LOCUS       NM_001413986            4294 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus adducin 3 (Add3), transcript variant 6, mRNA.
ACCESSION   NM_001413986 XM_030250962
VERSION     NM_001413986.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4294)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4294)
  AUTHORS   Chal,J., Al Tanoury,Z., Oginuma,M., Moncuquet,P., Gobert,B.,
            Miyanari,A., Tassy,O., Guevara,G., Hubaud,A., Bera,A., Sumara,O.,
            Garnier,J.M., Kennedy,L., Knockaert,M., Gayraud-Morel,B.,
            Tajbakhsh,S. and Pourquie,O.
  TITLE     Recapitulating early development of mouse musculoskeletal
            precursors of the paraxial mesoderm in vitro
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29555813
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4294)
  AUTHORS   Lou,H., Park,J.J., Phillips,A. and Loh,Y.P.
  TITLE     gamma-Adducin promotes process outgrowth and secretory protein exit
            from the Golgi apparatus
  JOURNAL   J Mol Neurosci 49 (1), 1-10 (2013)
   PUBMED   22706708
  REMARK    GeneRIF: C-terminal 38 amino acids of gamma-adducin interact with
            F-actins around the Golgi complex, to facilitate exit of POMC/ACTH
            vesicles.
REFERENCE   4  (bases 1 to 4294)
  AUTHORS   Gehman,L.T., Meera,P., Stoilov,P., Shiue,L., O'Brien,J.E.,
            Meisler,M.H., Ares,M. Jr., Otis,T.S. and Black,D.L.
  TITLE     The splicing regulator Rbfox2 is required for both cerebellar
            development and mature motor function
  JOURNAL   Genes Dev 26 (5), 445-460 (2012)
   PUBMED   22357600
REFERENCE   5  (bases 1 to 4294)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   6  (bases 1 to 4294)
  AUTHORS   Clee,S.M., Yandell,B.S., Schueler,K.M., Rabaglia,M.E.,
            Richards,O.C., Raines,S.M., Kabara,E.A., Klass,D.M., Mui,E.T.,
            Stapleton,D.S., Gray-Keller,M.P., Young,M.B., Stoehr,J.P., Lan,H.,
            Boronenkov,I., Raess,P.W., Flowers,M.T. and Attie,A.D.
  TITLE     Positional cloning of Sorcs1, a type 2 diabetes quantitative trait
            locus
  JOURNAL   Nat Genet 38 (6), 688-693 (2006)
   PUBMED   16682971
REFERENCE   7  (bases 1 to 4294)
  AUTHORS   Akai,J. and Storey,K.
  TITLE     Expression of gamma-adducin is associated with regions of
            morphogenetic cell movement in the chick embryo
  JOURNAL   Mech Dev 119 Suppl 1, S191-S195 (2002)
   PUBMED   14516684
REFERENCE   8  (bases 1 to 4294)
  AUTHORS   Suriyapperuma,S.P., Lozovatsky,L., Ciciotte,S.L., Peters,L.L. and
            Gilligan,D.M.
  TITLE     The mouse adducin gene family: alternative splicing and chromosomal
            localization
  JOURNAL   Mamm Genome 11 (1), 16-23 (2000)
   PUBMED   10602987
REFERENCE   9  (bases 1 to 4294)
  AUTHORS   Gilligan,D.M., Lozovatsky,L., Gwynn,B., Brugnara,C., Mohandas,N.
            and Peters,L.L.
  TITLE     Targeted disruption of the beta adducin gene (Add2) causes red
            blood cell spherocytosis in mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10717-10722 (1999)
   PUBMED   10485892
REFERENCE   10 (bases 1 to 4294)
  AUTHORS   Pinto-Correia,C., Goldstein,E.G., Bennett,V. and Sobel,J.S.
  TITLE     Immunofluorescence localization of an adducin-like protein in the
            chromosomes of mouse oocytes
  JOURNAL   Dev Biol 146 (2), 301-311 (1991)
   PUBMED   1864459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138174.9.
            
            On Nov 10, 2022 this sequence version replaced XM_030250962.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219383.33567.1,
                                           SRR13422598.1652055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC138174.9         135063-135356       c
            295-356             AC138174.9         74677-74738         c
            357-571             AC138174.9         61137-61351         c
            572-710             AC138174.9         51423-51561         c
            711-862             AC138174.9         46821-46972         c
            863-943             AC138174.9         45948-46028         c
            944-1093            AC138174.9         44977-45126         c
            1094-1237           AC138174.9         44436-44579         c
            1238-1336           AC138174.9         44229-44327         c
            1337-1519           AC138174.9         43191-43373         c
            1520-1777           AC138174.9         41301-41558         c
            1778-1897           AC138174.9         39630-39749         c
            1898-1984           AC138174.9         38659-38745         c
            1985-2108           AC138174.9         35525-35648         c
            2109-2204           AC138174.9         33747-33842         c
            2205-4294           AC138174.9         31065-33154         c
FEATURES             Location/Qualifiers
     source          1..4294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 47.18 cM"
     gene            1..4294
                     /gene="Add3"
                     /note="adducin 3"
                     /db_xref="GeneID:27360"
                     /db_xref="MGI:MGI:1351615"
     exon            1..294
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..356
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            357..571
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..2497
                     /gene="Add3"
                     /note="isoform a is encoded by transcript variant 6;
                     gamma-adducin; cytoskeletal protein; adducin-like protein
                     70; adducin 3 (gamma)"
                     /codon_start=1
                     /product="gamma-adducin isoform a"
                     /protein_id="NP_001400915.1"
                     /db_xref="GeneID:27360"
                     /db_xref="MGI:MGI:1351615"
                     /translation="MSSDTSPAVVTTPPPPSMPHKERYFDRINESDPEYLRERNMSPD
                     LRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPSGLLALQQIADYIVTSS
                     FSGFSSPSLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLADLFGWAHLANTY
                     ISVRISKEQDHIIIIPRGLSFSEATASTLVKVNIIGEVVDQGSTDLKIDHTGFSPHAA
                     IYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLILGDVAYYDYQGSLDEEEERI
                     ELQKVLGPSCKVLVLRNHGMVALGETLEEAFHYIFNVQMACEIQVQAVAGAGGVDNLL
                     VLDLQKYKAFTHGVAMSGGGGVNMASHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHP
                     LVREKPRHKSDVEIPATVTAFSFEDDSAPLSPLKFMAQRQQREKTRWLNSPNTYMKVN
                     VPEESRNGETSPRTKITWMKAEDSSKVSSGTPIKIEDPNQFVPLNTNPTEVLEKRNKI
                     REQNRYDLKTAGPQSQLLAGIVVDKPPSTMQFDDDDQGPPAPPNPFSHLLEGELEEYT
                     KTIERKQQGLDDAEQGSLSDDAASVSQIQSQTQSPQSVPERLEENHELFSKSFTSMDA
                     PVMIMNGKDEMHDVEDELAQRVSRLTTSTTIENIEITIKSPERTEEVLSPDGSPSKSP
                     SKKKKKFRTPSFLKKNKKKEKVEA"
     exon            572..710
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..862
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..943
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1093
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1237
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1336
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1519
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1777
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1897
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1984
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2108
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2204
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..4294
                     /gene="Add3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4273..4278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Add3"
                     /note="hexamer: AATAAA"
     polyA_site      4294
                     /gene="Add3"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgag gcgcccgccg gtaacggtcg tgcgggcgag gggctggagg gagaggaaag
       61 ggctttaaat gatgttttga agcagcgaga gctagacgcg tcggcgacca ggtgtcgcca
      121 cttcccgctg ccgagggctc ggcgtccagg tcctgcgtct ccacgccccc tcccttcccg
      181 gccctctcct cgggaaccga gcgagcgacg ttaagaggcg gctgcggcgg accgggcggc
      241 cgctgcagcc cggcggtggc gaaggagtgg gcacaaagcc ggctgcgctg cgagggtgag
      301 ttggtgaaaa cagaagacta aaatagggca cagtggctgg aaaagaaaga atccagagag
      361 gaagacgact ggagacatga gttccgacac cagcccagct gtggttacca cgcctcctcc
      421 tcccagcatg cctcacaaag agaggtattt tgaccgaatc aatgaaagtg atccggaata
      481 ccttcgagag aggaacatgt ctcctgatct acgacaggac ttcaatatga tggagcagag
      541 gaagcgagtc actcagatcc tgcagagccc tgcctttcgg gaagacctgg aatgcctcat
      601 ccaagagcag atgaagaaag gccacaaccc aagcggctta ttagcgttac agcagattgc
      661 ggattacatc gtgaccagct ccttctcggg cttctcctcg ccctccctga gtcttggcat
      721 ggtcacacct attaatgacc ttcctggtgc agatacatcc tcgtatgtga agggagaaaa
      781 gcttactcgc tgcaaacttg ccagcctcta caggcttgca gacttgtttg ggtgggcgca
      841 cctggcaaat acgtacatct cggtacgaat aagtaaggag caagaccaca ttataataat
      901 tcccagaggc ctctcttttt ctgaagcgac agcctccact ttggtgaaag tcaacataat
      961 cggagaagtg gtggaccagg ggagcactga tctgaaaatc gaccacacgg gcttcagccc
     1021 gcatgctgcc atctattcaa cacgccccga tgtgaagtgt gtgatccaca tccacaccct
     1081 tgccacagca gcggtgtcct ccatgaagtg tgggatcctt ccaatttccc aagagtctct
     1141 catcctggga gatgtcgcct actatgacta ccaggggtcg cttgatgagg aggaagaaag
     1201 aattgaactt cagaaagtgc tgggtccaag ctgtaaggtg ctcgtcctca ggaaccatgg
     1261 catggtggct cttggcgaga ccctcgagga ggctttccat tacatcttta atgtacagat
     1321 ggcctgtgag atccaggtgc aggcagtagc aggggcaggc ggagtagaca atctgctcgt
     1381 actggatctt cagaaatata aagctttcac ccacggtgtc gccatgtctg gaggaggcgg
     1441 tgtaaacatg gcttcccatc agaagtggaa ggttggcgag attgagtttg aagggctgat
     1501 gaggaccctg gacaacttgg gctacagaac aggctatgcg tacaggcatc ctctggtccg
     1561 agagaagcct aggcacaaga gtgacgtgga gatccctgca accgtgactg ccttctcctt
     1621 tgaagatgac agtgctccac tctctcccct caagttcatg gcacagagac agcagcgtga
     1681 aaaaacaaga tggctgaatt caccaaatac ttacatgaag gtgaatgtgc cggaggagtc
     1741 tcggaacggg gaaactagtc ccaggaccaa aatcacgtgg atgaaagcag aagactcctc
     1801 taaagtcagt agtgggacac cgatcaaaat tgaagacccc aatcagtttg ttcctttaaa
     1861 cacaaacccg acggaggtgc tagaaaagag aaataagatc cgggaacaga atcgctatga
     1921 tctgaagaca gcagggccgc agtctcagct gctggcgggg atcgttgtgg acaagccgcc
     1981 ttcgaccatg cagtttgacg atgacgatca gggcccacca gctcctccta acccattcag
     2041 ccacctcctg gaaggagaac tggaagagta tacgaagaca atcgagagaa agcagcaagg
     2101 cctggacgac gctgagcagg ggtcactctc agacgacgct gcatctgttt cacaaattca
     2161 gtctcaaact cagtcaccgc agagtgtccc tgagagatta gaagaaaacc acgagctgtt
     2221 ttccaagagc ttcacctcca tggacgcgcc tgtcatgatc atgaacggca aggacgagat
     2281 gcatgatgtc gaagacgagc ttgctcagcg agtcagtagg ctgaccacaa gcacgaccat
     2341 agagaacatc gagatcacca ttaagtcccc agaaagaact gaagaggtcc tgtcgcctga
     2401 tggctcacct tcaaagtcgc cctccaagaa aaagaagaaa ttccgcacgc cttcttttct
     2461 caaaaagaac aaaaaaaagg agaaagttga ggcctaagta gtccttttgt aatttgtata
     2521 ttacattgtg gcattgcaca cttaaatacc atattttagt taatcgttaa tatactgtgg
     2581 tagatcagat tgggagtatg tagcaaactg gactttaaaa aactggaaag aggttttact
     2641 aaaagaaaaa tattattgaa aactttcaaa ttcatctctt tttatatgtc cgaaaacggc
     2701 cgagcttttc agcagtggct ggcttggccg actctgccgt ccctggcaga gcgttgttac
     2761 tgttgctcct tagcagctgc tgcctggtgc ctaggcctct gcagcacatg tgctgggaag
     2821 gagctgccag tgagcacgag acaatgctta cttgtcacta atcagacctt gagtttatca
     2881 tcgtggttat tgactgtatc tttgggtccc cactgtttcc atgggcatta atgggatgtt
     2941 ttaaaagctt ctacaagact ctagagcatt agtatacatt ggcacatcat tttttaaaaa
     3001 atgttttaag aaaagatttg tctgggtttt tactcatagt atgaaattcc cctacctgaa
     3061 gtaactgttt gccaaaaagt cattttaata aactataatt tttgaagaac ttcctttttt
     3121 attagtttag aaaacccctt atttttcata gaggggattt tgtacacata atatgagtta
     3181 tttagtttaa ctcttgcaaa aaaacaattt ttgtatgtta aaacgtttgt ataccttcag
     3241 tataaggtgt catgtgcatg ttagccaatc agtcaggggt aaagcctgcc cgagtgccat
     3301 ccaggagtcc aggggcgtgg cacccaaggg catatcaagg cctcgagtcg tatttgaacc
     3361 atataatgta tttttctctt agtattgctg atggatgaag aggctgaggg gaagggaaga
     3421 gtaagagaca ggacaggact gagtcctgtg tccacagaag aaagaacatg gagatcgact
     3481 tgctgaaaat aaggcccaag tttctaaaat cctgtttcct gccaaaatca atgtcttggt
     3541 tgacatttga attttaaaag agttaaagtg tacatccttt tagaagacgg cactagaata
     3601 aatcagcagg tctaatccca ccagcgagaa aactaccacg tcttgatttt tgcaaactta
     3661 atcttgattt ttataaactt aaattttctt ttaacttcct ttctactgta aatacaaatt
     3721 taagcctaga tttaatatag ttttctccat ttccccaagt aatgtcgcag atcaatgtaa
     3781 atggatgacc ccaatactcc acgagtggaa gtaaagcgcc ctgcgggtga cttggcacgc
     3841 aaacgtgacg tgacgttggc cgcagtgctc tctgggctgg ctctgtctga ccctgtgatt
     3901 gatgctggtc ctcttagacc tcactaacta ctggagcctg ttaatctcgt agtggaaact
     3961 ttgagttgct gaattgtgca tctgaggatt gttttatgtc ctacatcatc tgtgttgtgc
     4021 tacaacgtgt ggagacacag ttacctgtga actctccttt tccataactt ttaaagaata
     4081 tatatatcta aatgaatgca atgtgcataa atatttttta aacacaacag taaactattg
     4141 cacctttcgc taacgcttct ctttacttgc tttgacataa tgaatgagcc agtgaactca
     4201 gtgtcctgtg gaaaatgtat aaaagttatc tgatattgct cttagatgtt atgctaatta
     4261 atgttaaatc acaataaacg gtattttaaa tata
//
