LOCUS       NM_133776               3504 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor F1 (Adgrf1), mRNA.
ACCESSION   NM_133776
VERSION     NM_133776.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3504)
  AUTHORS   Zhang,M., Ma,Z., Qi,H., Cui,X., Li,R. and Gao,X.
  TITLE     Comparative transcriptomic analysis of mammary gland tissues
            reveals the critical role of GPR110 in palmitic acid-stimulated
            milk protein and fat synthesis
  JOURNAL   Br J Nutr 130 (10), 1665-1677 (2023)
   PUBMED   36946032
  REMARK    GeneRIF: Comparative transcriptomic analysis of mammary gland
            tissues reveals the critical role of GPR110 in palmitic
            acid-stimulated milk protein and fat synthesis.
REFERENCE   2  (bases 1 to 3504)
  AUTHORS   Wu,M., Lo,T.H., Li,L., Sun,J., Deng,C., Chan,K.Y., Li,X., Yeh,S.T.,
            Lee,J.T.H., Lui,P.P.Y., Xu,A. and Wong,C.M.
  TITLE     Amelioration of non-alcoholic fatty liver disease by targeting
            adhesion G protein-coupled receptor F1 (Adgrf1)
  JOURNAL   Elife 12, e85131 (2023)
   PUBMED   37580962
  REMARK    GeneRIF: Amelioration of non-alcoholic fatty liver disease by
            targeting adhesion G protein-coupled receptor F1 (Adgrf1).
            Erratum:[Elife. 2024 Jan 22;13:. PMID: 38252482]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3504)
  AUTHORS   Banerjee,S., Park,T., Kim,Y.S. and Kim,H.Y.
  TITLE     Exacerbating effects of single-dose acute ethanol exposure on
            neuroinflammation and amelioration by GPR110 (ADGRF1) activation
  JOURNAL   J Neuroinflammation 20 (1), 187 (2023)
   PUBMED   37580715
  REMARK    GeneRIF: Exacerbating effects of single-dose acute ethanol exposure
            on neuroinflammation and amelioration by GPR110 (ADGRF1)
            activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3504)
  AUTHORS   Huang,B.X., Chen,H., Joo,Y., Kwon,H.S., Fu,C., Spector,A.A. and
            Kim,H.Y.
  TITLE     Interaction between GPR110 (ADGRF1) and tight junction protein
            occludin implicated in blood-brain barrier permeability
  JOURNAL   iScience 26 (4), 106550 (2023)
   PUBMED   37123219
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3504)
  AUTHORS   Kwon,H.S., Kevala,K., Qian,H., Abu-Asab,M., Patnaik,S., Marugan,J.
            and Kim,H.Y.
  TITLE     Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual
            Function Impaired by Optic Nerve Injury
  JOURNAL   Int J Mol Sci 24 (6), 5340 (2023)
   PUBMED   36982411
  REMARK    GeneRIF: Ligand-Induced Activation of GPR110 (ADGRF1) to Improve
            Visual Function Impaired by Optic Nerve Injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3504)
  AUTHORS   Ma,B., Zhu,J., Tan,J., Mao,Y., Tang,L., Shen,C., Zhang,H.,
            Kuang,Y., Fei,J., Yang,X. and Wang,Z.
  TITLE     Gpr110 deficiency decelerates carcinogen-induced
            hepatocarcinogenesis via activation of the IL-6/STAT3 pathway
  JOURNAL   Am J Cancer Res 7 (3), 433-447 (2017)
   PUBMED   28401002
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3504)
  AUTHORS   Lee,J.W., Huang,B.X., Kwon,H., Rashid,M.A., Kharebava,G., Desai,A.,
            Patnaik,S., Marugan,J. and Kim,H.Y.
  TITLE     Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in
            development of neurons and cognitive function
  JOURNAL   Nat Commun 7, 13123 (2016)
   PUBMED   27759003
  REMARK    GeneRIF: Study demonstrated orphan G-protein coupled receptor 110
            (GPR110, ADGRF1) as the synaptamide receptor, mediating
            synaptamide-induced bioactivity in a cAMP-dependent manner.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3504)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   9  (bases 1 to 3504)
  AUTHORS   Promel,S., Waller-Evans,H., Dixon,J., Zahn,D., Colledge,W.H.,
            Doran,J., Carlton,M.B., Grosse,J., Schoneberg,T., Russ,A.P. and
            Langenhan,T.
  TITLE     Characterization and functional study of a cluster of four highly
            conserved orphan adhesion-GPCR in mouse
  JOURNAL   Dev Dyn 241 (10), 1591-1602 (2012)
   PUBMED   22837050
REFERENCE   10 (bases 1 to 3504)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019869.1, BB661727.1, BB506964.2 and AW113731.1.
            
            [WARNING] On Jul 9, 2024 this sequence was replaced by NM_133776.3.
            
            On Apr 2, 2009 this sequence version replaced NM_133776.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AK019869.1         3-141
            140-2124            AK019869.1         143-2127
            2125-2488           AK019869.1         2129-2492
            2489-2870           BB661727.1         158-539
            2871-3468           BB506964.2         71-668
            3469-3504           AW113731.1         473-508
FEATURES             Location/Qualifiers
     source          1..3504
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.71 cM"
     gene            1..3504
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /note="adhesion G protein-coupled receptor F1"
                     /db_xref="GeneID:77596"
                     /db_xref="MGI:MGI:1924846"
     exon            1..138
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            139..217
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            218..358
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..3016
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /note="G-protein coupled receptor 110; internal gene name
                     of KIRIN laboratory:M5; G protein coupled receptor Gpr110"
                     /codon_start=1
                     /product="adhesion G-protein coupled receptor F1
                     precursor"
                     /protein_id="NP_598537.2"
                     /db_xref="CCDS:CCDS28795.1"
                     /db_xref="GeneID:77596"
                     /db_xref="MGI:MGI:1924846"
                     /translation="MRIGLLWLVPLFTLTEGTDGFLQQKNDGRRTKEIVSMVEERHPV
                     HEYEVLLQVTYRDPEEKRELKRFLKLLKSPSPSLRGPSKIIRVKATTYCRSRKGFLEC
                     ACEDSYTWFPPSCLDPQNCCLHTTGPVPSCNCSLRGLRQSINFCERAKVWGTFEIDEK
                     FPEDLWNSSSDVYAHYTVGIENQLKEAYRRVHGFESVRVTQFRKGSIVVGYEVTGSTS
                     PPELLFAIEQEAEKAQEALRRQFPVKYGSFRVFGKAPCNSISFGFGSENDEYTVPCSS
                     GFTGSMTVRCQSSGWQITRESCVLSQLEELKKELRMIAGKITEAGVASLVQNLSTILL
                     QSPSTTVGNLGSVVSLLSNISSLSLANSLTVSNLTLMNVINIADHILDSASITNWTIL
                     LQDAKDASSQLLKTLESISSLIPSMALPLNFSGKFIDWKGTPVTQIQSTRGYNYQMEM
                     RQNASLPIRGHVFIEPDQFQKSHPKTIISMASLTFGDILPITQRGNAWVNGPVISTLI
                     QNYSISEIFLNFSKIKGNLTQPRCVFWDFSQLQWSNAGCQLVNETLDTVLCRCSHLTS
                     FSMLMSPFVPSSVVPVVKWITYIGLSISIASLILCLIIESLFWKQTKRSQTSYTRNIC
                     LVNIAVSLLIADVWFIIAATVDPSVSPSGVCVAAVFFTHFFYLAVFFWMLVLGILLAY
                     RIILVFHHMALTTMMAIGFCLGYGCPLLISIITLAVTQPSNSYKRNDVCWLNWSDKSK
                     PLLAFVVPALTIVAVNLVVVLLVLRKLWRPAVGERLNQDDKATAIRMGKSLLVLTPLL
                     GLTWGFGIGTMANSHNLAWHVLFALLNAFQGFFIFCFGILLDTKLRQLLSNKLTTLSS
                     WKQTSKRNASDTVTQPKCLRTFNILQHRGMYALSHTGDSSSDITLTQFLSTE"
     exon            359..419
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            420..563
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            564..737
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            738..838
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            839..897
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1049
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1213
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1402
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2773
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2815
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2875
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2942
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3504
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /note="hexamer: AATAAA"
     polyA_site      3035
                     /gene="Adgrf1"
                     /gene_synonym="5031409J19Rik; Gpr110; KPG_009"
                     /note="major polyA site"
ORIGIN      
        1 ggtgatagat acatcagtgg acctgtggct gccagtcctg tcctgggtca ccagcgtccc
       61 ttggcatctc ccaacggtgt cagtggctgg ggaacattgg agaaaggctc agctgtgctg
      121 tgaagtccag agtcccaggt cagagagcag gagctgagag cagcgtctga tgggaatggc
      181 agtgtgcaca tgaagtttaa gtttgccaag aagcaagcac acagcctcca gggtgactag
      241 acacgggtgt ctgtgttcag tccagagagg agagaaggag ctactggata tgagaattgg
      301 acttctgtgg ctcgtccctc tcttcacgct cactgagggc accgatggct tcctgcagca
      361 gaaaaatgat ggccgaagaa caaaagaaat tgtcagtatg gttgaggaaa ggcatccagt
      421 ccacgagtat gaggtgctac tgcaggtgac atacagagat ccagaggaga agagagaact
      481 gaagagattt ctgaagctct tgaaatctcc gtcgccgagt ttacgtggtc ccagcaagat
      541 catcagagtg aaggccacca catactgcag aagccgaaaa gggttcctgg agtgtgcctg
      601 cgaagacagc tatacgtggt ttcctccctc ctgccttgac ccccagaact gctgccttca
      661 cacaactgga cccgtcccaa gctgcaattg ctctctcaga ggcctcaggc agagcattaa
      721 tttctgtgag agagcaaaag tttggggcac ttttgaaatc gatgaaaaat ttcctgaaga
      781 cctttggaat tcatcatctg atgtatatgc ccactacaca gttggaattg aaaatcaact
      841 taaagaagcg tacagaagag tccatggttt tgagtcagtt cgggtcaccc aatttcggaa
      901 gggaagcatc gttgttggct acgaagtgac cggctccact agccctccag aactcctctt
      961 tgccattgaa caggaggccg aaaaggcaca ggaggcccta aggaggcagt ttccagtcaa
     1021 atatggctct tttcgagtat tcgggaaagc tccgtgtaac agcatctcct ttggattcgg
     1081 gtctgagaat gatgaatata ctgtgccctg cagcagtggc ttcacaggaa gcatgacggt
     1141 caggtgccag tcctctgggt ggcagatcac cagggagtcc tgtgtgcttt ctcagctgga
     1201 agaactgaag aaggagctca ggatgatcgc aggcaagatc acagaggcgg gtgtggcatc
     1261 tttggtgcaa aacctttcca ccatcctttt gcaaagtcca tcgaccacag ttgggaacct
     1321 gggctctgtg gtgtcacttc tgagcaacat ttcatccctg tcgctggcaa actctttaac
     1381 tgtgtccaat ctgacactga tgaacgtcat caacatagct gatcatatcc tggattcagc
     1441 ctccataacg aactggacaa ttttattaca agatgcaaag gatgccagct cccagctact
     1501 aaagacattg gaaagcatca gtagtctcat cccttccatg gctctgcctc ttaatttttc
     1561 tggaaaattc attgactgga aagggacccc agtgacccaa atccagagca cacggggcta
     1621 caactatcag atggaaatga gacaaaatgc ctctctgcct atccgaggcc acgtgtttat
     1681 tgaaccagat caattccaga aatcgcatcc aaagactatt atcagcatgg cctcattgac
     1741 ctttggggac attctaccca ttacccagag aggaaatgca tgggtcaatg gcccagtgat
     1801 atccacactt attcaaaact attccatcag cgaaattttc ctgaactttt ccaaaataaa
     1861 gggaaacctg actcagcctc gctgtgtgtt ttgggatttt agccagttgc aatggagcaa
     1921 tgcaggctgc caactggtta atgaaactct ggacacggta ctgtgccgat gtagtcacct
     1981 gacctctttc tccatgctca tgtcaccctt tgtcccctct tctgttgttc ctgtggtaaa
     2041 atggatcacg tacatagggc tgagcatctc cattgcaagt ctaatcttat gcttgatcat
     2101 cgagtctctg ttttggaagc agaccaagag aagccaaacc tcctacacac gcaacatttg
     2161 cctggtgaac atcgccgtgt cactcttaat tgctgatgtt tggtttatca ttgctgccac
     2221 tgtggacccc tctgtgagtc cttctggagt ctgtgtggct gcggtgttct ttacccactt
     2281 tttctacctt gccgtattct tttggatgct cgttctgggc atcctgctgg cttatcgaat
     2341 tatcctagtg tttcatcaca tggctctgac taccatgatg gctattggct tttgcctagg
     2401 ctatgggtgc cctctcctta tatccatcat cacccttgct gtcacccaac ctagcaatag
     2461 ctataaaagg aacgatgtgt gttggcttaa ctggtctgac aagagcaaac ctctcttggc
     2521 gttcgttgtt cccgcgttga ctattgtggc tgtgaacttg gttgtggtgt tgctggtcct
     2581 caggaagctt tggaggccag cagttggaga aagactgaat caggatgaca aggccactgc
     2641 catccgcatg ggaaagagcc tcctcgtgct gaccccgttg ctagggctca cctggggctt
     2701 tggcatagga acaatggcga acagccacaa tctggcttgg catgttcttt ttgctttact
     2761 caatgctttc cagggatttt tcatcttctg ttttggaatt ctcctggata ccaagctgcg
     2821 gcaacttctg tccaacaagt tgactacatt aagttcatgg aagcaaacat caaaacggaa
     2881 cgcctcagat acagttactc agccgaaatg cttaaggaca ttcaacatac tacagcacag
     2941 aggcatgtat gcactttctc atactggaga ttcgtccagt gacatcacat taacccagtt
     3001 tctatcaacc gaataaagcc acgagtcaca agcaagggca atttttttct ttgagcaaca
     3061 tgccattcag agccacacag caggcagtga agacaagcac agagtcaggt gagactttgt
     3121 gacttgggag tccaaggata aaactggtta ctctgaggtt ggagagatgg ctcagcggct
     3181 aagagcactt gttgcttttg cagaggacct ggactcaatt cccagcaccc acgtggggga
     3241 tcacaaccac ctgttccaag ggatctactg ccctcttctg acttctatga gcacaacatg
     3301 cgtatgcggt acatagacgt acatgccgac aaaacattca tacacgaaat taatcttttt
     3361 gacaaaccca gtaggtgact tcagtgattc aactctgcct cctttattcc aaattaaata
     3421 gaaatgttat taattacaaa gtgagctaag aaatatcata cattgttcat acaagtcttt
     3481 gtcaatgagc acccccccac ccca
//
