LOCUS       NM_030067               3064 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor F4 (Adgrf4),
            transcript variant 1, mRNA.
ACCESSION   NM_030067 XM_001476141 XM_894986
VERSION     NM_030067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3064)
  AUTHORS   Chiba,Y., Yoshizaki,K., Saito,K., Ikeuchi,T., Iwamoto,T.,
            Rhodes,C., Nakamura,T., de Vega,S., Morell,R.J., Boger,E.T.,
            Martin,D., Hino,R., Inuzuka,H., Bleck,C.K.E., Yamada,A., Yamada,Y.
            and Fukumoto,S.
  TITLE     G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel
            mineralization mediated by ameloblasts
  JOURNAL   J Biol Chem 295 (45), 15328-15341 (2020)
   PUBMED   32868297
  REMARK    GeneRIF: G protein-coupled receptor Gpr115 (Adgrf4) is required for
            enamel mineralization mediated by ameloblasts.
REFERENCE   3  (bases 1 to 3064)
  AUTHORS   Lu,S., Liu,S., Wietelmann,A., Kojonazarov,B., Atzberger,A.,
            Tang,C., Schermuly,R.T., Grone,H.J. and Offermanns,S.
  TITLE     Developmental vascular remodeling defects and postnatal kidney
            failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4)
  JOURNAL   PLoS One 12 (8), e0183166 (2017)
   PUBMED   28806758
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3064)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   5  (bases 1 to 3064)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3064)
  AUTHORS   Promel,S., Waller-Evans,H., Dixon,J., Zahn,D., Colledge,W.H.,
            Doran,J., Carlton,M.B., Grosse,J., Schoneberg,T., Russ,A.P. and
            Langenhan,T.
  TITLE     Characterization and functional study of a cluster of four highly
            conserved orphan adhesion-GPCR in mouse
  JOURNAL   Dev Dyn 241 (10), 1591-1602 (2012)
   PUBMED   22837050
REFERENCE   7  (bases 1 to 3064)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019508.1 and D18369.1.
            
            On Jan 23, 2014 this sequence version replaced NM_030067.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, and 4 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3060              AK019508.1         4-3063
            3061-3064           D18369.1           296-299
FEATURES             Location/Qualifiers
     source          1..3064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.65 cM"
     gene            1..3064
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /note="adhesion G protein-coupled receptor F4"
                     /db_xref="GeneID:78249"
                     /db_xref="MGI:MGI:1925499"
     exon            1..219
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            220..329
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2339
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /note="probable G-protein coupled receptor 115; G
                     protein-coupled receptor 115; G protein coupled receptor
                     Gpr115"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor F4
                     precursor"
                     /protein_id="NP_084343.1"
                     /db_xref="CCDS:CCDS50113.1"
                     /db_xref="GeneID:78249"
                     /db_xref="MGI:MGI:1925499"
                     /translation="MKPWIAMVCCLVFFLTTECSHSKPKTHRKDEDKFQISLQKHEFR
                     PRQGKCDGLCSSSSSCNQSCPWNFRGEIVFTCNQNKWQKTIETCTSLSVDTLFQRIHP
                     AASLSLASSSVFPMSLIGNAAPVHIGNVFQGIQKYCPEDYVCIVDAVKSSAVTSGNIA
                     FIVELLKNISSNLQTSGIHDNVNWKKMKNYGKVANHILGPTAISNWAFIANKNASSDL
                     LESVNSFAKKLQIQGKSESIVDELFIQTKGSRISHSSSEHSLSLSVPRYNATEDVLVV
                     IEIPRQALQELSFNASQAIVVAFPTLGAILKEVHRPNTNLQKPIDDLILSLVLPEGLN
                     EIILTFDKINKSQSTSSQCVSWDPATGQWDESPCTVMSDINSTVKCRCRHTKAVTSFS
                     ILMSSKPVKNTILNHITFIGLSISIFSLVLCLVIEAIVWSRVVVTEISYMRHVCIVNI
                     AVSLLTANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFLSLFFWMLFKALLIVYGIL
                     VVFRRMMKSRMMAIGFAIGYGCPLVIAVITVTVTEPGEGYTRKDACWLNWNQTKALFA
                     FAIPALAIVAVNLLVVLAVAINTQRPLIGSSKSQDMAIVFRISKNVAILTPLLGLTWG
                     FGLTTLLEGVHLVFHIIFALLNAFQGFFILLFGTIMDHKIRDALRMRVSSLKGKSRAA
                     EKVSLSPANGSRILNR"
     exon            330..384
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            385..536
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            537..806
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            807..2189
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2231
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2291
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2348
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..3064
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /note="hexamer: AATAAA"
     regulatory      3035..3040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /note="hexamer: AATAAA"
     polyA_site      3040
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
     polyA_site      3064
                     /gene="Adgrf4"
                     /gene_synonym="4632435A09Rik; Gpr115"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggcca gattggcttc tcattacagg cagttgcttc tcacccgggc cttcgggact
       61 tccttttcaa aagatggagt cgggctgcta tcactgaagg gggctgaagg gtttcagcgc
      121 cgagacgtga tggtgaggca ccatcgtagg gagttcaatg ctgactttcc tgctaggtga
      181 ctatcggtct ctgggctgct agatctactt cctggatgcg ttaagatctc catgtgtgaa
      241 aaatgaagcc ctggattgcc atggtttgct gtttagtatt ttttctgaca acagaatgtt
      301 ctcattccaa acccaagact cacagaaaag atgaagataa atttcaaata tctctacaga
      361 agcatgagtt tagaccaaga cagggtaaat gtgatggact gtgcagctct tcttccagct
      421 gtaaccagag ctgtccttgg aacttccgtg gagaaatcgt attcacatgt aatcaaaaca
      481 aatggcaaaa aacaatcgaa acatgcacaa gtctctctgt ggacaccttg tttcagcgca
      541 tacatcctgc agctagccta tccttggcgt cttcttctgt ttttcccatg agcttaattg
      601 gcaatgcagc accagtccat attggaaatg tatttcaagg aatccaaaag tactgccccg
      661 aggactacgt ttgcattgtt gatgctgtga aatcctctgc agttacatct ggaaatattg
      721 cattcatagt agagttatta aaaaatatct cttcaaacct gcaaacttct ggaatacatg
      781 ataatgtgaa ttggaagaaa atgaagaact atggcaaagt ggccaaccat atccttggcc
      841 ccactgccat ttcaaattgg gctttcattg ccaacaaaaa tgccagctca gatctgttgg
      901 agtcggtgaa ctcttttgcc aagaaactcc aaatccaagg taaatctgag agcatcgtag
      961 atgaactctt tattcagacg aaaggctctc gtatctctca cagttcctca gagcacagcc
     1021 tcagcctctc tgtacccagg tacaatgcta cagaagatgt cttagtggtg atcgaaattc
     1081 ctaggcaagc attacaggag ctgtcgttca atgcctccca agccattgtt gtcgcttttc
     1141 caaccttggg ggccattcta aaagaagtcc atcggccaaa tacaaatctc caaaagccta
     1201 tagatgacct catcctatca ctggttttgc cagaaggtct gaacgaaatc atactcacct
     1261 ttgataaaat caataaatcc cagagcacca gcagccagtg tgtcagctgg gatcctgcaa
     1321 cagggcagtg ggatgagagc ccatgtacag tgatgtcaga catcaatagc acagtgaaat
     1381 gccggtgcag gcacaccaaa gctgtgacgt ccttctccat cctcatgtct tctaagcctg
     1441 taaagaatac gattctgaac catatcacct tcattggact cagcatctcc atctttagct
     1501 tggtgctctg cctggtcatt gaggccatcg tctggtcccg ggtggttgtt acagagatat
     1561 cctacatgcg ccacgtgtgc atcgtgaaca ttgcagtgtc cctcctgact gccaatgtgt
     1621 ggttcatcat tggctccaac ttcagtgcca acgttcagga ggatcacaag tggtgtgtgg
     1681 ctgtgacatt tctctgccac ttcttcttcc tctccctgtt cttctggatg ctcttcaaag
     1741 cgctgctcat agtctatgga atactggttg tcttccgcag gatgatgaag tctcggatga
     1801 tggccattgg ctttgccatt ggctatgggt gtccccttgt gatcgcggtc atcactgtta
     1861 ctgtcacaga gcctggggaa ggctacacca gaaaagatgc ctgttggctt aattggaacc
     1921 aaaccaaagc cctttttgct tttgctatcc cagccttggc cattgtggct gtgaatctcc
     1981 ttgtggttct ggcagttgct atcaacacac agaggccctt gattggcagt tcaaaatctc
     2041 aggatatggc cattgttttc aggatcagca aaaatgttgc catcctcacc ccacttctgg
     2101 gactgacctg gggttttggt ctaacaaccc tgctagaagg cgtacacctg gtattccata
     2161 taatcttcgc cttgctcaat gctttccagg gctttttcat cttgctgttt ggtaccatta
     2221 tggatcacaa gataagagat gctctgagga tgagggtatc ttcattgaag gggaaatcaa
     2281 gggcagcaga gaaggtgtca ttaagtccag ccaatggatc cagaatactg aatcgctgag
     2341 actgcaatag acaccttgct tgctgggatg gagagggctc caagagaagg atgcacaaat
     2401 gtctctggaa tgaagcaaca tcttcttcca gccaggagca ccacctaagt tggaaaacta
     2461 gctacgacac acagtgaatg agtggacttt aaaaaagatt gacctgcagc ctctcacctc
     2521 acaaaggctg actttttatt cacctcagca agtttcacaa tccagctgca aatcactgta
     2581 ctgtccatgg ctgatgggca gcctgcgaaa ttgtcaactt tcagcgtacc ttcccacccc
     2641 taggcttctc tgtggctctg gacccagaca tcctccctcg tgagggtatc ctgggtgtct
     2701 gggtgtctct gtgtgtgtgt ctgtgtgttg tctcaggtca gattcagtgt cagtggtggg
     2761 gttggagatc aaacatgaat gataatattg tatctacttt gcagattgtc cctggtaggt
     2821 ttcccaaaga cagggaatga acaacgggca ggtaggtggt gttcagtgtg cttactattg
     2881 taatccttga gtaaatcacc tgacgtgtag ggccttagct tctttacttg tgagacagac
     2941 acaacgctgt tccaggtctt actagttgtg tgcttatgac tgttttcctt ttaaacaact
     3001 gtaaataaag acatcctggg gcgtgatttc agaaaataaa gtaagttgca tttactttcc
     3061 tgaa
//
