LOCUS       NM_177469               4777 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus adhesion G protein-coupled receptor A1 (Adgra1), mRNA.
ACCESSION   NM_177469
VERSION     NM_177469.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4777)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4777)
  AUTHORS   Zhang,X.H., Shen,C.L., Wang,X.Y., Xiong,W.F., Shang,X., Tang,L.Y.,
            Zhang,H.X., Wan,Y.H., Wu,Y.B., Fei,J., Yi,Q.Z. and Wang,Z.G.
  TITLE     Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female
            Mice are Attributable to Elevated Neuron Dendrite Density,
            Upregulated PSD95 Expression, and Abnormal Activation of the
            PI3K/AKT/GSK-3beta and MEK/ERK Pathways
  JOURNAL   Neuroscience 503, 131-145 (2022)
   PUBMED   36115515
  REMARK    GeneRIF: Increased Anxiety-like Behaviors in Adgra1(-/-) Male But
            Not Female Mice are Attributable to Elevated Neuron Dendrite
            Density, Upregulated PSD95 Expression, and Abnormal Activation of
            the PI3K/AKT/GSK-3beta and MEK/ERK Pathways.
REFERENCE   3  (bases 1 to 4777)
  AUTHORS   Quilichini,E., Fabre,M., Nord,C., Dirami,T., Le Marec,A.,
            Cereghini,S., Pasek,R.C., Gannon,M., Ahlgren,U. and Haumaitre,C.
  TITLE     Insights into the etiology and physiopathology of MODY5/HNF1B
            pancreatic phenotype with a mouse model of the human disease
  JOURNAL   J Pathol 254 (1), 31-45 (2021)
   PUBMED   33527355
REFERENCE   4  (bases 1 to 4777)
  AUTHORS   Zhang,X.H., Tang,L.Y., Wang,X.Y., Shen,C.L., Xiong,W.F., Shen,Y.,
            Wan,Y.H., Wu,Y.B., Wang,Y.C., Zhang,H.X., Lu,S.Y., Fei,J. and
            Wang,Z.G.
  TITLE     ADGRA1 negatively regulates energy expenditure and thermogenesis
            through both sympathetic nervous system and
            hypothalamus-pituitary-thyroid axis in male mice
  JOURNAL   Cell Death Dis 12 (4), 362 (2021)
   PUBMED   33824276
  REMARK    GeneRIF: ADGRA1 negatively regulates energy expenditure and
            thermogenesis through both sympathetic nervous system and
            hypothalamus-pituitary-thyroid axis in male mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4777)
  AUTHORS   Pandya,N.J., Koopmans,F., Slotman,J.A., Paliukhovich,I.,
            Houtsmuller,A.B., Smit,A.B. and Li,K.W.
  TITLE     Correlation profiling of brain sub-cellular proteomes reveals
            co-assembly of synaptic proteins and subcellular distribution
  JOURNAL   Sci Rep 7 (1), 12107 (2017)
   PUBMED   28935861
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4777)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   7  (bases 1 to 4777)
  AUTHORS   Ashley,R.L., Henkes,L.E., Bouma,G.J., Pru,J.K. and Hansen,T.R.
  TITLE     Deletion of the Isg15 gene results in up-regulation of decidual
            cell survival genes and down-regulation of adhesion genes:
            implication for regulation by IL-1beta
  JOURNAL   Endocrinology 151 (9), 4527-4536 (2010)
   PUBMED   20660068
REFERENCE   8  (bases 1 to 4777)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   9  (bases 1 to 4777)
  AUTHORS   Ohara,R., Koga,H., Kikuno,R. and Ohara,O.
  TITLE     Method for systematic targeted isolation of homologous cDNA
            fragments in a multiplex format
  JOURNAL   Biotechniques 36 (5), 798-800 (2004)
   PUBMED   15152599
REFERENCE   10 (bases 1 to 4777)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG083237.2, BE651866.1, AK082207.1 and BC056493.1.
            
            On Apr 10, 2007 this sequence version replaced NM_177469.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.145125.1,
                                           SRR1660821.1970.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               BG083237.2         1-106
            107-122             BE651866.1         73-88
            123-3621            AK082207.1         2-3500
            3622-4777           BC056493.1         2905-4060
FEATURES             Location/Qualifiers
     source          1..4777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 84.89 cM"
     gene            1..4777
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /note="adhesion G protein-coupled receptor A1"
                     /db_xref="GeneID:52389"
                     /db_xref="MGI:MGI:1277167"
     exon            1..354
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     exon            355..549
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1139
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     CDS             1128..2864
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /note="G protein-coupled receptor 123; probable G-protein
                     coupled receptor 123; G protein coupled receptor Gpr123"
                     /codon_start=1
                     /product="adhesion G protein-coupled receptor A1"
                     /protein_id="NP_803420.2"
                     /db_xref="CCDS:CCDS40171.1"
                     /db_xref="GeneID:52389"
                     /db_xref="MGI:MGI:1277167"
                     /translation="MTQWDLKTVLSLPQYPGEFLHPVVYACTAVMLLCLLASVITYIL
                     HQSAIRISRKGRHALLNFCFHAALTFTVFAGGINRTQHPILCQAVGIALHYSTLSTML
                     WIGVTARNIYKQVTKKALPCPGADQPPYPKQPLLRFYLISGGVPFIICGVTAATNIRN
                     YGTEDEDVAYCWMAWEPSLGAFYGPAAFIALVTCVYFLCTYVQLRRHPERRYELRERT
                     EEQQRLAVPESGHRHGVRPGTPPTCDALAASQLQNEHSFKAQLRAAAFTLFLFTATWT
                     FGALAVSQGHFLDMIFSCLYGAFCVTLGLFVLIHHCAKREDVWQCWWSCCPSRGDTST
                     TKPGAHPTLDANGDALGHTACLQDSPCPGKLRGFGHPPASHCKMTNLQAAQGHVSCLS
                     PATPCCAKMHCEQLMEEEAAHIHMAEEDVYPHDPHLHDPHLHRCLKGRTKSHYFSRHQ
                     AAAAEREYAYHIPSSLDGSPHSSRSESPTSSLEGPMGMHTLACCAQADPFPMVSQPEG
                     GDTSPGLYGCPPHLSPGPAHLEMLRRTQSLPFGGPSQNGLLQGDVREGLPFGTDGTGN
                     IRTGPWKNETTV"
     exon            1140..1267
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1391
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1537
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1636
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..4758
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4525..4530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /note="hexamer: AATACA"
     polyA_site      4545
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /note="major polyA site"
     regulatory      4730..4735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
                     /note="hexamer: ATTAAA"
     polyA_site      4758
                     /gene="Adgra1"
                     /gene_synonym="2900059M17Rik; D7Ertd680e; Gpr123"
ORIGIN      
        1 cctgcttccc ggccggtcct tcattcccct ggctgttgct gcagaaatcc ggcgcgcagg
       61 cggctggcgt cccccaaccc agagctggaa actgcctgca gagagcgcat tggatgcctg
      121 ctcttctcgg ctctgactca ctccctccgg gtgcagagct ccgtccccag cgcagtgctc
      181 tggccacagc cagtcgccag gctgcagccc tgcaatctgt tgataactcc acttataagc
      241 tccaatctca tgcctttcgt catagaaagc tgttccctag cacgagggac atgccacatc
      301 tcgcctgtga gaagcaggag acctgtgcct cttcggctgc ctttaccaaa ataggtgggt
      361 cagcctgcag atccccattc atcttgacac agtcactctg aggtagcctt cccaggagct
      421 cgaccgtgac tgtgtgggac ttgaccttcc agatggccat ggaggctaga ggggagaagg
      481 gtgcaacata gtggtcggtg ccagcaaccc catcagtgcg cttgcctccc taactctgca
      541 gggctcatgg tctaaatggc tagaaacgtc tcagagctac agtcctgtca gacagagttt
      601 ttccaatctc aacagtcccc tgaactatcc acactaagaa agcaactgcc agcctagaag
      661 gaagcctcca taatactctt caagatgtct ttcttcaaat ctctccatga tttcatcgtc
      721 ccatatatcc ccctaaaaag aaaatcacag cacgctgtat tcatgtgtca tgcactggca
      781 ttgtgagaga atgagtgact taccttctgc ttgtcccatg gaaggctgat cgattgataa
      841 gatccagtta tcactgaaaa gacaggcaag gagatgcatc aggctctact gaaaccagtc
      901 ttggttggca cagaaccaac aaagaaaaaa aaaatccaga cccgagcaga gcaagaagac
      961 tgagcgagat gcacacggtg actcacactg gtgagcgcac cacttgagaa gctggggcag
     1021 ctacagactg agaccctgcc acaaaacaaa tggaaacgaa accacagatg gagacgagga
     1081 agactaccca ggaaaactga gtcgagagaa gaaccgaggc tgaggagatg actcagtggg
     1141 atttgaagac tgtcctctcc ctgccccagt acccagggga gttcctgcat cctgtggtgt
     1201 atgcctgcac cgcggtcatg ctcctgtgtc tccttgcctc tgtcatcacc tacatcttgc
     1261 atcagagtgc catccggata agccggaaag gccggcacgc actcctcaac ttctgcttcc
     1321 acgccgctct gaccttcacc gtgtttgctg gtggcatcaa tcgcacccaa caccccatcc
     1381 tgtgccaagc agtgggcatt gctctgcact attccacgct ttctaccatg ctgtggatcg
     1441 gtgtgactgc taggaacatc tacaaacagg tgaccaagaa ggccctgcca tgtcctggag
     1501 cagaccagcc accgtaccct aagcagccct tgctcaggtt ctacctcatc agcggagggg
     1561 tccctttcat catctgtggg gtcacagctg ccacaaacat cagaaattat ggcaccgagg
     1621 atgaggacgt ggcatactgc tggatggcct gggaacccag cctgggtgcg ttctatgggc
     1681 cggctgcctt cattgccctg gtcacctgcg tgtacttcct ctgcacctac gtgcagctgc
     1741 ggcgtcaccc ggagcgcagg tatgagctca gagagcgcac ggaggagcag cagcgactgg
     1801 ctgtgccaga gagcggccat cgccacggag tccgtcccgg gaccccaccc acctgtgatg
     1861 ccctggctgc ctcgcagctg cagaacgagc attccttcaa ggctcagctt cgtgccgctg
     1921 ccttcacact gttcctgttc acagctacat ggacctttgg ggccctggct gtgtctcagg
     1981 gccacttcct ggacatgatc ttcagctgtc tgtacggcgc cttctgcgtg acactgggac
     2041 tctttgtact tatccatcac tgcgccaagc gggaggacgt gtggcagtgc tggtggtcct
     2101 gctgcccttc ccggggagac acctccacca ccaagcccgg cgcccatcct acactcgatg
     2161 ccaacgggga tgcgctgggg catacggcct gcctgcagga ctcaccatgc cctgggaaac
     2221 tcagaggttt tggccatcca ccagccagcc actgcaagat gaccaacctg caggctgccc
     2281 agggccatgt cagctgtctg tcacctgcca ccccgtgctg tgccaagatg cactgtgagc
     2341 agttaatgga ggaggaggcg gcccacatcc acatggctga ggaggacgtc tacccacacg
     2401 atccccacct gcatgaccct cacctgcaca ggtgcctcaa gggcagaact aagtcccact
     2461 acttcagccg gcaccaggca gctgcggctg agagggagta tgcttaccac atcccctcca
     2521 gcctggatgg cagtccccac agttcacgtt cggagagccc caccagctct ctggagggcc
     2581 caatggggat gcacacattg gcctgctgtg cccaggctga ccccttcccc atggtcagcc
     2641 agcctgaggg tggagacaca agccctgggc tctatggctg ccccccacac ctatccccag
     2701 gccctgccca cttggagatg ctacgaagga cacagtccct gccttttggg ggccccagcc
     2761 agaatgggct gctccagggt gatgttcgag aaggcctgcc atttggcact gatgggacag
     2821 ggaacatccg aacaggaccc tggaaaaatg aaactacagt gtagccaggt tgggaacaca
     2881 acttcttcgc cagtgccacc acgtgtccct ggaggagctt cagagcaggg agtggccctt
     2941 tgctatgtgg actggaaggg ccatcaaatg accaagtggt tctgaaatgg ttcccagccc
     3001 tcagccatga tctcttttgt tgtataagaa cccatgggaa gaacactggg ccacatacaa
     3061 ccgccactag tccccaagct tacctccata agctagtcac ctgctttctg tttatagcac
     3121 cttccctcgc tgctgggagg gaagctggga ggacaccccc cccccaagac tccagctggt
     3181 gttcttgcct ttggtatata tatgttaggt tttgctctag ggaccaccgc agtggccctc
     3241 cagagctcgc tcacactggg cagtttcctg tcccctgctg tccttgcgtt acctcacacc
     3301 tgcatctcca ctgggggagc catctggcac ctcggcctac tcaccacctg cacctgtaat
     3361 gggaaatggc cctggcctgg tagcctgagg tcatttcaag tgctaaggat gggcctggta
     3421 tggagccatg gggaggggaa acaactcatg gctgtggcct tcagggagct ggctacagtc
     3481 tctctgggcc tgtgctgttg aaagttggcc tctatcagac tggattctgt cccattgtga
     3541 gcatgtagta gtcagattct ccgtcccaca aggaggggct gagtggggtg tgacggtcat
     3601 cacggatgaa ggtttcttat catggatgac ggtttctttt cctttttgcc attttcatga
     3661 tcattttggg tacaaagccc cacctcaaag agtatatttc aacaatgagc cttttgtaca
     3721 agcaagtgtc ttgtcccagg ggagatcctc acagaggtga gagcccagag atgccaacct
     3781 gtgactgtcc acccttcctc tccagctttc tcttcccagt ttgtagtgca tatgcctaca
     3841 tatgtataca cacacacaca cacacacaca cacacacaca cacactggca tacatatatg
     3901 aacacacctt tgtgtgtaca tacacttgtg tgtacacaca tgcttataca tatttacagt
     3961 tacactatgc acaccacata cacgtgcatc cacacgcttg cccaccacat gtatgcacgt
     4021 gcacatgcct gcacactacc acacatgcac acataccaca ctgtccacac acagacgcat
     4081 tggtgttcac acgcacccac aaacaattag tgtgtatcac agccctgagt gctgggtttc
     4141 tctgcagatg tgggtgagtc tgtgacttgc ttcacagagc atagccttcc cgataaccgc
     4201 ctcagagaac agggcatagg taagttccta gagcattgga ggcgaggcgg cagcattctg
     4261 cagcctgtgg tgggcagtgc catctagagg cagacacact cagtatctga gtaaggaggc
     4321 tagcaggcag agctgatatt cataagctcc tctgtgatat cccttaaagc agcattctgt
     4381 acccatccct caggtgggta gccaaggacc accaggctgt ttcagctcct ttcactaacg
     4441 gactttttta cctgcttgtg tagctgatgt gtgcagaacc caccatgctg tgtacgtact
     4501 gtagatacag accatccaga ggaaaataca gtgttttaca ttgtttgtcc ttggtcgggc
     4561 tggtcagtag cattcatgtg tgtgtttctc agtcttgaca aggaagacca gtatgggaga
     4621 ggcttggccc ccatccaggc tgctcccctg ggcctaatcc ctcatctttt ctaccacggt
     4681 gcctctggga gaacagagac acctcttcat tcaaccaaag aaattcggca ttaaatattg
     4741 aacctggctg tgtttcaaaa aaaaaaaaaa aaaaaaa
//
