LOCUS       NM_007407               6262 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adenylate cyclase activating polypeptide 1 receptor 1
            (Adcyap1r1), transcript variant 1, mRNA.
ACCESSION   NM_007407
VERSION     NM_007407.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6262)
  AUTHORS   Diao,M., Tao,Y., Liu,Q., Huang,L., Li,H. and Lin,X.
  TITLE     Rac1 promotes the lipopolysaccharide-induced inflammatory response
            and contraction-associated proteins (CAPs) expression in mouse
            uterine smooth muscle cells
  JOURNAL   Reprod Biol 24 (3), 100896 (2024)
   PUBMED   38833837
  REMARK    GeneRIF: Rac1 promotes the lipopolysaccharide-induced inflammatory
            response and contraction-associated proteins (CAPs) expression in
            mouse uterine smooth muscle cells.
REFERENCE   2  (bases 1 to 6262)
  AUTHORS   Son,H., Zhang,Y., Shannonhouse,J., Gomez,R. and Kim,Y.S.
  TITLE     PACAP38/mast-cell-specific receptor axis mediates repetitive
            stress-induced headache in mice
  JOURNAL   J Headache Pain 25 (1), 87 (2024)
   PUBMED   38802819
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6262)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6262)
  AUTHORS   Yavas,E., Zhuravka,I. and Fanselow,M.S.
  TITLE     PAC1 receptor modulation of freezing and flight behavior in
            periaqueductal gray
  JOURNAL   Genes Brain Behav 22 (6), e12873 (2023)
   PUBMED   37983568
  REMARK    GeneRIF: PAC1 receptor modulation of freezing and flight behavior
            in periaqueductal gray.
REFERENCE   5  (bases 1 to 6262)
  AUTHORS   Zhao,X., Wang,N., Li,Z. and Li,L.
  TITLE     Knockdown of PAC1 improved inflammatory pain in mice by regulating
            the RAGE/TLR4/NF-kappaB signaling pathway
  JOURNAL   Brain Res Bull 197, 49-56 (2023)
   PUBMED   36967091
  REMARK    GeneRIF: Knockdown of PAC1 improved inflammatory pain in mice by
            regulating the RAGE/TLR4/NF-kappaB signaling pathway.
REFERENCE   6  (bases 1 to 6262)
  AUTHORS   Sheward,W.J., Lutz,E.M. and Harmar,A.J.
  TITLE     Expression of pituitary adenylate cyclase activating polypeptide
            receptors in the early mouse embryo as assessed by reverse
            transcription polymerase chain reaction and in situ hybridisation
  JOURNAL   Neurosci Lett 216 (1), 45-48 (1996)
   PUBMED   8892388
REFERENCE   7  (bases 1 to 6262)
  AUTHORS   Pantaloni,C., Brabet,P., Bilanges,B., Dumuis,A., Houssami,S.,
            Spengler,D., Bockaert,J. and Journot,L.
  TITLE     Alternative splicing in the N-terminal extracellular domain of the
            pituitary adenylate cyclase-activating polypeptide (PACAP) receptor
            modulates receptor selectivity and relative potencies of PACAP-27
            and PACAP-38 in phospholipase C activation
  JOURNAL   J Biol Chem 271 (36), 22146-22151 (1996)
   PUBMED   8703026
REFERENCE   8  (bases 1 to 6262)
  AUTHORS   Hashimoto,H., Yamamoto,K., Hagigara,N., Ogawa,N., Nishino,A.,
            Aino,H., Nogi,H., Imanishi,K., Matsuda,T. and Baba,A.
  TITLE     cDNA cloning of a mouse pituitary adenylate cyclase-activating
            polypeptide receptor
  JOURNAL   Biochim Biophys Acta 1281 (2), 129-133 (1996)
   PUBMED   8664310
REFERENCE   9  (bases 1 to 6262)
  AUTHORS   Aino,H., Hashimoto,H., Ogawa,N., Nishino,A., Yamamoto,K., Nogi,H.,
            Nagata,S. and Baba,A.
  TITLE     Structure of the gene encoding the mouse pituitary adenylate
            cyclase-activating polypeptide receptor
  JOURNAL   Gene 164 (2), 301-304 (1995)
   PUBMED   7590347
REFERENCE   10 (bases 1 to 6262)
  AUTHORS   Spengler,D., Waeber,C., Pantaloni,C., Holsboer,F., Bockaert,J.,
            Seeburg,P.H. and Journot,L.
  TITLE     Differential signal transduction by five splice variants of the
            PACAP receptor
  JOURNAL   Nature 365 (6442), 170-175 (1993)
   PUBMED   8396727
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY286680.1, AK083108.1, CA320747.1, BC067039.1 and AI843743.1.
            
            On Nov 6, 2013 this sequence version replaced NM_007407.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042820.1, AK083108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BY286680.1         2-3
            3-871               AK083108.1         1-869
            872-3460            AK083108.1         871-3459
            3461-3996           CA320747.1         146-681
            3997-6238           BC067039.1         3846-6087
            6239-6262           AI843743.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..6262
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.38 cM"
     gene            1..6262
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="adenylate cyclase activating polypeptide 1 receptor
                     1"
                     /db_xref="GeneID:11517"
                     /db_xref="MGI:MGI:108449"
     exon            1..391
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            392..521
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..1961
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pituitary adenylate cyclase-activating
                     polypeptide type I receptor; PACAP type I receptor"
                     /codon_start=1
                     /product="pituitary adenylate cyclase-activating
                     polypeptide type I receptor isoform 1 precursor"
                     /protein_id="NP_031433.3"
                     /db_xref="CCDS:CCDS20167.1"
                     /db_xref="GeneID:11517"
                     /db_xref="MGI:MGI:108449"
                     /translation="MARTLQLSLTALLLLPMAIAMHSDCIFKKEQAMCLERIQRANDL
                     MGLNESSPGCPGMWDNITCWKPAQIGEMVLVSCPEVFRIFNPDQVWMTETIGDSGFAD
                     SNSLEITDMGVVGRNCTEDGWSEPFPHYFDACGFDDYEPESGDQDYYYLSVKALYTVG
                     YSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSSH
                     CFVSTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGT
                     PTVCVTVWAVLRLYFDDAGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIIILVQK
                     LQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGI
                     HYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNR
                     YFTMDFKHRHPSLASSGVNGGTQLSILSKSSSQLRMSSLPADNLAT"
     exon            522..627
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            628..735
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            736..756
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            757..798
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            799..908
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1006
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1139
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1293
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1354
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1424
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1516
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1600
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1730
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1772
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..6245
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2956..2961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="hexamer: ATTACA"
     polyA_site      2978
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="major polyA site"
     regulatory      5086..5091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="hexamer: AATAAA"
     polyA_site      5111
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="major polyA site"
     regulatory      6220..6225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="hexamer: AATAAA"
     polyA_site      6240
                     /gene="Adcyap1r1"
                     /gene_synonym="2900024I10Rik; PAC1; PAC1R; PACAP1-R"
                     /note="major polyA site"
ORIGIN      
        1 gaggtctgcc ggggaggcgg tggtctatcg cctccctcgg ccccgggcct ggctgcgcag
       61 cagaggcggc gcctctcccg caggacagag ccggtcgagt ggcacagggt gggctaaagg
      121 agacgaggga cgcctcgctc cgattcccga ctgcgactgg ctgcgacttt ggagcagcgc
      181 ggtcccttgt gcagtacgca cacaccgcgg cgcagggaca cacagacttg gctgctcgcg
      241 gccacacgca ccgagagacc aggctcggcg cgcgctccgc ggcgcacacg ctccagccag
      301 tgcggctctg ggcgcggatt cgcgggttgc gcgtcctcct gcaccttcag cccctgcgcc
      361 cagcagtccc gaccagcccc gaggccatca gcgctgcatg cacagtggag ggtggtgact
      421 gactccccaa ggctgggagc aacagccaga gacagtggct gggaagcacc atggccagaa
      481 ccctgcagct ctccctgact gctctcctcc tgctgcctat ggctattgct atgcactctg
      541 actgcatctt caagaaggag caagccatgt gcctggagag gatccagagg gccaacgacc
      601 tgatgggcct aaatgagtct tccccaggtt gccctggcat gtgggacaat atcacatgtt
      661 ggaagcctgc tcaaataggt gagatggtcc ttgtgagctg ccctgaggtc ttccggatct
      721 tcaacccgga ccaagtctgg atgacagaaa ccatagggga ttctggcttt gctgatagta
      781 attccttgga gatcacagac atgggggtcg tgggccggaa ctgcactgag gatggctggt
      841 cggagccctt cccccattac ttcgatgctt gtgggtttga tgactatgag cccgagtctg
      901 gggatcagga ttattactac ctgtcggtga aggccctcta cacagtcggc tacagcacct
      961 ccctcgtcac cctcaccact gccatggtca tcttgtgccg cttccggaag ctgcactgta
     1021 cccgtaactt catccacatg aacctgtttg tatccttcat gctgagagct atctctgtct
     1081 tcatcaaaga ctggatcttg tatgccgagc aggacagcag tcattgcttc gtttccaccg
     1141 tggaatgcaa agctgtcatg gttttctttc actactgcgt ggtgtccaac tacttctggc
     1201 tgttcattga aggcctatac ctctttacac tgctggtgga gaccttcttc cctgagagga
     1261 gatatttcta ctggtatacc atcattggct gggggacacc tactgtgtgt gtaactgtgt
     1321 gggctgtgct gaggctctac tttgatgatg cgggatgctg ggatatgaat gacagcacag
     1381 ctctgtggtg ggtgatcaaa ggccctgtag ttggctctat aatggttaac tttgtgcttt
     1441 tcatcggcat catcatcatc cttgtgcaga agctgcagtc cccagacatg ggaggcaatg
     1501 agtcgagcat ctacttcagc tgcgtgcaga aatgctactg caagccacag cgggctcagc
     1561 agcactcttg caagatgtca gaactatcca ccattactct acggctggcc cgctccaccc
     1621 tgctgctcat cccactcttt ggaatccact acacagtatt tgccttctct ccagagaacg
     1681 tcagcaagag ggaaagactt gtgtttgagc ttgggctggg ctccttccag ggctttgtgg
     1741 tggctgtact ctactgcttc ctgaatgggg aggtacaggc agagattaag aggaaatgga
     1801 ggagctggaa ggtgaaccgt tacttcacta tggacttcaa gcaccggcat ccatccctgg
     1861 ccagcagtgg agtgaacggg ggcacccagc tgtccatcct gagcaagagc agctcccagc
     1921 tccgcatgtc cagcctcccg gccgacaact tggccacctg agccctgtct cccttcttct
     1981 tctgcacagg ctggggctgc gggccagtgc ctgcgcatgt ttgtgcctct cccctctcct
     2041 tgggcaggcc ctgggtagga agctgggctc ctcctcaaag gggaagagag agatagggta
     2101 taggctgata ttgcccctcc tgtttgggtc ccatctactg tggtccactg agcccaattt
     2161 gatatgtaaa tacacctcaa atttggaaag ttgccccatc tctccccccc aacccatgcc
     2221 cctgctcacc tctgccaggt cccagcttga cctactgggt caaggccagc ctcggtgatg
     2281 gcctgatccc aggtacaagg ccttgtgaac tgagtttgaa acatgcctgc tttggagaga
     2341 ctggggcagt gaacacccca gcagcctttc agcaaattgg ctttggacat ggacccttct
     2401 cagcctgtac caagtactgc agctcagtgt catgagcatc ctttggagca ggtcaacctg
     2461 aggctccttt ggcttacatc taagttgtcc aggtgctcag ctcctgtgtg cctggatgat
     2521 gagagggctc tagggctctt tcagtcagag acttacattg aggtggggtg agggtcagag
     2581 aaagttctgg tgcttttcct gtgctctaag agctgagagc cagaaatgca gattcaattt
     2641 ggaaggagat gggatagctg aagaacttac cacgtccatg actgtgccct gactcaagac
     2701 cgtatcatgt ggtggcttta tttctacact tcttgcccac catggatggc ctgaagaagc
     2761 tgttctccag ccacaacaac cacagaaagc ccctcgctct cccctctctg ttttcccatt
     2821 aatcaaagcc atgtctagaa tgggccagcc accttgcagt aaaatcaatg agttctgaag
     2881 caaccttcaa ttttcataag ccaagtcttg ggtccaggga actccacagt gctcccaccc
     2941 ccaccccctc tactgattac aaggaatcct acatgccatc ttcagcctgg actcaattac
     3001 taaactcgga tttgtctgca agactttctc cacgtgccct tgacattgga atcacttgtg
     3061 gggcctccta gggtgtttgg aggtgatatg gtgtctatca tgtgcatagg cagaagctgc
     3121 tggtagaggg agtggtggct ttctagtgcc catcttggct ctccagctgc aagttgcaca
     3181 gccataacct aagactttaa aataaggcca cacccagatt tgggaaggta gagggggaaa
     3241 aaaagtagtg ccatggggcc acggggccca gcttattccg tgtagatgct tgtttttgtc
     3301 cctgcctccg aggaacttgt tcatgattgt gctctgaact gcatggggag tgtggggtgc
     3361 tgccttgctc gctgttatat taagtagaag gagttttagg atattcgaga cagtgcttct
     3421 ggaggagcca ttggaaagac tggagaagat tctaatggat aggatttaga gatgtgttct
     3481 gtgttcttga ccagtgaagt atgctcttgg gtctttggca aagctggaaa gagaaagggc
     3541 ctccttgttc tttcccagaa acattcagtg gcttggacca acccctgagt atatacattg
     3601 gctctttccc ccctgtacct tatctctccc ctccatcccc tcccctgttc tgagaaccag
     3661 gttatcagcc aaacaagaat cagttgatcc ccttgcactt tggacacttc aatggagcct
     3721 gagctgctta gaagccttgg ttcaggattc cagctgggtt catgactgtg aacacaatgt
     3781 gccctgtgct gggccacagc ttccttgttt atgaagtgag gtggtttcta gtgcttttcc
     3841 aggttctgcc ttagttaaaa actaaggcag gtaaacagag atgaatcctt gtgaaaagca
     3901 tctaaggggt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgcgtgcat
     3961 gtgtgtatta agagggatga catcctgttt attttcccat ttggatgcca catggtatcc
     4021 aaagctggta gagcagctat catgcctcag gccatggaca tttgaatggg agcctcaggc
     4081 atgatgtgca gaaatagcct tctacaccag gcagggacag gttgcctgtg gccccctcaa
     4141 tctgaggtgc accccttggg ctatggaccc cattcccttg ccatcacccc cgccagtggg
     4201 tctgcttcac tgtggaagga gaaactgtga ctttctggtt gcattactgc aaaacagcaa
     4261 aaaccgaata acccgagccc tgctgctttc tgagccctgg gcctgtgtcc tcctagaact
     4321 tccaggttcc cgttgctttg tttttctgtc tgaaggaatc tttttcttag tcttgtgagc
     4381 agatgtacct gaaggattct gctgttccat gagggtctgg ctctcaggct gtaggcagtg
     4441 atggggcagc acaaggctgg ataaatccct tccctattga ccttcttaca tagtgcaagc
     4501 aataagactt attgatctgt gtgtatccca gtgttcctct ggggttctgt ctaaacacca
     4561 accatcttct cttggaatgg gccccaggca aggcttgcag caatatagcc tggacccaga
     4621 aaagggaaaa cgataaggaa attctgtctg gtaggtgcaa agggcttcat ggatttggaa
     4681 acctggaggc aggaacatag cagatttaag gggtacccag ctgtggaagg tcattcctga
     4741 gaagtggggg cttgttttat gaaaccttaa aggccaaacg gactgtccca ttttggggat
     4801 caggacatcc ctgtccttat ctcctgtcat agctgtccaa ctgcagggta aggagcaagt
     4861 tgtgaggaaa ggtcctcaga acatgggatt ccacatgagg aatccttagg ctgccaggaa
     4921 gccagagggg tttagaggtg ctcagctttg agccccagta tgcactatgc ttaagctctg
     4981 acgactcttg cgtgcagcga ggaggtcctc cctgacatgc tcagcatccc gcagtgattc
     5041 ctctcatagc tctgggatgg ggcttggtta gggtgtcgtg atggaaataa acctgaacct
     5101 gttgcccagt accagggcct ctgctgtttg gtcttcactc tctcttcctt ggagggaaag
     5161 ctacaagaga ctctcttttt aattccttga gtaccctttg ccccacttcc aagagaggac
     5221 agcaagtccc ctgacactgc aaatttcatt tgagcctagg gagctgggaa aacagttggg
     5281 cctagtctgt ttttgaattg cattgcattg agttgtaccg gtattgcaca gccctgcgtg
     5341 tgagccagat gtaacactcc aagcagctgt gaaatgcaat gttccttttg caggagtggc
     5401 tgtacctgca gaaagcccag gggtccacag tacagtgcag gagaagcagc tgagttggcc
     5461 tggtctaagg atacccccta gcaaacttgg ccctctccat ctgttctggg actctatact
     5521 tccctaacct ggatccctgc tctgcaatga ggtggccgtg gttacaccat catctaccct
     5581 ctagctaggg atgaggtgga ggtaaaatgc tccctgtgag tttgcaagct ctgaaaacaa
     5641 caccgctgtg tgctcattct tagagtgaag accctgaaag gtatcccttt gcagcctgtc
     5701 tcctgttttg agccctttag gggtaactca tttgtaaaac caccagcctg agctcaagga
     5761 tgaggccaca gggctctggt ggacttcaaa tcccagcttt accgtcatca ctgttcagtt
     5821 ttcttcgaag gtacggatga ggagaaatct tctatgagca actccgtgct gtctgcctag
     5881 gaatccttca gtggtatggg acactcctca agtgagccaa atgcccgttc tttctccctt
     5941 ccttgaactc caggtcctgt gctgtgtctg tactcagcca tgtgtgtttt gtctgctgtc
     6001 tgtcttctga ggcttagcat ctgtcagggc tggggttggt tcagcccttg gtactccaga
     6061 tgtggttcca ggctcccttg tgggagctgg accggtctgg gtttaatctc ccacaataaa
     6121 gataaacccc acggacctca ctgctactgc tgcctccatt aacgctgtgc tcacacattg
     6181 tctgggattt taaggatgtc aaactgctgt agatgactca ataaatgtct tatcgttttt
     6241 cttggaaaaa aaaaaaaaaa aa
//
