LOCUS       NM_001404529            8731 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor F5 (Adgrf5),
            transcript variant 3, mRNA.
ACCESSION   NM_001404529 XM_006524124
VERSION     NM_001404529.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8731)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8731)
  AUTHORS   Rothe,J., Kraft,R., Ricken,A., Kaczmarek,I., Matz-Soja,M.,
            Winter,K., Dietzsch,A.N., Buchold,J., Ludwig,M.G., Liebscher,I.,
            Schoneberg,T. and Thor,D.
  TITLE     The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic
            islets regulating somatostatin release and islet development
  JOURNAL   Commun Biol 7 (1), 104 (2024)
   PUBMED   38228886
  REMARK    GeneRIF: The adhesion GPCR GPR116/ADGRF5 has a dual function in
            pancreatic islets regulating somatostatin release and islet
            development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8731)
  AUTHORS   Wang,Y., Wang,T., Xiang,Q., Li,N., Wang,J., Liu,J., Zhang,Y.,
            Yang,T. and Bian,J.
  TITLE     GPR116 promotes ferroptosis in sepsis-induced liver injury by
            suppressing system Xc-/GSH/GPX4
  JOURNAL   Cell Biol Toxicol 39 (6), 3015-3030 (2023)
   PUBMED   37266730
  REMARK    GeneRIF: GPR116 promotes ferroptosis in sepsis-induced liver injury
            by suppressing system Xc[-]/GSH/GPX4.
REFERENCE   4  (bases 1 to 8731)
  AUTHORS   Kui,M., Pluznick,J.L. and Zaidman,N.A.
  TITLE     The transcription factor Foxi1 promotes expression of V-ATPase and
            Gpr116 in M-1 cells
  JOURNAL   Am J Physiol Renal Physiol 324 (3), F267-F273 (2023)
   PUBMED   36603001
  REMARK    GeneRIF: The transcription factor Foxi1 promotes expression of
            V-ATPase and Gpr116 in M-1 cells.
REFERENCE   5  (bases 1 to 8731)
  AUTHORS   Senechal,C., Fujita,R., Jamet,S., Maiga,A., Dort,J., Orfi,Z.,
            Dumont,N.A., Bouvier,M. and Crist,C.
  TITLE     The adhesion G-protein-coupled receptor Gpr116 is essential to
            maintain the skeletal muscle stem cell pool
  JOURNAL   Cell Rep 41 (7), 111645 (2022)
   PUBMED   36384129
REFERENCE   6  (bases 1 to 8731)
  AUTHORS   Takase,H., Matsumoto,K., Yamadera,R., Kubota,Y., Otsu,A.,
            Suzuki,R., Ishitobi,H., Mochizuki,H., Kojima,T., Takano,S.,
            Uchida,K., Takahashi,S. and Ema,M.
  TITLE     Genome-wide identification of endothelial cell-enriched genes in
            the mouse embryo
  JOURNAL   Blood 120 (4), 914-923 (2012)
   PUBMED   22535667
REFERENCE   7  (bases 1 to 8731)
  AUTHORS   Kalsotra,A., Xiao,X., Ward,A.J., Castle,J.C., Johnson,J.M.,
            Burge,C.B. and Cooper,T.A.
  TITLE     A postnatal switch of CELF and MBNL proteins reprograms alternative
            splicing in the developing heart
  JOURNAL   Proc Natl Acad Sci U S A 105 (51), 20333-20338 (2008)
   PUBMED   19075228
REFERENCE   8  (bases 1 to 8731)
  AUTHORS   Wallgard,E., Larsson,E., He,L., Hellstrom,M., Armulik,A.,
            Nisancioglu,M.H., Genove,G., Lindahl,P. and Betsholtz,C.
  TITLE     Identification of a core set of 58 gene transcripts with broad and
            specific expression in the microvasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (8), 1469-1476 (2008)
   PUBMED   18483404
REFERENCE   9  (bases 1 to 8731)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   10 (bases 1 to 8731)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025700.16, AC169504.1 and CT010585.12.
            
            On Apr 11, 2022 this sequence version replaced XM_006524124.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.17693.1,
                                           SRR10223971.16667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               CT025700.16        178205-178468
            265-444             AC169504.1         43189-43368         c
            445-499             AC169504.1         36730-36784         c
            500-658             AC169504.1         24630-24788         c
            659-835             AC169504.1         22695-22871         c
            836-945             AC169504.1         22463-22572         c
            946-1004            AC169504.1         20943-21001         c
            1005-1150           AC169504.1         20202-20347         c
            1151-1372           AC169504.1         18620-18841         c
            1373-1576           AC169504.1         16579-16782         c
            1577-1747           AC169504.1         9600-9770           c
            1748-1867           AC169504.1         7491-7610           c
            1868-2077           AC169504.1         7126-7335           c
            2078-2296           AC169504.1         5284-5502           c
            2297-2449           AC169504.1         2147-2299           c
            2450-2658           AC169504.1         1074-1282           c
            2659-2838           AC169504.1         234-413             c
            2839-4242           CT010585.12        62067-63470
            4243-4284           CT010585.12        64555-64596
            4285-4344           CT010585.12        64691-64750
            4345-4429           CT010585.12        65346-65430
            4430-8731           CT010585.12        67531-71832
FEATURES             Location/Qualifiers
     source          1..8731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.73 cM"
     gene            1..8731
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /note="adhesion G protein-coupled receptor F5"
                     /db_xref="GeneID:224792"
                     /db_xref="MGI:MGI:2182928"
     exon            1..264
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            265..444
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..4509
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; G protein-coupled receptor 116; probable
                     G-protein coupled receptor 116; Ig-Hepta; G protein
                     coupled receptor Gpr116; G-protein coupled hepta-helical
                     receptor Ig-hepta"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor F5 isoform 3
                     precursor"
                     /protein_id="NP_001391458.1"
                     /db_xref="GeneID:224792"
                     /db_xref="MGI:MGI:2182928"
                     /translation="MRSPRTFTFYFLLLVICSSEAALSTPTEPIVQPSVSKAKPAVIS
                     SAQVFDFPILQEHELAGEELLRPKRAAAAGDRVAEEYMVDIEISFENVSFLESIRAHL
                     NNLSFPIRGTEADILNIAMTTVCTPAGNDLLCFCEKGYQWSEERCLHSLTCQDYDSAL
                     PGGYCSCLKGLPPQGPFCQLPEAFITLKLKVRLNIGFQEDLKNTSSALYRSYKTDLER
                     AFRAGYRTLPGFRSVTVTQFTKGSVVVNYVVRVTSAPLPGSIHKANEQVIQNLNHTYK
                     MDYNSFQGTPSNETKFTVIPEFIFEGDNVTLECETEFVTSNTSWYYGEKRSDIQNSDK
                     YSIHTTVINNISLITRLTIYNFTQHDAGMYGCNVTLDIFEYGTVRKLDVTPIRILAKE
                     ERKVVCDNHPISLNCCSENIANWSSIEWKQEGKISILGNPESDLESSCSTYTLKADGT
                     QCPSGSSGTTVIYTCEFVSAYGARGSKNIAVTFTSVGDNASYKGEVPEVLRHVMEVST
                     VQSTTGNSLETSKPQEQPANLTITRDPISVSEGQSFSITCLSDVSSFDEVYWNTSAGI
                     KIHPRFYTMRRYQDGAESVLMVKTSTREWNGTYHCIFRYKNSYSIATKDVTVHPLPLV
                     SDIMMDPLEASGLCTSSHQFKCCVEEDAGEEYAVTFHVDSSSFPAEREVIGKQACYTY
                     SLPANLPRCPKDIAVFCHFTNAANSSVRSPSMKLKLIPRENVTCQDPIIGIGDPGKVI
                     QKLCQFSGVYGSPGQAIGGTVTYKCVGTQWKEESRACISAPINGLLQVAKALIKSPTQ
                     DQKLPTYLRDLSVSAGKEEQDIRSSPGSLGAIISILDLLSTVPTQVNSEMMRDILATI
                     NVILDKSALNSWEKLLQQQSNQSSQFLHSVERFSQALQLGDSTPPFLAHPNVQMKSMV
                     IKRGHPQIYQQQFIFKDSDLWGDVAIDECQLGNLQPDSSIVTVAFPTLKAILAQDVQR
                     KTSSNSLVMTTTVSHNIVKPFRISMTFKNNHRSGGKPQCVFWNFSLANNTGGWDSSGC
                     SVEDDGRDNRDRVFCKCNHLTSFSILMSPDSPDPGSLLKILLDIISYIGLGFSIVSLA
                     ACLVVEAMVWKSVTKNRTSYMRHICIVNIAFCLLIADIWFIVAGAIHDGRYPLNETAC
                     VAATFFIHFFYLSVFFWMLTLGLMLFYRLIFILHDASKSTQKAIAFSLGYGCPLIISS
                     ITVGVTQPQEVYMRKNACWLNWEDTRALLAFAIPALIIVVVNVSITVVVITKILRPSI
                     GDKPGKQEKSSLFQISKSIGVLTPLLGLTWGFGLATVIQGSNAVFHIIFTLLNAFQGL
                     FILLFGCLWDQKVQEALLHKFSLSRWSSQHSKSTSIGSSTPVFSMSSPISRRFNNLFG
                     KTGTYNVSTPETTSSSLENSSSAYSLLN"
     exon            445..499
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            500..658
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            659..835
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            836..945
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1004
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1150
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1372
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1576
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1747
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1867
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2077
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2296
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2449
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2658
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2838
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..4242
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            4243..4284
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4344
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..4429
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..8731
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5747..5752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /note="hexamer: AATATA"
     polyA_site      5765
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /note="major polyA site"
     polyA_site      5877
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
     regulatory      5926..5931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
                     /note="hexamer: ATTAAA"
     polyA_site      5953
                     /gene="Adgrf5"
                     /gene_synonym="8430401C09Rik; 9330185D23; Gpr116;
                     mKIAA0758"
ORIGIN      
        1 aaatcgcttc ttgtttttct aacagcaaag aggctctagg ggatggctcc gtgagcttgg
       61 aggagtgcag ctcctggagg caaaagttga gcaaaggagt ggccagacct gttcataaag
      121 atgcctgccc cgctgcctcc cgattgtctg tgaggtcccc taagaaggct gcggggccaa
      181 tggccccgta gtgaaaaaca gagaagtttc tagacatctg ttgagagcag gcgcttgcct
      241 ggagacgaca acggtggtgg acaggcgaag ccactcagac ctgaagacat gagatcgcca
      301 aggaccttca cgttctactt cctgcttctt gtgatttgtt cttcagaagc tgcgctgagc
      361 acaccaacag agcccattgt tcaaccttca gtgagtaaag ctaaacctgc agtcatttcc
      421 tccgcccagg tctttgattt cccgattctc caagaacatg agctagccgg ggaagagcta
      481 ctgaggccaa aaagagcagc tgcagcgggt gatcgcgtgg cggaagaata catggtggat
      541 attgagatca gctttgaaaa tgtctccttc ctggagtcca tcagagctca cttgaacaac
      601 ctcagttttc caattcgagg gaccgaagct gacattttga acatagcaat gactacagtc
      661 tgcactcctg ctggaaatga cctcttgtgc ttctgtgaga aaggctacca gtggtctgag
      721 gaaaggtgtc tccactctct cacttgtcaa gactatgaca gtgccctgcc aggcggctac
      781 tgcagttgtc tgaaaggact tcctccccag ggacctttct gccagctccc agaagcattc
      841 attaccttaa aactcaaagt cagactgaac ataggatttc aagaagacct aaagaacacg
      901 tcttctgccc tctataggtc ctacaagact gatctggaaa gagcgttccg agcgggttac
      961 agaactttac caggattcag atcggtgact gtgacacagt tcaccaaggg cagcgtggtt
     1021 gtgaactacg tagtccgggt tacatcggca ccactgcctg gatctattca taaagccaat
     1081 gaacaagtca tacagaacct caaccatact tacaaaatgg actacaactc cttccaggga
     1141 accccgagca atgagacgaa attcactgtc ataccagaat tcatctttga gggagacaat
     1201 gtgactctgg agtgtgaaac tgagttcgtg acctccaaca cgtcttggta ctatggagaa
     1261 aaacgctctg acatccagaa cagcgacaaa tactccattc acaccactgt catcaacaat
     1321 ataagcctga tcacccgcct taccatttac aacttcacac agcatgatgc gggcatgtat
     1381 ggttgcaatg tgacattgga tatttttgaa tatggaacag tcagaaaatt agatgtcact
     1441 cccatccgga ttttggccaa ggaggagaga aaggtggtgt gtgacaacca tcctatatcg
     1501 ctgaactgct gcagcgagaa tattgcaaac tggagcagta ttgaatggaa acaggaaggg
     1561 aagataagca ttctagggaa cccagaatca gacctagagt ctagctgcag cacttacacg
     1621 ctcaaggcag atggaaccca gtgtcccagt gggtcttctg gaacaacagt catctacaca
     1681 tgcgagttcg tcagtgccta tggagccaga ggcagtaaga acatagctgt gaccttcacc
     1741 tctgtaggag ataatgccag ctacaaaggg gaagtgcccg aggtcctaag gcatgtgatg
     1801 gaagtgagta cagttcagag caccaccggg aacagcctag aaacaagtaa accccaggag
     1861 cagccagcca acctaacaat aacccgggac ccaatttctg tttctgaggg acaaagcttt
     1921 tctataacct gcctcagcga tgtgagtagc tttgatgagg tgtactggaa cacctcagct
     1981 ggtattaaaa tccacccaag gttttatacc atgaggaggt atcaggatgg agcagagtcg
     2041 gtgctgatgg tgaagacctc cacccgagag tggaacggaa cctaccactg catatttaga
     2101 tataagaatt catacagcat tgccaccaaa gatgtcaccg ttcacccgct gcctctggtg
     2161 tcagacatca tgatggatcc tttggaagcc agtggtctgt gtaccagttc ccatcaattc
     2221 aaatgctgcg tagaagagga tgcaggggaa gagtacgctg tgactttcca cgtggactcc
     2281 tcatcctttc ccgctgaaag agaagttatc ggcaagcaag catgctacac atacagtctc
     2341 ccagcgaact tacctcgatg tcccaaagac atcgcagtgt tctgccactt caccaatgca
     2401 gccaacagct cagtccggag cccatctatg aagctcaaac ttattccaag ggagaatgtc
     2461 acatgccagg atcccatcat tggcattggg gatcctggga aagtcattca gaagctgtgc
     2521 cagttctcag gtgtttacgg aagccctgga caggccatcg gcgggactgt cacttacaaa
     2581 tgtgtgggca cccagtggaa ggaggagtca agggcctgca tctcagctcc aatcaatggt
     2641 ttgctccagg tggccaaggc tttgatcaag agccccaccc aggaccagaa gctccctaca
     2701 tacctgaggg acctttctgt tagtgctggg aaggaagaac aggacatccg ctcatctcca
     2761 ggaagcctgg gagccatcat cagcatcctt gacttgctct caacggttcc cacccaagtg
     2821 aattcagaaa tgatgagaga catacttgct accattaacg tcatcttaga caagtctgcc
     2881 ttgaactcct gggagaagtt gctacagcaa cagagcaatc agagttctca gttcctgcac
     2941 tccgtggaaa ggttttccca agccctccag ctgggagaca gcactcctcc attcctcgcc
     3001 caccctaacg ttcagatgaa gagcatggtg ataaaacgtg gccaccccca aatctaccaa
     3061 cagcagttta tcttcaaaga ctctgacctg tggggtgatg tagccattga tgagtgtcag
     3121 ctgggaaact tgcagcctga ttcatcgatc gttactgtgg ctttcccaac tctcaaagcc
     3181 atccttgccc aggatgtaca gagaaagaca tcctccaaca gcttagtaat gacaaccact
     3241 gtcagccata acattgtcaa gccatttagg atttctatga cttttaagaa caaccatcgt
     3301 tcgggtggca agccacagtg tgtcttctgg aacttcagtc ttgccaacaa tacagggggc
     3361 tgggacagca gtgggtgctc tgtggaagat gatggtaggg acaataggga cagagtcttc
     3421 tgcaagtgta accacctgac gtcattctcc atcctcatgt ccccagactc cccagatcca
     3481 gggtctcttt taaaaatact tctggatatc atttcttaca tcgggttggg gttttccata
     3541 gtcagcttag ctgcctgtct agttgtggaa gccatggtgt ggaaatctgt gaccaagaac
     3601 cgaacttcct atatgcgcca catctgcata gtcaacattg ccttttgcct tctgattgct
     3661 gacatctggt tcattgtggc tggtgctatc cacgacggtc gctacccact caacgaaaca
     3721 gcctgtgtgg ccgccacatt cttcattcac ttcttctacc tcagtgtctt cttctggatg
     3781 ctaactctag gcctcatgct cttctaccgg ctgattttca ttctacacga tgcaagcaag
     3841 tccactcaga aagccatcgc attttctcta ggctatggct gtcccctcat tatctcctct
     3901 atcacagtgg gggttacgca gccacaggaa gtctacatga ggaagaacgc gtgttggctc
     3961 aactgggagg acaccagagc actgctggct tttgccatcc ccgcgttgat tattgtggtg
     4021 gtaaatgtga gcatcacagt tgtggtcatc accaagatcc tgaggccctc cattggggac
     4081 aagccaggca agcaagagaa gagcagccta ttccagatca gcaagagtat cggggtcctc
     4141 acaccactct tggggctcac ttggggtttc ggtcttgcca cagtgatcca gggaagcaat
     4201 gctgtgttcc acatcatatt tactctcctc aatgccttcc aggggctctt cattttgctc
     4261 tttggctgcc tctgggatca gaaggtgcag gaagctttgc tgcataagtt ttcattgtca
     4321 aggtggtctt ctcaacactc aaagtcaaca tccataggtt cgtcaacacc cgtgttttca
     4381 atgagttctc caatatcccg aagatttaat aatctttttg gtaaaacagg aacatataac
     4441 gtttccaccc cagagacaac cagttcatcc ctggaaaatt cctctagtgc ttactcactg
     4501 ctcaactagg accagacaaa gccaaatcca caggccctct ccgaaacagg gtccgtggca
     4561 ggaaaagaga cccatccaaa tctatgggta acgtgctctc tctgcagact tctgggagca
     4621 gatgctgaag agactctttc aatagagaag atgttttctt ttgtaaagac agactaaaag
     4681 caaaggccat gtttattttt gctcctagcc ctatcccatg tgtaatgcca actatgtata
     4741 gtatttaaaa gaaccctccc cacaaggctc aacttttctc tatgtactgt aaaatagaat
     4801 tttgaggaga tttttataca cacacccccc caaacacaca ctcacaccat tggctacaaa
     4861 gataagagtt gattgaaaca gtaagtaaaa ggctagtatc caggagttca gtgacttcaa
     4921 ggaaggaagg aaagatggag ggaatgaggg agataagcag gaaggaggaa agatgataga
     4981 atggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaaatgta
     5041 gaaaacatta gggagcacat tttaaggttt ccacagttgt gctctaatat ggccactcat
     5101 ctgccacagc tccgagaatg aaaatatatg gctcaaaaac aaaatgaaat gaagtcatgg
     5161 gggatatagt tagcaagttc ctgatctttc ccagctaaaa ggataaaaga gagaggcggg
     5221 aaagtagaaa agaaagtaga aaggaagagt cggcacgagg atgcttctgg ctggataata
     5281 atatttgcag gcaatgcacc caaggagaca cagttctcat gacaaggaca catatgaacc
     5341 tttgtatgtc aaggtctgag caaagcacag tgaacatgca gagcacgtat gacagccact
     5401 ctgtaagatt caagaaaggt tcatctctca tgatctgtca gatacgcatt gtatgctaat
     5461 ttgttcagcc ttttgaaagc catgcatgca tatgtacata ttttaatccc ataattgaca
     5521 aacttgatct accgcactga gctcagagtc ctacgtctgt cgtacatgta acaacagctt
     5581 taaccgggta ctctctgtgc attgtagaat agatttaata attatgtagc atgtacattt
     5641 ttattttgta ctcgtgactt cattgtgact gtggtgatga cagcccttgg tgtgctgtct
     5701 gtattgctgt gttctatccc ttcccagcct tctaagttcc taggccaata tacattcaga
     5761 gtttctatgg tctgattggt gtttcttgca gccacttgga aggagaaaaa ggacctggct
     5821 cgataagcaa atcgcagatc ccccaccccc acccccaaga attagattct gaatttatgc
     5881 ccgtgtggtt tttttgtatg tgtgtttctc aaattacaga tatttattaa aactgcatcc
     5941 atgttagaac tcaccaggtt ccatatccaa gagcaagcat gcaccccaca tcagggtgtc
     6001 aacccaaagg aacagtgtca gttaacttct cattgctgta gtaagacaca tggatgaaag
     6061 caacttacgg gagaaaaagg tttgttttgg tttacccttc ggaatatagc ccattacggc
     6121 agggagagca cggctgtagg agcatgaagc cagcccatca cacccaccac ctcagcagtc
     6181 tggaagtggg atcaggctat gagaactcaa agccctcaca cagtgacatc tttcctctag
     6241 gcaggttcca cctcctaaaa gttctataat cttcccaaac agcaccatca actgggggca
     6301 gagggttctg gtacgtggac ctatgggaga caattcacat ccaaacaacc acaagctgca
     6361 gaccctttag gaccgacgtg cagcattgag tttttataga gtgagagact gtgtgggtcc
     6421 ttcgttggga aagacaagat agaagagtct gaggtctgac atccatagtt ttaggtactt
     6481 tcagtctctt agttctaagc ttgaagtcta tttctgcttc tccgttcttc atagcggaag
     6541 ggcagagtgg ggcatacaaa gtcccgtccc ttgggttccg tttctgctta agtgccatct
     6601 tcccacactt gcgtgagaaa caccacacgc ctatcccaat ttaatggctc attatttaaa
     6661 gttcttacag gaaaggaatc cacaggaaat gtggataaga tctccaggga gtctccaaag
     6721 cagagcagag ttcagtagag ggaagacaag aggcgtctag gatgggacat cctttggatc
     6781 agaatcaggt gccagagaaa gaatggccag gaatgttcag ccccttgagt tgcactaagg
     6841 agcatcaagc cagagggatt tgcatggtat aacaaggcaa catggacgtc ttggaagctc
     6901 agcaccagga gaggctgggg ccgttgtgct caagaatgca aagatccaaa gtacactgag
     6961 ctttggccca cttcattggt gcctcttggg agccatgggg cttgaccttg taaggagatc
     7021 ctccacagta gcataatagt aggaactctg agctgaattc catagcatgc agatctggcc
     7081 ctctgcctgc ttgcattcag agagacacgt ctccctttca ccaattagca tgcctacaaa
     7141 ttctaatgca cacatgaatt catacacaga cctacagatt gatcaagaca cacaggaaca
     7201 tgtgtgcgca catgtgcacg cgcgcacaca cacatatgta tatgtatata ttcacgcaca
     7261 cacacacata cacaccccca ggcacatatg aacacacatt aacacccaaa tacacaggca
     7321 catacataca gacgtcatca tgagaaccac cacatctctg tcccagctga aaggcttttg
     7381 gtttaaaatc cccatgggaa gtttgctagt ttgtaaatgc aggattcagg agagggggca
     7441 gacatatcca ctccaacacg cacatacaca gacgtacctt gatctttcaa ggcacagccc
     7501 ttaatcccag aaaaggaggc tggagatgtt gctcagtggt taaggatata tactgctctt
     7561 ccagaggagt ctctagctcg gattccagca cccacgctgg gcagctcact accgcctgtt
     7621 accaccagct gacagcaatc tgttgctctc ctcttgactt tgaggctgca tgcatgtaca
     7681 tatccagata catttacaca tacttaaggg tttgaaaata aactccagaa aaatctatgt
     7741 aacgagatac agaaggagca cttcgtggtt tcctgcccac cactgtatat gcaaccccat
     7801 attaacattt ctaaatgaaa ccatgaaata aacatcgcat ccaaagttgt aaaagacaga
     7861 aacacgtagg gtctgtgcat tgcgtgaaag ctagagccgg tgcccagttc tgcggcagca
     7921 aggggggact gcgacagaga aggcatgttc tctgacctgg gtgccaagtg agtcatgttc
     7981 actttgctaa gagagcgcca cctactgccc acattcccac atgtctttat tatgtaaagt
     8041 agatttcctc caccggccac caactttcct taagggactt ttcattcagg cagtttcttg
     8101 caaaatgatc catgcgaatg tttcaggggt tgtgaagttg gagaatccag aaatacacca
     8161 ttaattcaca gcagtgttct cagggaatac cgtaagcatc acctacggag gaaaggaaga
     8221 aacgccaagg gaagtcaggg cctttgtgat ttgtgcaggg cacctcagag aggtctgtgt
     8281 tgggagaaaa tacacacaaa gatgagagag agtacagcag cagccagtgt ggagggaggc
     8341 atgtgggagt tattcgcagg tgagtggagc agtaagtcac agccagttac aaagacagaa
     8401 aaaaaaatta tgtgggctgg ttattcaggg agaaagtgtt ttatctgcac catgtagaaa
     8461 tgttgtgtat gggcttttgc accccaaaga ggaatccagg gacccaggtc aatagaagtc
     8521 tggttccttg agaatcctca aagaaggagc ttagaacaga catctctttc ttacttattg
     8581 ttaaagacaa tagaaatagc atttctattg caaccagatg ccgtaggtct ctagaattac
     8641 gactcagagt ttaaagtcat gtcctactaa aatatcagtg tattagtgat gctgtctttc
     8701 ctcataataa aatacctaat gatttgcccg g
//
