LOCUS       NM_173036               2454 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor G3 (Adgrg3), mRNA.
ACCESSION   NM_173036 XM_991966
VERSION     NM_173036.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2454)
  AUTHORS   Maglitto,A., Mariani,S.A., de Pater,E., Rodriguez-Seoane,C.,
            Vink,C.S., Piao,X., Lukke,M.L. and Dzierzak,E.
  TITLE     Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell
            development and differentiation
  JOURNAL   Blood Adv 5 (3), 829-842 (2021)
   PUBMED   33560396
  REMARK    GeneRIF: Unexpected redundancy of Gpr56 and Gpr97 during
            hematopoietic cell development and differentiation.
REFERENCE   2  (bases 1 to 2454)
  AUTHORS   Wang,J., Wang,X., Chen,X., Lu,S., Kuang,Y., Fei,J. and Wang,Z.
  TITLE     Gpr97/Adgrg3 ameliorates experimental autoimmune encephalomyelitis
            by regulating cytokine expression
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 50 (7), 666-675 (2018)
   PUBMED   29860267
  REMARK    GeneRIF: Results show that G protein-coupled receptor 97 protein
            (Gpr97) plays an important role in the development of experimental
            autoimmune encephalomyelitis (EAE) and may have a therapeutic
            potential for the treatment of central nervous system (CNS)
            autoimmunity.
REFERENCE   3  (bases 1 to 2454)
  AUTHORS   Fang,W., Wang,Z., Li,Q., Wang,X., Zhang,Y., Sun,Y., Tang,W., Ma,C.,
            Sun,J., Li,N. and Yi,F.
  TITLE     Gpr97 Exacerbates AKI by Mediating Sema3A Signaling
  JOURNAL   J Am Soc Nephrol 29 (5), 1475-1489 (2018)
   PUBMED   29531097
REFERENCE   4  (bases 1 to 2454)
  AUTHORS   Shi,J., Zhang,X., Wang,S., Wang,J., Du,B., Wang,Z., Liu,M.,
            Jiang,W., Qian,M. and Ren,H.
  TITLE     Gpr97 is dispensable for metabolic syndrome but is involved in
            macrophage inflammation in high-fat diet-induced obesity in mice
  JOURNAL   Sci Rep 6, 24649 (2016)
   PUBMED   27089991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2454)
  AUTHORS   Shi,J.P., Li,X.N., Zhang,X.Y., Du,B., Jiang,W.Z., Liu,M.Y.,
            Wang,J.J., Wang,Z.G., Ren,H. and Qian,M.
  TITLE     Gpr97 Is Dispensable for Inflammation in OVA-Induced Asthmatic Mice
  JOURNAL   PLoS One 10 (7), e0131461 (2015)
   PUBMED   26132811
  REMARK    GeneRIF: Our findings imply that Gpr97 might not be required for
            the development of airway inflammation in OVA-induced allergic
            asthma in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2454)
  AUTHORS   Valtcheva,N., Primorac,A., Jurisic,G., Hollmen,M. and Detmar,M.
  TITLE     The orphan adhesion G protein-coupled receptor GPR97 regulates
            migration of lymphatic endothelial cells via the small GTPases RhoA
            and Cdc42
  JOURNAL   J Biol Chem 288 (50), 35736-35748 (2013)
   PUBMED   24178298
  REMARK    GeneRIF: a possible role of GPR97 in lymphatic remodeling
REFERENCE   7  (bases 1 to 2454)
  AUTHORS   Wang,J.J., Zhang,L.L., Zhang,H.X., Shen,C.L., Lu,S.Y., Kuang,Y.,
            Wan,Y.H., Wang,W.G., Yan,H.M., Dang,S.Y., Fei,J., Jin,X.L. and
            Wang,Z.G.
  TITLE     Gpr97 is essential for the follicular versus marginal zone
            B-lymphocyte fate decision
  JOURNAL   Cell Death Dis 4 (10), e853 (2013)
   PUBMED   24113187
  REMARK    GeneRIF: Gpr97 deficiency results in an extensive reduction in
            B220(+) lymphocytes in mice.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2454)
  AUTHORS   Haid,D., Widmayer,P., Voigt,A., Chaudhari,N., Boehm,U. and Breer,H.
  TITLE     Gustatory sensory cells express a receptor responsive to protein
            breakdown products (GPR92)
  JOURNAL   Histochem Cell Biol 140 (2), 137-145 (2013)
   PUBMED   23436159
  REMARK    GeneRIF: The GPR92 is expressed in the majority of T1R1-positive
            taste cells.
REFERENCE   9  (bases 1 to 2454)
  AUTHORS   Parker,M.J., Licence,S., Erlandsson,L., Galler,G.R., Chakalova,L.,
            Osborne,C.S., Morgan,G., Fraser,P., Jumaa,H., Winkler,T.H., Skok,J.
            and Martensson,I.L.
  TITLE     The pre-B-cell receptor induces silencing of VpreB and lambda5
            transcription
  JOURNAL   EMBO J 24 (22), 3895-3905 (2005)
   PUBMED   16281060
  REMARK    GeneRIF: Data demonstrate that the pre-B-cell receptor is essential
            for monoallelic silencing of VpreB and lambda5 at the large
            pre-BII-cell stage.
REFERENCE   10 (bases 1 to 2454)
  AUTHORS   Sleckman,B.P., Khan,W.N., Xu,W., Bassing,C.H., Malynn,B.A.,
            Copeland,N.G., Bardon,C.G., Breit,T.M., Davidson,L., Oltz,E.M.,
            Jenkins,N.A., Berman,J.E. and Alt,F.W.
  TITLE     Cloning and functional characterization of the
            early-lymphocyte-specific Pb99 gene
  JOURNAL   Mol Cell Biol 20 (12), 4405-4410 (2000)
   PUBMED   10825203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103935.10 and BC064726.1.
            
            On Jul 18, 2009 this sequence version replaced NM_173036.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064726.1, AK154648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC103935.10        48094-48133
            41-959              BC064726.1         1-919
            960-1224            AC103935.10        69827-70091
            1225-2454           BC064726.1         1185-2414
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..2454
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /note="adhesion G protein-coupled receptor G3"
                     /db_xref="GeneID:54672"
                     /db_xref="MGI:MGI:1859670"
     exon            1..129
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1706
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /note="probable G-protein coupled receptor 97; pre B-cell
                     transcription factor 1; G 97"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor G3
                     precursor"
                     /protein_id="NP_766624.3"
                     /db_xref="CCDS:CCDS22554.1"
                     /db_xref="GeneID:54672"
                     /db_xref="MGI:MGI:1859670"
                     /translation="MATARSLGLLFFLLLTSDEETTEEPRNVCRRLQEGHEYDTFDLN
                     DTAQCFTKCGQSEHSPCDVGNLQRYWLNYESYLLENSMETVDMPFVKALIQNISTDVS
                     EDLLYSLMLSQIPRQVMQGEDEPADGVRLPKSLFGALPGNRSAVRLAITVLDIGAGNV
                     FKGPKLLEDKGSSVLNNRMVGLSVGQMHATGLSEPVEITFSHERQPPNVILTCVFWDM
                     AKGDWDSHGCSTVPGDGRTVCRCDHLTFFALLLRPILDLATAQTLTRISQAGSAVSMI
                     FLAFTMVLYVAFRFSLQRFKSEDAPKIHMALSISLFLLNLTFLINVGSSSQGPPASCW
                     VRAAIFHYFLLCVFTWMGLEAFHLYLLAIRVFNTYFGHYFLKLSLLAWGLPVLVVIGA
                     GSSNSYGVYTIRDQENRTSLELCWFQKEPALYATVHGYFLVTFLFGAVVLALVAWKIF
                     TLPSVTAGKGQGPTWKSVLTVLGLSSLVGMTWGLAVLTPLGLSTIYVFTLLNSLQGLF
                     IFCWFIILYFPTQSTTASSSGTARLDQAHSVSQE"
     exon            130..280
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            281..416
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            417..563
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            564..698
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            699..738
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            739..830
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            831..943
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1224
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1318
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1593
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..2439
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /note="hexamer: AATAAA"
     regulatory      2419..2424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /note="hexamer: AATAAT"
     polyA_site      2435
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /note="major polyA site"
     polyA_site      2439
                     /gene="Adgrg3"
                     /gene_synonym="A030001G24Rik; Gpr97; Pb1; Pb99"
                     /note="major polyA site"
ORIGIN      
        1 tcagggggca ggaagaaggt cagttggaca gtttgggact gagggaccac acagccatag
       61 aacttcgctg agcactgatg gcgacagcca ggagtctggg cctcctgttc tttctgctgc
      121 tgacttcaga tgaggagacc acggaagagc cgaggaatgt ctgccgtcgg cttcaggagg
      181 gccacgagta tgacaccttc gacttgaatg acactgctca gtgtttcacc aagtgtgggc
      241 aatcggagca cagcccctgt gacgtgggga acctgcagag atactggttg aactatgagt
      301 cctacctgct ggagaattcc atggagactg tggacatgcc ttttgttaag gcattgatcc
      361 agaacatcag cacggatgtc tcagaagacc tgctgtactc tctgatgctt tcccagatcc
      421 cgaggcaggt gatgcagggt gaggacgagc ctgctgatgg agtccgactt cccaagagcc
      481 tgtttggagc cctgcctggc aacaggtctg cagtccggtt ggccataact gttctagaca
      541 ttggtgcagg gaatgtcttt aagggcccca agctccttga ggacaagggc agcagcgtgt
      601 tgaacaaccg catggtgggt ttgagcgtgg gccagatgca cgccaccggg ctgtcggaac
      661 ctgtagagat caccttctcc catgagcgtc aaccacctaa cgtgatcctc acctgtgtat
      721 tctgggatat ggctaaagga gactgggatt cccacggctg ctccacggtg cccggggatg
      781 ggagaactgt ctgccgttgc gaccacttga ccttcttcgc cttgctgctg aggccgatct
      841 tggacctggc cacggcacag actctcactc gcatctccca ggcaggcagt gccgtctcca
      901 tgatcttcct ggccttcacc atggtgctct atgttgcctt caggttctct ctgcagaggt
      961 tcaagtctga agatgcccct aagatccaca tggctctgag catcagcctg tttctcctga
     1021 atcttacctt cctgatcaat gtggggagca gctcccaagg ccccccagcc tcctgctggg
     1081 tccgagctgc cattttccac tactttctgc tctgtgtctt cacctggatg ggtctggagg
     1141 ccttccacct ctacctgctg gccatcagag tcttcaatac ctactttgga cactatttcc
     1201 tgaagctgag cctgctggcc tggggcctgc ctgttcttgt agttattggt gctggaagta
     1261 gcaacagtta tggagtttac accattcgcg accaggagaa ccgcacatca ctggagttgt
     1321 gctggttcca gaaagagcct gctctttatg ctactgtcca cggctacttc cttgttacct
     1381 tcctcttcgg tgctgtggta ctggctttgg tggcctggaa gatcttcact ctgcccagtg
     1441 tcacagcggg caaaggacag gggccgacct ggaagtcggt cctcaccgtg ctgggcctct
     1501 ccagtctggt gggcatgacc tgggggctgg ctgttctcac ccccctcggc ttgtctacca
     1561 tctacgtctt caccctctta aactctctac aagggctctt catcttctgc tggttcatca
     1621 tcctctactt ccctactcag agcaccacag cctcctcctc cggcaccgcc cgcctggacc
     1681 aggcccactc cgtgtcccag gagtagatga tgggtggctg cagtttgctc tcacttctgg
     1741 ctggtttgtg tgaccttgaa cagctcccta cttccttctg ggctccactg tcttctctgt
     1801 acaggatgtc caaggacgga gagggtgagg accaagccag gccctgtggc ttcaaagttc
     1861 ccattcagga ggctggagac ttgacttgaa gaggacactg gttcagttcc cagcacccac
     1921 ataacatctc tcagctgtct gtgactctag ttccaagaga tctgacgctg tcctctggtc
     1981 tccaaagagt accaggcatg aatgtgctgg atatatacat gtgccactca tacatataaa
     2041 atagaaatta aaaaaaatat tttaacagct cccattcgga tgtgttcatg ggtccaaaaa
     2101 gctacaaatg cagatctgca ggactcaaaa gtccctgtaa gccttggagc cccagccaac
     2161 agtgttatct ttacccctgt tgctatggtg acagatctct agagctaagc agctgtggac
     2221 cacctttaat tcaccaggag agaaccagaa ccggaggctt gctccatcta tatatggcca
     2281 agggggaaaa gggagaaaaa gcagctcttc ccacgacgtc tgtactctta tgggacagcc
     2341 ttaccaacca tttcaaccca gcctgagcat caggcctggc tgtgtcaagc caataattgt
     2401 cacacattta aataaacaaa taattgttga ctgagcaaaa aaaaaaaaaa aaaa
//
