LOCUS       NM_001033493            3283 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor F2 (Adgrf2), mRNA.
ACCESSION   NM_001033493 XM_487485
VERSION     NM_001033493.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Chiba,Y., Yoshizaki,K., Sato,H., Ikeuchi,T., Rhodes,C., Chiba,M.,
            Saito,K., Nakamura,T., Iwamoto,T., Yamada,A., Yamada,Y. and
            Fukumoto,S.
  TITLE     Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes
            enamel hypomineralization in mice by alteration of the expression
            of kallikrein-related peptidase 4 (Klk4) during pH cycling process
  JOURNAL   FASEB J 37 (4), e22861 (2023)
   PUBMED   36929047
  REMARK    GeneRIF: Deficiency of G protein-coupled receptor Gpr111/Adgrf2
            causes enamel hypomineralization in mice by alteration of the
            expression of kallikrein-related peptidase 4 (Klk4) during pH
            cycling process.
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Promel,S., Waller-Evans,H., Dixon,J., Zahn,D., Colledge,W.H.,
            Doran,J., Carlton,M.B., Grosse,J., Schoneberg,T., Russ,A.P. and
            Langenhan,T.
  TITLE     Characterization and functional study of a cluster of four highly
            conserved orphan adhesion-GPCR in mouse
  JOURNAL   Dev Dyn 241 (10), 1591-1602 (2012)
   PUBMED   22837050
REFERENCE   4  (bases 1 to 3283)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   5  (bases 1 to 3283)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB662982.1, AK142836.1 and AC117257.4.
            
            On Mar 31, 2007 this sequence version replaced NM_001033493.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available transcript
            and homology data. The update adds a predicted signal peptide to
            the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142836.1, BC141353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               BB662982.1         2-625
            625-671             AK142836.1         626-672
            672-2644            AK142836.1         674-2646
            2645-3281           AK142836.1         2648-3284
            3282-3283           AC117257.4         122791-122792       c
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.66 cM"
     gene            1..3283
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /note="adhesion G protein-coupled receptor F2"
                     /db_xref="GeneID:435529"
                     /db_xref="MGI:MGI:2182728"
     exon            1..259
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /inference="alignment:Splign:2.1.0"
     exon            260..360
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2223
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /note="G protein-coupled receptor PGR20; G protein-coupled
                     receptor 111; probable G-protein coupled receptor 111; G
                     protein coupled receptor Gpr111"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor F2
                     precursor"
                     /protein_id="NP_001028665.2"
                     /db_xref="CCDS:CCDS28792.2"
                     /db_xref="GeneID:435529"
                     /db_xref="MGI:MGI:2182728"
                     /translation="MIPAHWLYCLMLLLPIESCRILCQASSKSKEKVTSRPHDVCDGV
                     CNNNGTPCFQSCPPDSEGNMKFACKAKKWHKVTETCHTLNTHSIFEEDKELYSVQSSD
                     STIRTHMFHRELKTIMDTLMEKCPKDLSCVIKGIERSPRMPGNIAVVVQLLHNISTTL
                     TKDVNEEKMQSYSAMANHILNSKSISNWTFIQDRNSSCVLLQSIHSFASKLFMKEHLI
                     NISHVFIHTLGTVVSRGSLGKNFTFSMRINETSDKVTGRLLLSPEELQKVPSAFQVIS
                     IAFPTLGAILEASLLENVTVNGLVLSVILPEELKNISLIFEKIRKSGERKSQCVGWHS
                     LESRWDWRACKTIQENSRQAVCRCRPNKLYTSFSILMSPNTLESPVLTYITYIGLGIS
                     ICSLIICLAIEVLVWSQVTKTEISYLRHLCIANIAATLLMADAWFIVASFLSGPVLHH
                     NGCVAATFFVHFFYLSVFFWMLAKALLILYGILIVFHTLPKSCLVASLFSVGYGCPLV
                     IAIITLAVTEPGKGYLRPEACWLNWDMTKALLAFVVPALAIVVVNLITVTMVIIKTQR
                     AAIGSSMFQEVRAIVRICKNIAILTPLLGLTWGFGIATVINGHSLAFHIIFSLLNALQ
                     VSPDAAVDSELRECVHRFCG"
     exon            361..403
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /inference="alignment:Splign:2.1.0"
     exon            404..558
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /inference="alignment:Splign:2.1.0"
     exon            559..798
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /inference="alignment:Splign:2.1.0"
     exon            799..3283
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3260..3265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrf2"
                     /gene_synonym="Gpr111; PGR20"
                     /note="putative"
ORIGIN      
        1 agatgctact ctcaggcagg acctgtctgt caggctgagg cacctctgca catgctgcag
       61 ctgtctgtgg gaggaagcac ccagcacggc ggtggcctca gttttggacg ctgccattgg
      121 ggctgaagtg actgctcagg acgtacagga gcccagttgc tgatctgaag ggagacgaca
      181 aagggaccag ctgatgttct tctctccagc tgtcagggaa gagggccagt gtccccgaga
      241 gtcttgttga ctagccacaa agcaagaaca cctgctgcgt ggaaaacaat gattcctgcc
      301 cattggttgt actgtttgat gcttcttttg cctatagaat cctgtaggat attatgccag
      361 gcctccagca aaagcaagga gaaggtgaca tccagaccac atgatgtctg tgatggtgtc
      421 tgtaataaca atggcacccc ctgctttcag tcttgtcctc cagacagtga gggcaacatg
      481 aaatttgcct gtaaggccaa gaaatggcac aaagtcactg aaacctgcca cactctcaat
      541 acccacagca tctttgagga ggataaggaa ctatattcag ttcaatcatc tgattcaacc
      601 atacgtacac acatgtttca tagagaactt aaaaccataa tggatacgtt gatggaaaag
      661 tgtccaaagg atttgtcttg tgtgatcaaa ggcattgaga gatctcctcg gatgccaggg
      721 aacattgctg tggtggtgca gctcttacac aacatctcaa caactctaac caaagacgtc
      781 aatgaggaaa agatgcagag ttacagtgcc atggctaacc acattcttaa cagtaaaagc
      841 atatcaaatt ggaccttcat ccaagacaga aacagcagct gtgtcttgct tcaatcaatc
      901 cattcatttg caagcaagct atttatgaag gaacatctca tcaacatatc acatgtcttt
      961 attcatacct tggggacggt cgtgtccagg ggcagccttg ggaagaattt cacgttctca
     1021 atgcgaatta atgagacaag tgataaggtc actgggaggc tactgctcag ccctgaagag
     1081 cttcagaagg tgccttctgc tttccaggtc atcagcattg ctttcccaac tcttggggcc
     1141 atcctggagg ccagtctttt ggaaaatgtg actgtgaatg ggctcgtcct gtctgtcatt
     1201 ttgcccgagg agcttaaaaa catctcactg atatttgaaa agatcagaaa atctggagag
     1261 aggaagtccc agtgtgtggg atggcactcc ttggagagca gatgggactg gagggcttgt
     1321 aaaacgattc aagaaaactc caggcaagct gtttgccgtt gtcggccgaa taagttatat
     1381 acttctttct ccattctaat gtctcccaac acgttggaaa gccctgttct aacttatatt
     1441 acatacatag gcctgggcat ttccatctgc agcttgatca tctgcctggc cattgaggtc
     1501 ttagtctgga gtcaagtgac aaagacagag atctcatatt tacgtcacct gtgcatcgct
     1561 aacattgcgg ccaccttgct gatggctgat gcgtggttca tcgtggcgtc tttcctcagt
     1621 ggcccagtac tacaccacaa tggatgtgtg gccgccacgt tttttgttca cttcttttac
     1681 ctgtccgtgt ttttctggat gcttgccaag gctctcctta tcctctatgg aattctcatt
     1741 gtgtttcata cactgcccaa gtcgtgcctg gtggcctctc tgttttccgt gggctatggg
     1801 tgccctttgg tcatcgccat tatcacactt gccgttacag agcctggaaa aggctacctc
     1861 cggcccgagg cctgctggct taattgggac atgaccaagg ctctcctggc ctttgtagta
     1921 ccagctctgg ccattgttgt agtaaacctg attacagtca caatggtcat catcaagacc
     1981 cagagagctg ccatcggtag ttccatgttc caggaagtaa gagccatcgt gaggatctgt
     2041 aagaacattg ccatcctcac accactgctg gggctgacct ggggatttgg gatagccaca
     2101 gtcattaatg gtcactccct ggccttccac attatcttct ccttactcaa tgcactccag
     2161 gtaagtccgg atgctgcagt agactctgaa ttgagagagt gtgtgcatcg gttttgtggg
     2221 taggagtcca tgtatcatgc tttaataaga caacgaaata gacataaata tttgtttcag
     2281 aaaggcctgg acttgaattc tgactctctt ctttaccaat aatatgtggc atgatctttg
     2341 tatgtttagt ttttcacaag catgtttttc tcattcagga agagagtatg atgctgccat
     2401 tttctggagg tgcttagaaa gtgaaagttc aaatattaaa attagatact aaagaccata
     2461 aactcctgtt aataggctga ggattttttt ttttttttga gacatgtctt atgtatccca
     2521 ggctggcctt gaacggacta tgacattaaa cttctgattt tcctgtctcc atctcccagg
     2581 tactgggatt acaggtgtgt acagccatgt accaattatg aagtcctgga catccaaccc
     2641 agggctttag acatgattgg caaatattct gtcaacagag ctgtatcctc agccctgagc
     2701 tgttactatt tggcaaagaa ttgatcactt cttctaaaat ttagtctcag agctggaggt
     2761 gttacatgtt atggttgttg tattttctgc tacttaagag tttatagata gctttggatg
     2821 ccaccttatt tgacgaaggc aagctataca aagaggcttt aatggtcatt tctttccact
     2881 cttctcatgc ttgatggatt aaggaatgtt cagtttcatg tgtatccttg ccagattcta
     2941 tatgccaata caaatatata cgtaatataa gaattgaaaa catatgtaga ttattatgta
     3001 cctttcaggc atttgggcct ccagcattcc atagatgaca ttggccatca aagtcagggc
     3061 gactatggtt tgctggatcc tgctttaccc actgaactac accatagcta ttatatagct
     3121 ttctttctca ctaaaaatca tattttatgc ttttactggt ctaatgtcta tgtatattta
     3181 atgtctagga tagtacttgc tatttaacat tttccttctt gattgaaatt gcacacatta
     3241 aatgtaaaga ttgcaattaa ttaaaaagaa agcttctagt ttc
//
