LOCUS       NM_001145972            2820 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor G5 (Adgrg5),
            transcript variant 1, mRNA.
ACCESSION   NM_001145972
VERSION     NM_001145972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Wilde,C., Fischer,L., Lede,V., Kirchberger,J., Rothemund,S.,
            Schoneberg,T. and Liebscher,I.
  TITLE     The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is
            mediated by its tethered agonist
  JOURNAL   FASEB J 30 (2), 666-673 (2016)
   PUBMED   26499266
  REMARK    GeneRIF: This study used cell culture-based assays to investigate 2
            natural splice variants within the Stachel sequence of the orphan
            Gs coupling aGPCR GPR114/ADGRG5.
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028878.1, BC144851.1 and BY547428.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AK028878.1         2-40
            40-1592             BC144851.1         1-1553
            1593-2479           AK028878.1         1586-2472
            2480-2810           AK028878.1         2474-2804
            2811-2820           BY547428.1         352-361
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.03 cM"
     gene            1..2820
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /note="adhesion G protein-coupled receptor G5"
                     /db_xref="GeneID:382045"
                     /db_xref="MGI:MGI:2685955"
     exon            1..64
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            65..151
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1662
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; probable G-protein coupled receptor 114; G
                     protein-coupled receptor 114; G-protein coupled receptor
                     PGR27; G protein coupled receptor Gpr114"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G5 isoform 1
                     precursor"
                     /protein_id="NP_001139444.1"
                     /db_xref="CCDS:CCDS52637.1"
                     /db_xref="GeneID:382045"
                     /db_xref="MGI:MGI:2685955"
                     /translation="MDPHGALFFYLCLLAAQVVLVETLSDLLVLMKRLEQPVGRGLSS
                     RARHIHSLEQKLLNASFGGHNLTLQTNSIQSLVFKLSCDFPGLSLSSTTLTNVSQVRA
                     PHAMQFPAELTKGACVTSRPAELRLICIYFFTAHLFQDDRNSSLLNNYVLGAQLDHRP
                     VNNLQKPVNISFWHNRSLEGYTVSCVFWKEGASKSSWGAWSPEGCYTEQPSATQVLCH
                     CNHLTYFAVLMQLSGDPVPAELQVPLEYISFVGCSISIVASLLTILLYAQSRKQSDST
                     TRIHMNLNGSVLLLNVTFLLSSQMTLPTMPRPVCKVLAAVLHYALLSSLTWMAIEGFN
                     LYLFLGRVYNAYIRRYLLKLCMLGWGFPALLVLLLLMIKSSVYGPCVTSLSKSQENGT
                     GFQNVSMCWIRSPMVHSILVMGYGGFTSLFNLVVLAWALWILCRLRAREKALSPWAYR
                     DTAMVLGLTVLLGTTWTLAFFSFGVFLLPQLFLFTIFNSLYGFFLFLWFCSQKRYSDA
                     EAKAEMEAVSSSQMTH"
     exon            152..227
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            228..384
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            385..504
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            505..621
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            622..774
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            775..896
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1165
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1283
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1561
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2820
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2795..2800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /note="hexamer: AAGAAA"
     polyA_site      2812
                     /gene="Adgrg5"
                     /gene_synonym="Gm1109; Gpr114; PGR27"
                     /note="major polyA site"
ORIGIN      
        1 gcagaagcta gaggaccatc tcgagacagc agtgaggacg tgactgccgc tgactgcttt
       61 acaggccagg agaatactgg cgaggacatg gatccacacg gcgccctttt cttctacctg
      121 tgccttctgg ctgctcaagt tgtcctagta gaaaccctgt cagacctact tgtcttgatg
      181 aagcgccttg agcagcccgt aggccggggc ttgtcttcca gagcgaggca tatccacagc
      241 ctggagcaga agctgctcaa tgccagcttc ggcgggcaca acttgacctt gcagacaaac
      301 tccatccagt ctcttgtctt caagctgagc tgcgactttc ctggtctttc cctgtccagc
      361 accacactga caaatgtctc ccaggtgcga gccccacatg ccatgcaatt ccctgctgag
      421 ctgaccaagg gtgcctgtgt gacctcccgg cctgctgagc ttcgactcat ctgcatctat
      481 ttcttcactg cacacctctt tcaggatgac cggaactcat cactgctcaa taactatgtc
      541 ctgggggccc agctggatca caggcctgtg aacaaccttc agaagccagt caacatcagc
      601 ttctggcata atcggagtct ggaagggtat acagtatcct gtgttttctg gaaggaggga
      661 gccagcaaga gcagctgggg ggcctggagc cctgagggct gttatacaga gcagccctca
      721 gccacccagg ttctctgcca ttgcaaccat ctcacctact tcgctgtgct tatgcagctc
      781 tctggagacc ccgtgcccgc tgagctgcag gtgcctcttg agtacatctc ctttgtgggt
      841 tgcagcatct ccatcgtggc ctcgctgctc accatactgc tgtacgctca gtccaggaag
      901 caaagcgatt ccaccacacg tatccacatg aacctgaatg gctctgttct gctcctgaac
      961 gtcaccttcc ttctgagctc ccagatgacc ctgcccacca tgcccaggcc cgtctgcaag
     1021 gtgctggctg ctgtcctaca ctacgcactg ctcagcagcc ttacctggat ggccatcgaa
     1081 ggcttcaacc tctacctttt cctggggcgt gtctacaacg cctacattcg ccgatacttg
     1141 ctcaagctct gcatgctggg ctgggggttt ccagccctct tggtgctgct gcttctgatg
     1201 atcaagagct cagtgtatgg accctgtgtg acctcactct ccaaaagcca ggaaaatggc
     1261 acaggcttcc agaatgtgtc catgtgctgg atccgaagtc ccatggtaca cagcatcctg
     1321 gtcatgggct atggtggctt cacatctctg ttcaacctgg tggtgctggc ctgggctctg
     1381 tggatcttgt gcaggcttcg ggcacgggag aaggcactga gtccctgggc ctaccgggac
     1441 actgccatgg tgttgggtct cactgtgctg cttggcacca cctggaccct agccttcttc
     1501 tccttcggtg tgttcctgct gcctcagctc ttcctcttta ccatcttcaa ctcgctctat
     1561 ggtttcttcc tcttcctgtg gttctgctca caaaagcgtt actcggatgc cgaagccaag
     1621 gcggagatgg aggcagtcag ctcctcccag atgacacact gacccagctc ccgccctgca
     1681 gcctctgccc tcactatttc caacagccca tggtcttggc tcctccaggg aaggtggtag
     1741 gctggcggcg ggacaacaga gtctactgta cccttcaggg atcttttcca tctctccgaa
     1801 ttacctggga tggaaggcag cgtgtggctc ttcatcctgg tccttcatgt ctggatgcag
     1861 ctccattggc caggctatgg acagagaact agcttggaag tcaggaagct agactagact
     1921 gaaccacacc ttgcaccctg ctcagcactt acagatactt acaggatcat ggcctatgct
     1981 tggggccact ctttctttca ccagtcccag gtgttgatga cgtcaacctt ctatctttcc
     2041 aacggtcagg aaatctagcc cttcctcctt cttctaaccc ccacagatgg tatagaccag
     2101 cagccaagac caggcctctt tctctttccc tgaaactgag tcagatgggc ttgagcgatc
     2161 tagatactat actactgtgt agatgtgggg tggtgtgttc aacatttaca aactctctgc
     2221 ccacagcggg agaacatctg ggctgcctgt cagaccaggt gggaataaga ccaggggttt
     2281 attaagtcag tgctatcccc aggatggaca gcagggggtg ccattggccc gcacgccaag
     2341 gcattggtgc caaaactgcc cctggaaatg cagatgttac ctgtctgagg acaacccttt
     2401 ggccagtagg taaatgggga cctccagcac acatccattg tctctttccc tgtgcagctg
     2461 accaaggtcg ctttaggggc tttgtcaggc gccagggcag ctagttgggt agattctcag
     2521 gtcccatgcc agctgttaga cacatgtact tgaacaataa ggggatcaga gctggatgcc
     2581 atcctccaca gagggttctc tgcctttctg ggtgtttctg ggtcattata ttcttagctc
     2641 ttcactggct ggagagtggg ataggctctg agccaggttg cctgggctca gattccagct
     2701 ctgtggctgt ggacaagccg ttcagtctct ctgtgcctta gtttccctat ccacagcgag
     2761 gacaatagta gtaactcttt ggaagattca ataaaagaaa gaattcaccc aagccttacc
//
