LOCUS       NM_001359828           12538 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus adhesion G protein-coupled receptor L3 (Adgrl3),
            transcript variant 7, mRNA.
ACCESSION   NM_001359828 XM_011249466
VERSION     NM_001359828.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12538)
  AUTHORS   Garbett,K., Tosun,B., Lopez,J.M., Smith,C.M., Honkanen,K. and
            Sando,R.C.
  TITLE     Synaptic Galpha12/13 signaling establishes hippocampal PV
            inhibitory circuits
  JOURNAL   Proc Natl Acad Sci U S A 121 (52), e2407828121 (2024)
   PUBMED   39693341
REFERENCE   2  (bases 1 to 12538)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12538)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 12538)
  AUTHORS   Wang,S., DeLeon,C., Sun,W., Quake,S.R., Roth,B.L. and Sudhof,T.C.
  TITLE     Alternative splicing of latrophilin-3 controls synapse formation
  JOURNAL   Nature 626 (7997), 128-135 (2024)
   PUBMED   38233523
  REMARK    GeneRIF: Alternative splicing of latrophilin-3 controls synapse
            formation.
REFERENCE   5  (bases 1 to 12538)
  AUTHORS   Perry-Hauser,N.A., VanDyck,M.W., Lee,K.H., Shi,L. and Javitch,J.A.
  TITLE     Disentangling autoproteolytic cleavage from tethered
            agonist-dependent activation of the adhesion receptor ADGRL3
  JOURNAL   J Biol Chem 298 (12), 102594 (2022)
   PUBMED   36244455
  REMARK    GeneRIF: Disentangling autoproteolytic cleavage from tethered
            agonist-dependent activation of the adhesion receptor ADGRL3.
REFERENCE   6  (bases 1 to 12538)
  AUTHORS   Wallis,D., Hill,D.S., Mendez,I.A., Abbott,L.C., Finnell,R.H.,
            Wellman,P.J. and Setlow,B.
  TITLE     Initial characterization of mice null for Lphn3, a gene implicated
            in ADHD and addiction
  JOURNAL   Brain Res 1463, 85-92 (2012)
   PUBMED   22575564
  REMARK    GeneRIF: Null mutant Lphn3 mice had a hyperactive phenotype in the
            open field test, independent of sex, and were more sensitive to
            locomotor stimulation.
REFERENCE   7  (bases 1 to 12538)
  AUTHORS   O'Sullivan,M.L., de Wit,J., Savas,J.N., Comoletti,D., Otto-Hitt,S.,
            Yates,J.R. 3rd and Ghosh,A.
  TITLE     FLRT proteins are endogenous latrophilin ligands and regulate
            excitatory synapse development
  JOURNAL   Neuron 73 (5), 903-910 (2012)
   PUBMED   22405201
REFERENCE   8  (bases 1 to 12538)
  AUTHORS   Krawchuk,D. and Kania,A.
  TITLE     Identification of genes controlled by LMX1B in the developing mouse
            limb bud
  JOURNAL   Dev Dyn 237 (4), 1183-1192 (2008)
   PUBMED   18351676
REFERENCE   9  (bases 1 to 12538)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 12538)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114425.14, AC114622.12, AC124825.8, AC122054.2, AC121837.2,
            AC102517.7, AC104196.8 and AC155075.10.
            
            On Jan 18, 2018 this sequence version replaced XM_011249466.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.222964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-594               AC114425.14        41161-41754         c
            595-625             AC114622.12        113013-113043       c
            626-691             AC124825.8         35017-35082
            692-900             AC124825.8         147322-147530
            901-1104            AC124825.8         167208-167411
            1105-1318           AC122054.2         55198-55411
            1319-1428           AC121837.2         97674-97783
            1429-1443           AC121837.2         142203-142217
            1444-2244           AC121837.2         144463-145263
            2245-2325           AC102517.7         87206-87286         c
            2326-2628           AC102517.7         1437-1739           c
            2629-2732           AC104196.8         151471-151574       c
            2733-2918           AC104196.8         139756-139941       c
            2919-2957           AC104196.8         136779-136817       c
            2958-3141           AC104196.8         111511-111694       c
            3142-3264           AC104196.8         110516-110638       c
            3265-3473           AC104196.8         106502-106710       c
            3474-3650           AC104196.8         105576-105752       c
            3651-3860           AC104196.8         75932-76141         c
            3861-4081           AC104196.8         73314-73534         c
            4082-4148           AC104196.8         61110-61176         c
            4149-4240           AC104196.8         59057-59148         c
            4241-4267           AC104196.8         42191-42217         c
            4268-4436           AC104196.8         39408-39576         c
            4437-4562           AC104196.8         33940-34065         c
            4563-4659           AC104196.8         28523-28619         c
            4660-10598          AC104196.8         1-5939              c
            10599-12538         AC155075.10        70378-72317
FEATURES             Location/Qualifiers
     source          1..12538
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 42.62 cM"
     gene            1..12538
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /note="adhesion G protein-coupled receptor L3"
                     /db_xref="GeneID:319387"
                     /db_xref="MGI:MGI:2441950"
     exon            1..594
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            595..625
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            626..691
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            692..900
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     CDS             846..5459
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /note="isoform 7 precursor is encoded by transcript
                     variant 7; latrophilin-3; G protein coupled receptor Lec3;
                     calcium-independent alpha-latrotoxin receptor homolog 3;
                     lectomedin-3"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L3 isoform 7
                     precursor"
                     /protein_id="NP_001346757.1"
                     /db_xref="GeneID:319387"
                     /db_xref="MGI:MGI:2441950"
                     /translation="MWPPQLLILTMLLAPVVHGGKHNERHPALAAPLRHAERSPGGAL
                     PPRHLLQQPAAERSTAHRGQGPRGAARGVRGPGAPGAQIAAQAFSRAPIPMAVVRREL
                     SCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCN
                     NRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFE
                     SDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDG
                     TGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLA
                     VDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVK
                     SVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNY
                     HVVKYSLDFGPLDSRSGPVHHGQVSYISPPIHLDSELERPPVRGISTTGSLGMGSTTT
                     STTLRTTTWNIGRSTTASLPGRRNRSTSTPSPAVEVLDDVTTHLPSAASQIPAMEESC
                     EAVEAREIMWFKTRQGQVAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVN
                     HITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGK
                     DSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDT
                     VEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFPENMGHGSTIQLSAN
                     TLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINK
                     EFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTH
                     TTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRG
                     LQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEG
                     VQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYF
                     IWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIG
                     AIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGK
                     CLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGD
                     INSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIAGGEYLSNCVQIIDRGYNHNE
                     TALEKKILKELTSNYIPSYLNNHERSSEQNRNMMNKLVNNLGSGSEDDAIVLDDAASF
                     NHEESLGLELIHEESDAPLLPPRVYSTDNHQPHHYSRRRFPQDHSESFFPLLTDEHTE
                     DLQSPHRDSLYTSMPALAGVPAADSVTTSTQTEAAAAKGGDAEDVYYKSMPNLGSRNH
                     VHPLHAYYQLGRGSSDGFIVPPNKDGASPEGTSKGPAHLVTSL"
     exon            901..1104
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1318
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1428
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1443
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..2244
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2325
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2628
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2732
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2918
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..2957
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3141
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3264
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3473
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3650
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3860
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4081
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4148
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4240
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4241..4267
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4268..4436
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4562
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4659
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     exon            4660..12538
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7009..7014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /note="hexamer: AATAAA"
     polyA_site      7031
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /note="major polyA site"
     regulatory      7845..7850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
                     /note="hexamer: AATAAA"
     polyA_site      7870
                     /gene="Adgrl3"
                     /gene_synonym="5430402I23Rik; CIRL-3; D130075K09Rik;
                     Gm1379; LEC3; Lphn3; mKIAA0768"
ORIGIN      
        1 ggtggaagat ttttggtctc ctcagcagct gcttttcttg cggcggcggc ggcggcggcg
       61 gctgcaggag gagggaaagc agctctggtt atgactgccg catgttaata gctcccgctt
      121 gggtccaccg gctgcagcga gagacacagc ctgactccga agttgtgcaa ctgtgccctg
      181 agagagacat ttgaaccctc cttctctttg ctccgctttt gcccccctgg ggcgtgtgaa
      241 gcgaggaaac gtaaaggaag actagcattg gctttcccgg cttccccttt ctccatggct
      301 gtgtagaaga agaaaggaaa agagacactt tttgttgttt ctttgactgg ggtctccacc
      361 ctcctgtcgt ctctgcggtt tgatcagtcg ttgcttggtg tgactggggt gtctacagtg
      421 ggacaggtcc atcttttttc tgttttcttt ttctttcttc ttcttttttt atttcttctt
      481 tttttgtgtg tgtgtgtgcc ccggggctca atggatggat tgtggaaaac tgcaccgggt
      541 tgcaggttgt tgagcaactg atgggaccat ctcagggacc ggcggttacg aaagatgctg
      601 atttgaagaa ctgccctgaa aactgaaatg attaattcag aaaggcagaa gacaaagcta
      661 tggattttta gcagtcacag aacaaattaa ggtgtctcaa gtgggatatc agtgtttatt
      721 tttgaggaat ttttctttct gtttgtgttt ggtttttaat cattgatatt ggagtactga
      781 agaggagcca gaagtctatt gatttggttt cacttcagac cagccattcc tccgagaaca
      841 cagtcatgtg gccaccacag ctactcatcc tcacgatgct tttagcacct gtagttcatg
      901 gtggcaagca caatgagaga catccagccc tcgctgctcc actgcgacac gctgagcgca
      961 gcccaggagg cgctctccct cccagacatc tccttcagca gccagcggca gagcgctcaa
     1021 cggctcatcg aggacagggg ccacgcggag ctgccagagg agtccgtgga ccaggtgccc
     1081 caggagcaca gattgcagcc caagctttca gccgcgcccc aattcccatg gcagtggtcc
     1141 gcagagagct ctcctgtgag agctacccca ttgagctccg ttgtccgggc acagacgtca
     1201 tcatgatcga gagcgccaac tacgggagga ccgatgacaa gatctgtgac tcggaccctg
     1261 ctcagatgga gaacattcgg tgttatctgc cagatgccta taagattatg tctcaaagat
     1321 gcaataacag aacccagtgt gcagtggtgg caggtcctga tgtatttcca gacccatgtc
     1381 cgggaacata taaatacctt gaagtgcagt atgaatgtgt cccttataaa gtggaacaaa
     1441 aagtttttct ttgtcctgga ctgctaaaag gagtgtacca gagtgaacac ttgtttgaat
     1501 ctgaccacca atctggggca tggtgcaagg accctctaca ggcttctgac aagatttact
     1561 atatgccctg gactccctac agaactgaca ccctgacaga gtattcgtcc aaagatgact
     1621 tcattgctgg aaggccaaca actacctaca agctccctca cagagtggat ggcactggat
     1681 ttgtagtata cgatggtgcc ctcttcttca acaaggagcg gacaaggaac attgtaaagt
     1741 ttgatttgag gactaggata aagagtggag aggcaatcat agcaaatgct aattaccatg
     1801 acacctcccc ataccgatgg ggtggcaagt ccgacataga cttggcagtg gatgaaaatg
     1861 gattatgggt aatctatgca acagaacaga acaatggcaa gattgtcatt agccagttga
     1921 acccttacac cctacggatt gaggggacat gggacactgc ctatgataaa aggtcagctt
     1981 ccaatgcatt catgatttgt gggattctgt atgtggtcaa atctgtatat gaggatgatg
     2041 acaacgaggc caccggtaat aagattgact acatttacaa cactgaccaa agcaaggata
     2101 gcttggtgga tgtacccttt cccaactctt accagtacat agcagctgtg gattacaatc
     2161 ccagggacaa tctgctctat gtgtggaata actaccacgt tgtgaaatac tctttggact
     2221 tcgggcctct ggatagtaga tcagggccgg tacatcatgg acaagtctcc tacatctctc
     2281 caccaattca cctcgactct gaactagaaa ggccccctgt cagagggatt tctaccacag
     2341 gatccctggg tatgggaagc acgaccacca gcaccaccct ccggaccaca acctggaaca
     2401 taggcaggag taccaccgca tccttgccgg gcagaagaaa ccgcagtacc agcacgccat
     2461 cccccgcggt agaggtgctg gatgacgtca ccacacacct gccctcggca gcctcccaaa
     2521 tcccagctat ggaagagagc tgcgaggctg tggaagcccg agaaatcatg tggtttaaga
     2581 ccagacaggg gcaggtagca aagcagccat gcccagcagg aaccataggt gtatcaactt
     2641 acctatgtct tgctcctgat ggaatatggg acccccaagg accagatctc agcaactgct
     2701 cttctccttg ggtcaatcac ataacacaga agctgaaatc cggagaaaca gctgccaata
     2761 ttgccagaga gctagcagaa cagacaagaa atcacttgaa cgctggggac atcacctact
     2821 ctgtccgtgc catggaccag ctggttggcc tcttggatgt ccagctcagg aatttgacac
     2881 cagggggaaa agacagcgca gcccgcagct tgaacaagct tcagaaaaga gagcgctctt
     2941 gcagagccta tgtccaggcg atggtggaga cagttaacaa cctccttcag ccacaagctt
     3001 tgaatgcctg gagagacctg acgacaagtg atcaactgcg tgcggccacc atgttgcttg
     3061 acactgtgga ggagagcgct ttcgtgttag ctgataacct tttgaagacc gacattgtca
     3121 gggagaatac agacaatatt cagttagaag ttgcaagact gagcacggaa ggaaacctag
     3181 aagatctaaa attcccagag aacatgggcc acggaagtac catccagctc tcagcaaaca
     3241 cattaaagca aaatggccgg aatggagaga ttagagtggc ttttgtcctg tataataacc
     3301 tgggtcctta tttgtctacg gagaatgcca gtatgaagtt gggcacagaa gctatgtcca
     3361 caaatcactc ggttatcgtc aattcccctg ttattacagc agcaataaat aaggaattca
     3421 gtaataaagt gtatttggct gatcctgtgg tatttactgt taaacacatc aagcagtcag
     3481 aagaaaattt caaccctaac tgttcatttt ggagctattc caagcgcaca atgacaggtt
     3541 attggtcaac acaaggctgt cgactcctga caaccaacaa gacacatact acatgctcct
     3601 gtaaccacct caccaacttt gcagtattga tggcacatgt ggaagttaag cacagcgatg
     3661 cagtccacga tcttcttctg gatgtgatca cgtgggttgg catcttgctg tcccttgtct
     3721 gtctcctgat ttgcatcttc acattctgct tcttccgggg actccagagt gaccgcaaca
     3781 ccattcacaa gaacctctgc atcagcctgt tcgtggcaga actgctcttc ctgattggaa
     3841 tcaacagaac cgaccaacca attgcctgtg cagtgttcgc ggctcttttg catttcttct
     3901 tcttggcggc cttcacctgg atgtttctag aaggggtgca gctgtatatc atgctggtgg
     3961 aggtctttga gagcgagcat tcccgtagga agtactttta tctggtcggc tatgggatgc
     4021 ccgcgctcat cgtggccgtt tctgcggccg tcgactacag gagctacgga acagacaaag
     4081 tatgttggct tcgccttgac acctacttca tttggagttt tataggaccg gcgaccttga
     4141 taattatgct gaatgtcatc ttccttggga ttgctttata caaaatgttt caccatactg
     4201 ccatactgaa acctgaatca ggctgtcttg acaatatcaa ctatgaggat aacagaccct
     4261 tcatcaagtc atgggttata ggtgcaatag ctctgctctg cctgttagga ttgacctggg
     4321 cctttggact catgtatatt aatgaaagca cagtcatcat ggcgtatctc ttcaccattt
     4381 tcaattctct acagggaatg tttatattca ttttccactg tgttctacag aagaaggtac
     4441 ggaaagagta tgggaaatgc ctccgcacgc attgctgtag tgggaaaagc acggagagtt
     4501 cgattggctc agggaaaaca tctggttctc gaactccagg acggtactcc acaggctcgc
     4561 agagccggat tcggagaatg tggaatgaca ctgtccgaaa gcagtcagag tcgtccttca
     4621 tcaccggaga cataaacagc tcagcatcgc tcaacagaga ggggcttctg aacaatgcca
     4681 gggatacaag tgtcatggat actctaccac tgaatggtaa ccatggcaac agttacagca
     4741 ttgctggcgg cgaatacctg agcaactgtg tgcaaattat agaccgtggc tataaccaca
     4801 acgagaccgc cctagagaaa aagatcctaa aggaactcac ttccaactat atcccttcat
     4861 acctgaacaa ccacgagcgc tccagcgaac agaaccggaa tatgatgaac aaactggtga
     4921 acaacttagg cagcgggagt gaagatgacg ccatcgtcct ggatgacgcc gcgtccttta
     4981 accacgagga gagtctgggc ctggaactca ttcacgagga atccgatgct cccttgctgc
     5041 ccccgagggt ttactccacg gataaccacc agccacacca ttacagcagg aggcggttcc
     5101 cccaggacca cagcgagagc ttcttccctc tgctaaccga cgagcacaca gaagacctgc
     5161 agtcaccgca cagggactct ctgtacacca gcatgccagc cctggccggc gtgcccgctg
     5221 cagacagtgt gaccaccagc acccagaccg aagccgcagc ggccaagggt ggtgacgccg
     5281 aagatgttta ctacaaaagc atgccaaacc tgggctccag aaaccacgtg cacccgctgc
     5341 acgcctacta ccagctgggg cgcggcagca gcgacggatt catagttcct cctaacaaag
     5401 atggggcctc tccggagggg acttccaaag gacccgcgca cttggtcact agtctataga
     5461 agatgacacg gggatggcaa ccaacaggac tgctaacacc tggtggacca ttctgagtcg
     5521 atagaagcag tggtcatcgt gtgtactccg acatctgatg ctgttctcga aagagagact
     5581 ctctgacaat ttttttttaa cttgaatttt taggtcagcc caggggagaa agctaactgc
     5641 tgagctcctc ctgtgcccca atctttccca gtcctttccc ctcagatgga gacttcatta
     5701 tgttaatgaa cgagataaga agaaaatggc gctcattgtg gccttgttga gttatgttgt
     5761 gtttgtttaa catctctgat gctctgttac tagaattaca aggacctgat ttttttgttt
     5821 ctttgttttt tttaaaaaaa acaaaaacag aggccagaac tattgtttga aattagtaac
     5881 aatgctgcat ctagattgga gtgctgccca gccatagaag cagagctgaa cagtatcaca
     5941 tagcgattca tggtcactcg caacctgagt tcaccacagc gggaatagct gtgagaaaca
     6001 caagcaaaac aacaaaatta ataatctgac ggaggggaat tctagaatta tatgctaaat
     6061 gcatatttta tgatttgctg tattaactga tgataaaact aatggcagaa aacaaattga
     6121 acaatttcta tgtaatgtac agatactagc attgcgcata tagtctgctt tctgttcctc
     6181 cagaatttga gtcctgttaa tgtagtggca aagaagaaag tttctttttc ttttgtgtta
     6241 gtcttgcaag tttgtctacc agtaaaagag caaagtttcc ttcctttctt gttttctttt
     6301 tattttttct tttgttccct cttccctccc accttttttt ttctttaaaa attcacctgg
     6361 caaaaaaata ataataataa ataaatgaag ctatcacttt ataagaatca ttttctagta
     6421 atgcaaacaa attatttttt aacaaaaaaa taaaataaaa taaataaaat tagacttcct
     6481 tccctcgcta tatatctatc tttatccagc ccgagtattt ccaacgtcat tttgcaaatt
     6541 agaacaggac aaattttatg tttccggggc acatatgttg tattgcaaag catatttggc
     6601 aagcagttca tcaccaaggc agtagctatg attctagaag ctaagaggtg tctatagagc
     6661 tagacgggct tctgcatgtg aaatgctgta ttccatagga gttaaaagtg ctgactgagc
     6721 agtctgaccc ccacgtgggc acctgcacta ccagttgtta gaggaaattc actccctcct
     6781 agtgagagtt gaaaggtcaa attattttga agacattttt tttttttaaa gttttctgtt
     6841 aacaggaaaa tttatttatt tgacaggatt ttaagtaatg taggaataca aatggtaaat
     6901 tagcagcaca tataattttt tttaaattta tgatccattt tgtatggtct caagttggat
     6961 gacctcatta ctaatatttg ttgtaaaagt gaaacttgtt tgccgaccaa taaacaactg
     7021 attgagattt agaagagatt gctttgacgt atgtactgta ttatcaagtc ctcttttgac
     7081 ttttcttgcc tttccttttc tctgattttc agaatctaaa ctctctttaa cctttgtgac
     7141 ccaagtgagc aacacacaca cacacacaca cacacacaca cacacacaca cacacacaca
     7201 caaacacaca cactatatct gacttgaata tccaaacaca gcatggtaca ggtttttgca
     7261 gacaaactgg accaggaaaa tgggatgggc tgaagccagg tacatagctc ccagtcaagt
     7321 ggaataacaa aggtcctgtg tactttcttc aaacccatct ctcctcacta ggcttttgac
     7381 taaagacagt tatgcagtgg tttaaatatc acatgagatg caatcatctc cctgtcccct
     7441 ttttgtggag aaatttgtaa atttaaattt cctcagttgg ctaagaaatg caatagtaat
     7501 aggaaagagg ttattcattg cacaagaaga gtttaagacc tttaacacca acacagagcg
     7561 ttggtttctt tatggcaacc tcaaacaaaa tttgttgtgt tgattcttgt cctccatccc
     7621 tctgactccc cttctgtggc ctctgacacc tcaccctgtc cctgctgtac ccttcccacc
     7681 ttcatgccac atatgtaaga ctgttttaca ttattttcat cttcttcaat gtttgggggg
     7741 gggggaacgg acaaaaataa ttccttcaaa agaactttct agatcatgct gttcctatac
     7801 gaccagtatc gaaggaacga gtattttcaa ggagccccat gtagaataaa gctcaaatga
     7861 actttccaaa ctgtattttc tcttgtggta tatccttagg cttactttac aaaagcctac
     7921 ccaatagcta tctataaatg atatcttaaa tcaaggtgag aggcgttgag agtcacccat
     7981 agacactata aagtctgtga cagaagaaat tgtgccaggc cagagcaccc atttgttaat
     8041 ctgaaagaat ccatggatca ttccatttta gtcagctggt ggcaatattt tcttgaaatc
     8101 catagacatt ttaatttgga ggagaagcat aagcattaga agtaatcact tttcttactc
     8161 tatgccttga gattttacca atcttaccaa cattactgat aacctatata ctgataacct
     8221 atatttggta attttttttt taaatccctc tgtgggcaaa tctaacgaag cctcagaact
     8281 aaggctctgt ttgcaggctg caggtagttg tgcttggttt aaaaaacagt attcccaagt
     8341 gaaaatatca gtaaaaggtc agcttcatgg aatagtgggg aaacgacttc agttcaggtg
     8401 ttgagttgtc ccatgctcag gcttaactac tttcctatac atggtacttt gtgtttcatt
     8461 acccagaatt tgaaacaggt aaccttcccg tttgttctgg gaacaaactg aagaaagatc
     8521 acttgagtac atatataaaa tcgcatataa ggcctctgca tattgtgtgt taactttgca
     8581 cttgcctcaa gatgaaaggg ccgttgtaga tctctcatat atcagaaacg aagtgcttca
     8641 gaaagtcgag ctgctttgct atgtgactct aattaaacaa aaggaagagt aggtaaagta
     8701 tttaactgtg cgtcacttca gtagaaattt gtgtatccaa ttactcctga ttatagcagc
     8761 tctatgagtt tctgaccctc tcttccacct gacattccat gtaaagaaac tgatccattt
     8821 atgctattca ctttttcttt gttctagaac cttttgtcga ttctaggtgt tcagtaccca
     8881 atggcattca ttgataggct tatttgcata gtttccatga agtaaatttc taccaaacag
     8941 actcactgta catacatggc acattattta gccagttgag aaagtcatgt aaatgaaaca
     9001 agccaattat tgcttcctag taaataatat ttttgtaata ttttacgctt gaagttttta
     9061 cctctttgag gtcttaagta gtgagatact ttgtcagggc actaactaaa ggacctcagg
     9121 tttaatcaat tcttgtattg atggcttgtt gcatagccaa ggttgttaat tatataagta
     9181 aatagaaatt caaagaagaa aattggttgg aattcagtta catttcgtga gcatccttct
     9241 ttgtttttaa cagtaaattt gaacacatgg gaaataaata ctagaatact cttagtgagt
     9301 aaaattaatt ggcaagagaa taatcacaat tatattaaaa taaaaataaa cagcaaaagc
     9361 aaaggcagct aattaagtta atcataattt cctataaaaa aaacccatgg tggttccaaa
     9421 ttaaaacaca gtttatgatc tatgctgttt ttaagaccac ctctacaatt taaaagttaa
     9481 tacactaaaa aaattcttta aaaaattagg cttttaatct tgagtgttaa aagtgtgatg
     9541 aagctctgac ttaaattata actttaaaaa catttgtcag tgacagactg tagttttgta
     9601 agaaggggga agaaagcttt tgtctaacaa gtaactctga actgaattgt atccacgcta
     9661 caggaatgaa gtatttagtt ttttaggttg ttaattaaca ctgtatcaaa ctcccagtac
     9721 ttgagatata ttttgttgga aaacaaaaac caccaataaa acaaacaaaa aaaaaagcca
     9781 ctttaactat aaatgaatgt caacttacat gtaaagtgtc aaaaataaac catctgaatt
     9841 tataatctaa ttttaagtgg gacattggca ttaatgtttt actctaagaa aaataattgg
     9901 tataaaatac tatatacaag cttcccaata tattatattt agaatacaaa gatttaattg
     9961 ctcaggttta gaatatcata atctgtcaca taaacaatta ctatgcattc ctaattagaa
    10021 tctatatatt agatctctgc atgtcaaatt ttaggaagtt gaagacacaa aagggacaca
    10081 agtacacaca aaacagattt ttggaagcat ttttctacaa atgaattcta tgtagaaaaa
    10141 cttttttaga gttcataaaa tagattccaa agactaaact caattttgta atcaggatat
    10201 ttgtgtgtct tataccattt gaaaaatatg gttttagaca tctcaaattt catttataat
    10261 ccaaaagcta tagccagttg ctataggtgt ttgtgtccat agaggacatt tatttaaggc
    10321 aatcatttac ctcgatgata tcatgtttgc tttaaaaggg aaagcggtct ttaaattgtc
    10381 acctgtttat gtgtttacac agtctaattt ttaataagat ttcagaggaa gtaactcttt
    10441 tacaagtttt cacttgtggt attttccaat taggtagttt tgtatattct cattttaagt
    10501 aattacttta gtctttttat ttaaattaca atcattagtt tgcctctagc acttttaagt
    10561 tactattaaa atgtctcagt ccaaatatgt ttttgatcct ttacctgttt taccagtata
    10621 ttgattattc ttctctccat ttatagctct gcacccacac acccttgtag aacatgataa
    10681 aagtaagtgg aaaactgatt tatgtgaatc aaggaacagc tcacagacgc catcttcttt
    10741 taaccagcca ggattttctt aaacatagta tgaatttttt cccaactaca caaaactgac
    10801 attagaattt tagagaaaag ttttagggaa aagtggtgaa atggcttatg ataaaaagct
    10861 gttgtaccta aaactactga tgtattaaaa gatgtaaatt cacatacttt cataatttta
    10921 ataccacaga aaatacaaca tgcttttagc cattcttttg tttgtttgtt tgttttagat
    10981 atttcttacc tggttagatc ttgttgcaca gaaatgtaaa tacttcataa aagtttctaa
    11041 aatgtaagta ttttacatca actcaccttc accttctgat ctgctattga gcaccaacac
    11101 acttaatgct aaccgaggct tttttttttt ttatgaatct ctctagtaaa cattgaattc
    11161 atattagaag tatatgcatt atgcaaaata attgacaacc aatagtctca ttacaaaata
    11221 atttggcatt tatatataaa tgctattgac ctaccaaatg accaccatgc tgacagtcct
    11281 gtcttctacc actggagtca cttcacacaa ttctgcatag agctgtacat attctggact
    11341 gctaaaatat ctaacattac aaagcttcag aatggatccc cagtgcttct tccaaggtag
    11401 aaaagtgaag ggaagatttt gaaggaggaa gtaatccagg cttcgagaga tctgacttag
    11461 tcattgttct tgagacccaa tagtttaatg ttgacgtgct atgatctttg aactaaggag
    11521 gaagttgcaa aaaaaaaaaa tctaattaac ccagaagaat ttagatttgt tttattagcc
    11581 aacactgcaa atattcttat tatgtgaatc agaaatagct tcttaaggta actgtacaaa
    11641 ccttaaaaat tgctttgttt ctgctgttcg aaacagggaa attgctcctg atacccttat
    11701 tgattgactt cagaagatgt ctcacgaaag tagagaatca tgatactgag gagcagtggg
    11761 gttcttcaga gttgtagcac agtggctaga aaagtgtagc cactaatact aaaagccaat
    11821 tatcattata cagtattgct ttcaatgtct caaattccaa ctaatggctg atcatttcac
    11881 tgacattttg aatcacaaag gacaaataaa atcactgaat gctttgtttt cataccccag
    11941 tgaaaagtaa agatatgctt ttccatccta aataataaag aaccgtggtg tcccacagag
    12001 ttgtagatag ctggatgtgt gtgtgtatgt gtgtgtgtgc tttgtagata tgtctctgtc
    12061 atctatgtat tctaacactg atgctaatat tctaacatct aatatttcct ggaaactata
    12121 aattcaaaac cagtagaacc agatttttct ccctcagctt atgtgaacac tttgggacag
    12181 gacagataat tgggaaagtt tttcatattt gtttttcttc ttgacaagat tttcatttaa
    12241 tttaatacat gtctcttaaa aatagtttct tttgaagact aacaactaat cgagctactc
    12301 ctccctgata tgaaaaatca cttttagaag taaatacgta gctattgcaa cattggtctc
    12361 agagaattgc cctaggttca catataaccc tcttctggcc atacacacca ataaatttta
    12421 aggcactgga tccccacttc gctcttgttc aatcctttta tccttttttt ttaatgcttt
    12481 gtacaatcac atgtaaaact atgagctaca aaactcaata aaatatcagt aaacaacc
//
