LOCUS       NM_001290715            5434 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor B2 (Adgrb2),
            transcript variant 3, mRNA.
ACCESSION   NM_001290715
VERSION     NM_001290715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5434)
  AUTHORS   Wang,C.Y., Liu,Z., Ng,Y.H. and Sudhof,T.C.
  TITLE     A Synaptic Circuit Required for Acquisition but Not Recall of
            Social Transmission of Food Preference
  JOURNAL   Neuron 107 (1), 144-157 (2020)
   PUBMED   32369733
REFERENCE   3  (bases 1 to 5434)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   4  (bases 1 to 5434)
  AUTHORS   Speca,D.J., Trimmer,J.S., Peterson,A.S. and Diaz,E.
  TITLE     Whole exome sequencing reveals a functional mutation in the GAIN
            domain of the Bai2 receptor underlying a forward mutagenesis
            hyperactivity QTL
  JOURNAL   Mamm Genome 28 (11-12), 465-475 (2017)
   PUBMED   28894906
  REMARK    GeneRIF: Surface expression of Bai2 R619W is markedly reduced
            relative to wild-type Bai2.
REFERENCE   5  (bases 1 to 5434)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   6  (bases 1 to 5434)
  AUTHORS   Okajima,D., Kudo,G. and Yokota,H.
  TITLE     Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by
            proteolytic processing
  JOURNAL   J Recept Signal Transduct Res 30 (3), 143-153 (2010)
   PUBMED   20367554
  REMARK    GeneRIF: BAI2 is a functional GPCR regulated by proteolytic
            processing and activates the NFAT pathway
REFERENCE   7  (bases 1 to 5434)
  AUTHORS   Jeong,B.C., Kim,M.Y., Lee,J.H., Kee,H.J., Kho,D.H., Han,K.E.,
            Qian,Y.R., Kim,J.K. and Kim,K.K.
  TITLE     Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP
            that acts as a transcriptional repressor
  JOURNAL   FEBS Lett 580 (2), 669-676 (2006)
   PUBMED   16412436
  REMARK    GeneRIF: Results point out that brain-specific angiogenesis
            inhibitor 2 controls VEGF transcription through GA-binding protein
            under normal conditions and cerebral ischemia.
REFERENCE   8  (bases 1 to 5434)
  AUTHORS   Kee,H.J., Ahn,K.Y., Choi,K.C., Won Song,J., Heo,T., Jung,S.,
            Kim,J.K., Bae,C.S. and Kim,K.K.
  TITLE     Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in
            normal brain and implications for BAI3 in ischemia-induced brain
            angiogenesis and malignant glioma
  JOURNAL   FEBS Lett 569 (1-3), 307-316 (2004)
   PUBMED   15225653
REFERENCE   9  (bases 1 to 5434)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 5434)
  AUTHORS   Kee,H.J., Koh,J.T., Kim,M.Y., Ahn,K.Y., Kim,J.K., Bae,C.S.,
            Park,S.S. and Kim,K.K.
  TITLE     Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in
            normal and ischemic brain: involvement of BAI2 in the
            ischemia-induced brain angiogenesis
  JOURNAL   J Cereb Blood Flow Metab 22 (9), 1054-1067 (2002)
   PUBMED   12218411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626774.23.
            
            On Dec 12, 2019 this sequence version replaced NM_001290715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY168407.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849379 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               AL626774.23        129809-130246
            439-1264            AL626774.23        136993-137818
            1265-1348           AL626774.23        149964-150047
            1349-1513           AL626774.23        150329-150493
            1514-1678           AL626774.23        151691-151855
            1679-1843           AL626774.23        152501-152665
            1844-2011           AL626774.23        152749-152916
            2012-2113           AL626774.23        153011-153112
            2114-2220           AL626774.23        153262-153368
            2221-2415           AL626774.23        154150-154344
            2416-2484           AL626774.23        154421-154489
            2485-2593           AL626774.23        154593-154701
            2594-2930           AL626774.23        154997-155333
            2931-3036           AL626774.23        156252-156357
            3037-3080           AL626774.23        156541-156584
            3081-3207           AL626774.23        156764-156890
            3208-3311           AL626774.23        157215-157318
            3312-3414           AL626774.23        157413-157515
            3415-3565           AL626774.23        158432-158582
            3566-3635           AL626774.23        158761-158830
            3636-3702           AL626774.23        159262-159328
            3703-3788           AL626774.23        159490-159575
            3789-3887           AL626774.23        159874-159972
            3888-4059           AL626774.23        162001-162172
            4060-4155           AL626774.23        162468-162563
            4156-4195           AL626774.23        162854-162893
            4196-4815           AL626774.23        163600-164219
            4816-4851           AL626774.23        166158-166193
            4852-4950           AL626774.23        166502-166600
            4951-5434           AL626774.23        167089-167572
FEATURES             Location/Qualifiers
     source          1..5434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.43 cM"
     gene            1..5434
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="adhesion G protein-coupled receptor B2"
                     /db_xref="GeneID:230775"
                     /db_xref="MGI:MGI:2451244"
     exon            1..438
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..1264
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..5139
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; G protein-coupled receptor brain-specific
                     angiogenesis inhibitor 1; brain-specific angiogenesis
                     inhibitor 2"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor B2 isoform 3
                     precursor"
                     /protein_id="NP_001277644.1"
                     /db_xref="CCDS:CCDS80164.1"
                     /db_xref="GeneID:230775"
                     /db_xref="MGI:MGI:2451244"
                     /translation="MTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQD
                     LFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCTHFAPRLLPLDHYLVNFTCLRPGP
                     EEATARAESEVGRPEEEEEEAAAAASGLELCGGSGPFTFLHFDKNFVQLCLSAEPSEA
                     PRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPG
                     EAGANPATTTSPGPPVAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEE
                     EPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGT
                     LCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKAC
                     EGPELQTKLCSMAACPVEGQWLEWGPWGPCSSSCANGTQQRSRKCSVAGPAWATCAGA
                     LTDTRECSNLDCPATDGKWGPWNAWSLCSKTCDTGWQRRFRMCQASGTQGYPCEGTGE
                     EVKPCSEKRCPAFHEMCRDEYVMLMTWKRAAAGEIIYNKCPPNASGSASRRCLLSAQG
                     VAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYS
                     GDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDSENKDKWDDAQQVSPGS
                     VHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPISAVSSDITFPMRGRRGMK
                     DWVRHSEDRLFLPKEVLSLSSPGKPATPGAATAGSPGRGRGPGTVPPGPGHAHQRLLP
                     ADPEESSSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVEL
                     SYIINGTTDPHCASWDYSRADTNSGDWNTESCQTLETQAAHTRCQCQHLSTFAVLAQP
                     PKDLTLELAGAPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILA
                     SNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRK
                     RFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLI
                     GIIVFNKLMARDGVSDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMA
                     SLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQ
                     DVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTIT
                     GTLSRLSLDEDEEPKSCLVGPEGGLSFSPLPGNILVPMAASPGLGEPPPPQETNPVYM
                     CGEGGLRQLDLTWIRQSEPGSEGDYMVLPRRTLSLQPGGGGTAGEEAPRARPEGTPRR
                     AAKTVAHTEGYPSFLSVEHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERS
                     RTMPRTVPGSTMKLGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRS
                     QSSAKEKPSPPGGRPGLSQHRRHQSWSTFKSMTLGSLPPKPRERLALHRTAAWEPTEP
                     PDGDFQTEV"
     exon            1265..1348
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1513
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1678
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1843
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2011
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2113
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2220
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2415
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2484
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2593
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2930
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3036
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3080
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3207
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3311
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3312..3414
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3565
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3635
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3702
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3788
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3887
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4059
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4155
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4195
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4815
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4816..4851
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4852..4950
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     exon            4951..5434
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5230
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
     regulatory      5415..5420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="hexamer: AATAAA"
     polyA_site      5434
                     /gene="Adgrb2"
                     /gene_synonym="Bai2"
                     /note="major polyA site"
ORIGIN      
        1 actcggcccg gcgcgcgctg cgggcagcgg ccggagcggc cggaggaatc cggttcggtg
       61 gcagcggcgg cgctgggagg cagagaggag gatgcggcac cggcgatcag aggctggggc
      121 tgcggccgcc acccgcgaat aggaggcggc gcgcggcgcg ggcggtgctc ggggcgggga
      181 gcggggggcg gcgcggcgag gaggcggcgg cggcggcagg agcccgcgcc cggcccggcg
      241 cccgcccgcc cgccccgtgc agctccgcgg tgcttgctct gcacccgccg ctcggcggag
      301 cgggagcctc gggcctcggc gcggctgcgg cgagctgccc tgcgcccagc ccggcccccg
      361 ccttagggat ggcaaacttg cgccccgcgg ccgcctccac tagcgccggc ccccgctcct
      421 gctgctgacg gcgcccaggg caagggacat aggatgaccc cagcctgtcc cctcttactg
      481 tctgtgattc tgtccctgcg cctggccacg gccttcgacc ctgcccccag tgcctgctct
      541 gccctggcct cgggcgtgct ctacggggcc ttctcgctgc aggacctctt tcccaccatc
      601 gcctcgggct gctcctggac cctggagaac ccagacccca ccaagtactc cctctacctg
      661 cgcttcaacc ggcaggagca ggtttgcaca cactttgccc cgcgcctgct gcccctggac
      721 cactacctgg tcaactttac ctgcctgcgg cctggtccag aggaagccac agcccgggct
      781 gagtcggagg tgggacggcc agaggaggag gaggaggagg cggcggcagc agcatcaggg
      841 ttggagttgt gtggtggctc aggccccttt acctttctgc acttcgacaa gaactttgtg
      901 cagctgtgcc tgtcggctga gccctctgag gcccctcgtc tgctagcgcc tgctgccctg
      961 gccttccgtt ttgtggaggt cttgctgatc aacaacaaca actccagcca gttcacctgt
     1021 ggtgtgctct gccgctggag tgaggagtgt ggccgggctg caggcagggc ttgtggcttt
     1081 gcacagccag ggtgtagttg tcctggggag gcaggggcca accccgccac caccacatct
     1141 ccggggcctc cggttgccca caccctgtcc aatgccctgg tgcccggggg cccagcccct
     1201 cctgctgagg ccgacttgca ctcggggagc agcaatgacc tgttcaccac cgagatgaga
     1261 tatggtgagg agccggaaga ggaaccgaag gtgaaaaccc agtggccaag gtctgcagat
     1321 gagcctgggc tatacatggc gcagacaggc gacccagcag ctgaggagtg gtccccgtgg
     1381 agcgtgtgtt ccctgacgtg tgggcagggt ctgcaggtgc ggacccgctc ctgcgtgtcc
     1441 tccccctatg ggaccctgtg cagcgggccc cttcgggaga cccggccttg caacaattca
     1501 gccacctgcc cagtgcacgg cgtgtgggag gagtgggggt cctggagcct gtgctcccgc
     1561 agctgcgggc gggggtctcg gagccggatg cggacctgcg tgccccccca gcacggcggc
     1621 aaggcctgcg agggtcccga gctgcagact aaactctgca gtatggccgc ctgcccggtg
     1681 gaaggccagt ggctagaatg gggtccctgg ggcccatgct catcatcttg tgccaatggg
     1741 acccagcagc gcagccggaa atgcagtgtg gcgggtccag cctgggccac gtgcgcaggt
     1801 gccctcacgg atacccgtga gtgcagcaat ctcgattgcc cggccactga cggcaagtgg
     1861 gggccgtgga acgcgtggag cctgtgctcc aagacgtgtg acacgggctg gcaacgccgc
     1921 ttccgcatgt gccaggcttc tggcacacag ggctaccctt gcgagggcac aggagaggag
     1981 gtgaaaccct gcagtgagaa gaggtgtcca gccttccatg agatgtgcag ggatgagtac
     2041 gtgatgttga tgacatggaa gagggcggca gctggcgaga tcatttacaa caagtgtccc
     2101 cctaatgcct cgggttctgc tagccgccgc tgtctcctca gtgcccaggg cgtagcatac
     2161 tggggactgc ccagctttgc tcgttgcata tcccatgaat accgctacct gtacctgtca
     2221 cttcgggaac acctggctaa gggccagcgc atgctggcag gtgagggcat gtcacaggtg
     2281 gtgcggagcc tgcaggagct actggcacgg cgcacttact acagcgggga cctgctcttc
     2341 tctgtggaca tcctaaggaa cgtcactgac accttcaaga gggccaccta tgtcccttcc
     2401 gccgatgacg tgcagcgttt cttccaggtg gtgagcttca tggtggattc agaaaacaag
     2461 gacaaatggg atgatgctca gcaggtgtca ccgggctctg tgcacctgct gcgtgttgtg
     2521 gaagatttca ttcacctcgt gggcgacgct ctcaaggcct tccagagctc tctcattgtc
     2581 acggacaatc tggtgatcag cattcagaga gagcctatct ccgccgtgtc cagtgacatc
     2641 acgtttccca tgcggggccg caggggcatg aaggactggg tgcgacactc agaggatcgt
     2701 ctctttctac ccaaggaggt gctcagcctg tcctccccag gaaagccagc cacacctggg
     2761 gcagccacag caggcagccc gggcaggggg aggggcccag gaacggtgcc ccctggccca
     2821 ggccacgccc accagcgcct tctcccagct gaccccgaag agtcctcctc ctactttgtg
     2881 atcggtgctg tgctctaccg cacccttggc ctcatcctgc cgccccccag gcctccactt
     2941 gctgtcacct cccgggtgat gacagtgact gtgcgtcccc ccacccagcc tccagctgag
     3001 cccctcatta cagtggaact ctcgtacatc atcaatggca ccaccgatcc ccactgtgcc
     3061 agctgggact actccagagc agataccaac tcgggggact ggaacactga gagctgccag
     3121 accttggaga cccaggcggc tcacacccgc tgccagtgcc agcacctgtc cacctttgcc
     3181 gtcctggccc agccacccaa ggacctgacc ctggagctgg caggtgctcc ctctgtcccc
     3241 ctggtgatcg gctgtgcagt gtcctgcatg gctctgctca ccctgctggc catctatgca
     3301 gccttctgga ggtttataaa atcagaacgc tccatcatct tgctgaactt ctgcctgtcc
     3361 atcctggctt ccaacattct gatcctggtg ggccagtccc gggtgctgag caagggcgta
     3421 tgcaccatga cggctgcctt cctacacttc ttctttctgt cctccttttg ctgggtgctt
     3481 acagaggcct ggcaatccta tctggctgtc atcgggcgga tgcgcacccg cctggttcgc
     3541 aagcgcttcc tctgcctggg ctggggtcta cctgccctgg tggtggctgt gtctgttggc
     3601 tttactcgca ccaaaggata tggtacatcc agctactgct ggctgtccct agagggcggc
     3661 ctgctctatg ccttcgtggg tccagcagca gtcattgtcc tggtgaacat gctcatcggg
     3721 attatcgtct tcaacaagct catggctcgc gatggcgtct cagacaaatc taagaagcag
     3781 agggctgggt cggagcggtg cccctgggcc agcctgctcc ttccctgctc agcgtgtgga
     3841 gcggtcccca gccccctgct cagctcagcc tcggccagga atgccatggc ttcactctgg
     3901 agttcctgcg tggtactgcc tctcctggcg cttacctgga tgtctgccgt cctggccatg
     3961 acagatcgcc gctccgtcct cttccaggca ctctttgccg ttttcaactc tgcacaaggc
     4021 tttgtcatca ccgctgtgca ctgcttcctg cgccgagagg tccaggatgt ggtaaagtgt
     4081 cagatgggtg tgtgtcgggc tgatgagagt gaagactccc cagactcgtg caagaacggg
     4141 cagctgcaga tcctgtcaga ctttgaaaag gacgtggatc tggcttgtca gacagttctg
     4201 ttcaaggagg tcaacacctg caacccgtcc accattaccg gcactctgtc ccgcctgtct
     4261 ctggatgagg atgaggagcc caagtcctgt ctcgtgggtc ctgagggtgg cctcagcttc
     4321 tcaccactgc ctgggaacat cctggtaccc atggcagcct caccaggtct aggggagcca
     4381 ccaccacccc aggagaccaa ccctgtgtac atgtgtgggg agggtggcct gcggcagttg
     4441 gaccttacat ggatacggca gagtgaacca ggctctgagg gggactacat ggttctgccc
     4501 cggcggactt tgagcctgca gcctggtggt gggggtacag cgggtgagga ggccccaagg
     4561 gcccggcctg aggggacccc ccggcgggct gccaaaacgg tagcccacac tgaaggctac
     4621 cccagcttcc tgtctgtgga gcactcgggt ctagggctgg gccctgccta tgggtctctc
     4681 cagaacccgt atggaatgac cttccaacca ccaccaccaa cacccagcgc ccgccaagta
     4741 ccagagccag gagaacgtag ccggaccatg ccccgtacag tgcctggttc caccatgaag
     4801 ctgggctccc ttgagcgaaa gaagcttcgg tattcggact tggactttga gaaggtgatg
     4861 cacactcgga aacggcactc ggaactctac cacgaactca accagaagtt ccacactttc
     4921 gaccgctacc gtagccagtc ctcagccaag gagaaaccca gcccccccgg gggacgccct
     4981 ggcttgtccc agcacaggag gcatcaaagc tggagcacct tcaaatctat gacactgggc
     5041 tcactgcccc ccaagccccg agaacggctg gccctgcacc ggacagcagc ctgggagccc
     5101 acagaaccgc cagacggcga cttccagaca gaggtgtgag tgccacgccg gactgcccac
     5161 tgcacagaaa tatatatcta ttttcacact ccactttgga actaccagga gccagcgccc
     5221 ctccccctcc cgaggctggg caggaggcgc agaggactca gcctggctgg gggcagccag
     5281 actggcaggg cctggggggc cagggcccct ccttgttctc agaggtccct tagccaccca
     5341 ctggagcctc atctttgccc cggcctgtct gtccctgtcc tgggctgggg aggggggagg
     5401 gaaactttgt tgggaataaa cttcactctg tgga
//
