLSTENNFIWSFI
                     GPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCYENIRSCARGALALLFLLGTTWIF
                     GVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR"
     exon            124..273
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..423
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..573
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..644
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..824
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1008
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1125
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1328
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1505
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1709
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1930
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1997
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2089
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2258
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..4106
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4083..4088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /note="hexamer: AATAAA"
     polyA_site      4106
                     /gene="Adgrl4"
                     /gene_synonym="1110033N21Rik; Eltd1; Etl; ETL1"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcacagg ggacagagcg agaccctgcg gtgcctgcct agctccagga cagacccgca
       61 ctctagccta gagcgctctg ccgccagctc cggggcttcc aatgagactc ctcccgcttc
      121 tagtgggttt ctccactttg ctgaattgtt cctacacaca aaactgcagc aagacaacgt
      181 gtctccccaa tgccaagtgc gaagtgcaca atggtgtgga agcctgcttc tgcagccagg
      241 ggtactctgg gaatggcgtc acgatttgtg aagatataga tgagtgcagc gagtcttctg
      301 tctgcggtga tcatgctgtg tgtgaaaacg tgaacggggg cttcagctgc ttctgcaggg
      361 aaggttatca gaccgctacg gggaagtcac agttcacacc taatgatggc tcttactgcc
      421 aagatataga tgagtgcagc gagtcttctg tctgcggtga tcatgctgtg tgtgaaaacg
      481 tgaacggggg cttcagctgc ttctgcaggg aaggttatca gaccgccacg gggaagtcac
      541 agttcacacc taatgatggc tcttactgcc aagaaagcat gaattcaaat tgccacttag
      601 agcatgcctg catcgctgca aacattaata aaactttaaa aagaattgga cccataacag
      661 aacagacaac tttactccaa gaaatctaca gaaattctga ggctgagctc tctctgatgg
      721 atatagtcac atacatagag atcctaactg aatcatcctc actactaggc cacccgaaca
      781 gcaccacttc atacaaggat gcccacttca actcaactct tactgaattt ggggaaacca
      841 tcaataattt tgttgaaagg agtacacata aaatgtggga ccagttaccg acaaatcaca
      901 gaagacttca tctcacaaaa ctgatgcaca ctgctgagct agtcacctta cagatcgctc
      961 agaacaccca gaagaattct cagtttgata tgaattctac tgacttggct ctcaaggttt
     1021 ttgcttttga ttcaactcac atgaagcatg ctcaccccca catgaatgtg gatggaggct
     1081 atgtgaaaat atccccaagg agaaaggctg cacatggcac aactggcaat gtagtagttg
     1141 cattcctctg ctataagagc attggtccct tgctatcctc atctgacaac ttcttactgg
     1201 acactcaaaa tgataattct gaaggaaagg aaaaagtcat ttcttcagtg atttctgcct
     1261 caattagctc aaatccaccc acattatatg aacttgaaaa aattacattt acactaagtc
     1321 atgtaaagct ctcagataag caccggaccc agtgtgcctt ttggaactac tcagttgatg
     1381 ccatgaacaa tggcagctgg tcaacggagg gctgtgagct gacacactca aacgacaccc
     1441 acacctcctg ccgctgtagt cacctgacac actttgcgat tttgatgtcc tctacttctt
     1501 ccattgggat taaggattat aatatcctga cgaggatcac tcaactcggg ataatcatct
     1561 ccctgatctg cctcgccatc tgcatcttca ccttctggtt cttcagtgaa atccaaagca
     1621 ccaggaccac gattcacaag aacctgtgct gcagcctctt tcttgcagaa cttgtttttc
     1681 ttattgggat caacataaat acgaataagt tggtctgctc tatcattgct ggcctgctcc
     1741 attacttctt cttagctgcc tttgcctgga tgtgcatcga aggcattcac ctatacctca
     1801 tcgttgtcgg cgtcatctac aacaaggggt ttttacacaa gaacttttat atctttggct
     1861 atctcagccc agctgtagtt gttggattct cagcatcttt aggatacaga tattatggaa
     1921 ccacgaaagt atgttggctg agcactgaaa acaacttcat ttggagcttt ataggaccag
     1981 cgtgtctaat cattcttgtg aatctcttgg cttttggagt tatcatatac aaagttttcc
     2041 gccacactgc tggactgaaa ccagaagtta gttgctatga gaacataagg tcttgtgcca
     2101 gaggtgccct agccctcctc ttccttctgg gtaccacctg gatctttggg gttctccatg
     2161 tagtgcatgc atctgttgtg acagcctacc tcttcacagt cagcaatgct ttccaaggga
     2221 tgttcatttt cttattccta tgcgttttgt ctagaaagat tcaagaggaa tattatagat
     2281 tgttcaaaaa tgtcccctgc tgctttggat gtttaagata aacaatgaga agtcatgata
     2341 attacagctg caatgagatg aaaattccaa gattcagata acctgtgtgg caaaaaatga
     2401 gcctgttttt attgttagta attaatttca aatccatttt tctgttcaca gtataagaga
     2461 tgtagttaat gtgagataaa attatggacc agagagctac agtgtgtttt cttacatgac
     2521 atagttagag atatgtcaaa aatagtactg cagatatttg gaaagtaatt ggtttctctg
     2581 gagtgatatc actgtgccca aggaaagatt tctttctaac acgagaaata tatgaatgtc
     2641 ctcaaggaaa ccactggctt gatatctttg tgactcatgt tgcctttcaa acgagttccc
     2701 taccacctta gtaatgagtt cctttgcagg aaggagagca taagagacgt ggaggggcag
     2761 agtatgaagc agtgacgaag gcttctctga caaggaattg tcattccaat aaactcagct
     2821 tctctaaact tgatgagaaa atctcaagat aaaataacga gaaaggaaat atatcctagc
     2881 agtttgggaa ttggtctgaa gtaaaaagcc ccagatctaa atttgctaca tccatgttct
     2941 tccttactct tctaaaacca gagaaaagcc ttacaactga cattatcaga gatggatgct
     3001 cttacactaa cattagattt gagtgtaaaa tgttttcatt ccacacagat taagacttca
     3061 aatatgtagt cagtaaaaca tagatttgtc aaagtataat actgtttatg tctttagtga
     3121 aaagaatgtg tgcagtattt tgtctataat attttactgt tatgaaaatt accttttaat
     3181 attaaatcag tatacttgaa tactttgctg tttttaatct tacaaatagt gtaattcatg
     3241 ttgcaacagg cccttttaat tgactgtaca taaaaggtca ttataaattt aaagtattga
     3301 tgaagtgaat tataattctt ttctgatcag aaaatacaca attaaagcat tatttataac
     3361 aaataagaag tcactgagtg ctgtaggggt ttcacagtgg gtctagtttt agactgtttc
     3421 tactatctct caaagtctat tggctcaaat gtatggctct atctattctc ttgttcaaat
     3481 gaagaggcag attttttttc agaagtgagt cattgttctg aaccttcctg aaagcataat
     3541 tcaatctact ggacattgca attttaattc ttgtgctgtt gaatgaagcc tgtcgagacc
     3601 tctcctgaaa aatgaacagt cagctggatg aagcagccct atcgctgcct gaccgagttg
     3661 ttctctcagg agagaccact cacctgtcaa gaagggcttt gcatttctag agcctgtgag
     3721 atggtacact ttgactaaat ctctggattt cttctgtgct aagtctgtgg cccatgactg
     3781 ccattgtcat tctgggttgg gactgtagaa ataggatatc aaaacctagt ctgctcaatc
     3841 agtggatatg aaactattgc acgtggtaga cagagtgacc ctccacaaat atctgtacgc
     3901 tcctcttcag agcctgtggc tgtggtggat ggcgaggagc aggagggccc tgtggggagg
     3961 gagggtagct gacctccact cagttggagc actctcacta ccctgaggga agtcagcatg
     4021 ctgctgatgt atttcagtgt gggtctcctg gtttggaact ctcatttcta gagctacaag
     4081 acaataaaat tctattatca aagcca
//
