LOCUS       NM_001002268            6505 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus adhesion G protein-coupled receptor G6 (Adgrg6), mRNA.
ACCESSION   NM_001002268 XM_136924
VERSION     NM_001002268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6505)
  AUTHORS   Bian,F., Hansen,V., Feng,H.C., He,J., Chen,Y., Feng,K.,
            Ebrahimi,B., Gray,R.S., Chai,Y., Wu,C.L. and Liu,Z.
  TITLE     The G protein-coupled receptor ADGRG6 maintains mouse growth plate
            homeostasis through IHH signaling
  JOURNAL   J Bone Miner Res 39 (11), 1644-1658 (2024)
   PUBMED   39236220
REFERENCE   2  (bases 1 to 6505)
  AUTHORS   Kakogiannos,N., Scalise,A.A., Martini,E., Maderna,C.,
            Benvenuto,A.F., D'Antonio,M., Carmignani,L., Magni,S.,
            Gullotta,G.S., Lampugnani,M.G., Iannelli,F., Beznoussenko,G.V.,
            Mironov,A.A., Cerutti,C., Bentley,K., Philippides,A., Zanardi,F.,
            Bacigaluppi,M., Sigismund,S., Bassani,C., Farina,C., Martino,G., De
            Giovanni,M., Dejana,E., Iannacone,M., Inverso,D. and Giannotta,M.
  TITLE     GPR126 is a specifier of blood-brain barrier formation in the mouse
            central nervous system
  JOURNAL   J Clin Invest 134 (15), e165368 (2024)
   PUBMED   39087467
  REMARK    GeneRIF: GPR126 is a specifier of blood-brain barrier formation in
            the mouse central nervous system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6505)
  AUTHORS   Kosters,P., Cazorla-Vazquez,S., Kruger,R., Daniel,C., Vonbrunn,E.,
            Amann,K. and Engel,F.B.
  TITLE     Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression
            Profiling in Diseased Mouse, Rat, and Human Kidneys
  JOURNAL   Cells 13 (10), 874 (2024)
   PUBMED   38786096
  REMARK    GeneRIF: Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6)
            Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6505)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6505)
  AUTHORS   Cazorla-Vazquez,S., Kosters,P., Bertz,S., Pfister,F., Daniel,C.,
            Dedden,M., Zundler,S., Jobst-Schwan,T., Amann,K. and Engel,F.B.
  TITLE     Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish,
            Mouse, and Human Kidney
  JOURNAL   Cells 12 (15), 1988 (2023)
   PUBMED   37566066
  REMARK    GeneRIF: Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in
            Zebrafish, Mouse, and Human Kidney.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6505)
  AUTHORS   Vogl,M.R., Reiprich,S., Kuspert,M., Kosian,T., Schrewe,H.,
            Nave,K.A. and Wegner,M.
  TITLE     Sox10 cooperates with the mediator subunit 12 during terminal
            differentiation of myelinating glia
  JOURNAL   J Neurosci 33 (15), 6679-6690 (2013)
   PUBMED   23575864
REFERENCE   7  (bases 1 to 6505)
  AUTHORS   Monk,K.R., Oshima,K., Jors,S., Heller,S. and Talbot,W.S.
  TITLE     Gpr126 is essential for peripheral nerve development and
            myelination in mammals
  JOURNAL   Development 138 (13), 2673-2680 (2011)
   PUBMED   21613327
  REMARK    GeneRIF: Analysis shows that Gpr126 is required for Schwann cell
            myelination in mammals, and defines new roles for Gpr126 in axonal
            sorting, formation of mature non-myelinating Schwann cells and
            organization of the perineurium.
REFERENCE   8  (bases 1 to 6505)
  AUTHORS   Waller-Evans,H., Promel,S., Langenhan,T., Dixon,J., Zahn,D.,
            Colledge,W.H., Doran,J., Carlton,M.B., Davies,B., Aparicio,S.A.,
            Grosse,J. and Russ,A.P.
  TITLE     The orphan adhesion-GPCR GPR126 is required for embryonic
            development in the mouse
  JOURNAL   PLoS One 5 (11), e14047 (2010)
   PUBMED   21124978
  REMARK    GeneRIF: Data show that GPR126 is required for embryonic viability
            and cardiovascular development.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6505)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 6505)
  AUTHORS   Moriguchi,T., Haraguchi,K., Ueda,N., Okada,M., Furuya,T. and
            Akiyama,T.
  TITLE     DREG, a developmentally regulated G protein-coupled receptor
            containing two conserved proteolytic cleavage sites
  JOURNAL   Genes Cells 9 (6), 549-560 (2004)
   PUBMED   15189448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB183545.1 and AC118202.8.
            
            On Apr 4, 2008 this sequence version replaced NM_001002268.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript consistent with
            the reference genome strain was available for the full length of
            the gene. The extent of this transcript is supported by transcript
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB183545.1, SRR17253014.933693.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4131              AB183545.1         2-4132
            4132-6505           AC118202.8         149850-152223
FEATURES             Location/Qualifiers
     source          1..6505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 5.43 cM"
     gene            1..6505
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /note="adhesion G protein-coupled receptor G6"
                     /db_xref="GeneID:215798"
                     /db_xref="MGI:MGI:1916151"
     exon            1..123
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..3619
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /note="developmentally regulated G-protein-coupled
                     receptor; probable G-protein coupled receptor 126; G
                     protein coupled receptor Gpr126"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G6
                     precursor"
                     /protein_id="NP_001002268.1"
                     /db_xref="CCDS:CCDS35848.1"
                     /db_xref="GeneID:215798"
                     /db_xref="MGI:MGI:1916151"
                     /translation="MMFDTLGKRCCPWRLKPSALLFLFVLCVTCVPLSVCGCGSCRLV
                     LSNPSGTFTSPCYPNDYPNTQSCSWTLRAPAGYIIQITFNDFDIEEAPNCIYDSLSLD
                     NGESQTKFCGATAKGLSFNSSVNEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVIL
                     PQTLDAYQVSVAKSISIPELKAFTLCFEASKVGNEGGDWTAFSYSDESLTQLLSLEKA
                     SNGYFLSISGSRCLLNNALPVKDKEDIFTENLEQLCLVWNNSWGSIGINFKKNYETVP
                     CDSTISAVVPGDGTLLLGSDRDEVASLRGSIYNFRLWNFTMDLKALSNLSCSVSGNVI
                     DWHNDFWSISTQALKAEGNLSCGSYLIQLPAAELTNCSELGTLCQDGIMYRISVVIHN
                     DFNHPEVKVQTKVAEWLNSTFQNWNYTVYVVNISFHQKVGEDRMKVKRDIMDDDKRLV
                     LWALLVYNATNNVSLNEEKIKQKLMTNNASLEDGLRLCEVDVNQLGMCSALEDPDGFS
                     WPATLPSVYKQPCPNKPGFFMTRACLSNGTSTFWGPVDTSNCSRQSNEVANEILNQTG
                     DGQNLTSANINSIVEKVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSTEAL
                     KTIDELAFKIDLNSTPHVNIETQNLALGVSSLIPGTNAPSNFSIGLPSNNESYFQMDF
                     GNGQTDPLASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGSQRKVLVSYVM
                     ACSIGNITIQNLKDPVQIKIKHTRTQEVHHPICAFWDMNKNKSFGGWNTSGCVAHSDL
                     DAGETICLCSHFTHFGVLMDLPRSASQIDGRNTKVLTFITYIGCGISAIFSAATLLTY
                     VAFEKLRRDYPSKILMNLSSALLFLNLIFLLDGWVTSFGVAGLCTAVAALLHFFLLAT
                     FTWMGLEAIHMYIALVKVFNTYIHRYILKFCIIGWGLPALVVSIILVSRRQNEVYGKE
                     SYGKDQDDEFCWIQDPVVFYVSCAGYFGVMFFLNVAMFIVVMVQICGRNGKRSNRTLR
                     EEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMK
                     ENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSK
                     SKSSSTTYFKRNSHSDNFS"
     exon            124..224
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            225..566
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1190
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1259
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1345
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1398
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1464
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1607
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1719
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1775
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1986
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2158
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2299
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2419
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2465
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2572
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2700
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2969
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3066
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3350
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3452
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            3453..3605
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3651
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..6505
                     /gene="Adgrg6"
                     /gene_synonym="1190004A11Rik; DREG; Gm222; Gpr126"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgcggg tcgcggtccc gaaagccggg atcttcttcg gtggagcttg agggcaacaa
       61 cgcagagagc gctggaggat gagtgtgcgg cctctgggaa tctccacacg gtaatgccag
      121 catgatgttt gacactctcg ggaagaggtg ctgcccttgg agactgaagc caagcgccct
      181 gctgttcctg tttgttttat gtgttacctg tgttcctctc tcagtgtgcg gatgtggcag
      241 ctgcagactt gtcctgtcca atccttccgg tacctttacg tctccgtgtt accctaatga
      301 ctaccctaat acccagtctt gttcgtggac cctccgagcc cctgccggct acatcattca
      361 gataacgttc aatgacttcg acattgaaga agctcccaac tgtatctatg actcattgtc
      421 cctcgataat ggagagagcc agacaaaatt ctgtggagcg actgccaagg gcctgtcatt
      481 taactccagc gtgaatgaga tgcatgtgtc cttttcaagt gactttagta tccagaagaa
      541 aggtttcaac gccagctaca tcagagttgc tgtgtccttg aggaatcaaa aggtcatttt
      601 gccccagaca ttagatgctt accaggtatc agttgcaaaa agcatctcca ttcctgaact
      661 caaagctttc acgctctgtt ttgaagcctc caaagttggc aatgaaggtg gtgactggac
      721 agctttctcc tactcagacg agtcccttac acagctgctc agtcttgaaa aggccagtaa
      781 tggctacttc ctgtccatct ctggctcaag atgcttgttg aacaatgcgt tacctgtgaa
      841 ggacaaagag gacatcttca cagaaaactt ggagcagctc tgtcttgtgt ggaataattc
      901 ttggggctcc attggtataa atttcaaaaa gaactatgaa acagttccat gtgattccac
      961 catcagtgct gtcgtacccg gggatgggac attgctgttg ggctccgaca gagatgaggt
     1021 cgcctctcta aggggcagca tctataactt tcgactttgg aattttacca tggatctgaa
     1081 agccctctcc aacctcagct gtagtgtgtc tgggaatgtc atagactggc acaatgactt
     1141 ttggagcatc tcaacccaag ctctgaaagc cgagggcaac ctgagctgtg gttcctacct
     1201 gatccagctt cctgcagcag agctgacaaa ctgttcagaa ctggggactc tctgtcaaga
     1261 cggaataatg tatcgaatat ctgttgtgat tcacaatgac tttaatcacc ctgaagtaaa
     1321 agtgcagacc aaagtagcag aatggctcaa ttcaaccttt cagaattgga actacactgt
     1381 ttatgtggtt aatataagtt ttcatcaaaa agtaggagag gacaggatga aagtcaagag
     1441 agacatcatg gacgatgaca aaaggttggt gctctgggcc cttctagtct acaatgctac
     1501 caataacgtc agcctgaatg aagagaagat taaacaaaag cttatgacaa ataatgcatc
     1561 actagaggat ggactgaggc tgtgtgaagt cgacgtgaac cagctgggta tgtgtagcgc
     1621 cttggaggat ccagacggct ttagttggcc agccacctta ccctctgtct acaaacaacc
     1681 atgtccaaac aagcctggct tttttatgac tcgagcgtgc ctttctaatg gaacatcaac
     1741 cttctggggc cctgttgaca cttccaactg ttcaagacaa tcaaatgaag tggccaatga
     1801 gattttaaac caaactggtg atgggcagaa cctcacctcg gctaatatca acagcattgt
     1861 agaaaaggtc aaacggatcg tgaacaaaga agaaaacatt gacatcaccc tcggctccac
     1921 tctaatgaat atattttcta atatcttaag cagttcagat agcgatttgc ttgagtcttc
     1981 tactgaagct ttaaaaacaa ttgacgagct agccttcaaa atagacctga atagcacccc
     2041 acatgtgaac attgagacac agaatttggc ccttggagtc tcatccctaa ttccaggaac
     2101 aaatgcacct tcaaatttta gcattggcct tccaagcaat aatgaatcgt acttccagat
     2161 ggacttcggg aacggacaga cagatccact ggcatctgtg attttgcctc caaatttgct
     2221 tgagaattta agccccgaag attctgtatt ggtcaggaga gcacagttca ctttcttcaa
     2281 caaaaccgga cttttccagg atgttggatc tcaaagaaaa gtcctcgtga gttatgtgat
     2341 ggcgtgcagc attggaaaca ttactatcca gaatctgaaa gatccggttc aaatcaaaat
     2401 caaacacacc agaacacagg aagtgcatca tcctatctgt gccttctggg atatgaacaa
     2461 aaacaaaagt ttcggggggt ggaacacctc aggatgtgtt gcccactctg atttggacgc
     2521 tggtgagacc atttgtctgt gcagccactt cactcacttt ggagttctga tggatcttcc
     2581 aaggagtgcc tcacaaatag atggaagaaa cacaaaagtc ctcacgttca ttacctatat
     2641 tgggtgcgga atatctgcca ttttctcagc tgcaactctc ctgacatatg ttgcttttga
     2701 gaagctgcgc agggattatc cctccaaaat cctgatgaat ctgagctcgg ccttgctctt
     2761 cctgaatctc atcttcctcc tggatggctg ggtcacttcc tttggcgtgg ctggactctg
     2821 cacggctgtg gctgccctgt tgcacttctt cctcctggct accttcacct ggatggggct
     2881 ggaagccatc cacatgtaca ttgctcttgt gaaagtgttt aacacttaca tccaccgcta
     2941 tattctaaaa ttctgcatca taggctgggg tctgccagcc ttggtggtgt caattattct
     3001 agtgagcaga agacaaaatg aagtatatgg aaaagaaagt tatgggaaag atcaggatga
     3061 tgaattctgc tggattcagg atcctgtggt gttttatgtg agctgtgccg ggtacttcgg
     3121 agtcatgttc ttcctgaatg tcgccatgtt cattgtggtc atggtgcaga tctgtgggag
     3181 gaatggaaag agaagcaacc ggaccctgag agaagaggtt ttaagaaacc tgcgcagtgt
     3241 ggtcagcctg accttcctgc ttggcatgac gtgggggttt gctttctttg cctggggacc
     3301 cttaaatatt cctttcatgt acctcttctc catcttcaat tcattacaag gtttatttat
     3361 attcatcttc cactgtgcga tgaaggagaa tgttcagaaa cagtggaggc gtcacctctg
     3421 ctgtggcagg tttcggctag cagacaactc agattggagt aagacagcta ccaatatcat
     3481 caagaagagc tccgataacc tggggaaatc tttgtcttca agctccattg gctccaattc
     3541 aacatatctc acatccaaat caaagtccag ctccactacc tatttcaaaa gaaacagcca
     3601 ctcggataat ttctcctaag agaattcctt caacaaaagt ggatcactca gacagcactt
     3661 ccacggacaa gtccctgtca aaactgaccc atgctggtgg agaacagacg tcaatcattc
     3721 ccgtccatca ggttattgat aaggtcaagg gttactgtaa tgcccattcc gataacttct
     3781 ataaaaatat catcctgtca gatgccttca gccacagcac aaagttttaa tgtcattgag
     3841 aggggaaaca aagggaaaag aaagcctgtc tggagaagtg tgatgcccaa gaagcacgga
     3901 aagctacgcc ggtggaatgt cagtgtgctg ctctgtaggg aactgcagag cttagaggac
     3961 tgactgcatc ttgttaggga agcatctttg agatgcagaa ttcatctttt ttggaatatt
     4021 tccatggtgg agctcagtca tcacacttca agagctgaga acactctgag cccggcaaga
     4081 atacaggact tcttagactg taattgaatc aaactcatca gaatcggggg gaggggggga
     4141 aggcgttaaa attataggcc ttgagaggag aaccccaaga agaaatttga gtttagctct
     4201 catataccac acctcatagt taggcttggc agtggcctga ctcttgtaaa gacaatgtag
     4261 aaaacacact aattactgtt tgtagtgtct ttggatgctc acgggttctg ttccagtgct
     4321 attttctatg aatatagcag catcgtttcc tttttcagtg aaatttcaac cataagtaga
     4381 aaagaattgt ttactatttg acccacatat taaacatgct ttttttctct attatggcaa
     4441 atattgaata ttcatgaaca taacttgcta aacaagtatt ccaaaaattt gatctagtca
     4501 atccattgtg tgaatctcaa atatctcaag acacgcagcc taagcatctc cattatcccg
     4561 tgcacataag ccaatccagt tgaatgtgga cattacgttc aagtgggcct cctggaactt
     4621 aagaacaagc acctctcctg tccccttctg tgtgcacata ggtccatagg ctcattagag
     4681 ggatgagagt tcccattaag cactccatgc aatggcctct cactgtttaa agaacacact
     4741 tttgagatta tgtggtccta tccttgtttt aatgattaaa aaaaaaaaga cattccaaat
     4801 cacataaact tcagaggcct ctggctccct ctagtgacaa gtttgttcca agggacatac
     4861 actgaaacat acagctgtct aggttataaa tgtgtaggtc tacaactgct agtctaaaaa
     4921 ctgtttgcac cgagccctct gatcagagtg gatgagaccc tacagagggc tggcaggatt
     4981 tactaatcta gtggaatatg catggatcag actgtggcat acaagtcgtg cagagcatga
     5041 agcagcttac ctaactctta aactatccta agcaatgtgt gcttgcctgt tagtgagggt
     5101 gtaggttgag cccaagtggt ggagtcctat tcatgggcct cagtgcatgc tggctttagc
     5161 cccatgctca gggttctctg ggaagtttca ggtttccaag atagcacagt gaccacaaag
     5221 ggagatttta gcagagccag cctgctagaa ggcaggagta gccagaatgg aacatctgtg
     5281 cagaaagtag gccattctca gctaggatgt agaagaactt gcaggctttg aaacagccaa
     5341 cagatcccct tagctctctg tcagtcacga agctatatgc caggctgcaa aggatgtcaa
     5401 tagcatgtgg caatgggggt ttttattgcc attcattctt tagcaacctg gactgccatc
     5461 ttggcagacc tgaactttgc tgagcctgat tttcacaaag gagtaggcca tgtaggagaa
     5521 agggatagtg acttagtctt aaggtgacta agattcacct cagcagagcc aatctttttg
     5581 gggggatggg agggagactt atattagcag gctgctcatt gtaccacagg atacatatag
     5641 gtagaatata atctcgatag acactgacta ttgatatacg cccccaaact taaggtgttc
     5701 atgttagatt ttaattagct gtgagattta tgcacaaagt gaatatttag ctgatagaaa
     5761 ttatgatttt gtttcaaatg tggctttgct tttgttttgt tttgttttgt tttttcttac
     5821 tagcattgag atctgagaaa gatctttttt tatttttttc atatttggca atgatgtcag
     5881 ctccatttta aaaatctcca ataaccaggt aagaaaagaa agaaaaaaat taagaaacaa
     5941 caggccaaac atatttgcaa gtggatttaa acgactggtc caaattttgc cttcagttac
     6001 aagtctgtgg ctctcatttg cctcctcaga agagtgggac agggctccat gggagaccca
     6061 gagttcaggc tacacacagc tgtaaaacag ccccaatcct gactctggct attcgcttcc
     6121 caccctctcc tttcactgtg atgtgttcca ggtttagcct agggtccatt cttgtcactg
     6181 tttcttactg tgtagagtac ctttggcaat gtctcttctg tacatattta tttatttgtg
     6241 ttcacgtcag tttgtttcat atcttagctt tctttcaccc agctttgttg ttttaattaa
     6301 ctgcccatta gagagactgt actttttttc tagaaaaaaa tattgtgaaa cagttttctg
     6361 tagtgatatt gttgaatatg acaggtaaag caactgtgag ggcaaactag aattagtagt
     6421 gagaaactgc taaagctgat ttgccatttt actgaaatgg aaaatgattt tttttcaaat
     6481 aaatacttat attgttcatg ttcca
//
