LOCUS       NM_139138               3491 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor E4 (Adgre4), mRNA.
ACCESSION   NM_139138
VERSION     NM_139138.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3491)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3491)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   3  (bases 1 to 3491)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3491)
  AUTHORS   Caminschi,I., Vandenabeele,S., Sofi,M., McKnight,A.J., Ward,N.,
            Brodnicki,T.C., Toy,T., Lahoud,M., Maraskovsky,E., Shortman,K. and
            Wright,M.D.
  TITLE     Gene structure and transcript analysis of the human and mouse
            EGF-TM7 molecule, FIRE
  JOURNAL   DNA Seq 17 (1), 8-14 (2006)
   PUBMED   16753812
  REMARK    GeneRIF: Two alternatively spliced human FIRE transcripts were
            identified, neither are predicted to express the TM7 cassette.
            Thus, if the human FIRE exists, it is likely to be expressed as a
            soluble secreted molecule.
REFERENCE   5  (bases 1 to 3491)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   6  (bases 1 to 3491)
  AUTHORS   Kwakkenbos,M.J., Kop,E.N., Stacey,M., Matmati,M., Gordon,S.,
            Lin,H.H. and Hamann,J.
  TITLE     The EGF-TM7 family: a postgenomic view
  JOURNAL   Immunogenetics 55 (10), 655-666 (2004)
   PUBMED   14647991
  REMARK    Review article
REFERENCE   7  (bases 1 to 3491)
  AUTHORS   Rautava,J., Soukka,T., Heikinheimo,K., Miettinen,P.J.,
            Happonen,R.P. and Jaakkola,P.
  TITLE     Different mechanisms of syndecan-1 activation through a
            fibroblast-growth-factor-inducible response element (FiRE) in
            mucosal and cutaneous wounds
  JOURNAL   J Dent Res 82 (5), 382-387 (2003)
   PUBMED   12709506
  REMARK    GeneRIF: activated in mucosal [and cutaneous]wounds
REFERENCE   8  (bases 1 to 3491)
  AUTHORS   Stacey,M., Chang,G.W., Sanos,S.L., Chittenden,L.R., Stubbs,L.,
            Gordon,S. and Lin,H.H.
  TITLE     EMR4, a novel epidermal growth factor (EGF)-TM7 molecule
            up-regulated in activated mouse macrophages, binds to a putative
            cellular ligand on B lymphoma cell line A20
  JOURNAL   J Biol Chem 277 (32), 29283-29293 (2002)
   PUBMED   12023293
  REMARK    GeneRIF: the first EGF-TM7 receptor known to mediate the cellular
            interaction between myeloid cells and B cells
REFERENCE   9  (bases 1 to 3491)
  AUTHORS   Caminschi,I., Lucas,K.M., O'Keeffe,M.A., Hochrein,H., Laabi,Y.,
            Kontgen,F., Lew,A.M., Shortman,K. and Wright,M.D.
  TITLE     Molecular cloning of F4/80-like-receptor, a seven-span membrane
            protein expressed differentially by dendritic cell and
            monocyte-macrophage subpopulations
  JOURNAL   J Immunol 167 (7), 3570-3576 (2001)
   PUBMED   11564768
REFERENCE   10 (bases 1 to 3491)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Nikolic,J.M., Min,H., Black,D.L. and
            Francke,U.
  TITLE     Mapping of the KHSRP gene to a region of conserved synteny on human
            chromosome 19p13.3 and mouse chromosome 17
  JOURNAL   Genomics 56 (3), 350-352 (1999)
   PUBMED   10087204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036459.1, AF396935.1, AK037483.1 and CT573084.4.
            
            On Mar 26, 2009 this sequence version replaced NM_139138.2.
            
            Sequence Note: This RefSeq is annotated with the 5'-most in-frame
            translational start codon. This start codon has a weak Kozak signal
            and appears to be mouse-specific. Two other possible start codons
            exist, and their use would reduce the length of the protein
            N-terminus by 2 aa and 8 aa, respectively. Due to leaky scanning by
            ribosomes, it is possible that all three start codons are used.
            PMID:11564768 reports the use of the first start codon, whereas
            PMID:11564768 reports the use of the third start codon, which has a
            strong Kozak signal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037483.1, AK036459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AK036459.1         2-50
            50-3127             AF396935.1         8-3085
            3128-3481           AK037483.1         3073-3426
            3482-3482           CT573084.4         44909-44909         c
            3483-3491           AK037483.1         3428-3436
FEATURES             Location/Qualifiers
     source          1..3491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 28.98 cM"
     gene            1..3491
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /note="adhesion G protein-coupled receptor E4"
                     /db_xref="GeneID:52614"
                     /db_xref="MGI:MGI:1196464"
     exon            1..109
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            110..200
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2215
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /note="seven-span membrane protein FIRE;
                     F4/80-like-receptor; EGF-like module-containing mucin-like
                     hormone receptor-like 4; EGF-like module receptor 4;
                     EGF-like module containing, mucin-like, hormone
                     receptor-like sequence 4"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E4
                     precursor"
                     /protein_id="NP_631877.2"
                     /db_xref="CCDS:CCDS50148.1"
                     /db_xref="GeneID:52614"
                     /db_xref="MGI:MGI:1196464"
                     /translation="MLMGATRDMGSRCLLHASVPGMLLIWSILQMMNISASCPQCNEN
                     ASCFNSTHCVCKEGFWTGSENRRIIEPHEKCQDINECLLKELVCKDVSYCRNKIGTYI
                     CSCVVKYPLFNWVAGIINIDHPDCYVNKSKNTGSKTHTLGVLSEFKSKEEVAKGATKL
                     LRKVEHHILNENSDIPKKDENPLLDIVYETKRCKTMTLLEAGNNTMKVDCTSGFKEHN
                     SGGETAVAFIAYKSLGNLLNGSFFSNEEGFQEVTLNSHIVSGAIRSEVKPVLSEPVLL
                     TLQNIQPIDSRAEHLCVHWEGSEEGGSWSTKGCSHVYTNNSYTICKCFHLSSFAVLMA
                     LPHEEDGVLSALSVITYVGLSLSLLCLFLAAITFLLCRPIQNTSTTLHLQLSICLFLA
                     DLLFLTGINRTKPKVLCSIIAGMLHYLYLASFMWMFLEGLHLFLTVSNLKVANYSNSG
                     RFKKRFMYPVGYGLPAFIVAVSAIAGHKNYGTHNHCWLSLHRGFIWSFLGPAAAIILI
                     NLVFYFLIIWILRSKLSSLNKEVSTLQDTKVMTFKAIVQLFVLGCSWGIGLFIFIEVG
                     KTVRLIVAYLFTIINVLQGVLIFMVHCLLNRQVRMEYKKWFHRLRKEVESESTEVSHS
                     TTHTKMGLSLNLENFCPTGNLHDPSDSILPSTEVAGVYLSTPRSHMGAEDVNSGTHAY
                     WSRTISD"
     exon            201..251
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            252..374
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            375..527
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            528..568
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            569..704
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            705..806
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            807..991
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1159
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1363
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1599
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1666
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1758
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1939
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2035
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..3491
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3285..3290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /note="hexamer: AATAAA"
     polyA_site      3307
                     /gene="Adgre4"
                     /gene_synonym="D17Ertd479e; Egf-tm7; Emr4; Fire; Gpr127"
                     /note="major polyA site"
ORIGIN      
        1 aacattcctt gagaaagaga gaacaagata agcagtggtg cacttcctcc ttcattgctg
       61 ctgagaatgt tccaggctga gtgagaagta aaaattcatc atctctgaag aactcttacc
      121 cagccctgtt gaagaaattc ccagaatgtt gatgggagca actagagata tgggaagcag
      181 gtgccttctg catgcctcag ttcctggaat gctgcttatc tggtcaatat tacaaatgat
      241 gaatatttca gcttcctgtc cccagtgcaa tgaaaatgcc agctgcttca acagcaccca
      301 ctgtgtttgt aaagaaggat tctggacggg ctctgagaat agaagaatta ttgagcccca
      361 tgagaaatgt caagatatta atgagtgtct actgaaagaa ttggtatgca aggatgtgtc
      421 gtactgcaga aataaaattg ggacttacat atgcagctgt gtagtaaaat atcctttgtt
      481 caactgggta gctggcatta ttaatattga tcaccctgat tgttatgtga acaagagcaa
      541 gaatacagga tcaaaaacac atactttggg agtactgagt gaatttaaat ccaaagagga
      601 ggttgcaaaa ggagctacca agttacttcg caaagtggaa catcacatct tgaatgaaaa
      661 ctcagatata ccaaaaaagg atgaaaatcc tttattggat atagtgtatg aaactaagag
      721 gtgcaagacg atgactcttc tagaagctgg caacaacaca atgaaggttg actgcactag
      781 tggtttcaaa gagcacaaca gtggaggtga aactgcagtg gctttcattg catataagtc
      841 tcttgggaat cttctaaatg gttccttttt tagtaatgaa gaagggtttc aggaagtgac
      901 actgaactct cacatcgtta gtggagccat tcgctcagag gtcaaacctg tcctctctga
      961 acctgtactc ctgactttac aaaatattca gcccattgac tcaagagcag aacatctctg
     1021 tgtccattgg gaaggatcag aggaaggggg gagctggtct accaaaggat gctctcacgt
     1081 gtacaccaat aattcctaca ccatttgcaa gtgtttccac ctgtccagct ttgctgtgct
     1141 catggctcta ccccatgagg aggatggtgt gctttctgca ctctctgtga tcacctatgt
     1201 gggactgagt ctttctctct tgtgcctatt tctggcggcc atcacttttc tcctgtgccg
     1261 acccattcag aataccagca cgacactcca cctgcagctc tccatctgcc ttttcctggc
     1321 tgacctcctc ttcctcacag gcatcaacag aactaagcct aaggtgctgt gctccatcat
     1381 agcggggatg ttgcactacc tctacttggc ttccttcatg tggatgtttc tggaagggct
     1441 acatcttttt ctcactgtga gcaatctcaa agtggccaac tacagcaact caggcagatt
     1501 caagaagagg ttcatgtatc ctgtaggata tgggcttcct gcttttattg ttgctgtatc
     1561 tgcaatagct ggccacaaga attatggaac acacaaccac tgctggctca gccttcatcg
     1621 aggattcatc tggagcttct tggggccagc ggcagccatt atcttgataa acctggtgtt
     1681 ctactttcta ataatatgga ttttgagaag caaactttct tctctcaata aagaagtttc
     1741 tacacttcaa gacacaaagg ttatgacatt taaagccatt gtccagttat ttgtgttggg
     1801 atgttcttgg ggcattggct tgtttatttt cattgaagtt gggaagacag tgagactgat
     1861 cgttgcctat ctgttcacca tcatcaatgt cctgcagggt gttttgatat ttatggtaca
     1921 ttgtctgctt aatcgccagg tgcggatgga atataagaag tggtttcata gactgcggaa
     1981 ggaagttgaa agtgaaagca ctgaagtgtc tcattctact actcacacaa aaatgggtct
     2041 ttctctgaac ctggaaaatt tctgcccaac aggaaacctc catgatcctt ctgactccat
     2101 ccttccaagt actgaagtag caggtgtata tctaagcaca cccaggtctc acatgggtgc
     2161 tgaggatgtg aactcaggta ctcacgctta ctggagcaga actattagtg attgaatcag
     2221 ctccttcccc caagcctctt acagtacatt ttaacttgta ctgtgccatg cacatgaagc
     2281 tataattgct agtctggtaa aacaactgtt gcatattcca tgatcatttc attttatctc
     2341 tacttgcaaa agttagcttt ctttttatat catttttatt tctctttctt ttgtttatat
     2401 atagcttcag ttgagtgggt ttctagtctt aatgttctag atcactattt tcttttcagt
     2461 taacctttat tggtatttag ttcctgtgta gtgtatacca ctggaatatt tttatttctt
     2521 taattttgag gttaaaatat agttacatca tttttccttt ttttctttcc cacaatcctc
     2581 ctgtatactt tttccctggt gtctatttta ttgtttctac atgcatatat attttatgca
     2641 aaacatatat atgtataaat ataaatatat attcttatat gcatgaaaac catctacttc
     2701 atccaaataa tgttccttct atgtatgttt tcaggacagg gacaacaata gctatggtag
     2761 catggcaggg gaaagcccac aggacctcag ccttatacaa agaatcagag gcaactgagg
     2821 agtgctgagt tgaaggaatt gtcttaccca ggggagggca cattaattgg ttatctaata
     2881 caaaatgttc agccccaaaa ctgttaagat aaaagcctat atgcatctta ggaagtatct
     2941 accttgatac acctttattg gaatatcatc cacatgttta ttgtgtgttc tgaagagggt
     3001 ctgttgaatt tctaagggtt gatcagttta attgtgccat tttatattca gggtgtttgg
     3061 ctttgttgta gtgaataatg ctatatttcc ctgtatgtgt catctttgac tgttattttt
     3121 tcctggcaat actttattca acaagaacct agagccttgg tttattactt tttcttccat
     3181 agaaaaacta tttgtcttcc aggattagat atgatcaata tttcttatat gcatgtatca
     3241 aatatcatga tgaaatatat tactgtgtat aattaataac tggcaataaa gtccaaggga
     3301 aaaggaatat tactgttaat gtatattctt taattaacta aacattcctg aatttgaaaa
     3361 atattaaatc atgaaacaca ttctataaac ctgtatttac attcaagaaa tcagaaggag
     3421 aactgaaatt ggtggtaatt ttatctcata cctgtgaaat tataaaagga aactatatgt
     3481 acttattact g
//
