LOCUS       NM_001403768            3721 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus adhesion G protein-coupled receptor G1 (Adgrg1),
            transcript variant 7, mRNA.
ACCESSION   NM_001403768
VERSION     NM_001403768.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Wu,J., Wang,Z., Cai,M., Wang,X., Lo,B., Li,Q., He,J.C., Lee,K. and
            Fu,J.
  TITLE     GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in
            Glomerular Endothelial Cells
  JOURNAL   Diabetes 72 (11), 1652-1663 (2023)
   PUBMED   37579299
  REMARK    GeneRIF: GPR56 Promotes Diabetic Kidney Disease Through eNOS
            Regulation in Glomerular Endothelial Cells.
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Liu,D., Zhang,P., Zhang,K., Bi,C., Li,L., Xu,Y., Zhang,T. and
            Zhang,J.
  TITLE     Role of GPR56 in Platelet Activation and Arterial Thrombosis
  JOURNAL   Thromb Haemost 123 (3), 295-306 (2023)
   PUBMED   36402131
  REMARK    GeneRIF: Role of GPR56 in Platelet Activation and Arterial
            Thrombosis.
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Li,T., Luo,R., Schmidt,R., D'Alessandro,N., Kishore,P., Zhu,B.,
            Yu,D. and Piao,X.
  TITLE     GPR56 S4 variant is required for microglia-mediated synaptic
            pruning
  JOURNAL   Glia 71 (3), 560-570 (2023)
   PUBMED   36336959
  REMARK    GeneRIF: GPR56 S4 variant is required for microglia-mediated
            synaptic pruning.
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Nojima,Y., Toriyama,M., Tago,K., Mizuno,N., Morishita,K. and
            Itoh,H.
  TITLE     GPR56 C-terminal fragment mediates signal received by N-terminal
            fragment of another adhesion GPCR Latrophilin1 in neurons
  JOURNAL   Genes Cells 28 (2), 83-96 (2023)
   PUBMED   36453010
  REMARK    GeneRIF: GPR56 C-terminal fragment mediates signal received by
            N-terminal fragment of another adhesion GPCR Latrophilin1 in
            neurons.
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Yu,Y., Mu,C., Xu,Y., Li,Y., Ren,S., Kong,S., Deng,W., Wang,Y.,
            Wang,H. and Lu,J.
  TITLE     Adgrg1 is a new transcriptional target of Hand1 during trophoblast
            giant cell differentiation
  JOURNAL   J Reprod Immunol 154, 103753 (2022)
   PUBMED   36228547
  REMARK    GeneRIF: Adgrg1 is a new transcriptional target of Hand1 during
            trophoblast giant cell differentiation.
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Piao,X., Hill,R.S., Bodell,A., Chang,B.S., Basel-Vanagaite,L.,
            Straussberg,R., Dobyns,W.B., Qasrawi,B., Winter,R.M., Innes,A.M.,
            Voit,T., Ross,M.E., Michaud,J.L., Descarie,J.C., Barkovich,A.J. and
            Walsh,C.A.
  TITLE     G protein-coupled receptor-dependent development of human frontal
            cortex
  JOURNAL   Science 303 (5666), 2033-2036 (2004)
   PUBMED   15044805
  REMARK    GeneRIF: preferential expression in neuronal progenitor cells of
            the cerebral cortical ventricular and subventricular zones duing
            periods of neurogenesis
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Terskikh,A.V., Easterday,M.C., Li,L., Hood,L., Kornblum,H.I.,
            Geschwind,D.H. and Weissman,I.L.
  TITLE     From hematopoiesis to neuropoiesis: evidence of overlapping genetic
            programs
  JOURNAL   Proc Natl Acad Sci U S A 98 (14), 7934-7939 (2001)
   PUBMED   11438738
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Liu,M., Parker,R.M., Darby,K., Eyre,H.J., Copeland,N.G.,
            Crawford,J., Gilbert,D.J., Sutherland,G.R., Jenkins,N.A. and
            Herzog,H.
  TITLE     GPR56, a novel secretin-like human G-protein-coupled receptor gene
  JOURNAL   Genomics 55 (3), 296-305 (1999)
   PUBMED   10049584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103935.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC103935.10        25101-25401
            302-417             AC103935.10        27703-27818
            418-492             AC103935.10        32841-32915
            493-930             AC103935.10        33638-34075
            931-1063            AC103935.10        35616-35748
            1064-1211           AC103935.10        36155-36302
            1212-1343           AC103935.10        36602-36733
            1344-1460           AC103935.10        37224-37340
            1461-1506           AC103935.10        37672-37717
            1507-1610           AC103935.10        37967-38070
            1611-1729           AC103935.10        38773-38891
            1730-1998           AC103935.10        39908-40176
            1999-2107           AC103935.10        40904-41012
            2108-2376           AC103935.10        41947-42215
            2377-3721           AC103935.10        43259-44603
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..3721
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /note="adhesion G protein-coupled receptor G1"
                     /db_xref="GeneID:14766"
                     /db_xref="MGI:MGI:1340051"
     exon            1..301
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..417
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..492
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             429..2507
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /EC_number="2.7.11.25"
                     /note="isoform a precursor is encoded by transcript
                     variant 7; G-protein coupled receptor 56; serpentine
                     receptor cyt28; secretin receptor"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor G1 isoform a
                     precursor"
                     /protein_id="NP_001390697.1"
                     /db_xref="GeneID:14766"
                     /db_xref="MGI:MGI:1340051"
                     /translation="MAVQVLRQMVYFLLSLFSLVQASASSGAHSGSPREDFRFCGQRN
                     QTQQSTLHYDQSSEPHIFVWNTEETLTIRAPFLAAPDIPRFFPEPRGLYHFCLYWSRH
                     TGRLHLRYGKHDYLLSSQASRLLCFQKQEQSLKQGAPLIATSVSSWQIPQNTSLPGAP
                     SFIFSFHNAPHKVSHNASVDMCDLKKELQQLSRYLQHPQKAAKRPTAAFISQQLQSLE
                     SKLTSVSFLGDTLSFEEDRVNATVWKLPPTAGLEDLHIHSQKEEEQSEVQAYSLLLPR
                     AVFQQTRGRRRDDAKRLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNLSDPV
                     VLTFQHQPQPKNVTLQCVFWVEDPASSSTGSWSSAGCETVSRDTQTSCLCNHLTYFAV
                     LMVSSTEVEATHKHYLTLLSYVGCVISALACVFTIAAYLCSRRKSRDYTIKVHMNLLS
                     AVFLLDVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFG
                     TYVPGYLLKLSIVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPERVTYPSMCWIRDS
                     LVSYVTNLGLFSLVFLFNLAMLATMVVQILRLRPHSQNWPHVLTLLGLSLVLGLPWAL
                     VFFSFASGTFQLVILYLFSIITSFQGFLIFLWYWSMRFQAQGGPSPLKNNSDSAKLPI
                     SSGSTSSSRI"
     exon            493..930
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1063
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1211
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1343
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1460
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1506
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1610
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1729
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1998
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2107
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2376
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..3721
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /note="hexamer: AATAAA"
     polyA_site      3721
                     /gene="Adgrg1"
                     /gene_synonym="Cyt28; Gpr56; TM7LN4; TM7XN1"
                     /note="major polyA site"
ORIGIN      
        1 aaacagcctg gagagccatc aggaagtggt taggggtggc cacactccct acctctccag
       61 ctgaacattt ttgagtctca gctgtcacag cataggtctc agagaagggt agtgggagat
      121 aactagacaa ggagaattgg aaataccaca gccttgggaa gagccagaga ggagctgaga
      181 tccattgtca cctgggtaag ttcatgcaga cccttggact ggggtcttgc gcagatggca
      241 gtctgcttca cccaaggaga ccatttcact atgacttcta aagagaggct ctcactagca
      301 ggtcttctgc tgggctggcg ctcaatgccc acagctcccc tccctcagtt tccccatggg
      361 gcagggcttg gcagagggta ttgcagctca tggatgttgg caggaaatca caagaaggta
      421 ggagtataat ggctgtccag gtgctgcggc agatggtcta cttcctactg agtctgtttt
      481 ctctggtgca agcctctgcc tcctcaggtg cacacagtgg cagcccccga gaagacttcc
      541 gcttctgtgg ccagcggaac cagacccaac agagcaccct ccactatgat caatcttcag
      601 agcctcacat ctttgtgtgg aacacagagg agaccctcac aattcgtgcc cccttcctgg
      661 cagccccaga tattccccgc ttcttcccag agcctagagg gctctatcac ttctgcctct
      721 actggagtcg ccacactggg agactccact tgcgctatgg caagcatgac tacctgctta
      781 gtagccaagc ctccagactc ctctgcttcc agaaacagga gcagagcctg aagcagggag
      841 ccccgctgat cgccacctct gtcagctcct ggcagattcc ccagaacacc agcctgcctg
      901 gggctccgag cttcatcttc tccttccaca atgccccaca caaggtctcc cacaatgcat
      961 ctgtggacat gtgtgatctc aagaaggaat tgcagcagct tagcaggtac ctgcagcacc
     1021 ctcaaaaggc tgccaagcgg cccaccgcag cgttcatcag ccagcagtta cagagcctgg
     1081 agtcaaagct gacctctgtg agcttcctgg gagacacatt atcctttgag gaggaccggg
     1141 tcaatgctac agtgtggaag ctgccaccca cagccggtct agaggatctg catatccact
     1201 cccagaagga ggaggagcag agtgaggtcc aggcatactc gctgttgctt ccccgggccg
     1261 tattccagca gaccagaggc cgtcgccggg atgacgccaa gaggctcctg gtagtagact
     1321 tcagcagcca agctttgttc caggacaaga attctagcca agtcctgggt gagaaggtct
     1381 tgggtattgt cgtgcagaac accaaagtca ccaacctctc agatccggtg gtactcacct
     1441 tccagcacca gcctcagcca aaaaatgtga ctctgcagtg cgtgttctgg gttgaagacc
     1501 cggcatcaag cagcacaggg agctggagca gtgcaggctg cgagacagtg agcagagaca
     1561 cacagacatc ctgcctgtgc aaccacctga cctactttgc agtgctgatg gtgtcatcca
     1621 cagaggtaga agccactcac aaacactacc tcacgctcct gtcctacgtg ggctgtgtca
     1681 tctctgctct ggcttgtgtc ttcactattg ctgcctacct ctgctccagg aggaagtcac
     1741 gtgactacac catcaaagtc cacatgaacc tgctgtccgc tgtcttcctg ctggacgtga
     1801 gcttcctgct cagcgagcct gtggcactga cgggctccga agcagcctgt cgcaccagtg
     1861 ccatgttcct gcacttctcc ctgcttgcct gcctctcctg gatgggcctc gagggctaca
     1921 atctctaccg actggtggtg gaggtcttcg gtacctatgt gcccggctat ctgctcaagc
     1981 tgagcatcgt gggctggggt tttcctgtct tcctggtcac tctggtggcg ttggtggatg
     2041 tgaataacta cggccccatt atcctagctg tgcgccggac tccggaacgt gtcacctacc
     2101 cctctatgtg ctggatccgg gactccctgg tgagctatgt caccaacctg ggcctcttca
     2161 gtctggtgtt cctgttcaac ctggctatgc tggccaccat ggtggtgcag atcctgcggc
     2221 ttcgcccgca cagccagaac tggccccacg tgctgaccct gctgggcctc agcctggtcc
     2281 ttggcctccc ctgggccttg gtcttctttt cctttgcttc cggcaccttc cagcttgtca
     2341 tcctctacct cttcagcatc ataacttcct tccaaggctt cctcatcttc ctgtggtact
     2401 ggtccatgcg gttccaggcc caaggcggcc cctcccctct gaagaacaac tcagacagcg
     2461 ccaaactccc catcagctcc ggcagcacct cctccagccg catctaagcc accgccacac
     2521 ctcccctccg ggaggacaca tgcatggcgt ccgctcacga tgtctgtggc ccagtgctgt
     2581 gcccacccag cctttgttgg ttagtggcat actagagaag gccctggtcc ttgaaggcgt
     2641 agggctgttg ctctggtagg tagataccta gcttgccttg gggacgactc tggtcctcaa
     2701 agggctcaga agcacactgc cattctgttt gtggggccgt ttcagtctgg agctaaggcc
     2761 ttgtctttct ggccacctct gggtccagct gttgctgctg ggtgttgaga cctgcagacc
     2821 caagctgggg ttagatctcg aaggaggctg acacatccgg cctgagacac agctaactgt
     2881 cttgacttgc tgctctgtct ctgtggtcac catgcagatc ccgagggtgg cactgggggt
     2941 aaatgttctg ggagaaggtt tggaggcaga gcaccttagg agctgagcat ctcccccagc
     3001 ctttctgcaa accctcctct tcattcccca tccccaaccc ctcctctgtg ttcccctaac
     3061 cctccacctg aagcctgggg tcctagacca atgctgtgat ttggggtggt agttcccagc
     3121 agtttcctgg tgccagctat caacttctgt ctgttgtgtg ggctttggcc tctgactcag
     3181 ggcaggtttc tgtctgagcc ctctctccaa gctgcctcac ctttgctcgc acctcagagg
     3241 gacctccatc tctcctgaag cctcctccct ctggcaagta ctgggataca gccacccttt
     3301 caacccagca ctctgaagac caagacagcc ccctctggtg acactggcca agcttgatct
     3361 ttttcctaag aagtggtctt cagatccctg caggtcgctc agaagacact gggctgccta
     3421 gtgtgaattc tgtcctacta acgtacagtg agcagctcct cacccccacc cccgcaaaag
     3481 ctctcaccaa gtcctggagt gtcaggcagg gggctggaaa tccaggagga cttcctgcaa
     3541 aaggcagcat ttcatcttga cctcagcctt caggttgggg agaatgttct ttttaaatac
     3601 cagttcattt gtcttttgat attaaagctc tttatagaga gtctggaaac tgtaggcgat
     3661 tgtcgagaag agaaataaaa atgagctgtt atctaatgcc atggcaaagc agcacagttt
     3721 g
//
