LOCUS       NM_018882               3520 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus adhesion G protein-coupled receptor G1 (Adgrg1),
            transcript variant 2, mRNA.
ACCESSION   NM_018882
VERSION     NM_018882.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Wu,J., Wang,Z., Cai,M., Wang,X., Lo,B., Li,Q., He,J.C., Lee,K. and
            Fu,J.
  TITLE     GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in
            Glomerular Endothelial Cells
  JOURNAL   Diabetes 72 (11), 1652-1663 (2023)
   PUBMED   37579299
  REMARK    GeneRIF: GPR56 Promotes Diabetic Kidney Disease Through eNOS
            Regulation in Glomerular Endothelial Cells.
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Liu,D., Zhang,P., Zhang,K., Bi,C., Li,L., Xu,Y., Zhang,T. and
            Zhang,J.
  TITLE     Role of GPR56 in Platelet Activation and Arterial Thrombosis
  JOURNAL   Thromb Haemost 123 (3), 295-306 (2023)
   PUBMED   36402131
  REMARK    GeneRIF: Role of GPR56 in Platelet Activation and Arterial
            Thrombosis.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Li,T., Luo,R., Schmidt,R., D'Alessandro,N., Kishore,P., Zhu,B.,
            Yu,D. and Piao,X.
  TITLE     GPR56 S4 variant is required for microglia-mediated synaptic
            pruning
  JOURNAL   Glia 71 (3), 560-570 (2023)
   PUBMED   36336959
  REMARK    GeneRIF: GPR56 S4 variant is required for microglia-mediated
            synaptic pruning.
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Nojima,Y., Toriyama,M., Tago,K., Mizuno,N., Morishita,K. and
            Itoh,H.
  TITLE     GPR56 C-terminal fragment mediates signal received by N-terminal
            fragment of another adhesion GPCR Latrophilin1 in neurons
  JOURNAL   Genes Cells 28 (2), 83-96 (2023)
   PUBMED   36453010
  REMARK    GeneRIF: GPR56 C-terminal fragment mediates signal received by
            N-terminal fragment of another adhesion GPCR Latrophilin1 in
            neurons.
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Yu,Y., Mu,C., Xu,Y., Li,Y., Ren,S., Kong,S., Deng,W., Wang,Y.,
            Wang,H. and Lu,J.
  TITLE     Adgrg1 is a new transcriptional target of Hand1 during trophoblast
            giant cell differentiation
  JOURNAL   J Reprod Immunol 154, 103753 (2022)
   PUBMED   36228547
  REMARK    GeneRIF: Adgrg1 is a new transcriptional target of Hand1 during
            trophoblast giant cell differentiation.
REFERENCE   6  (bases 1 to 3520)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 3520)
  AUTHORS   Piao,X., Hill,R.S., Bodell,A., Chang,B.S., Basel-Vanagaite,L.,
            Straussberg,R., Dobyns,W.B., Qasrawi,B., Winter,R.M., Innes,A.M.,
            Voit,T., Ross,M.E., Michaud,J.L., Descarie,J.C., Barkovich,A.J. and
            Walsh,C.A.
  TITLE     G protein-coupled receptor-dependent development of human frontal
            cortex
  JOURNAL   Science 303 (5666), 2033-2036 (2004)
   PUBMED   15044805
  REMARK    GeneRIF: preferential expression in neuronal progenitor cells of
            the cerebral cortical ventricular and subventricular zones duing
            periods of neurogenesis
REFERENCE   8  (bases 1 to 3520)
  AUTHORS   Terskikh,A.V., Easterday,M.C., Li,L., Hood,L., Kornblum,H.I.,
            Geschwind,D.H. and Weissman,I.L.
  TITLE     From hematopoiesis to neuropoiesis: evidence of overlapping genetic
            programs
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7934-7939 (2001)
   PUBMED   11438738
REFERENCE   9  (bases 1 to 3520)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   10 (bases 1 to 3520)
  AUTHORS   Liu,M., Parker,R.M., Darby,K., Eyre,H.J., Copeland,N.G.,
            Crawford,J., Gilbert,D.J., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     GPR56, a novel secretin-like human G-protein-coupled receptor gene
  JOURNAL   Genomics 55 (3), 296-305 (1999)
   PUBMED   10049584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103935.10.
            
            On Apr 4, 2022 this sequence version replaced NM_018882.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141886.1, BC034678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC103935.10        14829-15059
            232-306             AC103935.10        32841-32915
            307-729             AC103935.10        33653-34075
            730-862             AC103935.10        35616-35748
            863-1010            AC103935.10        36155-36302
            1011-1142           AC103935.10        36602-36733
            1143-1259           AC103935.10        37224-37340
            1260-1305           AC103935.10        37672-37717
            1306-1409           AC103935.10        37967-38070
            1410-1528           AC103935.10        38773-38891
            1529-1797           AC103935.10        39908-40176
            1798-1906           AC103935.10        40904-41012
            1907-2175           AC103935.10        41947-42215
            2176-3520           AC103935.10        43259-44603
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..3520
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /note="adhesion G protein-coupled receptor G1"
                     /db_xref="GeneID:14766"
                     /db_xref="MGI:MGI:1340051"
     exon            1..231
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..306
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2306
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /EC_number="2.7.11.25"
                     /note="isoform c precursor is encoded by transcript
                     variant 2; G-protein coupled receptor 56; serpentine
                     receptor cyt28; secretin receptor"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G1 isoform c
                     precursor"
                     /protein_id="NP_061370.2"
                     /db_xref="CCDS:CCDS22553.1"
                     /db_xref="GeneID:14766"
                     /db_xref="MGI:MGI:1340051"
                     /translation="MAVQVLRQMVYFLLSLFSLVQGAHSGSPREDFRFCGQRNQTQQS
                     TLHYDQSSEPHIFVWNTEETLTIRAPFLAAPDIPRFFPEPRGLYHFCLYWSRHTGRLH
                     LRYGKHDYLLSSQASRLLCFQKQEQSLKQGAPLIATSVSSWQIPQNTSLPGAPSFIFS
                     FHNAPHKVSHNASVDMCDLKKELQQLSRYLQHPQKAAKRPTAAFISQQLQSLESKLTS
                     VSFLGDTLSFEEDRVNATVWKLPPTAGLEDLHIHSQKEEEQSEVQAYSLLLPRAVFQQ
                     TRGRRRDDAKRLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQ
                     HQPQPKNVTLQCVFWVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAVLMVSS
                     TEVEATHKHYLTLLSYVGCVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLSAVFLL
                     DVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPG
                     YLLKLSIVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPERVTYPSMCWIRDSLVSYV
                     TNLGLFSLVFLFNLAMLATMVVQILRLRPHSQNWPHVLTLLGLSLVLGLPWALVFFSF
                     ASGTFQLVILYLFSIITSFQGFLIFLWYWSMRFQAQGGPSPLKNNSDSAKLPISSGST
                     SSSRI"
     exon            307..729
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..862
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1010
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1142
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1259
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1305
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1409
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1528
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1797
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1906
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2175
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..3520
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3473..3478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /note="hexamer: AATAAA"
     polyA_site      3520
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /note="major polyA site"
ORIGIN      
        1 gttctccagc tccacacagc ctgctgcctg ggctctatct actatagaga aggggctgct
       61 ggcttggtag gagcctcccc aaagcctctc cccaccccca gccagtgcac ttgcttgctc
      121 tagctcacac tcttacccag agacccagac tgtaaaattc agcattggag gtgaatcctg
      181 aaaggtggtt cagctgcctg gctccttcca gaacccgtcg cctggcacca ggtaggagta
      241 taatggctgt ccaggtgctg cggcagatgg tctacttcct actgagtctg ttttctctgg
      301 tgcaaggtgc acacagtggc agcccccgag aagacttccg cttctgtggc cagcggaacc
      361 agacccaaca gagcaccctc cactatgatc aatcttcaga gcctcacatc tttgtgtgga
      421 acacagagga gaccctcaca attcgtgccc ccttcctggc agccccagat attccccgct
      481 tcttcccaga gcctagaggg ctctatcact tctgcctcta ctggagtcgc cacactggga
      541 gactccactt gcgctatggc aagcatgact acctgcttag tagccaagcc tccagactcc
      601 tctgcttcca gaaacaggag cagagcctga agcagggagc cccgctgatc gccacctctg
      661 tcagctcctg gcagattccc cagaacacca gcctgcctgg ggctccgagc ttcatcttct
      721 ccttccacaa tgccccacac aaggtctccc acaatgcatc tgtggacatg tgtgatctca
      781 agaaggaatt gcagcagctt agcaggtacc tgcagcaccc tcaaaaggct gccaagcggc
      841 ccaccgcagc gttcatcagc cagcagttac agagcctgga gtcaaagctg acctctgtga
      901 gcttcctggg agacacatta tcctttgagg aggaccgggt caatgctaca gtgtggaagc
      961 tgccacccac agccggtcta gaggatctgc atatccactc ccagaaggag gaggagcaga
     1021 gtgaggtcca ggcatactcg ctgttgcttc cccgggccgt attccagcag accagaggcc
     1081 gtcgccggga tgacgccaag aggctcctgg tagtagactt cagcagccaa gctttgttcc
     1141 aggacaagaa ttctagccaa gtcctgggtg agaaggtctt gggtattgtc gtgcagaaca
     1201 ccaaagtcac caacctctca gatccggtgg tactcacctt ccagcaccag cctcagccaa
     1261 aaaatgtgac tctgcagtgc gtgttctggg ttgaagaccc ggcatcaagc agcacaggga
     1321 gctggagcag tgcaggctgc gagacagtga gcagagacac acagacatcc tgcctgtgca
     1381 accacctgac ctactttgca gtgctgatgg tgtcatccac agaggtagaa gccactcaca
     1441 aacactacct cacgctcctg tcctacgtgg gctgtgtcat ctctgctctg gcttgtgtct
     1501 tcactattgc tgcctacctc tgctccagga ggaagtcacg tgactacacc atcaaagtcc
     1561 acatgaacct gctgtccgct gtcttcctgc tggacgtgag cttcctgctc agcgagcctg
     1621 tggcactgac gggctccgaa gcagcctgtc gcaccagtgc catgttcctg cacttctccc
     1681 tgcttgcctg cctctcctgg atgggcctcg agggctacaa tctctaccga ctggtggtgg
     1741 aggtcttcgg tacctatgtg cccggctatc tgctcaagct gagcatcgtg ggctggggtt
     1801 ttcctgtctt cctggtcact ctggtggcgt tggtggatgt gaataactac ggccccatta
     1861 tcctagctgt gcgccggact ccggaacgtg tcacctaccc ctctatgtgc tggatccggg
     1921 actccctggt gagctatgtc accaacctgg gcctcttcag tctggtgttc ctgttcaacc
     1981 tggctatgct ggccaccatg gtggtgcaga tcctgcggct tcgcccgcac agccagaact
     2041 ggccccacgt gctgaccctg ctgggcctca gcctggtcct tggcctcccc tgggccttgg
     2101 tcttcttttc ctttgcttcc ggcaccttcc agcttgtcat cctctacctc ttcagcatca
     2161 taacttcctt ccaaggcttc ctcatcttcc tgtggtactg gtccatgcgg ttccaggccc
     2221 aaggcggccc ctcccctctg aagaacaact cagacagcgc caaactcccc atcagctccg
     2281 gcagcacctc ctccagccgc atctaagcca ccgccacacc tcccctccgg gaggacacat
     2341 gcatggcgtc cgctcacgat gtctgtggcc cagtgctgtg cccacccagc ctttgttggt
     2401 tagtggcata ctagagaagg ccctggtcct tgaaggcgta gggctgttgc tctggtaggt
     2461 agatacctag cttgccttgg ggacgactct ggtcctcaaa gggctcagaa gcacactgcc
     2521 attctgtttg tggggccgtt tcagtctgga gctaaggcct tgtctttctg gccacctctg
     2581 ggtccagctg ttgctgctgg gtgttgagac ctgcagaccc aagctggggt tagatctcga
     2641 aggaggctga cacatccggc ctgagacaca gctaactgtc ttgacttgct gctctgtctc
     2701 tgtggtcacc atgcagatcc cgagggtggc actgggggta aatgttctgg gagaaggttt
     2761 ggaggcagag caccttagga gctgagcatc tcccccagcc tttctgcaaa ccctcctctt
     2821 cattccccat ccccaacccc tcctctgtgt tcccctaacc ctccacctga agcctggggt
     2881 cctagaccaa tgctgtgatt tggggtggta gttcccagca gtttcctggt gccagctatc
     2941 aacttctgtc tgttgtgtgg gctttggcct ctgactcagg gcaggtttct gtctgagccc
     3001 tctctccaag ctgcctcacc tttgctcgca cctcagaggg acctccatct ctcctgaagc
     3061 ctcctccctc tggcaagtac tgggatacag ccaccctttc aacccagcac tctgaagacc
     3121 aagacagccc cctctggtga cactggccaa gcttgatctt tttcctaaga agtggtcttc
     3181 agatccctgc aggtcgctca gaagacactg ggctgcctag tgtgaattct gtcctactaa
     3241 cgtacagtga gcagctcctc acccccaccc ccgcaaaagc tctcaccaag tcctggagtg
     3301 tcaggcaggg ggctggaaat ccaggaggac ttcctgcaaa aggcagcatt tcatcttgac
     3361 ctcagccttc aggttgggga gaatgttctt tttaaatacc agttcatttg tcttttgata
     3421 ttaaagctct ttatagagag tctggaaact gtaggcgatt gtcgagaaga gaaataaaaa
     3481 tgagctgtta tctaatgcca tggcaaagca gcacagtttg
//
