LOCUS       NM_010130               3245 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus adhesion G protein-coupled receptor E1 (Adgre1),
            transcript variant 1, mRNA.
ACCESSION   NM_010130
VERSION     NM_010130.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3245)
  AUTHORS   Tang YC, Ponsin K, Graham-Paquin AL, Luthold C, Homsy K, Schindler
            M, Tran V, Cote JF, Bordeleau F, Khadra A and Bouchard M.
  TITLE     Coordination of non-professional efferocytosis and actomyosin
            contractility during epithelial tissue morphogenesis
  JOURNAL   Cell Rep 42 (3), 112202 (2023)
   PUBMED   36871220
REFERENCE   2  (bases 1 to 3245)
  AUTHORS   Gu X, Heinrich A, Li SY and DeFalco T.
  TITLE     Testicular macrophages are recruited during a narrow fetal time
            window and promote organ-specific developmental functions
  JOURNAL   Nat Commun 14 (1), 1439 (2023)
   PUBMED   36922518
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3245)
  AUTHORS   Rupani DN, Thege FI, Chandra V, Rajaei H, Cowan RW, Wormann SM, Le
            Roux O, Malaney P, Manning SL, Hashem J, Bailey-Lundberg J, Rhim AD
            and McAllister F.
  TITLE     Adar1 deletion causes degeneration of the exocrine pancreas via
            Mavs-dependent interferon signaling
  JOURNAL   Development 150 (2) (2023)
   PUBMED   36458554
REFERENCE   4  (bases 1 to 3245)
  AUTHORS   Sterling NA, Park JY, Park R, Cho SH and Kim S.
  TITLE     An entosis-like process induces mitotic disruption in Pals1
            microcephaly pathogenesis
  JOURNAL   Nat Commun 14 (1), 82 (2023)
   PUBMED   36604424
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3245)
  AUTHORS   Chen X, Tang AT, Tober J, Yang J, Leu NA, Sterling S, Chen M, Yang
            Y, Mericko-Ishizuka P, Speck NA and Kahn ML.
  TITLE     Mouse placenta fetal macrophages arise from endothelial cells
            outside the placenta
  JOURNAL   Dev Cell 57 (23), 2652-2660 (2022)
   PUBMED   36473461
REFERENCE   6  (bases 1 to 3245)
  AUTHORS   Lin HH, Stubbs LJ and Mucenski ML.
  TITLE     Identification and characterization of a seven transmembrane
            hormone receptor using differential display
  JOURNAL   Genomics 41 (3), 301-308 (1997)
   PUBMED   9169125
REFERENCE   7  (bases 1 to 3245)
  AUTHORS   McKnight AJ and Gordon S.
  TITLE     EGF-TM7: a novel subfamily of seven-transmembrane-region leukocyte
            cell-surface molecules
  JOURNAL   Immunol Today 17 (6), 283-287 (1996)
   PUBMED   8962632
  REMARK    Review article
REFERENCE   8  (bases 1 to 3245)
  AUTHORS   McKnight AJ, Macfarlane AJ, Dri P, Turley L, Willis AC and Gordon
            S.
  TITLE     Molecular cloning of F4/80, a murine macrophage-restricted cell
            surface glycoprotein with homology to the G-protein-linked
            transmembrane 7 hormone receptor family
  JOURNAL   J Biol Chem 271 (1), 486-489 (1996)
   PUBMED   8550607
REFERENCE   9  (bases 1 to 3245)
  AUTHORS   Timsit S, Martinez S, Allinquant B, Peyron F, Puelles L and Zalc B.
  TITLE     Oligodendrocytes originate in a restricted zone of the embryonic
            ventral neural tube defined by DM-20 mRNA expression
  JOURNAL   J Neurosci 15 (2), 1012-1024 (1995)
   PUBMED   7869079
REFERENCE   10 (bases 1 to 3245)
  AUTHORS   Chen HL, Kamath R, Pace JL, Russell SW and Hunt JS.
  TITLE     Gestation-related expression of the interferon-gamma receptor gene
            in mouse uterine and embryonic hematopoietic cells
  JOURNAL   J Leukoc Biol 55 (5), 617-625 (1994)
   PUBMED   8182339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY197649.1, AK133202.1 and BY493080.1.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_010130.5.
            
            On Apr 18, 2008 this sequence version replaced NM_010130.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151682.1, U66888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY197649.1         2-26
            26-3240             AK133202.1         2-3216
            3241-3245           BY493080.1         488-492
FEATURES             Location/Qualifiers
     source          1..3245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.8 cM"
     gene            1..3245
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /note="adhesion G protein-coupled receptor E1"
                     /db_xref="GeneID:13733"
                     /db_xref="MGI:MGI:106912"
     exon            1..71
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..2836
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; EGF-like module-containing mucin-like hormone
                     receptor-like 1; cell surface glycoprotein F4/80; EMR1
                     hormone receptor; EGF-like module receptor 1; EGF-like
                     module containing, mucin-like, hormone receptor-like
                     sequence 1"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor E1 isoform 1
                     precursor"
                     /protein_id="NP_034260.1"
                     /db_xref="CCDS:CCDS50160.1"
                     /db_xref="GeneID:13733"
                     /db_xref="MGI:MGI:106912"
                     /translation="MWGFWLLLFWGFSGMYRWGMTTLPTLGQTLGGVNECQDTTTCPA
                     YATCTDTTDSYYCTCKRGFLSSNGQTNFQGPGVECQDVNECLQSDSPCGPNSVCTNIL
                     GRAKCSCLRGFSSSTGKDWILGSLDNFLCADVDECLTIGICPKYSNCSNSVGSYSCTC
                     QPGFVLNGSICEDEDECVTRDVCPEHATCHNTLGSYYCTCNSGLESSGGGPMFQGLDE
                     SCEDVDECSRNSTLCGPTFICINTLGSYSCSCPAGFSLPTFQILGHPADGNCTDIDEC
                     DDTCPLNSSCTNTIGSYFCTCHPGFASSNGQLNFKDLEVTCEDIDECTQDPLQCGLNS
                     VCTNVPGSYICGCLPDFQMDPEGSQGYGNFNCKRILFKCKEDLILQSEQIQQCQAVQG
                     RDLGYASFCTLVNATFTILDNTCENKSAPVSLQSAATSVSLVLEQATTWFELSKEETS
                     TLGTILLETVESTMLAALLIPSGNASQMIQTEYLDIESKVINEECKENESINLAARGD
                     KMNVGCFIIKESVSTGAPGVAFVSFAHMESVLNERFFEDGQSFRKLRMNSRVVGGTVT
                     GEKKEDFSKPIIYTLQHIQPKQKSERPICVSWNTDVEDGRWTPSGCEIVEASETHTVC
                     SCNRMANLAIIMASGELTMEFSLYIISHVGTVISLVCLALAIATFLLCRAVQNHNTYM
                     HLHLCVCLFLAKILFLTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAVMLFLMVR
                     NLKVVNYFSSRNIKMLHLCAFGYGLPVLVVIISASVQPRGYGMHNRCWLNTETGFIWS
                     FLGPVCMIITINSVLLAWTLWVLRQKLCSVSSEVSKLKDTRLLTFKAIAQIFILGCSW
                     VLGIFQIGPLASIMAYLFTIINSLQGAFIFLIHCLLNRQVRDEYKKLLTRKTDLSSHS
                     QTSGILLSSMPSTSKMG"
     exon            72..134
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            135..281
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            282..437
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..557
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..704
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            705..854
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..995
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1142
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1231
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1315
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1493
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1610
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1795
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1966
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2161
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2397
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2464
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2556
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2725
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2830
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3245
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /note="putative"
     polyA_site      3240
                     /gene="Adgre1"
                     /gene_synonym="DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480;
                     Ly71; TM7LN3"
                     /note="putative"
ORIGIN      
        1 aaagggaagg ctttcttcat tgaatgactg ccacagtacg atgtggggct tttggctgct
       61 cctcttctgg ggcttcagtg ggatgtacag atgggggatg accacacttc ccaccctggg
      121 acaaacactt ggtggtgtga atgagtgtca agatactacc acttgcccag cttatgccac
      181 ctgcactgac accacagaca gttattactg cacctgtaaa cgaggcttcc tgtccagcaa
      241 tggacaaacc aactttcaag gcccaggagt ggaatgtcaa gatgttaacg aatgtcttca
      301 aagtgactca ccttgtggtc ctaactcagt ctgcaccaat atcctgggga gagccaagtg
      361 cagctgtctt agaggcttct cttcttccac tgggaaagac tggattctgg gaagtttgga
      421 taattttctc tgcgcagatg ttgatgagtg tctgacaatt gggatctgcc ctaagtattc
      481 caactgctct aactctgtgg gaagctacag ctgtacctgt caaccaggct ttgtcttgaa
      541 tggctccatt tgtgaagatg aagatgaatg tgtgactcga gacgtttgcc ctgaacatgc
      601 aacctgccac aacactctcg gaagctatta ttgtacgtgc aactcaggac ttgaatctag
      661 tggaggaggg ccaatgttcc agggcctgga cgaatcctgt gaagatgtgg atgagtgctc
      721 caggaattca actctctgtg gtcccacctt catttgcatc aacactctgg gatcctacag
      781 ctgctcatgc ccagctggat tctctttgcc aacttttcag atccttggcc atccggcaga
      841 tgggaattgt acagatatcg atgagtgtga tgacacatgt cctttgaatt catcatgtac
      901 caacactatt gggagctact tctgcacttg ccaccctggc tttgcatcta gcaatggaca
      961 gctgaatttc aaagacctag aggtgacatg tgaagatatt gatgagtgca cccaagatcc
     1021 attacaatgt ggactgaatt ctgtctgcac caatgtacca ggctcctaca tctgtggctg
     1081 cctccctgac tttcaaatgg atccagaagg ctcccaagga tatggaaact tcaactgcaa
     1141 aaggatcctc ttcaagtgta aggaagactt gatactccaa agtgagcaga tacagcaatg
     1201 ccaagcagtg cagggcaggg atcttggtta tgcttccttc tgtacacttg tgaatgctac
     1261 cttcacaatc cttgataata cctgtgagaa caaaagtgcc ccagtgtcct tacagagtgc
     1321 agctacaagt gtctccctcg tgctggagca agcgaccaca tggtttgagc tcagcaagga
     1381 ggagacatcc actctgggca ccatcttgct ggagactgtg gaaagcacca tgttagctgc
     1441 tcttctgata ccctctggga atgccagtca gatgattcag acggagtacc tagacatcga
     1501 aagcaaagtc atcaatgaag agtgcaagga gaatgagtcc attaacttgg cagccagagg
     1561 ggacaagatg aatgttggct gtttcataat caaagaatca gtatctacag gggccccagg
     1621 agtggctttt gtctcatttg cacacatgga atcagtttta aatgaacgct tctttgaaga
     1681 tggccagtcc ttccggaagc tgaggatgaa ttcccgtgtt gttggtggca ctgtgaccgg
     1741 ggagaagaag gaggacttct ccaagcctat tatctatacc ctccagcaca tccagccaaa
     1801 gcagaagtct gagaggccta tctgtgtctc ctggaacact gatgtggagg atgggagatg
     1861 gacaccctcg ggctgtgaga ttgtggaagc atccgagaca cacacagtct gcagctgtaa
     1921 ccggatggca aacttggcta tcatcatggc ttctggggag cttacgatgg aattctcctt
     1981 gtatatcatc agccatgtgg gtacagtcat ctccctggta tgtcttgcct tggccatagc
     2041 caccttcctg ctgtgtcgtg ctgttcagaa ccacaatacc tacatgcacc tgcatctttg
     2101 tgtgtgtctc ttcttggcca agattctctt cctcaccggt atagacaaga ctgacaacca
     2161 gacggcttgt gccatcattg cgggattcct acactatctt ttcctcgcct gcttcttctg
     2221 gatgctagtg gaggcagtga tgctcttcct gatggtgaga aacctgaagg tggtgaatta
     2281 tttcagctct cgcaacatca agatgctgca cctctgtgcc tttggctatg ggcttccagt
     2341 cctggtggtc ataatctctg cttctgtaca gccacggggc tatgggatgc ataatcgctg
     2401 ctggttgaat acagagacgg ggtttatctg gagtttcctg gggcctgtct gcatgatcat
     2461 cacgataaac tctgtcctcc ttgcctggac actgtgggtt ctgaggcaga agctctgcag
     2521 tgtcagctca gaagtctcta aactcaagga cacgaggttg ctgaccttca aggccattgc
     2581 ccagattttc atcttgggct gctcctgggt gctgggcatt ttccagattg gccccttggc
     2641 aagcatcatg gcatacctgt tcaccattat caacagtctg cagggggctt tcatcttcct
     2701 cattcactgt ctgctcaacc gtcaggtacg ggatgaatat aagaaactcc tcaccaggaa
     2761 gactgacctt agctcccatt cccagacttc tgggatttta ctgtcatcta tgccatccac
     2821 ttccaagatg ggttaacatc ctttcttgct tttaaatata ttatggaaca atgtctgaag
     2881 attgtaagtg ctttaaggat catactttta ataactatct agcttatgga aatttagggt
     2941 atcatgagtt gatggcagtt ttgtttttag ctcaaaacat ggatagatgg aaccaaactc
     3001 caggagtttc atgcaccaag gagaaacaca ggatatctac ccaaataagt ttgtcttttg
     3061 tgccttacaa ctatgaagct ccacatgttt tgaaaagagc acgtcctatt tcaacggtac
     3121 aagagattac catttttgtg tttcctatgc actttcttgt ggtgttccag aaattctcat
     3181 ttaataccca tcaagcagta aacacagact aactcttaat aaattatttg ttctctctct
     3241 gaatg
//
