LOCUS       NM_001331082            4150 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus adducin 1 (Add1), transcript variant 6, mRNA.
ACCESSION   NM_001331082 XM_006503668
VERSION     NM_001331082.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4150)
  AUTHORS   Moztarzadeh,S., Radeva,M.Y., Sepic,S., Schuster,K., Hamad,I.,
            Waschke,J. and Garcia-Ponce,A.
  TITLE     Lack of adducin impairs the stability of endothelial adherens and
            tight junctions and may be required for cAMP-Rac1-mediated
            endothelial barrier stabilization
  JOURNAL   Sci Rep 12 (1), 14940 (2022)
   PUBMED   36056066
  REMARK    GeneRIF: Lack of adducin impairs the stability of endothelial
            adherens and tight junctions and may be required for
            cAMP-Rac1-mediated endothelial barrier stabilization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4150)
  AUTHORS   O'Neil,S.D., Racz,B., Brown,W.E., Gao,Y., Soderblom,E.J., Yasuda,R.
            and Soderling,S.H.
  TITLE     Action potential-coupled Rho GTPase signaling drives presynaptic
            plasticity
  JOURNAL   Elife 10, e63756 (2021)
   PUBMED   34269176
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4150)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4150)
  AUTHORS   Zheng,K., Hu,F., Zhou,Y., Zhang,J., Zheng,J., Lai,C., Xiong,W.,
            Cui,K., Hu,Y.Z., Han,Z.T., Zhang,H.H., Chen,J.G., Man,H.Y., Liu,D.,
            Lu,Y. and Zhu,L.Q.
  TITLE     miR-135a-5p mediates memory and synaptic impairments via the
            Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's
            disease
  JOURNAL   Nat Commun 12 (1), 1903 (2021)
   PUBMED   33771994
  REMARK    GeneRIF: miR-135a-5p mediates memory and synaptic impairments via
            the Rock2/Adducin1 signaling pathway in a mouse model of
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4150)
  AUTHORS   Thauland,T.J., Khan,H.A. and Butte,M.J.
  TITLE     The Actin-Capping Protein Alpha-Adducin Is Required for T-Cell
            Costimulation
  JOURNAL   Front Immunol 10, 2706 (2019)
   PUBMED   31824498
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4150)
  AUTHORS   Suriyapperuma,S.P., Lozovatsky,L., Ciciotte,S.L., Peters,L.L. and
            Gilligan,D.M.
  TITLE     The mouse adducin gene family: alternative splicing and chromosomal
            localization
  JOURNAL   Mamm Genome 11 (1), 16-23 (2000)
   PUBMED   10602987
REFERENCE   7  (bases 1 to 4150)
  AUTHORS   Gilligan,D.M., Lozovatsky,L., Gwynn,B., Brugnara,C., Mohandas,N.
            and Peters,L.L.
  TITLE     Targeted disruption of the beta adducin gene (Add2) causes red
            blood cell spherocytosis in mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10717-10722 (1999)
   PUBMED   10485892
REFERENCE   8  (bases 1 to 4150)
  AUTHORS   Nasir,J., Lin,B., Bucan,M., Koizumi,T., Nadeau,J.H. and Hayden,M.R.
  TITLE     The murine homologues of the Huntington disease gene (Hdh) and the
            alpha-adducin gene (Add1) map to mouse chromosome 5 within a region
            of conserved synteny with human chromosome 4p16.3
  JOURNAL   Genomics 22 (1), 198-201 (1994)
   PUBMED   7959767
REFERENCE   9  (bases 1 to 4150)
  AUTHORS   Grosson,C.L., MacDonald,M.E., Duyao,M.P., Ambrose,C.M.,
            Roffler-Tarlov,S. and Gusella,J.F.
  TITLE     Synteny conservation of the Huntington's disease gene and
            surrounding loci on mouse Chromosome 5
  JOURNAL   Mamm Genome 5 (7), 424-428 (1994)
   PUBMED   7919654
REFERENCE   10 (bases 1 to 4150)
  AUTHORS   Pinto-Correia,C., Goldstein,E.G., Bennett,V. and Sobel,J.S.
  TITLE     Immunofluorescence localization of an adducin-like protein in the
            chromosomes of mouse oocytes
  JOURNAL   Dev Biol 146 (2), 301-311 (1991)
   PUBMED   1864459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115695.11.
            
            On Sep 8, 2016 this sequence version replaced XM_006503668.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.213714.1,
                                           SRR1660825.182524.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC115695.11        66095-66344         c
            251-465             AC115695.11        38470-38684         c
            466-628             AC115695.11        35156-35318         c
            629-780             AC115695.11        34029-34180         c
            781-861             AC115695.11        29736-29816         c
            862-1011            AC115695.11        29369-29518         c
            1012-1155           AC115695.11        26577-26720         c
            1156-1254           AC115695.11        26391-26489         c
            1255-1431           AC115695.11        25648-25824         c
            1432-1776           AC115695.11        23101-23445         c
            1777-1878           AC115695.11        20557-20658         c
            1879-1968           AC115695.11        19874-19963         c
            1969-2055           AC115695.11        19090-19176         c
            2056-2212           AC115695.11        14573-14729         c
            2213-2311           AC115695.11        11495-11593         c
            2312-4150           AC115695.11        7700-9538           c
FEATURES             Location/Qualifiers
     source          1..4150
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.9 cM"
     gene            1..4150
                     /gene="Add1"
                     /note="adducin 1"
                     /db_xref="GeneID:11518"
                     /db_xref="MGI:MGI:87918"
     exon            1..250
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..465
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2658
                     /gene="Add1"
                     /note="isoform 5 is encoded by transcript variant 6;
                     alpha-adducin; erythrocyte adducin subunit alpha; adducin
                     1 (alpha)"
                     /codon_start=1
                     /product="alpha-adducin isoform 5"
                     /protein_id="NP_001318011.1"
                     /db_xref="GeneID:11518"
                     /db_xref="MGI:MGI:87918"
                     /translation="MNGDTRAAVVTSPPPTTAPHKERYFDRVDENNPEYLRERNMAPD
                     LRQDFNMMEQKKRVSMILQSPAFCEELESMIQEQFKKGKNPTGLLALQQIADFMTASV
                     PNVYPAAPQGGMAALNMSLGMVTPVNDLRGSDSIAYDKGEKLLRCKLAAFYRLADLFG
                     WSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVKVNLQGDIVDRGSTNLGVNQ
                     AGFTLHSAVYAARPDAKCIVHIHTPAGAAVSAMKCGLLPISPEALSLGDVAYHDYHGI
                     LVDEEEKILIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQVRTLAS
                     AGGPDNLVLLDPGKYKAKSRSPGTPAGEGSGSPPKWQIGEQEFEALMRMLDNLGYRTG
                     YPYRYPALRERSKKYSDVEVPASVTGHSFASDGDSGTCSPLRHSFQKQQREKTRWLHS
                     GRGDDASEEGQNGSSPKSKTKVWTNITHDHVKPLLQSLSSGVCVPSCITNCLWTKEDG
                     HRTSTSAVPNLFVPLNTNPKEVQEMRNKIREQNLQDIKTAGPQSQVLCGVMMDRSLVQ
                     DAPLSDCTETIEGLAEQTFSPAKSVSFRKGELVTASKAIIEKEYQPHVIVSTTGPNPF
                     NTLTDRELEEYRREVERKQKGSEENLDETREQKEKSPPDQSAVPNTPPSTPVKLEEDL
                     PQEPTSRDDSDATTFKPTPPDLSPDEPSEALAFPAVEEEAHASPDPTQPPAEADPEPA
                     SAPTPGAEEVASPATEEGSPMDPGSDGSPGKSPSKKKKKFRTPSFLKKSKKKSDS"
     exon            466..628
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..780
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..861
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1011
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1155
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1254
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1431
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1776
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1878
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1968
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2055
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2212
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2311
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..4150
                     /gene="Add1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4119..4124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Add1"
                     /note="hexamer: AATAAA"
     polyA_site      4139
                     /gene="Add1"
                     /note="major polyA site"
ORIGIN      
        1 gctggacggc ggtagggcgt tcagaccaat ggggctgtgc attgttgggc cgcagcgccg
       61 caggccgcac ccagcttggc ggcgggggcg agtagagggg tgagggttga gggcgggaga
      121 ggacgagggc tgctgcaggc ggcggggggt gcgcggcagc cagggggcgg agcccagcgc
      181 gagccgcagg cgaggcggcg gccgcactcg gacccgggaa gccgtgctct ctccccgatt
      241 ctccgcggag gaccctagga aaattgtgca atgaatggtg acactcgggc cgcagtggtg
      301 acctcaccac ctccaaccac agcccctcac aaggagaggt attttgacag agtcgatgag
      361 aacaacccag aatatttgcg ggagaggaac atggcaccag accttcgtca ggacttcaat
      421 atgatggagc agaagaagag ggtgtctatg attctacaga gtcctgcctt ctgtgaagag
      481 ctggagtcta tgatacagga acagtttaag aagggcaaga accccacagg cctgctggca
      541 ttgcagcaga ttgcagattt catgactgcg agtgtaccaa atgtctaccc ggcagctcct
      601 caaggaggaa tggccgccct gaacatgagt cttggtatgg tcactcctgt gaatgacctt
      661 agagggtcgg attctatcgc atatgacaaa ggggagaagt tactgcggtg taaactggca
      721 gcattttaca gactggcaga tctctttggc tggtcccagc ttatctacaa tcatatcaca
      781 accagagtga actctgagca ggaacacttc ctcatcgtac cttttggact tctctacagt
      841 gaagtgactg catccagctt ggttaaggtc aatctacaag gagatatagt agaccgtgga
      901 agtactaacc taggggtgaa tcaggcgggc ttcactctgc actcggcagt gtatgctgcg
      961 cgaccagatg ccaagtgtat tgtgcacatc cacaccccag cgggggcagc ggtctctgcg
     1021 atgaagtgtg gactcttgcc tatctccccg gaggcacttt cccttggaga tgttgcttat
     1081 catgactatc atggcattct ggttgatgaa gaggaaaaaa ttttgattca gaaaaatctg
     1141 ggccctaaaa gcaaggtcct cattctgcgg aatcacggac tcgtgtcagt tggagagagc
     1201 gtggaggagg ccttctatta catccataac cttgtggttg catgtgagat ccaggttcgg
     1261 actctggcaa gtgctggagg accagacaac ttagttctgc tggatcctgg gaagtacaaa
     1321 gccaaatccc gttctccagg gactccagca ggggaaggct ctggatcacc tcccaagtgg
     1381 cagattgggg agcaggaatt tgaagctctt atgcggatgc tcgataatct gggctacaga
     1441 actggctacc cttatcgata ccctgctctg agagagagat ctaaaaagta cagcgatgtg
     1501 gaagtccctg ccagtgtcac aggccactcc tttgctagtg atggcgattc gggcacttgc
     1561 tcgccgctca ggcacagttt tcagaagcag cagcgagaga agacaagatg gctgcactct
     1621 ggccggggtg atgacgcttc tgaggagggg cagaacggaa gcagtcccaa gtcgaagact
     1681 aaggtgtgga cgaacattac acacgatcac gtgaaaccct tgctgcagtc tctctcgtcc
     1741 ggtgtctgcg tgccaagctg tattaccaac tgcttgtgga ctaaagagga tggacataga
     1801 acttccacct ctgctgtccc taacctgttt gttccattga acactaaccc aaaagaggtc
     1861 caggagatga ggaacaagat tcgagagcag aacttacagg acattaagac ggcaggacct
     1921 cagtcccagg ttttgtgtgg tgtgatgatg gacagaagcc ttgttcagga cgcacccctc
     1981 tctgactgta cggaaactat cgaagggctc gcagagcaga cctttagtcc cgctaagtct
     2041 gtctctttta gaaaggggga gctggtgacg gcctccaaag ccatcattga gaaggaatac
     2101 cagccccatg taattgtgag caccacaggt cccaacccct tcaacacgct gacagaccgt
     2161 gaactggaag aataccgacg agaggtggag cggaagcaga agggctctga agagaacctg
     2221 gatgagacaa gagagcagaa agagaagagt cctccagacc agtcagctgt ccccaacact
     2281 cctcccagta ctcctgtcaa gcttgaagaa gaccttcccc aggagccgac atccagggac
     2341 gacagtgatg ccaccacctt caagccgacg ccccctgacc tctcccctga tgagccttca
     2401 gaagcacttg ccttcccagc agtggaggag gaagcccatg cttccccaga ccccactcag
     2461 ccccctgctg aggctgaccc tgagccagcc tcagccccaa ctccaggagc tgaagaggta
     2521 gcctcccctg ccacggagga ggggtctccc atggaccctg gcagtgatgg gtctccaggc
     2581 aagtccccat ccaaaaagaa gaagaagttc cgtaccccgt ccttcctgaa gaagagcaag
     2641 aagaagagtg actcctgaag gcccaccctg catactctca tgtctacagg cctggctctg
     2701 tcaggattcc ctcttcttgt cttgtgttct atcctcctgt gtaatggaat gcaaacaacc
     2761 aaaacctcca tgtaactaga gccccctccc atgtatagtc agcccctgca ccagtgctaa
     2821 cccagtgtgt gctcagcctc cctaccctgg gccttgggtt ctgtggggag ctgggcttag
     2881 cctgcacctg tgagttgtgc ccccctgcag gagggggaca ctgatcctgg tcctggctgg
     2941 aaggcattgg aggcttctgc cagctctggt tacagcgtca ccctcctgag ccttgcctct
     3001 cactctcctt tctgtcgtga gtatcgaatt gtctgctcag tttccctcca ctctgtggag
     3061 tctcaggtgg ctgatttgga ctcggctttt gctggcatcc tctgcttggt gatgtcagtt
     3121 atcccataca caggtatcca cataccccag ccatggtctg agaaaacact ctcatgtcca
     3181 tcagcggccc agggcactgt ggctgcctta aagaaatggg ttgcagctgc tgcgctagca
     3241 gtgagcaacc ctgtgtatac ccagcacaac gctatgcatg gtctaactgg tgaccctatg
     3301 accaaaacca cattcaggcg ctcatagttg atcttactgg ggtcttggat tcccatctta
     3361 gggaacagat accaggaggg tgaagagtcc gttctaaaac tttctttcag caggtttgca
     3421 atttagctta cattttaact gtgaatttga ataggccact ctttgcgtta gtttttgttg
     3481 tagagcctgt gacagactgc agcagaacac tcttgacttg tgtggggagg ttttacataa
     3541 agggtaactc atggtagaag ccagccttgg aggtaccatc taatgtgttg catcattcat
     3601 agagcccatg acctcttgat ccatccttta tgaattttta cttaactttc atccctggaa
     3661 aagggcttag tggggagcgc cgagtgtcag gtggaatcct aatggggcct tgttcaggag
     3721 ctgccactgc cagcctggct agagtgagga agcctgctgg agccctgctg gagccctcga
     3781 cacccctgct gcagttgggc ctgcagagca ggtgctcagg tgtggacaga gccctgtgat
     3841 cctcccatgg ggcaccaagc agggccccac agcctcttgc actgctagtc tcaccagtca
     3901 ccacggtggc ctgagctctt acctggtccc cagtcccctc atccggactc ttcctcatcc
     3961 ttccttttgg cccttccttt atcccacata tgcaatgact cttctcactt ttgtagtcta
     4021 attctttgta ttacacatga aatatcgttg catatatgga cagacttgga ggacaggtcc
     4081 tgtgtgtcct ctcctcattg taacaggttt tactcacaaa taaaagtctt taagcagttt
     4141 ccttgtctaa
//
