LOCUS       NM_175642               5522 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus adhesion G protein-coupled receptor B3 (Adgrb3), mRNA.
ACCESSION   NM_175642
VERSION     NM_175642.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5522)
  AUTHORS   Saegusa,C., Kakegawa,W., Miura,E., Aimi,T., Mogi,S., Harada,T.,
            Yamashita,T., Yuzaki,M. and Fujioka,M.
  TITLE     Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in the Cochlea
            and Is Necessary for Hearing Function in Mice
  JOURNAL   Int J Mol Sci 24 (23), 17092 (2023)
   PUBMED   38069416
  REMARK    GeneRIF: Brain-Specific Angiogenesis Inhibitor 3 Is Expressed in
            the Cochlea and Is Necessary for Hearing Function in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5522)
  AUTHORS   Shiu,F.H., Wong,J.C., Bhattacharya,D., Kuranaga,Y., Parag,R.R.,
            Alsharif,H.A., Bhatnagar,S., Van Meir,E.G. and Escayg,A.
  TITLE     Generation and initial characterization of mice lacking full-length
            BAI3 (ADGRB3) expression
  JOURNAL   Basic Clin Pharmacol Toxicol 133 (4), 353-363 (2023)
   PUBMED   37337931
  REMARK    GeneRIF: Generation and initial characterization of mice lacking
            full-length BAI3 (ADGRB3) expression.
REFERENCE   4  (bases 1 to 5522)
  AUTHORS   Luo,L., Ambrozkiewicz,M.C., Benseler,F., Chen,C., Dumontier,E.,
            Falkner,S., Furlanis,E., Gomez,A.M., Hoshina,N., Huang,W.H.,
            Hutchison,M.A., Itoh-Maruoka,Y., Lavery,L.A., Li,W., Maruo,T.,
            Motohashi,J., Pai,E.L., Pelkey,K.A., Pereira,A., Philips,T.,
            Sinclair,J.L., Stogsdill,J.A., Traunmuller,L., Wang,J., Wortel,J.,
            You,W., Abumaria,N., Beier,K.T., Brose,N., Burgess,H.A.,
            Cepko,C.L., Cloutier,J.F., Eroglu,C., Goebbels,S., Kaeser,P.S.,
            Kay,J.N., Lu,W., Luo,L., Mandai,K., McBain,C.J., Nave,K.A.,
            Prado,M.A.M., Prado,V.F., Rothstein,J., Rubenstein,J.L.R.,
            Saher,G., Sakimura,K., Sanes,J.R., Scheiffele,P., Takai,Y.,
            Umemori,H., Verhage,M., Yuzaki,M., Zoghbi,H.Y., Kawabe,H. and
            Craig,A.M.
  TITLE     Optimizing Nervous System-Specific Gene Targeting with Cre Driver
            Lines: Prevalence of Germline Recombination and Influencing Factors
  JOURNAL   Neuron 106 (1), 37-65 (2020)
   PUBMED   32027825
REFERENCE   5  (bases 1 to 5522)
  AUTHORS   Hamoud,N., Tran,V., Aimi,T., Kakegawa,W., Lahaie,S., Thibault,M.P.,
            Pelletier,A., Wong,G.W., Kim,I.S., Kania,A., Yuzaki,M., Bouvier,M.
            and Cote,J.F.
  TITLE     Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and
            Stabilin-2 controls myoblast fusion
  JOURNAL   Nat Commun 9 (1), 4470 (2018)
   PUBMED   30367035
  REMARK    GeneRIF: The secreted complement component 1, q subcomponent-like
            protein 4 (C1qL4) repress myoblast fusion by specifically
            interacting with G protein-coupled receptor BAI3 (BAI3). Stabilin-2
            interacts with BAI3 and stimulates its fusion promoting activity.
            The resulting activated heterotrimeric G-proteins contribute to the
            initial recruitment of Elmo proteins to the membrane, which are
            then stabilized on BAI3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5522)
  AUTHORS   Wang,Y., Zhang,Z., Yan,Y., Lemon,W.J., LaRegina,M., Morrison,C.,
            Lubet,R. and You,M.
  TITLE     A chemically induced model for squamous cell carcinoma of the lung
            in mice: histopathology and strain susceptibility
  JOURNAL   Cancer Res 64 (5), 1647-1654 (2004)
   PUBMED   14996723
REFERENCE   7  (bases 1 to 5522)
  AUTHORS   Horie,K., Yusa,K., Yae,K., Odajima,J., Fischer,S.E., Keng,V.W.,
            Hayakawa,T., Mizuno,S., Kondoh,G., Ijiri,T., Matsuda,Y.,
            Plasterk,R.H. and Takeda,J.
  TITLE     Characterization of Sleeping Beauty transposition and its
            application to genetic screening in mice
  JOURNAL   Mol Cell Biol 23 (24), 9189-9207 (2003)
   PUBMED   14645530
REFERENCE   8  (bases 1 to 5522)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 5522)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 5522)
  AUTHORS   Kee,H.J., Koh,J.T., Kim,M.Y., Ahn,K.Y., Kim,J.K., Bae,C.S.,
            Park,S.S. and Kim,K.K.
  TITLE     Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in
            normal and ischemic brain: involvement of BAI2 in the
            ischemia-induced brain angiogenesis
  JOURNAL   J Cereb Blood Flow Metab 22 (9), 1054-1067 (2002)
   PUBMED   12218411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116556.14, AK129162.1, BC032251.1 and AK044248.1.
            
            On Mar 12, 2008 this sequence version replaced NM_175642.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099951.1, SRR1660817.218725.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AC116556.14        84978-85223
            247-1018            AC116556.14        87910-88681
            1019-1995           AK129162.1         345-1321
            1996-3449           BC032251.1         312-1765
            3450-5522           AK044248.1         884-2956
FEATURES             Location/Qualifiers
     source          1..5522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 10.39 cM"
     gene            1..5522
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /note="adhesion G protein-coupled receptor B3"
                     /db_xref="GeneID:210933"
                     /db_xref="MGI:MGI:2441837"
     exon            1..246
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            247..1018
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..4830
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /note="G protein-coupled receptor BAI3; brain-specific
                     angiogenesis inhibitor 3"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor B3
                     precursor"
                     /protein_id="NP_783573.4"
                     /db_xref="CCDS:CCDS14855.1"
                     /db_xref="GeneID:210933"
                     /db_xref="MGI:MGI:2441837"
                     /translation="MKAVRNLLIYIFSTYLLVMFGFNAAQDFWCSTLVKGVIYGSYSV
                     SEMFPKNFTNCTWTLENPDPTKYSIYLKFSKKDLSCSNFSLLAYQFDHFSHEKIKDLL
                     RKNHSIMQLCSSKNAFVFLQYDKNFIQIRRVFPTDFPGLQKKVEEDQKSFFEFLVLNK
                     VSPSQFGCHVLCTWLESCLKSENGRTESCGIMYTKCTCPQHLGEWGIDDQSLVLLNNV
                     VLPLNEQTEGCLTQELQTTQVCNLTREAKRPPKEEFGMMGDHTIKSQRPRSVHEKRVP
                     QEQADAAKFMAQTGESGVEEWSQWSACSVTCGQGSQVRTRTCVSPYGTHCSGPLRESR
                     VCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPC
                     NIALCPVDGQWQEWSSWSHCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNP
                     ECTANGQWNQWGHWSGCSKSCDGGWERRMRTCQGAAVTGQQCEGTGEEVRRCSEQRCP
                     APYEICPEDYLISMVWKRTPAGDLAFNQCPLNATGTTSRRCSLSLHGVASWEQPSFAR
                     CISNEYRHLQHSIKEHLAKGQRMLAGDGMSQVTKTLLDLTQRKNFYAGDLLVSVEILR
                     NVTDTFKRASYIPASDGVQNFFQIVSNLLDEENKEKWEDAQQIYPGSIELMQVIEDFI
                     HIVGMGMMDFQNSYLMTGNVVASIQKLPAASVLTDINFPMKGRKGMVDWARNSEDRVV
                     IPKSIFTPVSSKELDESSVFVLGAVLYKNLDLILPTLRNYTVVNSKVIVVTIRPEPKT
                     TDSFLEIELAHLANGTLNPYCVLWDDSKSNESLGTWSTQGCKTVLTDASHTKCLCDRL
                     STFAILAQQPREIVMESSGTPSVTLIVGSGLSCLALITLAVVYAALWRYIRSERSIIL
                     INFCLSIISSNILILVGQTQTHNKSICTTTTAFLHFFFLASFCWVLTEAWQSYMAVTG
                     KIRTRLIRKRFLCLGWGLPALVVATSVGFTRTKGYGTDHYCWLSLEGGLLYAFVGPAA
                     AVVLVNMVIGILVFNKLVSRDGILDKKLKHRAGQMSEPHSGLTLKCAKCGVVSTTALS
                     ATTASNAMASLWSSCVVLPLLALTWMSAVLAMTDKRSILFQILFAVFDSLQGFVIVMV
                     HCILRREVQDAFRCRLRNCQDPINADSSSSFPNGHAQIMTDFEKDVDIACRSVLHKDI
                     GPCRAATITGTLSRISLNDDEEEKGTNPEGLSYSTLPGNVISKVIIQQPTGLHMPMSM
                     NELSNPCLKKENTELRRTVYLCTDDNLRGADMDIVHPQERMMESDYIVMPRSSVSTQP
                     SMKEESKMNIGMETLPHERLLHYKVNPEFNMNPPVMDQFNMNLDQHLAPQEHMQNLPF
                     EPRTAVKNFMASELDDNVGLSRSETGSTISMSSLERRKSRYSDLDFEKVMHTRKRHME
                     LFQELNQKFQTLDRFRDIPNTSSMENPAPNKNPWDTFKPPSEYQHYTTINVLDTEAKD
                     TLELRPAEWEKCLNLPLDVQEGDFQTEV"
     exon            1019..1129
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1291
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1456
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1621
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1786
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1888
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1995
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2190
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2259
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2368
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2518
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2594
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2697
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2741
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2868
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2972
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3075
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3226
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3296
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3363
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3449
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3548
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3720
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3816
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3856
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..4500
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4536
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            4537..4641
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     exon            4642..5522
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5426..5431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /note="hexamer: AATAAA"
     polyA_site      5443
                     /gene="Adgrb3"
                     /gene_synonym="A830096D10Rik; Bai3"
                     /note="major polyA site"
ORIGIN      
        1 ggctctggcc gctggatacc accgcccccc cccctattat ttttttttcc tttttttccc
       61 tctgcctttc gtttgcatgc attatttttt ttccaatcat aaatcttaat atttgaagct
      121 gaaccggggg gaaaaatggg caacggtgat tgggaccgaa ggggagtctc tccatcactg
      181 ttgttgggac gtgtgcctgt tctggtgtct tagatcaaga gcctcccgga gctttcggag
      241 tggaaggcca aatgacatag gatgaaggct gttcgtaacc tgctgattta tatattttcc
      301 acctatctcc tggttatgtt tggatttaat gctgcccaag acttctggtg ttccactttg
      361 gtgaagggag tcatttatgg atcctattct gtaagtgaaa tgtttcccaa aaactttaca
      421 aactgcacct ggacactgga aaatccagat ccaaccaaat atagcattta cctgaaattt
      481 tccaaaaagg accttagctg ctctaacttt tcccttctgg cttatcagtt tgatcatttt
      541 tcccatgaaa aaataaagga tcttttgaga aagaaccatt ccataatgca actttgcagt
      601 tccaagaatg cttttgtttt tctacagtac gataaaaatt tcattcagat acgccgggta
      661 tttccaactg atttcccagg attacagaaa aaagtcgaag aggatcagaa atcttttttt
      721 gagtttttgg tactgaacaa ggtgagcccg agccagtttg gttgccatgt cttatgcact
      781 tggttggaaa gctgcttaaa atccgaaaat gggagaaccg agtcttgtgg aattatgtac
      841 acaaaatgca cgtgccccca gcacttggga gagtggggaa tagatgacca gtccctggtt
      901 ctgttaaata acgtcgtgtt acccctgaat gagcagacgg agggttgcct gactcaggag
      961 ctgcaaacta ctcaagtctg caatctgacc agggaggcca agagaccacc caaagaagaa
     1021 tttggaatga tgggagatca tacaattaaa agtcagcgac ctcgatctgt ccatgagaaa
     1081 agggtccctc aggaacaagc tgatgctgct aaatttatgg cacaaactgg tgaatctggt
     1141 gtggaagagt ggtcccagtg gagcgcatgc tcagttactt gtggtcaagg gtcgcaggtg
     1201 cgaaccagaa cttgtgtatc accttacggg acacactgca gcggcccatt aagagaatca
     1261 agggtttgca ataacactgc cctctgtcca gtacatggag tttgggagga atggtcacct
     1321 tggagcttat gctccttcac atgtggccga ggccaaagaa cacgaaccag gtcatgcaca
     1381 cctcctcagt atggaggaag gccctgtgag ggacctgaaa ctcatcacaa gccttgtaat
     1441 attgccctct gtccagttga cggacagtgg caggaatgga gttcatggag ccactgctca
     1501 gtgacatgtt ctaatgggac acagcagagg agtcggcagt gcacagcagc tgctcatgga
     1561 ggctctgagt gccgaggacc atgggctgaa agcagggagt gctacaaccc tgaatgtaca
     1621 gccaatggtc agtggaatca gtggggtcac tggagtggat gttccaagtc ctgtgatggt
     1681 ggctgggaga ggagaatgag gacttgtcag ggcgcagctg taacaggaca gcagtgtgaa
     1741 ggcacaggtg aagaggtacg aagatgcagt gagcagcggt gcccagcacc ttatgaaata
     1801 tgcccagagg attatcttat atcaatggtg tggaaaagga ctcctgcagg cgacctggca
     1861 ttcaatcaat gtccactgaa tgccacaggc accactagca gacgctgctc tctcagtctt
     1921 catggagtgg cctcctggga acagccgagc tttgcaagat gcatatccaa tgagtacaga
     1981 cacttgcagc attcaattaa agagcacctt gcgaaggggc agcggatgct ggcaggtgat
     2041 ggaatgtccc aggtcaccaa gacactattg gatttaaccc agaggaaaaa tttctatgca
     2101 ggtgaccttc tggtgtctgt ggaaatcctg agaaatgtga cagacacgtt taaaagggca
     2161 agttacatcc ctgcgtctga tggggtccag aacttctttc aaatagttag caaccttctt
     2221 gatgaagaaa acaaggagaa atgggaagac gcacaacaga tttacccagg ctcaatagag
     2281 ttaatgcagg tgattgaaga ttttatacac attgttggaa tggggatgat ggactttcaa
     2341 aattcatacc taatgactgg aaatgtagtg gcgagcattc agaagctccc tgctgcatct
     2401 gttctaaccg acatcaactt ccccatgaaa ggccggaaag gaatggtaga ctgggcaaga
     2461 aattcagaag atcgcgttgt gattccaaaa agcattttca ctcccgtgtc ttcaaaagaa
     2521 ttagatgaat catctgtttt tgttcttgga gcggtcctat acaaaaactt agacctaatt
     2581 ttgcctactt tgagaaatta cactgtcgtc aattctaaag tcatcgtggt cacaatcagg
     2641 cctgaaccta aaacaactga ctcatttttg gagatagagc tagctcactt ggcaaatggc
     2701 actttgaatc catattgcgt gttatgggat gactcaaaat cgaacgagtc tttgggaacg
     2761 tggtccaccc agggatgtaa aactgtgctt accgatgcat cccatacgaa atgcttatgt
     2821 gatcggctct ctaccttcgc cattttggct cagcaaccta gagaaatagt catggaatcc
     2881 tctggtaccc cctcagttac cctcatagta ggcagtggcc tctcctgcct ggccttgata
     2941 actctagcag ttgtgtacgc agcactatgg aggtatattc gctctgagag gtccatcatt
     3001 ctaattaact tctgcctgtc tatcatctca tccaatatcc tcatactggt tggacagact
     3061 cagacacaca ataagagcat ctgcacgacc accaccgcgt tcctgcattt tttcttcctg
     3121 gcttcattct gttgggtctt gacagaggcg tggcagtcgt atatggctgt gacaggaaaa
     3181 atcaggaccc ggcttataag aaaacgcttt ttgtgccttg gatgggggct gccagcttta
     3241 gtagtggcca catctgtagg cttcactagg acgaaaggat acggcacgga tcactactgc
     3301 tggctgtctc tagaaggagg actgctctat gccttcgttg gacctgcagc ggctgttgtc
     3361 ctggtcaaca tggtgattgg cattttggta tttaataaac ttgtttccag agatgggatc
     3421 ctagataaaa agctaaaaca cagagccggt cagatgagtg agcctcatag cggtctgacg
     3481 ctcaaatgtg ccaagtgtgg agtagtttct acaacagctt tgtcagccac caccgccagt
     3541 aacgccatgg cctctctttg gagctcctgt gtggtgctac cgcttctggc tctgacatgg
     3601 atgtctgcag ttctggccat gacagataaa cgctccatat tgtttcagat actttttgcc
     3661 gtgtttgatt cattacaagg ctttgtgata gtcatggtcc actgcattct tcggagagag
     3721 gttcaagatg catttagatg ccggttgaga aactgccagg atccaatcaa tgctgattct
     3781 tcaagttctt ttcctaatgg acatgctcaa atcatgacag actttgaaaa ggacgtagac
     3841 attgcttgcc gatcagtgct tcataaggat atcggcccct gccgcgcagc aaccataaca
     3901 ggaacactct ccaggatttc tctaaatgat gatgaggaag aaaagggaac aaaccctgaa
     3961 gggctaagct actcaacatt gcctggaaat gtcatttcca aagtcatcat tcaacagccc
     4021 acaggcctgc acatgcctat gagtatgaac gagctaagca atccgtgtct gaaaaaagag
     4081 aacactgaac tgcggagaac tgtgtactta tgcacggatg acaatctgag aggggccgat
     4141 atggacattg tccaccccca agaacgaatg atggaaagtg actatattgt gatgcctaga
     4201 agttctgtaa gcacccagcc atcaatgaaa gaggagagca agatgaatat tggcatggaa
     4261 accttgccgc atgaaaggct attacactac aaagtaaacc ctgaattcaa tatgaatccc
     4321 cccgtaatgg accagtttaa tatgaactta gatcagcatc ttgcacccca ggaacatatg
     4381 cagaatttac cctttgagcc tcgcacagct gtgaagaatt tcatggcctc tgagttggat
     4441 gataatgtgg gactgtcaag aagtgaaact ggatcaacga tatcaatgag ttctctagag
     4501 agaagaaaat cgcggtattc tgaccttgac tttgagaagg tcatgcacac aaggaagagg
     4561 cacatggaat tgtttcagga actaaatcag aagtttcaga ctttggacag atttcgggac
     4621 ataccaaaca caagcagtat ggaaaaccca gcaccaaaca agaatccatg ggacactttc
     4681 aaacccccca gtgaatacca acattacacc acaatcaatg tcttagacac ggaggcaaag
     4741 gatactctgg agctgaggcc ggccgagtgg gagaagtgtc tgaatttgcc tctggatgtg
     4801 caagagggtg attttcaaac agaagtgtaa ggcaatcaaa aagaacttag gtagagacac
     4861 agtcaaatac actgacactg agacttggga agcctgacat ttccacctgg acagtgtgac
     4921 tttcctctgt caggaccctt cttgtgccaa catcagtgtt ttcttatggc aatttctcac
     4981 tggtcaggct agtggagaga gacggccaag tgtacagttc tcaccacccc gtgttgtaag
     5041 tacccgtgga atggatttgt aaggtaatct ttatagataa acctcaagca aggatttcat
     5101 gttgtaacag cttcatgtgg tttagttttc agaaaacttc accatgaagc acaatgtata
     5161 tatttatgca gtttttaaag tttataacag tctgtttggc cattactaca ctttttactt
     5221 tataatataa aagcaaagtt tttgtcatta aatgaatgtt tgttgagcta cattcttcat
     5281 tgctttaaat gcaataaagt aataatctca cttttatatg aataatatat ttcacatctt
     5341 tattattgca gttttctcta gaaggctctg agtagctttc tctgctgcag ctgtgtataa
     5401 aatatttaaa atgttgtatg gtgtaaataa acttttgtct acatatcagt tttttagtgc
     5461 attttatttt ggatttgttg aacagaaatt tacatattta taaagttttc tttttcaata
     5521 cc
//
