LOCUS       NM_001414296            2980 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor E5 (Adgre5),
            transcript variant 5, mRNA.
ACCESSION   NM_001414296
VERSION     NM_001414296.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2980)
  AUTHORS   Liu,D., Winer,B.Y., Chou,M.Y., Tam,H., Xu,Y., An,J., Gardner,J.M.
            and Cyster,J.G.
  TITLE     Dynamic encounters with red blood cells trigger splenic marginal
            zone B cell retention and function
  JOURNAL   Nat Immunol 25 (1), 142-154 (2024)
   PUBMED   38049580
REFERENCE   2  (bases 1 to 2980)
  AUTHORS   Chang,H., Hou,P., Wang,X., Xiang,A., Wu,H., Qi,W., Yang,R.,
            Wang,X., Li,X., He,W., Zhao,G., Sun,W., Wang,T., He,D.C., Wang,H.,
            Gao,Y. and He,H.
  TITLE     CD97 negatively regulates the innate immune response against RNA
            viruses by promoting RNF125-mediated RIG-I degradation
  JOURNAL   Cell Mol Immunol 20 (12), 1457-1471 (2023)
   PUBMED   37978243
  REMARK    GeneRIF: CD97 negatively regulates the innate immune response
            against RNA viruses by promoting RNF125-mediated RIG-I degradation.
REFERENCE   3  (bases 1 to 2980)
  AUTHORS   Liu,D., Duan,L., Rodda,L.B., Lu,E., Xu,Y., An,J., Qiu,L., Liu,F.,
            Looney,M.R., Yang,Z., Allen,C.D.C., Li,Z., Marson,A. and
            Cyster,J.G.
  TITLE     CD97 promotes spleen dendritic cell homeostasis through the
            mechanosensing of red blood cells
  JOURNAL   Science 375 (6581), eabi5965 (2022)
   PUBMED   35143305
  REMARK    GeneRIF: CD97 promotes spleen dendritic cell homeostasis through
            the mechanosensing of red blood cells.
REFERENCE   4  (bases 1 to 2980)
  AUTHORS   Cerny,O., Godlee,C., Tocci,R., Cross,N.E., Shi,H., Williamson,J.C.,
            Alix,E., Lehner,P.J. and Holden,D.W.
  TITLE     CD97 stabilises the immunological synapse between dendritic cells
            and T cells and is targeted for degradation by the Salmonella
            effector SteD
  JOURNAL   PLoS Pathog 17 (7), e1009771 (2021)
   PUBMED   34314469
  REMARK    GeneRIF: CD97 stabilises the immunological synapse between
            dendritic cells and T cells and is targeted for degradation by the
            Salmonella effector SteD.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2980)
  AUTHORS   Hofmann,F., Thalheim,T., Rother,K., Quaas,M., Kerner,C.,
            Przybilla,J., Aust,G. and Galle,J.
  TITLE     How to Obtain a Mega-Intestine with Normal Morphology: In Silico
            Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse
  JOURNAL   Int J Mol Sci 22 (14), 7345 (2021)
   PUBMED   34298973
  REMARK    GeneRIF: How to Obtain a Mega-Intestine with Normal Morphology: In
            Silico Modelling of Postnatal Intestinal Growth in a
            Cd97-Transgenic Mouse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2980)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2980)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 2980)
  AUTHORS   Hamann,J., van Zeventer,C., Bijl,A., Molenaar,C., Tesselaar,K. and
            van Lier,R.A.
  TITLE     Molecular cloning and characterization of mouse CD97
  JOURNAL   Int Immunol 12 (4), 439-448 (2000)
   PUBMED   10744645
REFERENCE   9  (bases 1 to 2980)
  AUTHORS   Qian,Y.M., Haino,M., Kelly,K. and Song,W.C.
  TITLE     Structural characterization of mouse CD97 and study of its specific
            interaction with the murine decay-accelerating factor (DAF, CD55)
  JOURNAL   Immunology 98 (2), 303-311 (1999)
   PUBMED   10540231
REFERENCE   10 (bases 1 to 2980)
  AUTHORS   Carver,E.A., Hamann,J., Olsen,A.S. and Stubbs,L.
  TITLE     Physical mapping of EMR1 and CD97 in human Chromosome 19 and
            assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic
            duplication
  JOURNAL   Mamm Genome 10 (10), 1039-1040 (1999)
   PUBMED   10501980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164432.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.2363090.1,
                                           ERR3363658.2652156.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC164432.3         27346-27422
            78-134              AC164432.3         34177-34233
            135-251             AC164432.3         34404-34520
            252-404             AC164432.3         34963-35115
            405-551             AC164432.3         38272-38418
            552-695             AC164432.3         39004-39147
            696-742             AC164432.3         39226-39272
            743-820             AC164432.3         39395-39472
            821-980             AC164432.3         40089-40248
            981-1097            AC164432.3         40318-40434
            1098-1321           AC164432.3         40561-40784
            1322-1486           AC164432.3         42500-42664
            1487-1678           AC164432.3         43183-43374
            1679-1908           AC164432.3         43531-43760
            1909-1978           AC164432.3         43842-43911
            1979-2070           AC164432.3         44000-44091
            2071-2239           AC164432.3         44169-44337
            2240-2338           AC164432.3         44452-44550
            2339-2980           AC164432.3         44643-45284
FEATURES             Location/Qualifiers
     source          1..2980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.22 cM"
     gene            1..2980
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /note="adhesion G protein-coupled receptor E5"
                     /db_xref="GeneID:26364"
                     /db_xref="MGI:MGI:1347095"
     exon            1..77
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            78..134
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            135..251
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            252..404
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..551
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..695
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..742
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..820
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..980
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1097
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1321
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1486
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1678
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1908
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..1978
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2070
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2239
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2338
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2980
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /note="hexamer: ATTAAA"
     polyA_site      2861
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /note="major polyA site"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
                     /note="hexamer: AATAAA"
     polyA_site      2980
                     /gene="Adgre5"
                     /gene_synonym="Cd97; TM7LN1"
ORIGIN      
        1 agccctctat caaccccaga cgctgtccgt tccgtgccgc gccaccatga ggggcgtcag
       61 atgccccggc ctgcttgtgg tgtgcatttt actgagtctc tcaggagctg gaacccagaa
      121 ggcagagagt aagaactgtg ccaagtggtg ccctatcaac tcaaaatgtg tcagtaacag
      181 aagctgtgtc tgcaagcccg gcttcagctc ggagaaggaa ttgatcacta accctgcaga
      241 gagctgtgaa gacatcaacg agtgtttact acctggattt tcctgtggag actttgccat
      301 gtgtaagaac tcagagggga gttacacctg cgtctgtaac ctgggatata agctcctttc
      361 tggtgcagaa tcttttgtta acgagagtga gaatacatgt caagatgtga atgagtgcat
      421 ctccgggcaa aaccattgcc accaatccac ccactgcatc aacaaattgg gtggctattc
      481 ttgcatctgt cgtcaaggct ggaaacctgt tcctggatcc cccaatggcc ctgtcagcac
      541 agtgtgcgaa gatgtggatg agtgcagctc tgggcagcat caatgtcaca attccaccgt
      601 ctgcaaaaac accgtaggct cctacaagtg ccactgccgt ccaggttgga agccaacttc
      661 tgggtccctc cgtggtccag acaccatatg ccaagagcca ccgttcccta cttggacact
      721 gctgcccaca gcccacagtc agactctctt gagattctct gttgaagtcc agaatctgct
      781 ccgtgacttc aatccagcca cggtcaacta caccatccag aaactcatcg aggctgtgga
      841 caagctgctg gaagacccca tggagactga aacccaacaa gtagctgccc agttgctctc
      901 gaacctggaa caaagccttc ggaccttggc tcagttttta cccaaaggcc ccttcaccta
      961 cacgtcccct tcaaatactg aactgtccct gatggtgaag gagcaagaca acaaagatgt
     1021 taccacagtg caccacggcc aaacttggat ggagctggac tgggctgtga cagctggagc
     1081 caaaatctca gaaaatggct cctcggtggc aggcatcctg tccagcccaa acatggaaaa
     1141 gctgctgggc aacaccccgc tgaacttgga gcagagaagg gcctccttgg aggacttcta
     1201 tggaagcccg attccgagtg tctcacttaa gcttctctca aacatcaatt ctgtcttcct
     1261 gaccaacacg aacactgaaa agctcgcctc gaatgtcacg ttcaagttcg actttacttc
     1321 tgtggagtca attgagccac gtcatgagct gatatgtgcc ttctggaaag cccacaacgg
     1381 gaatgggtac tgggacaccg acggctgctc aatgaatggc actggcttct gccactgcaa
     1441 ccacctgacc agctttgcca tcctaatggc tcagtaccat gtgcaggacc caaggctgga
     1501 attgatcacc aaggtggggc tgttgttgtc cctgatctgc ctgctgctgt gcatcctgac
     1561 cttcctgctg gtgaagccca tccagagctc tcgaaccatg gtgcacctgc acctgtgcat
     1621 ctgcctcttc ctgggctcaa tcatattcct ggtcggcgtg gagaatgaag ggggtgaggt
     1681 gggcctgcgc tgccgcctgg tggccgtgat gctgcatttc tgcttcctgg ccgccttctg
     1741 ctggatggca ctggagggcg tggagctcta cttcctggtg gtgcgtgtgt tccagggcca
     1801 aggcctgagt acatggcaac gctgcctgat tggctacggg gtgcccctcc tcatcgtggc
     1861 catctcaatg gcagttgtca aaatggatgg ctatgggcat gcaacatact gctggctgga
     1921 ctttaggaag cagggctttc tctggagctt ttcgggaccc gtggccttca tcattttctg
     1981 caatgctgcc attttcgtga tcactgtctg gaagctcaca aagaagtttt ctgaaatcaa
     2041 cccaaacatg aagaagttaa ggaaggcgag ggtgctgacc atcacctcca tcgcccagct
     2101 ccttgtgctg ggctgcacct ggggcttcgg cctgttcctc ttcaaccccc atagcacatg
     2161 gctatcctac atctttaccc tgctcaactg cctgcagggc ctattcctct atgtgatgct
     2221 ctgcctgctc aacaaaaagg tgagggaaga gtactggaaa tgggcctgca tggtcactgg
     2281 gagcaagtac acagagttca actcttccac aacaggcact ggcaccagcc aaacacggaa
     2341 tcagggatgt gaaggcgagt tccatgaagg acagcagcac atactcacgg ctgtcattct
     2401 gccttctgtt cctgccacct ttcggccttt gaccccactt catataaaga agggatgcaa
     2461 acccagcaat gagccctgcc acggggcaag gggtcgctgg tcctgcttct ggttgtctct
     2521 gcctcaccac agctactgcc taccagagaa acagaatgca gccagcccag acctgcagcc
     2581 cactgcctgg tacacgaggc aggcagtcct aggacaaagg gaagagccct tgagacctgg
     2641 gctctttgcc agggtgctgg gttcagtttc cttaagctaa gactgtggat gccacgtcag
     2701 ccactgaagc ccgcctgctg ctgaggctca cggtacagag gcctcgctgc tccacatcca
     2761 gggcagaagg tctcacagct aaagactagg ttttgtaatt tttttaacct gtaaaccttt
     2821 caatgttgac acacaaaatt aaatatcata ttgataaaaa agatggcacg tttgctggtg
     2881 agaagtttgc tggcttgacc caaccccatg agatgttgac cgaaagggat ggggctggag
     2941 ccatgcattc acaataaaag tttattctta catcactaaa
//
