LOCUS       NM_001271857            8223 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adducin 2 (Add2), transcript variant 1, mRNA.
ACCESSION   NM_001271857
VERSION     NM_001271857.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8223)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8223)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8223)
  AUTHORS   Yaguchi,H., Yabe,I., Takahashi,H., Watanabe,M., Nomura,T., Kano,T.,
            Matsumoto,M., Nakayama,K.I., Watanabe,M. and Hatakeyama,S.
  TITLE     Sez6l2 regulates phosphorylation of ADD and neuritogenesis
  JOURNAL   Biochem Biophys Res Commun 494 (1-2), 234-241 (2017)
   PUBMED   29032200
  REMARK    GeneRIF: Sez6l2 is one of the auxiliary subunits of the AMPA
            receptor and acts as a scaffolding protein to link GluR1 to ADD.
            Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation,
            whereas siRNA-mediated downregulation of Sez612 prevents ADD
            phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal
            transduction.
REFERENCE   4  (bases 1 to 8223)
  AUTHORS   Rabenstein,R.L., Addy,N.A., Caldarone,B.J., Asaka,Y.,
            Gruenbaum,L.M., Peters,L.L., Gilligan,D.M., Fitzsimonds,R.M. and
            Picciotto,M.R.
  TITLE     Impaired synaptic plasticity and learning in mice lacking
            beta-adducin, an actin-regulating protein
  JOURNAL   J Neurosci 25 (8), 2138-2145 (2005)
   PUBMED   15728854
  REMARK    GeneRIF: beta-Adducin may play an important role in the cellular
            mechanisms underlying activity-dependent synaptic plasticity
            associated with learning and memory.
            Erratum:[J Neurosci. 2005 Apr 6;25(14):1 p following 3627]
REFERENCE   5  (bases 1 to 8223)
  AUTHORS   Suriyapperuma,S.P., Lozovatsky,L., Ciciotte,S.L., Peters,L.L. and
            Gilligan,D.M.
  TITLE     The mouse adducin gene family: alternative splicing and chromosomal
            localization
  JOURNAL   Mamm Genome 11 (1), 16-23 (2000)
   PUBMED   10602987
REFERENCE   6  (bases 1 to 8223)
  AUTHORS   Gilligan,D.M., Lozovatsky,L., Gwynn,B., Brugnara,C., Mohandas,N.
            and Peters,L.L.
  TITLE     Targeted disruption of the beta adducin gene (Add2) causes red
            blood cell spherocytosis in mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10717-10722 (1999)
   PUBMED   10485892
REFERENCE   7  (bases 1 to 8223)
  AUTHORS   Ciciotte,S.L., Tsai,F.Y. and Peters,L.L.
  TITLE     Gata2 maps to mouse chromosome 6
  JOURNAL   Mamm Genome 8 (1), 69-70 (1997)
   PUBMED   9021157
REFERENCE   8  (bases 1 to 8223)
  AUTHORS   White,R.A., Angeloni,S.V. and Pasztor,L.M.
  TITLE     Chromosomal localization of the beta-adducin gene to mouse
            chromosome 6 and human chromosome 2
  JOURNAL   Mamm Genome 6 (10), 741-743 (1995)
   PUBMED   8563174
REFERENCE   9  (bases 1 to 8223)
  AUTHORS   Scaramuzzino,D.A. and Morrow,J.S.
  TITLE     Calmodulin-binding domain of recombinant erythrocyte beta-adducin
  JOURNAL   Proc Natl Acad Sci U S A 90 (8), 3398-3402 (1993)
   PUBMED   8475088
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1993 Aug 15;90(16):7908]
REFERENCE   10 (bases 1 to 8223)
  AUTHORS   Pinto-Correia,C., Goldstein,E.G., Bennett,V. and Sobel,J.S.
  TITLE     Immunofluorescence localization of an adducin-like protein in the
            chromosomes of mouse oocytes
  JOURNAL   Dev Biol 146 (2), 301-311 (1991)
   PUBMED   1864459
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY146240.1, AK147544.1,
            AK014496.1, CB722600.1, BU708888.1, CB524359.1, BU058008.1,
            BY712734.1, CB519116.1, BE951615.1 and AI835294.1.
            
            Summary: This gene encodes the beta subunit of the adducin family.
            Adducins, encoded by alpha, beta and gamma genes, are heteromeric
            proteins that crosslink actin filaments with spectrin at the
            cytoskeletal membrane. This protein, primarily found in the brain
            and hematopoietic cells, is regulated by phosphorylation and
            calmodulin interactions as it promotes spectrin assembly onto actin
            filaments, bundles actin and caps barbed ends of actin filaments.
            In mouse, deficiency of this gene can lead to mild hemolytic anemia
            and impaired synaptic plasticity. Mutations of this gene in mouse
            serve as a pathophysiological model for hereditary spherocytosis
            and hereditary elliptocytosis. Alternative splicing results in
            multiple transcript variants that encode different protein
            isoforms. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 2, 3 and
            4 encode the same isoform (1, also known as beta-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147544.1, SRR7652917.741876.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               BY146240.1         1-133
            134-1126            AK147544.1         7-999
            1127-3231           AK014496.1         893-2997
            3232-3851           AK147544.1         3110-3729
            3852-4508           CB722600.1         62-718
            4509-4708           BU708888.1         428-627
            4709-5387           CB524359.1         57-735
            5388-6205           AK147544.1         5267-6084
            6206-6472           BU058008.1         168-434
            6473-6965           BY712734.1         266-758
            6966-7345           CB519116.1         255-634
            7346-8001           BE951615.1         38-693              c
            8002-8223           AI835294.1         1-222               c
FEATURES             Location/Qualifiers
     source          1..8223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.55 cM"
     gene            1..8223
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /note="adducin 2"
                     /db_xref="GeneID:11519"
                     /db_xref="MGI:MGI:87919"
     exon            1..266
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            267..368
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            369..585
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..2580
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-adducin; erythrocyte adducin subunit beta; snoRNA
                     MBII-396; adducin 2 (beta)"
                     /codon_start=1
                     /product="beta-adducin isoform 1"
                     /protein_id="NP_001258786.1"
                     /db_xref="CCDS:CCDS20308.1"
                     /db_xref="GeneID:11519"
                     /db_xref="MGI:MGI:87919"
                     /translation="MSEDTVPEAASPPPSQGQHYFDRFSEDDPEYLRLRNRAADLRQD
                     FNLMEQKKRVTMILQSPSFREELEGLIQEQMKKGNNSSNIWALRQIADFMASTSHAVF
                     PASSMNFSMMTPINDLHTADSLNLAKGERLMRCKISSVYRLLDLYGWAQLSDTYVTLR
                     VSKEQDHFLISPKGVSCSEVTASSLIKVNILGEVVEKGSSCFPVDTTGFSLHSAIYAA
                     RPDVRCAIHLHTPATAAVSAMKCGLLPVSHNALLVGDMAYYDFNGEMEQEADRINLQK
                     CLGPTCKILVLRNHGMVALGDTVEEAFYKVFHLQAACEVQVSALSSAGGTENLILLEQ
                     EKHRPHEVGSVQWAGSTFGPMQKSRLGEHEFEALMRMLDNLGYRTGYTYRHPFVQEKT
                     KHKSEVEIPATVTAFVFEEDGVPVPALRQHAQKQQKEKTRWLNTPNTYLRVNVADEVQ
                     RNMGSPRPKTTWMKADEVEKSSSGMPIRIENPNQFVPLYTDPQEVLDMRNKIREQNRQ
                     DIKSAGPQSQLLASVIAEKSRSPSTESQLMSKGDADTKDESEETVPNPFSQLTDQELE
                     EYKKEVERKKLEQEQEGEKDIATEKPGSPVKSTPASPVQSPSKAGTKSPAVSPSKTSE
                     DTKKTEVSEANTEPEPVKPEGLVVNGKEEEPSVEEALSKGLGQMTTNADTDGDSYKDK
                     TESVTSGPLSPEGSPSKSPSKKKKKFRTPSFLKKSKKKEKVES"
     exon            586..724
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            725..876
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            877..957
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1107
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1251
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1350
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1527
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1785
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1905
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..1995
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2149
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2275
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..8208
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8181..8186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /note="hexamer: AGTAAA"
     polyA_site      8208
                     /gene="Add2"
                     /gene_synonym="2900072M03Rik; add97"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgcact cgcccggccc tttgtcatca cgcactgctg ggagctcaca cttcttccag
       61 cctcccgcgg gctctggact tgactctgac tgcagcgccc gcctcgggga cgcggatcta
      121 gggcctttgt cccgagctgt gggatgcgcg ggaagcgcca cgcagcggaa gagctgtgag
      181 tccaggaagc ggatcccaga gtcgaggagc gctgcccagc cttgctgggt gaatttgggg
      241 atggatgcga gaccgcagag tacgagcagt tcctacctgg ctgtgtgaag tgtggctgtg
      301 ccagccctcc taattgtgaa gacctgtctc tgaagacaga gactggacag gcccagttca
      361 gcctactggg ttccaggagt ggattgaagc cttagcagga ccatgagcga ggacacggtt
      421 cccgaggcgg cctccccgcc accctctcag gggcagcact actttgaccg gttctctgaa
      481 gatgatcctg agtacttgcg acttcgcaac cgtgcagctg acctgcgaca ggacttcaac
      541 ttgatggagc agaagaagag ggtcaccatg atcctgcaga gcccttcttt cagggaggag
      601 ctggaaggcc tcatccagga gcaaatgaag aagggcaaca actcctccaa catctgggcc
      661 ctccgacaga tcgcggactt catggccagc acctcccacg cagtcttccc agcttcttcc
      721 atgaacttct ccatgatgac acccatcaac gacctccaca ctgccgactc cctgaacctg
      781 gccaaggggg agaggcttat gcggtgcaag atcagcagcg tctaccgtct cctggacctc
      841 tacggctggg cgcagctcag tgacacctac gtcacgctga gagtgagcaa ggagcaggac
      901 cacttcctga tcagccccaa gggggtttcc tgcagcgagg tcacagcctc cagcctgatt
      961 aaagtgaaca ttctgggaga ggtggtggag aagggcagca gttgcttccc ggtggacacc
     1021 acgggcttca gtctgcactc agccatctat gccgccaggc ccgacgtgcg gtgtgccatc
     1081 cacctgcaca cgcctgccac cgcagcggtg tcagctatga agtgcggcct cctgccggtc
     1141 tcccataatg ccctgctggt gggggacatg gcctactatg acttcaatgg ggaaatggag
     1201 caggaagctg accgaatcaa cttgcagaag tgccttggac ccacctgcaa gattctggtg
     1261 ctaagaaacc atggcatggt cgccctgggt gacaccgtgg aggaagcttt ctacaaggtc
     1321 ttccatctgc aggctgcgtg tgaggtacag gtgtcggctc tgtccagtgc tgggggcact
     1381 gagaacctca tcctcttgga gcaagagaaa caccggccgc acgaggtggg ctctgtgcag
     1441 tgggccggca gcaccttcgg gcccatgcag aagagccggc tgggagagca tgaatttgaa
     1501 gccctcatga ggatgctgga caatttaggc tacagaacag gctatacgta ccgccacccc
     1561 tttgtccaag agaaaaccaa acacaaaagt gaagtggaga tcccagccac agtcactgcc
     1621 tttgtgtttg aagaggatgg agtcccagtc cccgccctgc gccagcacgc ccagaagcag
     1681 cagaaggaaa agacccgctg gcttaacact cccaacacct acctgcgggt gaacgtggct
     1741 gacgaggtgc agaggaacat gggcagtccc cgaccaaaga ccacgtggat gaaggctgat
     1801 gaagtggaaa agtccagcag cggcatgccc atacggattg aaaacccaaa ccaatttgtg
     1861 cctctctaca ctgaccccca ggaagttctg gacatgagga acaagattcg agagcaaaac
     1921 cgacaagaca taaagtcagc cgggcctcag tctcagctct tggccagtgt catcgcagag
     1981 aagagccgga gtccgtctac agagagccag ctgatgtcca agggcgatgc agataccaaa
     2041 gatgaatcgg aggagacggt gcccaacccc ttcagccaac tcactgacca ggagctggag
     2101 gagtacaaga aggaggtgga aaggaagaag ctagaacagg agcaggaagg ggagaaggac
     2161 atagccacag agaagcctgg ttcacctgta aagtccacac ctgcatcccc agtgcagagc
     2221 ccatcaaaag ccgggaccaa gagcccagcg gtctctcctt ccaagacttc agaggatacc
     2281 aagaagacag aagtcagcga agccaacaca gagcctgagc cagtgaaacc agaagggctg
     2341 gtggtgaatg ggaaggagga ggagccgagc gtagaagagg ccctcagcaa aggactgggc
     2401 cagatgacca ccaacgctga cactgatggc gacagctaca aggacaaaac cgagtcagtt
     2461 accagtggcc ccttgtcccc agagggctcg ccctctaagt caccctccaa aaagaaaaag
     2521 aaattccgaa ccccctcgtt cctgaagaaa agcaagaaga aggagaaggt ggaatcctga
     2581 ttagtggctc tgtgggtcct gctgcatccc tgccctcctt ccttaccctt ctcccaactc
     2641 tgcccctgga acatagggcc aaggagggat ggaggaggtc ctgggatcac actcagaggg
     2701 gaacttagag cctgccttcc cagagcaacc aggggtcttg tccatagtca cagttagttg
     2761 gcagcagagc ctgccctaga tttgagcttc ctgattccca tggccatggt catgctctgc
     2821 cctgttttca acactgccta gtctgggctg cctatgttag gacaccacct gcccacctga
     2881 gcccagggta ggaaggccaa acaccaggca aggtcatgga tgctcacaga ccaaggtttc
     2941 ttctgaataa ggtccatctc ttcccaggaa tcctgcctcc tgctgatgga gcaatctcca
     3001 cagcaagaag ccatgcttct ctcttccatt ttgggtccct ggccccccca caaccccagc
     3061 tcaaagtaac caggcagact gatctgtccc cgccaataga agttaatctt tgatccccag
     3121 gctgatggct tagcttgcgc ttttccaaac actaaccctg agctttctcc atggaaccca
     3181 ttgagtgagt gatggatgga agaactctaa gagccaacag atagagggca agctaagtcg
     3241 cctagttggg ggggggggag agggggatca ccaatctatg agcccaggag cctgatctgt
     3301 ctgtattgtg cttctcacag gctgaaaaat taaacccagc tgtagcttaa gaagtctcat
     3361 gctcagggaa gaaattctgg gacatccaaa tctgttgttg ctggcattga gttgtgtgag
     3421 gaggtcagat acccctttgg ctttgcatgc tatgcagggc tgtatctgcc tcactcttgc
     3481 ctggcagcca ggtgtccctt ggccttccca catccccaag ggctcttgcc cacagaccag
     3541 aaaatcttgc tcttggcatc ttgaccttgg ctttttgggt cccaactctg agtcagaggg
     3601 tacaggagag gatggtcaga aatgagtcct ttggggttaa ttctctctca ccaactctta
     3661 aagacacggc tggcattccc aagcccatca ctctcttgca tcctgaagct tggcaatagg
     3721 cagagctgtt attttaaacg ccaacactgg tttccccacc catatcctcc taaggaggag
     3781 tgttggttag tgaacacttc tggctccaag acaatccatc ttccttaaag cacagtgtct
     3841 tcaaagagcg tttctctttt ttcgtcctga tcattgtaaa ggtattttgg aagtttctta
     3901 gctcatcggt tttcactttg cacacatgtg tctacaagca ctgcgcgggc tttcccttct
     3961 gccttctcaa ctgaaccctt tcagggataa ctgacttact gagcaggatg cgaagactcg
     4021 gtttgaaccc aggactgtct gagccaagtc ctgcctcttc ccagctgtga tgaatggaca
     4081 atggctttgg cccattagcc atctccgcag ttggtcttgg ctgtggagta ttagcactgg
     4141 agatgaaggt agagaggcca cctgtggtca cggtcagtgg tgcaggcagc tgtggatggt
     4201 gggatgtctc tgcctctgac aagggagagc tgagccctct ggttgaagca ggaaatccca
     4261 ccacagtcgg ctgtctcttg aacagagctg agaggctggt gcagatctgg ggctgctgca
     4321 cagaccctgt tttgctctgc tttctggctg ggtcaagtct aatgagagac aactcagtgt
     4381 tgttgtgtac agatgctcag agacttctac tctcctgtag gagatgcctt cttaaaaata
     4441 agatttcaca ttcattcatt cattctctct cagcattcat taggcatcca ttttatcagc
     4501 cacttttaaa aagatgagaa gagttgaccc tgcagaggcg gcatttgtgt gagccggtgc
     4561 tgagagataa agttggtctg tggactctgt ccagtgagct ctctttaccc atccctgtta
     4621 tgtagcaccg gagcttgctt aggttaaaat gtcagagctt tccctgagca tcatccttcc
     4681 agatcattga tggctgattt ggttttttaa aaagagagga acttctgggg gaaaaaaaaa
     4741 agtcaacaga ggcagataga tgtgggagcg tgggactcca cactgtgtcc ttctgggcca
     4801 tgccagagca ttttgtaaaa ggtgacaggg agtggttcac atcccgggtg agcaggcctg
     4861 ggtcttaaga acccttgtag acagtgtgag agatctgaat tttaccacat tctggacact
     4921 gaggactgtt aattagggta gaatcacaag tgtgttgtag ggtccctttg gtggctgagg
     4981 gagtgtgtac aagggaggct gctggccatc tctcaggctg tattcccccc tactgcatgg
     5041 ttaaaacacc tgaagaagtt tttactgagc taaattgctg ggtcctcagc ctcagacccc
     5101 agttttcttt cggattagat caccggagaa gtgtaaagac attttatcaa ttttcttctt
     5161 cccttgcaca taaaggatgt ggtgtgcaca gccttgagga ctgtagaagt ggctgtgtgt
     5221 cccacacagg acattccttt ggctctgcaa acactggttc gaggtttgac tggtgaggag
     5281 ggatcgtata agctaagggc ttgtttctca ttgagccact gtagttccta cagagaaggg
     5341 tcagagggtt gaactggtgc tactgtgtga ccagctgacc ggaagagtaa agtggcttcc
     5401 acagcctatt tttacacact gtagagtgct aaagagagag acaagccaca ctcctctaga
     5461 gtgtggatgg ctagacgtca tacactggga gtggttgtgg tctgcgacta tcccccaaac
     5521 taaaaaacaa aaacccctgc ccagaggtgt tctgcaccac agcctgaagc tggcctgttc
     5581 tcagctgacc caaggtcggt tccctcttaa accttgggaa gagctggcca acacttggga
     5641 atgagtgtga agtccttgct ctgtggatag agggcctgag aaacatgggt gaggaccatg
     5701 agtctttcac attccccatt gtaaggcact gctctgagac acccactcat gagacagtac
     5761 ctgagcctag cccctgtggg atggcaaggt gaccagatgg cagatgcctg gccttgtgct
     5821 aacagggcct ctgctctggt tgacgtgagc agaaatgctg tcatggatct gtaagaacca
     5881 ttctatttgc tcctgtgatg tgagtgtgga tggctagacc taagtttgga catagtaggg
     5941 aaggtttgtt taaggacagg acacagccct atttagacta gtgtgccagg ccttttcata
     6001 aatgtgaatt gtatgtctta gttctgggcc aaatgtcatg agttcttgac agccaaacag
     6061 gactattgaa acacccatcc ctgtgctcgt tttacacaca ttgctccaca aatacccatg
     6121 ggctcctggc atagttgcca tccactgagg acagagggac catgaggctt atatccttgc
     6181 ttgtcactaa gcccaaccga actctctatg atcccatata attcagaaag actgagaaat
     6241 gaacaaaatg ctagataccc actctcattt cccacagaaa ggacgaggca cctcacagct
     6301 taaagtgcag tagggattca tgcctgagat gggtgcttta acatgagaag gaagggtcca
     6361 gaggcaactg aaattcatga aacacgtgta tgtggttttt gcatgcacac cctctttctc
     6421 caaggtgaag aggcacccat agtactgtga ttacttccca gagccctagc tagccaggat
     6481 gcagtgctct tcctgtcaga aacaagaggc cacatataaa gctctgttcc caaggcaccc
     6541 aattgccccc cactggggaa gccaccttgt ccagaagtct gtggggatcc cacacagtgg
     6601 aatttactgc agtggacaaa gtgcctttta tcatagtctt tgcactgata gtgccctgga
     6661 gaaggcaggc ttcttttcat aggaacaatg tgcaaagcag tatttgggtg accctagaaa
     6721 gtatggaaga agccacattc tgcctcattc acatgtgggt gacattagac ttttgccaaa
     6781 ttgacttttg tgctgacatg ggtgaggacc atgagtctct cacattctcc attgtaaggc
     6841 actgctctga gccacccaat cataagacag tgcctgagtc tagcccctgt gggatggcaa
     6901 tgtgaccagg tgacagatgc ctggccttgt gctaacaggg cctccgcact ggttgacgtg
     6961 agcagaaatg ctgtcatgta tctgtaagaa ccatttgctc ctgtattctc caagattctc
     7021 ccataaattg ggtgatcagt ttgaggacat agggtcagag atagaagagg ctcttcgtgc
     7081 tgggaaggct caggcgcagg ctagcctgag aaggcagtct tccatgggag tctgagaagg
     7141 cagtcttcca tgggagtcag gtcctcagct cctcccctca cccaccctgt cctaaccccc
     7201 cccccccagg gggaggctgg accctgaggg ctcttcccta gctcttgggt agaaatgaca
     7261 tctcaggagc tgaggggatg gtgagaaggg tctaacctct cctccctcca caaaccatcc
     7321 tgtgtatctt ttaaggaccc ctttaatatg aatcagggtg gcagttggac ctaaacccag
     7381 ggggtcgcac ttgagacaca tcaggaaccc ttataagatg gtaatgcatt tggggatgcc
     7441 tcatttccat gccatcttgc tcctgtgggt ctctgttggt gaatcatacc acaggattgt
     7501 cctctataaa tttttgaact gctggaagtg atgagtccct aacacttccc aaagtgtgtg
     7561 acccatctct gttggatatt tggggctctt ggggaggtgg gagttagaaa gggggctcgg
     7621 gtacctcaca ggacccatgg gatgcagggt cacaggaacc caggctggcc agggagtgca
     7681 gtgtctcgta agtaatgctg tgggtggttt tggtgaactg tctgtctgac aatcgtcaca
     7741 tgagcgtatg acttactgtc ttcccttgta cataggctgt ctgtgtttgg cttttcctag
     7801 tactgtgagg tttcccacag ggattccatg tagtactctg tgctgtgaca atgccactct
     7861 tcccccaaga tcacacatca tccccacaaa tggttctgcc tttctctatg ctaacacatg
     7921 gagccactga gatgcagttg ggtggttagg ctcttggatt ttattttgca attttatata
     7981 tatacatata taatatatat atttatgggt tggttttata tggttttctg tttgaatcta
     8041 tgagcaacaa agcttccctt cgattttcat gagaactttc caaaggcctt ttgctgcttt
     8101 ggtgtctgac tgtgtttggg gtggactctg cttgtgggtt tctctgtgtg tgccgttatt
     8161 tcacctgcag atcttaccct agtaaaccag atgtgcttgg cttcccaaaa aaaaaaaaaa
     8221 aaa
//
