LOCUS       NM_001081298            6774 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus adhesion G protein-coupled receptor L2 (Adgrl2),
            transcript variant 1, mRNA.
ACCESSION   NM_001081298 XM_888040
VERSION     NM_001081298.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6774)
  AUTHORS   Garbett,K., Tosun,B., Lopez,J.M., Smith,C.M., Honkanen,K. and
            Sando,R.C.
  TITLE     Synaptic Galpha12/13 signaling establishes hippocampal PV
            inhibitory circuits
  JOURNAL   Proc Natl Acad Sci U S A 121 (52), e2407828121 (2024)
   PUBMED   39693341
REFERENCE   2  (bases 1 to 6774)
  AUTHORS   Liakath-Ali,K., Refaee,R. and Sudhof,T.C.
  TITLE     Cartography of teneurin and latrophilin expression reveals
            spatiotemporal axis heterogeneity in the mouse hippocampus during
            development
  JOURNAL   PLoS Biol 22 (5), e3002599 (2024)
   PUBMED   38713721
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6774)
  AUTHORS   Murphy,T.R., Amidon,R.F., Donohue,J.D., Li,L. and Anderson,G.R.
  TITLE     Synaptic cell-adhesion molecule latrophilin-2 is differentially
            directed to dendritic domains of hippocampal neurons
  JOURNAL   iScience 27 (2), 108799 (2024)
   PUBMED   38318388
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6774)
  AUTHORS   Yang,J., Yin,G.N., Kim,D.K., Han,A.R., Lee,D.S., Min,K.W., Fu,Y.,
            Yun,J., Suh,J.K., Ryu,J.K. and Kim,H.M.
  TITLE     Crystal structure of LRG1 and the functional significance of LRG1
            glycan for LPHN2 activation
  JOURNAL   Exp Mol Med 55 (5), 1013-1022 (2023)
   PUBMED   37121976
  REMARK    GeneRIF: Crystal structure of LRG1 and the functional significance
            of LRG1 glycan for LPHN2 activation.
REFERENCE   5  (bases 1 to 6774)
  AUTHORS   Lee,C.S., Cho,H.J., Lee,J.W., Son,H.J., Lee,J., Kang,M. and
            Kim,H.S.
  TITLE     The G Protein-Coupled Receptor Latrophilin-2, A Marker for Heart
            Development, Induces Myocardial Repair After Infarction
  JOURNAL   Stem Cells Transl Med 11 (3), 332-342 (2022)
   PUBMED   35356977
  REMARK    GeneRIF: The G Protein-Coupled Receptor Latrophilin-2, A Marker for
            Heart Development, Induces Myocardial Repair After Infarction.
REFERENCE   6  (bases 1 to 6774)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   7  (bases 1 to 6774)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   8  (bases 1 to 6774)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   9  (bases 1 to 6774)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 6774)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138591.10, AC114679.10 and AC113315.8.
            
            On May 9, 2022 this sequence version replaced NM_001081298.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-891               AC138591.10        89729-90619
            892-1064            AC138591.10        124474-124646
            1065-1278           AC114679.10        107008-107221       c
            1279-1388           AC114679.10        82196-82305         c
            1389-1400           AC114679.10        77023-77034         c
            1401-2201           AC114679.10        75329-76129         c
            2202-2495           AC114679.10        69163-69456         c
            2496-2599           AC114679.10        68491-68594         c
            2600-2785           AC114679.10        67432-67617         c
            2786-2824           AC114679.10        66362-66400         c
            2825-3008           AC114679.10        63445-63628         c
            3009-3134           AC113315.8         186532-186657       c
            3135-3340           AC113315.8         185996-186201       c
            3341-3514           AC113315.8         184451-184624       c
            3515-3724           AC113315.8         183239-183448       c
            3725-3945           AC113315.8         182191-182411       c
            3946-4012           AC113315.8         180749-180815       c
            4013-4104           AC113315.8         175364-175455       c
            4105-4149           AC113315.8         174428-174472       c
            4150-4176           AC113315.8         174099-174125       c
            4177-4345           AC113315.8         173252-173420       c
            4346-4474           AC113315.8         170583-170711       c
            4475-4571           AC113315.8         169842-169938       c
            4572-4700           AC113315.8         168167-168295       c
            4701-6774           AC113315.8         162742-164815       c
FEATURES             Location/Qualifiers
     source          1..6774
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 74.1 cM"
     gene            1..6774
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /note="adhesion G protein-coupled receptor L2"
                     /db_xref="GeneID:99633"
                     /db_xref="MGI:MGI:2139714"
     exon            1..891
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1064
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     CDS             992..5455
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; latrophilin 1; calcium-independent
                     alpha-latrotoxin receptor homolog 2; latrophilin-2;
                     calcium-independent alpha-latrotoxin receptor 2; G protein
                     coupled receptor Lec1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor L2 isoform 1
                     precursor"
                     /protein_id="NP_001074767.1"
                     /db_xref="CCDS:CCDS80059.1"
                     /db_xref="GeneID:99633"
                     /db_xref="MGI:MGI:2139714"
                     /translation="MVSSGCRMRSLWFIIIISFSPSTEGFSRAALPFGLVRRELSCEG
                     YSIDLRCPGSDVIMIESANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQ
                     CIVVTGSDVFPDPCPGTYKYLEVQYECVPYMEQKVFVCPGTLKAIVDSPCIYEAEQKS
                     GAWCKDPLQAADKIYFMPWTPYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVV
                     YDGAVFFNKERTRNIVKFDLRTRIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENG
                     LWVIYATEQNNGMIVISQLNPYTLRFEATWETAYDKRAASNAFMICGVLYVVRSVYQD
                     NESEAGKNTIDYIYNTRLSRGEYVDVPFPNQYQYIAAVDYNPRDNQLYVWNNNFILRY
                     SLEFGPPDPAQVPTTAVTITSSAELFKTTISTTSSASQRGPVSSTAAGPQDGSRGTKP
                     PPAVSTTKIPPVTNIFPLPERFCEALDWKGIKWPQTQRGMMVERPCPKGTRGTASYLC
                     MASTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAASLANELAKHTKGHVFAGDVSSS
                     VRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREKTCRAYLKAIVDTVDNLLRAE
                     ALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTRVSMPTENIVLEVAVLSTE
                     GQVQDFKFPLGLKGLGSSIQLSANTVKQNSRNGLAKLVFIIYRSLGQFLSTENATIKL
                     GADLMGRNSTIAVNSPVISVSINKESSRVYLTDPVLFTLPHIDPDNYFNANCSFWNYS
                     ERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHHLLLTVITW
                     VGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYTIAC
                     PVFAGLLHFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVGVS
                     AAIDYKSYGTVQACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKPD
                     SSRLENINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFALLCLLGLTWSFGLLFVNE
                     ETVVMAYLFTAFNAFQGLFIFIFHCALQKKVRKEYGKCFRHWYCCGGLPTESPHSSVK
                     ASTTRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNP
                     LLRPHGTNNPYNTLLAETVVCNAPSAPAFNSPGHSLNNARDTSAMDTLPLNGNFNNSY
                     SLRKADYHDGVQVVDCGLSLNDTAFEKMIISELVHNNLRGGNKTHNLELKLPVKPVIG
                     GSSSEDDAIVADASSLMHGDNPGLEFRHKELEAPLIPQRTHSLLYQPQKKVKPEATDS
                     YVSQLTAEADDHLQSPNRDSLYTSMPNLRDSPYPESSPDMAEDLSPSRRSENEDIYYK
                     SMPNLGAGRHLHMCYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL"
     exon            1065..1278
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1388
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1400
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..2201
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2495
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2599
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2785
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2824
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3008
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3134
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3340
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3514
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3724
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3945
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4012
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4013..4104
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4149
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4176
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4177..4345
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4346..4474
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4571
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4572..4700
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..6774
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6751..6756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /note="hexamer: AATAAA"
     polyA_site      6774
                     /gene="Adgrl2"
                     /gene_synonym="CIRL-2; Gm619; Lec1; Lphh1; Lphn2;
                     mKIAA0786"
                     /note="major polyA site"
ORIGIN      
        1 actctctccc ggctcacaca cgctcacaca cactcgcact cacaggcaca cacacttgca
       61 cacacacaca cacacacgcg cgcgcgcacc cgcacgcaga ggtgcccgag cgccatcggg
      121 agcttaccgg aggattctta gcgattgttg aggggaccgg cctccctccg cggctgtgca
      181 gcggcgctgc tcctcctcgc tcctcccgtc gctctccccg aacccgagtt cctcacctcc
      241 tgcatccgcc gggcgccccc tctcccgccc cccagcccgg gagacccgac atgtgaggaa
      301 gggctggcgg cagagtcgtg ccccaggccg caggggcggc gcgtgcgccg gatgcaggtc
      361 ctgccgccgc tgcccgcgcg caccgggctc ctccggactg actgacggac ttggcctcgc
      421 tccccggcgg ccgtactccc gccgcggcta ggggactccg gagtcggcgc acctccgcca
      481 gccttgctct ctcatccccc gcatcttttg gttttgattt ttgatttttt tttccggctc
      541 cggagggagc gtgcagcggt aggcgcgcgc gtgtgtgggc aaagccccca gggtcgcgga
      601 acggcgtgtg ggaaactgcg ggaagatgtt gacttagccc cccggcagcc gcccgggccg
      661 ctgggctgct tggctggact cggcggctga cggcggtgga gactcgagtc ggaggacacg
      721 ccgaagagcc gcgcggcgcc gtgtccggcc cgccagccgc cgcctccccg cgcgcgctca
      781 gccagcagga gcaccccgcg ccggtcgcct cggcccttcc ttcgcgcccg tgtccccgcg
      841 cggctccccg cgccagattg gccctccccc ggggcgcgct cgcacaccga gatatgagga
      901 tcaatgatgc agactgctgg gttcgatgaa gctgggcatt tataactaga ttcattaagg
      961 aatacaaaga aaatatttaa agggatcaat aatggtgtct tctggctgca gaatgcgaag
     1021 tctgtggttt atcattataa tcagtttctc accgagtaca gaaggtttca gcagagcagc
     1081 cttaccattc gggttagtta gacgagagct atcctgtgag ggttattcta tagacctgcg
     1141 atgtccgggc agtgacgtca tcatgatcga gagtgcgaac tacggtcgga cggacgacaa
     1201 gatctgcgat gcagacccct ttcaaatgga gaacacagac tgctacctcc ctgatgcctt
     1261 caaaatcatg actcaaaggt gcaacaatcg aacacagtgt atagtagtta ccgggtcaga
     1321 tgtatttcct gatccatgtc ccggaactta caaatacctt gaagttcaat atgaatgtgt
     1381 cccttacatg gagcaaaaag tctttgtgtg tcctggaacc ttgaaagcaa ttgtggactc
     1441 accatgtata tatgaagctg agcagaagtc aggggcttgg tgcaaggacc cccttcaggc
     1501 tgcagataaa atttatttta tgccctggac tccctaccgc accgatacgt taatagaata
     1561 tgcctcttta gaagattttc aaaacagccg ccagacaaca acatacaaac ttccaaaccg
     1621 agtagacggt actggatttg tggtgtatga tggagccgtc ttctttaaca aggaaagaac
     1681 cagaaacatt gttaagtttg acttgaggac tagaatcaag agcggcgagg ctatcatcaa
     1741 ctatgccaac taccacgata cgtcacccta cagatggggt gggaagacag acattgacct
     1801 cgcagtggat gagaacggct tatgggtcat ttatgccacg gagcagaaca atggaatgat
     1861 cgtgatcagc cagctcaacc cttacactct tcgattcgag gcaacctggg agacagcgta
     1921 tgacaagcgt gcggcgtcca atgctttcat gatatgtggg gttctctatg tggtcaggtc
     1981 agtgtaccaa gacaatgaaa gcgaagcagg caagaacacc attgactaca tctacaacac
     2041 gcgactaagc cggggcgagt acgtggacgt tccttttccc aaccagtacc agtatattgc
     2101 tgcagtggat tataatccaa gagacaacca actctacgta tggaacaata acttcatttt
     2161 acggtattcc ctggagtttg gtcctcctga ccctgcccaa gtgcctacca cagctgtgac
     2221 aataacttct tcagctgagc tgttcaaaac cacaatatcc accacgagca gtgcctccca
     2281 gcgaggcccc gtgagcagca ctgcagctgg tcctcaggac ggaagcagag ggacaaagcc
     2341 acctccagcc gtctctacaa ccaaaattcc tcctgtaaca aatatttttc ccctgccaga
     2401 gagattctgc gaagcgttag actggaaggg gataaagtgg cctcagacac aaagggggat
     2461 gatggttgag cgaccctgtc ccaagggaac aagagggacg gcctcgtatc tgtgcatggc
     2521 ttccacggga acatggaacc cgaagggccc tgatcttagc aactgcacgt ctcactgggt
     2581 gaaccagctg gcccagaaga tcagaagtgg agagaatgct gcgagcctgg ccaatgaact
     2641 agctaagcac accaaggggc atgtgtttgc aggggacgtg agctcctctg tgaggctgat
     2701 ggaacagttg gtggacatcc tggatgctca gctgcaggag ctgaagccga gtgagaagga
     2761 ttcggctggg aggagctata acaagctcca aaaacgagag aagacatgca gggcttacct
     2821 taaggcaatt gtggacacgg tagacaacct tctgagagct gaggctttgg aatcctggaa
     2881 acacatgaat tcttcagagc aggcgcacac agccacaatg ttgttggata ccttggaaga
     2941 aggagcattc gtcctagcag acaacctttt ggaaccaacc agggtctcca tgccaacaga
     3001 aaatattgtt ttagaagttg ctgtcctcag cacggaaggg caggtccaag actttaaatt
     3061 ccctctgggc ttaaaggggt tgggcagctc catccagctc tctgccaaca cggtcaaaca
     3121 gaacagcagg aatgggctgg ccaagctggt attcatcatt taccggagcc tgggacaatt
     3181 cctaagcact gagaacgcaa ccataaagct gggtgcagac ctcatgggtc ggaacagcac
     3241 cattgcggtg aactctcccg tcatctccgt ctccatcaat aaggagtcca gccgcgtgta
     3301 cctgacagat cccgtgcttt tcacactgcc acacattgat cctgacaatt atttcaatgc
     3361 aaactgctcc ttctggaact actcagagag aaccatgatg ggatattggt ctacccaggg
     3421 ctgcaagctg gttgacacta ataaaactcg cacaacgtgc gcttgcagcc acctaaccaa
     3481 ttttgctatt ctcatggccc acagggaaat tgcgtataaa gatggagtgc accacctgtt
     3541 gctgacagtc atcacctggg tgggcatcgt tgtctccctc gtctgcctgg ctatctgcat
     3601 cttcaccttc tgtttcttcc gagggctaca aagtgaccgc aatactatcc acaagaacct
     3661 ttgtatcaac cttttcattg ctgaatttat ttttctcatc ggcatcgata agacaaaata
     3721 cacgattgca tgccccgtgt tcgcagggct tcttcacttt ttcttcctgg ctgctttttc
     3781 ctggatgtgc ctggaaggtg tgcagctcta cctaatgttg gttgaggttt tcgagagcga
     3841 atattcaagg aagaaatatt actatgtcgc tgggtacctg ttcccggcca cagtggtcgg
     3901 cgtctcagca gccattgact acaagagtta cgggacagtc caggcttgct ggcttcacgt
     3961 tgataactat ttcatatgga gtttcatcgg gcctgttact ttcattattc tgctaaatat
     4021 tattttcctg gtgatcacgc tgtgcaaaat ggtgaaacat tcaaacactc tgaaaccaga
     4081 ttctagcagg ttggaaaaca ttaataatta ccgtgtttgt gatggctact ataatacgga
     4141 cttacctggc tatgaagata ataagccatt tatcaagtct tgggtacttg gcgcgttcgc
     4201 cctgctgtgt ctcctgggcc tcacctggtc ctttgggttg ctttttgtta acgaggagac
     4261 tgttgtcatg gcgtatctct tcaccgcctt taatgctttc cagggactct tcattttcat
     4321 cttccactgt gctcttcaaa agaaagtacg aaaagagtat ggcaagtgct tcagacactg
     4381 gtactgctgt ggcggcctcc cgaccgagag cccgcacagc tctgtgaagg catccaccac
     4441 ccgcaccagt gctcggtact cctctggcac acagagccgt ataagaagga tgtggaatga
     4501 caccgtgagg aagcagtctg aatcgtcttt tatctcaggt gacatcaata gcacttctac
     4561 ccttaaccaa gggatgactg gcaattacct actaacaaac cctcttctcc ggccccacgg
     4621 cactaacaac ccctataaca ccctgctcgc tgaaacagtt gtatgcaatg ccccttcagc
     4681 tcctgcgttt aactcgccag gacattcact gaacaatgcc cgggacacaa gtgccatgga
     4741 tactctaccg ctaaatggta acttcaacaa cagctattcc ctgcgcaagg cggactacca
     4801 cgacggcgtg caggtcgtgg actgtggact aagtctgaac gacaccgcgt ttgagaaaat
     4861 gatcatttca gagttagtgc acaacaacct ccggggcggc aacaaaaccc acaacttgga
     4921 gctcaagctc ccggttaaac cggtgattgg cggcagcagc agtgaagatg acgcgattgt
     4981 ggctgacgcc tcatctttga tgcatggtga caacccaggg ctggagttcc gccacaaaga
     5041 gctggaggcg ccgctcatcc cccagcggac tcactcgctt ctgtaccaac cccagaaaaa
     5101 agtgaagccg gaggcaacag acagctacgt ctcccagctg acggccgagg ccgacgacca
     5161 cctccagtcc cccaacagag actctctgta cacgagcatg cccaacctaa gagactctcc
     5221 ctacccggag agcagcccag acatggcaga ggacctgtct ccctccagga ggagtgagaa
     5281 cgaggacatt tactataaaa gtatgcccaa ccttggagct ggccgccatc tccacatgtg
     5341 ctaccagatc agcaggggca atagcgatgg ttacatcatc cccattaaca aagaagggtg
     5401 catccctgag ggggacgtcc gggaaggaca gatgcagctg gtgacaagtc tttaatagta
     5461 cggctaagga attcctaggg ccacatgcaa gtattaattg atagagacgc tgccagtggg
     5521 gccctgcagc tccctccaac tcggccagaa gactcggctc tgttggccca tggttctcca
     5581 cttgtagtaa aacggatcag actgaacctc acagtcctgt gaatttttat aaaacatgca
     5641 aaaactttgt atatacacag agtatactaa attgaattat ttgttacaaa gaaaaaagaa
     5701 atgccaacca ggtattttac gtttctgctg ctgtgtagag agattgtaaa acaaacaaga
     5761 gaccctccct cccggccatg ttccttgcgg cagttggtga actgagtctg taaatagggc
     5821 cctaccggtt tttgtttttg ttttgttttg tttttctgta ggcctgcatt gtattatata
     5881 caagacgtag gcttcaagat cctgtgggac aaattgactg tatcttactt ttcctgacaa
     5941 gacttggaaa agcaggagag agattctgca cccgtttgca cttccctgca aaccttttac
     6001 attacggcaa caactgaaac catgtcgaac cagtagcaat caagccacag gccttatttc
     6061 atgtcttctc aactgtacaa tgaactattc tcatgaaaaa aaaaatggct aaagaaatta
     6121 tattttgttc tattgctagg gtaaaataaa tacatttgtg tccaactaaa aatatcatta
     6181 aaataatttt aaaagagttt ggagaaaata ttgtgtcgag ctcttggttg cacaaaatag
     6241 gcaaagtttc ttcttccacc catcatggtg acctctgccc atcgttgttg atttcccact
     6301 gtagacggcg tctgctgcgg ccacttagtc ccctttctta catttaaatt tcttattgcc
     6361 aaaagagtgt gttttatggg gagaaaactt tttgaagtcc tgccatgcct tgcacaaatg
     6421 tggggaaatc tggaggtctt gagtcacccc tctgtttatt ctggaacaga gggcgaaggg
     6481 gtcaccgggc acttctcaca gactttctag tgaacaaaag gtgcctattc ttttttaaaa
     6541 aataaaataa aaataaaata aaacagaaat attactcttc catattcctt ctggctatat
     6601 ttagtaatta atttatttta tggtaaagtt ctaatgacat gtaaattgtt tcagcaaagc
     6661 tctgctcttc tttcaagctc tttgtgtaaa gctgttaata acgagcctat tactaatatc
     6721 cagtgtaaag tttaacacgg tttgacagta aataaatgtg aattttttca agta
//
