LOCUS       NM_178712               4723 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor G2 (Adgrg2),
            transcript variant 1, mRNA.
ACCESSION   NM_178712
VERSION     NM_178712.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4723)
  AUTHORS   Kiyozumi,D. and Ikawa,M.
  TITLE     Adhesion G protein-coupled receptor G2 is dispensable for lumicrine
            signaling regulating epididymal initial segment differentiation and
            gene expressiondagger
  JOURNAL   Biol Reprod 109 (4), 474-481 (2023)
   PUBMED   37531264
REFERENCE   2  (bases 1 to 4723)
  AUTHORS   Grunddal,K.V., Tonack,S., Egerod,K.L., Thompson,J.J., Petersen,N.,
            Engelstoft,M.S., Vagne,C., Keime,C., Gradwohl,G., Offermanns,S. and
            Schwartz,T.W.
  TITLE     Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively
            expressed in mature intestinal tuft cells
  JOURNAL   Mol Metab 51, 101231 (2021)
   PUBMED   33831593
  REMARK    GeneRIF: Adhesion receptor ADGRG2/GPR64 is in the GI-tract
            selectively expressed in mature intestinal tuft cells.
REFERENCE   3  (bases 1 to 4723)
  AUTHORS   Sun,Y., Zhang,D., Ma,M.L., Lin,H., Song,Y., Wang,J., Ma,C., Yu,K.,
            An,W., Guo,S., He,D., Yang,Z., Xiao,P., Hou,G., Yu,X. and Sun,J.P.
  TITLE     Optimization of a peptide ligand for the adhesion GPCR ADGRG2
            provides a potent tool to explore receptor biology
  JOURNAL   J Biol Chem 296, 100174 (2021)
   PUBMED   33303626
  REMARK    GeneRIF: Optimization of a peptide ligand for the adhesion GPCR
            ADGRG2 provides a potent tool to explore receptor biology.
REFERENCE   4  (bases 1 to 4723)
  AUTHORS   Zhang,D.L., Sun,Y.J., Ma,M.L., Wang,Y.J., Lin,H., Li,R.R.,
            Liang,Z.L., Gao,Y., Yang,Z., He,D.F., Lin,A., Mo,H., Lu,Y.J.,
            Li,M.J., Kong,W., Chung,K.Y., Yi,F., Li,J.Y., Qin,Y.Y., Li,J.,
            Thomsen,A.R.B., Kahsai,A.W., Chen,Z.J., Xu,Z.G., Liu,M., Li,D.,
            Yu,X. and Sun,J.P.
  TITLE     Gq activity- and beta-arrestin-1 scaffolding-mediated ADGRG2/CFTR
            coupling are required for male fertility
  JOURNAL   Elife 7, e33432 (2018)
   PUBMED   29393851
  REMARK    GeneRIF: The authors demonstrated that the ubiquitous G
            protein-coupled receptor signaling proteins Gq and beta-arrestin-1
            are essential for fluid reabsorption because they mediate coupling
            between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4723)
  AUTHORS   Yoo,J.Y., Ahn,J.I., Kim,T.H., Yu,S., Ahn,J.Y., Lim,J.M. and
            Jeong,J.W.
  TITLE     G-protein coupled receptor 64 is required for decidualization of
            endometrial stromal cells
  JOURNAL   Sci Rep 7 (1), 5021 (2017)
   PUBMED   28694502
  REMARK    GeneRIF: Study identified Gpr64 as a P4-PGR target gene in the
            mouse uterus.  P4 induced GPR64 expression in the epithelial and
            stromal cells of the uterus in ovariectomized wild-type mice, but
            not in PRKO mice. ChIP analysis confirmed that PGR proteins were
            recruited on progesterone response element of Gpr64 gene in the
            uteri of wild-type mice treated with P4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4723)
  AUTHORS   Davies,B., Behnen,M., Cappallo-Obermann,H., Spiess,A.N.,
            Theuring,F. and Kirchhoff,C.
  TITLE     Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor
            gene disruption
  JOURNAL   Mol Reprod Dev 74 (5), 539-553 (2007)
   PUBMED   17034053
  REMARK    GeneRIF: The knockout of the HE6/Gpr64 receptor was mainly
            associated with the downregulation of genes specific to the initial
            segment.
REFERENCE   7  (bases 1 to 4723)
  AUTHORS   Eng,S.R., Dykes,I.M., Lanier,J., Fedtsova,N. and Turner,E.E.
  TITLE     POU-domain factor Brn3a regulates both distinct and common programs
            of gene expression in the spinal and trigeminal sensory ganglia
  JOURNAL   Neural Dev 2, 3 (2007)
   PUBMED   17239249
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4723)
  AUTHORS   Davies,B., Baumann,C., Kirchhoff,C., Ivell,R., Nubbemeyer,R.,
            Habenicht,U.F., Theuring,F. and Gottwald,U.
  TITLE     Targeted deletion of the epididymal receptor HE6 results in fluid
            dysregulation and male infertility
  JOURNAL   Mol Cell Biol 24 (19), 8642-8648 (2004)
   PUBMED   15367682
REFERENCE   9  (bases 1 to 4723)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 4723)
  AUTHORS   Obermann,H., Samalecos,A., Osterhoff,C., Schroder,B., Heller,R. and
            Kirchhoff,C.
  TITLE     HE6, a two-subunit heptahelical receptor associated with apical
            membranes of efferent and epididymal duct epithelia
  JOURNAL   Mol Reprod Dev 64 (1), 13-26 (2003)
   PUBMED   12420295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY769670.1, BC116644.1 and AL731801.11.
            
            On Mar 13, 2014 this sequence version replaced NM_178712.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.98483.1,
                                           SRR17253012.8829253.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY769670.1         2-61
            61-4482             BC116644.1         6-4427
            4483-4723           AL731801.11        138761-139001
FEATURES             Location/Qualifiers
     source          1..4723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.95 cM"
     gene            1..4723
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /note="adhesion G protein-coupled receptor G2"
                     /db_xref="GeneID:237175"
                     /db_xref="MGI:MGI:2446854"
     exon            1..60
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            61..105
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            106..224
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..3136
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LNB-TM7 heptahelical receptor Me6; G-protein
                     coupled receptor 64; epididymis-specific protein 6; G
                     protein coupled receptor He6"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G2 isoform 1
                     precursor"
                     /protein_id="NP_848827.1"
                     /db_xref="CCDS:CCDS41196.1"
                     /db_xref="GeneID:237175"
                     /db_xref="MGI:MGI:2446854"
                     /translation="MLFSGGQYSPVGRPEEVLLIYKIFLVIICFHVILVTSLKENGNS
                     SLLSPSAESSLVSLIPYSNGTPDAASEVLSTLNKTEKSKITIVKTFNASGVKSQRNIC
                     NLSSLCNDSVFFRGEIVFQHDEDHNVTQNQDTANGTFAGVLSLSELKRSELNKTLQTL
                     SETYFIVCATAEAQSTVNCTFTVKLNETMNVCAMMVTFQTVQIRPMEQCCCSPRTPCP
                     SSPEELEKLQCELQDPIVCLADQPHGPPLSSSSKPVVPQATIISHVASDFSLAEPLDH
                     ALMTPSTPSLTQESNLPSPQPTIPLASSPATDLPVQSVVVSSLPQTDLSHTLSPVQSS
                     IPSPTTPAPSVPTELVTISTPPGETVVNTSTVSDLEAQVSQMEKALSLGSLEPNLAGE
                     MVNRVSKLLHSPPALLAPLAQRLLKVVDAIGLQLNFSSTTISLTSPSLALAVIRVNAS
                     NFNTTTFAAQDPTNLQVSLETPPPENSIGAITLPSSLMNNLPANDVELASRIQFNFFE
                     TPALFQDPSLENLTLISYVISSSVTNMTIKNLTRNVTVALKHINPSPDDLTVKCVFWD
                     LGRNGGKGGWSSDGCSVKDKRMNETICTCSHLTSFGILLDLSRTSLPPSQMMALTFIT
                     YIGCGLSSIFLSVTLVTYIAFEKIRRDYPSKILIQLCAALLLLNLIFLLDSWIALYNT
                     RGFCIAVAVFLHYFLLVSFTWMGLEAFHMYLALVKVFNTYIRKYILKFCIVGWGIPAV
                     VVSIVLTISPDNYGIGSYGKFPNGTPDDFCWINSNVVFYITVVGYFCVIFLLNVSMFI
                     VVLVQLCRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAWGPVNVTFMYLF
                     AIFNTLQGFFIFIFYCAAKENVRKQWRRYLCCGKLRLAENSDWSKTATNGLKKQTVNQ
                     GVSSSSNSLQSSCNSTNSTTLLVNSDCSVHASGNGNASTERNGVSFSVQNGDVCLHDL
                     TGKQHMFSDKEDSCNGKSRIALRRTSKRGSLHFIEQM"
     exon            225..257
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            258..305
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            306..344
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            345..386
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            387..440
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            441..496
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            497..552
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            553..592
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            593..630
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            631..725
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            726..792
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1184
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1347
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1504
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1648
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1771
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1817
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1921
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2043
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2312
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2412
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2696
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2798
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2951
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..4723
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4695..4700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /note="hexamer: AATAAA"
     polyA_site      4717
                     /gene="Adgrg2"
                     /gene_synonym="B830041D06Rik; Gpr64; Me6"
                     /note="major polyA site"
ORIGIN      
        1 agaaagggga aaaggagggc ccgaggacgc cagcagccaa ccggtcaccg ggacccgcag
       61 atgcacacgg agtttcctcc ctatttcctc tgaacttcct gtcaggatgc ttttctctgg
      121 tgggcagtac agccctgttg gcagacctga agaggtttta ctgatataca agatattcct
      181 tgtcatcatt tgttttcatg tcattctcgt tacatccctg aaagaaaacg gtaattccag
      241 tttgttatca ccatctgctg aatcatctct tgtcagtctc atcccctact ccaatggtac
      301 accagatgct gcttcagaag ttttgtcgac tttaaacaaa acagaaaaat ctaaaatcac
      361 tatagtaaaa accttcaatg catcaggagt caaatcccag agaaatatct gcaatttgtc
      421 atctctttgc aatgactcag tattttttag aggtgagata gtgtttcaac atgatgaaga
      481 ccacaatgtt acccagaatc aagatacagc taatggcacc ttcgctggag tcctgtctct
      541 aagtgaactg aagcgatcag agctcaacaa aactctacag accttaagtg agacttactt
      601 tatagtgtgt gctacagcag aggcccaaag cacggtaaac tgtacattca cagtaaaact
      661 caatgagacc atgaatgtgt gtgccatgat ggttactttc caaactgtac agattcggcc
      721 aatggaacag tgctgctgtt ccccgaggac tccctgccct tcctcaccag aagagttaga
      781 aaaactacag tgtgaactgc aggatcccat tgtctgtctt gctgatcaac cgcatggccc
      841 accgttatcg tcttccagca agcctgttgt acctcaggcc accattattt cccatgttgc
      901 tagtgacttc tctttggctg aaccccttga tcatgccctt atgaccccaa gcacaccctc
      961 tctgacacaa gaaagtaacc ttccatctcc tcagcctacg atccccctgg cttccagtcc
     1021 tgccactgac ttgccagttc aatctgtagt ggtctcttct ttgcctcaaa ctgatctttc
     1081 ccacaccctg tcaccggtgc agtcctccat tccctctcct accacaccag ccccatctgt
     1141 ccctacagaa ctggtcacca tcagcacacc tcctggtgag acagttgtca acactagcac
     1201 tgtttctgat ctggaagccc aagtatccca gatggagaaa gctttgtctt tgggtagctt
     1261 agagcctaat cttgcaggcg aaatggtaaa ccgagtcagc aaactccttc actctccacc
     1321 tgccttgcta gcccctctag ctcaaaggtt gctaaaagtg gtagatgcca ttggcttaca
     1381 gctgaatttt tcatctacaa ctatcagtct aacttcacct tctttggctc ttgctgtgat
     1441 cagagtgaat gccagtaatt tcaataccac gacttttgca gcccaagacc caacaaatct
     1501 ccaggtttct ctggaaaccc cacctcctga gaatagtatt ggtgccatta ctctgccctc
     1561 atcactgatg aataatttgc cagctaatga tgtagaattg gcttcaagga ttcagttcaa
     1621 tttctttgaa acacccgccc tgtttcagga tccttccctg gagaacctca ctctgataag
     1681 ctatgtcata tcatcaagtg tcacaaacat gaccatcaag aacttgacaa gaaacgtgac
     1741 agtcgcactg aaacacatca acccaagtcc ggatgactta actgtgaaat gtgtattctg
     1801 ggacttgggc agaaatggtg gcaaaggagg ttggtcatct gatggctgtt ccgtcaaaga
     1861 caagagaatg aatgaaacca tctgtacctg tagccatctt acaagttttg gcatcctatt
     1921 ggacctatct cgaacatcct taccaccaag tcaaatgatg gctctgacat ttatcacgta
     1981 tattggctgt gggctttcat caatttttct gtcagttact cttgtaacct acatcgcctt
     2041 tgaaaagatc cggagggatt acccctccaa aatcctcatc cagctgtgtg ctgccctgct
     2101 tctgctcaac ctgatcttcc tcctagactc ctggattgcg ctgtataata cccgaggttt
     2161 ctgcattgcc gtggctgtat ttcttcacta ttttctcttg gtctcattca catggatggg
     2221 attagaagca ttccacatgt acctagcact ggtcaaggtg tttaatactt acatccgaaa
     2281 gtacatcctt aaattctgca ttgttggctg gggcatacca gctgtggttg tgtccatcgt
     2341 cctgactata tccccagata actatgggat tggatcctat ggaaaattcc ccaatggcac
     2401 accagatgac ttttgctgga tcaacagcaa tgtggtgttc tatatcacgg ttgtgggata
     2461 tttctgtgtg atatttctac tgaacgtcag catgttcatc gtggtcttgg ttcagctctg
     2521 tcgaattaaa aagaagaagc agctgggagc ccagcgcaaa actagtattc aagacctcag
     2581 gagtatcgct ggcctcacat ttttactggg aattacttgg ggctttgcct tctttgcctg
     2641 gggaccagtt aatgtcacct tcatgtatct ctttgccatc tttaacacct tacaagggtt
     2701 tttcatattc attttttact gtgcagcaaa agagaatgtc agaaaacagt ggaggcggta
     2761 tctttgttgt ggaaaattac ggctggctga aaattctgac tggagtaaaa ctgctactaa
     2821 tggtttaaag aagcagactg taaaccaagg agtatccagc tcttcaaatt ccttacagtc
     2881 aagctgtaac tccactaact ccaccacact cctagtgaat agtgattgct cagtgcacgc
     2941 aagcgggaat ggcaatgcat ctaccgagag gaatggggtt tctttcagtg ttcagaatgg
     3001 agacgtgtgc cttcatgatc tcactggcaa acagcatatg tttagtgaca aagaggactc
     3061 ctgcaatggt aaaagccgga tagcgctcag aaggacttcg aagcggggaa gcttacactt
     3121 tatcgagcaa atgtgattct cttcttctaa aatcaaagca tgatgtggat ggtgtgaagt
     3181 gtccagtttt cctttaacac aatgtgagat gtatgaaaag cgctggtttt ctattcagca
     3241 acctcgaaag gaacataagc taaatgaggg caaccagtta ctatcagaag aaaccacgac
     3301 tggttatggt ttctagacgt ttgcagtttg gtttcttatc tctcattttc aaaggcattg
     3361 gtgttaaaac cacagaataa gatccaggaa agaaaaatga aagtttgttt ccactcacat
     3421 tttaaagagg ctgttatcct tgataacatc ctaagaaaga aggaaaaaaa gaaggaaaga
     3481 aagaaagaaa gagagagaga gagagagaaa gaaaaaagaa agaaagatgt ttacttcagt
     3541 ctgttggtaa gtttagttgt gcatgccttt gttgtatata agctaaattc tagtgaccca
     3601 catgtcaaaa aatcttctct ttaccttttt ttatatttat tttctactgt gtaaatttat
     3661 tcttttgtag aatcatggtt gtgtcgcctt ctctaatgtg ataacttacc agtgacttct
     3721 aaacctcctt tagaagatca tataggatgt gaaattcaga aacttcactg aaatcaagaa
     3781 ataatgataa aggcagtctg aacaattata aatagacaat tagctcagaa agtgcctttg
     3841 agcaatcaag aaaaggtgcc cccactgggc agatatagcc ttgtgagctt atggtttgga
     3901 aaacagtcgg gccacatttt agccctgatg atcctcctgg gtaccttatg cagggtcctc
     3961 atgaagggtc cttatgcagg gaatgacttg tatgactata tgtgacatga aatagtgata
     4021 ccaatggcca gacttcatcc ctaatgacca gattatagaa tctctacacc atggttgtta
     4081 gaggctaaaa ctgtaatcta aaccatgtta ggaaaatcgt gatggtagaa aagatacaca
     4141 ctgccacttc tcaaataccc agagcctttc aaaagagggg atcagagtag gattactttt
     4201 ccagagtgta tatatggcaa acaaagtagg tctttaaaag acgctgcatg atatgttatt
     4261 gttgcaactg ctacattctg gtccagtcat acttgtatgt atttttaaaa acatgtcaaa
     4321 tcttgaagag tgtatagtga caagggggag cagctactgg gaagagtgaa ttatcctgtg
     4381 atattgttgt ttgtatgtaa taacatatat ccaaccttga ttgttcctag ttctagaggg
     4441 cctatcctat ttctcacctt taccagcttg agtggtgcct caagcagtgt gattattagg
     4501 aacatttcaa aatcctttag ttaggtcttt cactaaggct cccttgcata tatttcaaat
     4561 aaatgttgta tctgagacta gccacagtag taacatctgt ttctgtgtgt gctcattgtc
     4621 tttgcaaaat tcttctccaa attatttaat tattttgtat ttatatgtta tgattgacaa
     4681 aactgttaaa aaccaataaa aatcaatttg cagttaagtc ctt
//
