LOCUS       NM_133911               4475 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor A3 (Adgra3), mRNA.
ACCESSION   NM_133911 XM_132089 XM_991709
VERSION     NM_133911.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4475)
  AUTHORS   Nybo,M.L., Kvam,J.M., Nielsen,J.E., Frederiksen,H., Spiess,K.,
            Jensen,K.H.R., Gadgaard,S., Walser,A.L.S., Thomsen,J.S., Cowin,P.,
            Juul,A., Blomberg Jensen,M. and Rosenkilde,M.M.
  TITLE     Loss of Adgra3 causes obstructive azoospermia with high penetrance
            in male mice
  JOURNAL   FASEB J 37 (2), e22781 (2023)
   PUBMED   36688818
  REMARK    GeneRIF: Loss of Adgra3 causes obstructive azoospermia with high
            penetrance in male mice.
REFERENCE   2  (bases 1 to 4475)
  AUTHORS   Spina,E., Simundza,J., Incassati,A., Chandramouli,A., Kugler,M.C.,
            Lin,Z., Khodadadi-Jamayran,A., Watson,C.J. and Cowin,P.
  TITLE     Gpr125 is a unifying hallmark of multiple mammary progenitors
            coupled to tumor latency
  JOURNAL   Nat Commun 13 (1), 1421 (2022)
   PUBMED   35302059
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4475)
  AUTHORS   Sun,H., Wang,T., Atkinson,P.J., Billings,S.E., Dong,W. and
            Cheng,A.G.
  TITLE     Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for
            Cochlear Development and Hearing
  JOURNAL   Front Cell Dev Biol 9, 690955 (2021)
   PUBMED   34395423
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4475)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4475)
  AUTHORS   Hamann,J., Aust,G., Arac,D., Engel,F.B., Formstone,C.,
            Fredriksson,R., Hall,R.A., Harty,B.L., Kirchhoff,C., Knapp,B.,
            Krishnan,A., Liebscher,I., Lin,H.H., Martinelli,D.C., Monk,K.R.,
            Peeters,M.C., Piao,X., Promel,S., Schoneberg,T., Schwartz,T.W.,
            Singer,K., Stacey,M., Ushkaryov,Y.A., Vallon,M., Wolfrum,U.,
            Wright,M.W., Xu,L., Langenhan,T. and Schioth,H.B.
  TITLE     International Union of Basic and Clinical Pharmacology. XCIV.
            Adhesion G protein-coupled receptors
  JOURNAL   Pharmacol Rev 67 (2), 338-367 (2015)
   PUBMED   25713288
  REMARK    Review article
REFERENCE   6  (bases 1 to 4475)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 4475)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   8  (bases 1 to 4475)
  AUTHORS   Pickering,C., Hagglund,M., Szmydynger-Chodobska,J., Marques,F.,
            Palha,J.A., Waller,L., Chodobski,A., Fredriksson,R.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The Adhesion GPCR GPR125 is specifically expressed in the choroid
            plexus and is upregulated following brain injury
  JOURNAL   BMC Neurosci 9, 97 (2008)
   PUBMED   18834514
  REMARK    GeneRIF: Data show that GPR125 is specifically expressed in cells
            of the choroid plexus and is upregulated following traumatic brain
            injury.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4475)
  AUTHORS   Seandel,M., James,D., Shmelkov,S.V., Falciatori,I., Kim,J.,
            Chavala,S., Scherr,D.S., Zhang,F., Torres,R., Gale,N.W.,
            Yancopoulos,G.D., Murphy,A., Valenzuela,D.M., Hobbs,R.M.,
            Pandolfi,P.P. and Rafii,S.
  TITLE     Generation of functional multipotent adult stem cells from GPR125+
            germline progenitors
  JOURNAL   Nature 449 (7160), 346-350 (2007)
   PUBMED   17882221
  REMARK    GeneRIF: GPR125+ multipotent adult stem cells generated derivatives
            of the three germ layers and contributed to chimaeric embryos, with
            concomitant downregulation of GPR125 during differentiation into
            GPR125- cells
REFERENCE   10 (bases 1 to 4475)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052391.1, AK028929.1 and AV238761.1.
            
            On or before Jun 25, 2009 this sequence version replaced
            XM_991709.1, XM_132089.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052391.1, AK028929.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               BC052391.1         1-308
            309-309             AK028929.1         248-248
            310-4470            BC052391.1         310-4470
            4471-4475           AV238761.1         241-245
FEATURES             Location/Qualifiers
     source          1..4475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 26.85 cM"
     gene            1..4475
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /note="adhesion G protein-coupled receptor A3"
                     /db_xref="GeneID:70693"
                     /db_xref="MGI:MGI:1917943"
     exon            1..445
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..4154
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /note="probable G-protein coupled receptor 125; G
                     protein-coupled receptor 125; G protein coupled receptor
                     Gpr125"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor A3
                     precursor"
                     /protein_id="NP_598672.1"
                     /db_xref="CCDS:CCDS51500.1"
                     /db_xref="GeneID:70693"
                     /db_xref="MGI:MGI:1917943"
                     /translation="MEPPPPLLLLPLALLALLWGGERGAAALPAGCKHDGRARGTGRA
                     AAAAEGKVVCSSLELAQVLPPDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLR
                     NNLISRIAPGAFWGLSSLKRLDLTNNRIGCLNADVFRGLTNLVRLNLSGNLFTSLSQG
                     TFDYLGSLRSLEFQTEYLLCDCNILWMHRWVKERNITVRDTRCVYPKSLQAQPVTGVK
                     QELLTCDPPLELPSFYMTPSHRQVVFEGDSLPFQCMASYIDQDMQVLWYQDGRIVETD
                     ESQGIFVEKSMIHNCSLIASALTISNIQAGSTGNWGCHVQTKRGNNTRTVDIVVLESS
                     AQYCPPERVVNNKGDFRWPRTLAGITAYLQCTRNTHSSGIYPGSAQDERKAWRRCDRG
                     GFWADDDYSRCQYANDVTRVLYMFNQMPLNLTNAVATARQLLAYTVEAANFSDKMDVI
                     FVAEMIEKFGRFTREEKSKELGDVMVDVASNIMLADERVLWLAQREAKACSRIVQCLQ
                     RIATHRLASGAHVYSTYSPNIALEAYVIKAAGFTGMTCSVFQKVAASDRAGLSDYGRR
                     DPDGNLDKQLSFKCNVSSTFSSLALKNTIMEASIQLPSSLLSPKHKREARAADDALYK
                     LQLIAFRNGKLFPATGNSTKLADDGKRRTVVTPVILTKIDGATVDTHHIPVNVTLRRI
                     AHGADAVAAQWDFDLLNGQGGWKSDGCCILYSDENITTIQCGSLGNYAVLMDLTGTEL
                     YTPAASLLHPVVYTTAITLLLCLLAVIISYMYHHSLIRISLKSWHMLVNLCFHILLTC
                     VVFVGGITQTRNASVCQAVGIILHYSTLATVLWVGVTARNIYKQVTKKAKRCQDPDEP
                     PAPPRPMLRFYLIGGGIPIIVCGITAAANIKNYGSRPSAPYCWMAWEPSLGAFYGPAS
                     FITFVNCMYFLSIFIQLKRHPERKYELKEPTEEQQRLAANENGEINHQDSMSLSLIST
                     STLENEHSFQSQLLGASLTLLLYVILWMFGAMAVSLYYPLDLVFSFFFGATCLSFSAF
                     MMVHHCINREDVRLAWIMMCCPGRSSYSVQVNVQPPNSSATNGEAPKCTNSSAESSCT
                     NKSASSFKNSSQGCKLTNLQAAAAQYHSNALPVNATPQLDNSLTEHSMDNDIKMHVAP
                     LDVQFRTNVHPSRHHKNRSKGHRASRLTVLREYAYDVPTSVEGSVQNGLPKSRPGSNE
                     GHSRSRRAYLAYRERQYNPPQQDSSDACSTLPKSSRNVEKPVSTSSKKDAPRKPAAAD
                     LESQQKSYGLNLAVQNGPVKSNGQEGPLLATDVTGNVRTGLWKHETTV"
     exon            446..517
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            518..589
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            590..661
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            662..733
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            734..894
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1108
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1273
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1475
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1631
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1793
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1997
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2211
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2420
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2545
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2669
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2815
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2911
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..4475
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4452..4457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /note="hexamer: AATAAA"
     polyA_site      4470
                     /gene="Adgra3"
                     /gene_synonym="3830613O22Rik; Gpr125; Tem5-like"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcgctc ccgcgggccg agcggcgagc tgggacccgg cggccctgac cccgcggctc
       61 cgcggagggc gagcgcggcc gcggacaaag gagcatgtcg tcgcgaagcg ggaccgatcc
      121 tcgggccgcc gggaggctcg ggccaccgcc agggccgccc cgccccgccg ccgcccgcta
      181 ggccggtgcc gtctctcggc cccgcaggcc cggtcagcgg catggagccg ccgccgccgc
      241 tgctgctgct gccgctggcg ctgctcgctc tgctgtgggg aggagagcgc ggggccgcgg
      301 cgctgcccgc gggctgcaag cacgacggtc gggcccgggg taccggccga gcggccgccg
      361 ccgccgaggg gaaggtggtg tgcagcagcc tggagctcgc gcaggttctg cccccggaca
      421 cgctgcccaa ccgcacggtc accctgattt taagcaacaa caagatctcc gagctgaaga
      481 atggttcatt ttctggctta agtctcctcg aaagactgga cctccggaac aaccttatta
      541 gtaggatagc cccaggtgcc ttttggggac tgtcttcact gaagagattg gacctgacga
      601 acaaccgaat aggttgtctg aatgcagatg tatttcgagg actcaccaat ctggttcggc
      661 taaacctttc agggaatctg tttacttcac tgtctcaagg aacttttgat tatcttggct
      721 cgttgcggtc tttagaattt cagactgagt accttctgtg tgactgtaac attctgtgga
      781 tgcatcgctg ggtaaaggag agaaacatca ctgtgcgaga caccaggtgt gtttatccca
      841 agtcactgca ggcccagcct gtcacggggg tgaaacagga gctcctcact tgcgatcctc
      901 cccttgaact gccgtccttc tacatgactc cgtcgcaccg ccaggttgtg tttgaaggag
      961 acagccttcc cttccagtgc atggcttcct atatagatca ggacatgcaa gtgctgtggt
     1021 atcaggatgg gcgcattgtt gagaccgatg agtcccaagg gatctttgtg gagaaaagca
     1081 tgattcacaa ttgctccttg atcgccagtg ccctaaccat ttctaatatt caagctggat
     1141 ctactggaaa ttggggctgt catgttcaga cgaaacgtgg gaataacaca agaactgttg
     1201 acattgtggt attagaaagc tccgcccaat actgtccacc agagagggtt gtgaacaaca
     1261 aaggtgattt cagatggccc aggacactgg cgggcatcac agcatatctc cagtgtaccc
     1321 ggaacaccca cagcagtggg atctaccctg gaagcgcaca ggatgaaagg aaggcgtggc
     1381 gccgatgcga cagaggtggc ttttgggcag atgatgatta ttctaggtgc cagtatgcaa
     1441 atgacgtcac tagagtcctg tatatgttta atcagatgcc cctcaacctt acaaatgcgg
     1501 tcgctacagc tcggcagctg ctggcttaca cagtggaggc cgccaacttc tctgacaaaa
     1561 tggacgttat atttgtggct gaaatgatag aaaagtttgg aagatttacc agagaggaaa
     1621 aatcaaaaga gcttggtgat gtaatggtcg atgtggcaag caacatcatg ttggctgatg
     1681 agcgggtcct gtggctggca cagagggaag caaaggcctg cagtcggatt gtccagtgcc
     1741 tgcagcgcat tgccacacat cgcctggcca gtggggccca cgtgtactcc acgtactcgc
     1801 ccaacattgc tctggaggct tacgtcatca aggctgctgg cttcacagga atgacctgct
     1861 ccgtgttcca gaaggtggct gcctccgacc gtgcaggtct ttctgactat gggcgaaggg
     1921 acccggatgg aaacctggat aagcagctga gcttcaaatg caatgtctcc agcaccttct
     1981 caagcctggc cctgaagaac accatcatgg aggcctccat tcagcttcct tcctcccttt
     2041 tgtcaccaaa acacaagcga gaagcccgag cggcggatga cgccctctat aagctccagc
     2101 tcattgcctt ccgcaacgga aagctttttc cagccacagg aaattcaaca aagttggcag
     2161 acgatggcaa gcggcggaca gtagtgaccc ctgtgatcct cacgaaaata gatggtgcaa
     2221 ccgtagatac ccaccacatc cctgttaatg tgacgctgcg ccgaattgcc cacggagcag
     2281 atgcggttgc agcgcagtgg gactttgatt tgctgaacgg acaaggaggc tggaagtcag
     2341 atgggtgctg tatactctac tcggatgaga acatcaccac cattcagtgc ggctccctgg
     2401 gcaactatgc tgtgctaatg gatctgactg ggacagagtt gtacacccca gcagccagtc
     2461 tcctgcaccc tgtggtttac accactgcca tcactctcct cttgtgtctc ttggctgtta
     2521 tcatcagtta catgtaccac cacagcttga tccgaatcag tctcaagagc tggcacatgc
     2581 ttgtgaacct gtgctttcac attctcctga cctgcgtggt gtttgtggga ggaataaccc
     2641 agaccagaaa tgccagcgtc tgtcaagcag ttgggatcat tcttcattat tctacccttg
     2701 ccacggtatt gtgggttgga gtcactgcta gaaatatcta taaacaagtc accaagaaag
     2761 ccaagagatg ccaggatcca gatgagccac ccgctcctcc acgaccgatg ctgaggttct
     2821 acctgattgg tggtgggatc cccatcatag tgtgtggtat caccgcggca gcaaacatca
     2881 agaactatgg cagtcggccc agtgcaccgt attgctggat ggcctgggaa ccgtccttgg
     2941 gagccttcta cggacctgcc agcttcatca cttttgtaaa ctgtatgtat tttctaagca
     3001 tatttattca gttgaaaaga caccctgagc gcaaatatga gctcaaggag ccgacagaag
     3061 agcagcagag attggcagcc aatgaaaatg gtgaaatcaa ccatcaggac tccatgtctc
     3121 tgtctctcat ctctacgtcc acgttggaga acgagcacag ttttcagtct cagcttctgg
     3181 gcgccagcct tactttgctt ttgtatgtca tcttgtggat gtttggggcc atggctgttt
     3241 ctctgtatta ccctctggac ttggttttta gcttcttctt cggagccact tgtttaagct
     3301 tcagtgcttt catgatggtg caccactgca tcaacaggga ggacgtgaga cttgcgtgga
     3361 tcatgatgtg ctgcccaggg cggagctcgt actccgtgca agtcaacgtc caacctccca
     3421 actcaagcgc cactaatgga gaggctccaa agtgcaccaa tagcagcgca gagtcttcgt
     3481 gcacgaacaa aagcgcatcg agcttcaaaa actcttccca gggctgcaag ctgacaaact
     3541 tgcaggctgc tgcggcacag taccacagca atgccctacc tgtgaatgcc acgccgcagc
     3601 ttgataacag tctgaccgaa cactcgatgg acaacgatat taaaatgcat gtggctcctt
     3661 tagacgtgca gtttcgaaca aacgtgcacc caagccgcca ccacaaaaac cgaagtaaag
     3721 gacaccgggc cagcaggctc acagtcctgc gagagtatgc ctatgacgtc ccaacaagtg
     3781 tggaaggaag cgtgcagaat ggcttaccta aaagccggcc aggcagcaat gaaggacatt
     3841 caaggagtag gagagcttat ttagcctaca gagagagaca gtacaaccca ccccaacaag
     3901 acagcagtga tgcttgtagc acacttccca aaagtagccg aaatgttgaa aagcctgttt
     3961 caactagtag taagaaagat gcaccaagga agccagctgc agccgacctt gaaagtcagc
     4021 agaaatctta cggcctgaac ttggctgttc agaatggacc agttaaaagc aatgggcagg
     4081 aaggaccctt gctagctacc gacgtcactg gtaatgttag gactgggtta tggaaacacg
     4141 aaacaactgt gtagcattgc aggggcttcc aagacaaggt gaaactgtgg tactcacatt
     4201 cctttaagct atgaactctt agaaacaaac tgtttacagc caccttgggg atacaaagcc
     4261 gttctgagta ttcttgtgag ctttgggatt tacttatttt atattcccaa attgtccccc
     4321 actcccccca agagttaaaa atgttttaaa acattgtttt acttgtcaaa gcaccaataa
     4381 gatattttgg aagttgaaaa tataatttct tagaatctgt tatatctgcg taacatctga
     4441 gacttgtatt taataaacta aatagaagtt tgtca
//
