LOCUS       NM_009623               5064 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus adenylate cyclase 8 (Adcy8), transcript variant 1,
            mRNA.
ACCESSION   NM_009623
VERSION     NM_009623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5064)
  AUTHORS   Agrimi,J., Menicucci,D., Qu,J.H., Laurino,M., Mackey,C.D.,
            Hasnain,L., Tarasova,Y.S., Tarasov,K.V., McDevitt,R.A.,
            Hoover,D.B., Gemignani,A., Paolocci,N. and Lakatta,E.G.
  TITLE     Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain
            Communication
  JOURNAL   JACC Clin Electrophysiol 9 (11), 2219-2235 (2023)
   PUBMED   37737772
  REMARK    GeneRIF: Enhanced Myocardial Adenylyl Cyclase Activity Alters
            Heart-Brain Communication.
REFERENCE   2  (bases 1 to 5064)
  AUTHORS   Zhang,M. and Wang,H.
  TITLE     Ca2+-stimulated ADCY1 and ADCY8 regulate distinct aspects of
            synaptic and cognitive flexibility
  JOURNAL   Front Cell Neurosci 17, 1215255 (2023)
   PUBMED   37465213
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5064)
  AUTHORS   Fuchsberger,T., Clopath,C., Jarzebowski,P., Brzosko,Z., Wang,H. and
            Paulsen,O.
  TITLE     Postsynaptic burst reactivation of hippocampal neurons enables
            associative plasticity of temporally discontiguous inputs
  JOURNAL   Elife 11, e81071 (2022)
   PUBMED   36226826
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5064)
  AUTHORS   Liu,S.B., Wang,X.S., Yue,J., Yang,L., Li,X.H., Hu,L.N., Lu,J.S.,
            Song,Q., Zhang,K., Yang,Q., Zhang,M.M., Bernabucci,M., Zhao,M.G.
            and Zhuo,M.
  TITLE     Cyclic AMP-dependent positive feedback signaling pathways in the
            cortex contributes to visceral pain
  JOURNAL   J Neurochem 153 (2), 252-263 (2020)
   PUBMED   31665810
REFERENCE   5  (bases 1 to 5064)
  AUTHORS   Kong,X., Li,B., Deng,Y. and Ma,X.
  TITLE     FXR Mediates Adenylyl Cyclase 8 Expression in Pancreatic beta-Cells
  JOURNAL   J Diabetes Res 2019, 8915818 (2019)
   PUBMED   31485455
  REMARK    GeneRIF: FXR is a critical transcription factor that mediates ADCY8
            expression in pancreatic beta-cells and the chromatin modification
            associated with Adcy8 transcription.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5064)
  AUTHORS   Schaefer,M.L., Wong,S.T., Wozniak,D.F., Muglia,L.M., Liauw,J.A.,
            Zhuo,M., Nardi,A., Hartman,R.E., Vogt,S.K., Luedke,C.E., Storm,D.R.
            and Muglia,L.J.
  TITLE     Altered stress-induced anxiety in adenylyl cyclase type
            VIII-deficient mice
  JOURNAL   J Neurosci 20 (13), 4809-4820 (2000)
   PUBMED   10864938
REFERENCE   7  (bases 1 to 5064)
  AUTHORS   Watson,E.L., Jacobson,K.L., Singh,J.C., Idzerda,R., Ott,S.M.,
            DiJulio,D.H., Wong,S.T. and Storm,D.R.
  TITLE     The type 8 adenylyl cyclase is critical for Ca2+ stimulation of
            cAMP accumulation in mouse parotid acini
  JOURNAL   J Biol Chem 275 (19), 14691-14699 (2000)
   PUBMED   10799557
REFERENCE   8  (bases 1 to 5064)
  AUTHORS   Wong,S.T., Athos,J., Figueroa,X.A., Pineda,V.V., Schaefer,M.L.,
            Chavkin,C.C., Muglia,L.J. and Storm,D.R.
  TITLE     Calcium-stimulated adenylyl cyclase activity is critical for
            hippocampus-dependent long-term memory and late phase LTP
  JOURNAL   Neuron 23 (4), 787-798 (1999)
   PUBMED   10482244
REFERENCE   9  (bases 1 to 5064)
  AUTHORS   Muglia,L.M., Schaefer,M.L., Vogt,S.K., Gurtner,G., Imamura,A. and
            Muglia,L.J.
  TITLE     The 5'-flanking region of the mouse adenylyl cyclase type VIII gene
            imparts tissue-specific expression in transgenic mice
  JOURNAL   J Neurosci 19 (6), 2051-2058 (1999)
   PUBMED   10066258
REFERENCE   10 (bases 1 to 5064)
  AUTHORS   Ding,W.G. and Gromada,J.
  TITLE     Protein kinase A-dependent stimulation of exocytosis in mouse
            pancreatic beta-cells by glucose-dependent insulinotropic
            polypeptide
  JOURNAL   Diabetes 46 (4), 615-621 (1997)
   PUBMED   9075801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138244.1 and BC094231.1.
            
            On Feb 3, 2007 this sequence version replaced NM_009623.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U85021.1, SRR1660821.158342.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849378 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2295              AK138244.1         2-2296
            2296-5064           BC094231.1         1734-4502
FEATURES             Location/Qualifiers
     source          1..5064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 29.03 cM"
     gene            1..5064
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /note="adenylate cyclase 8"
                     /db_xref="GeneID:11514"
                     /db_xref="MGI:MGI:1341110"
     exon            1..2145
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             1192..4941
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate cyclase type 8; adenylyl cyclase 8; ATP
                     pyrophosphate-lyase 8; adenylate cyclase type VIII;
                     ca(2+)/calmodulin-activated adenylyl cyclase"
                     /codon_start=1
                     /product="adenylate cyclase type 8 isoform 1"
                     /protein_id="NP_033753.2"
                     /db_xref="CCDS:CCDS27506.1"
                     /db_xref="GeneID:11514"
                     /db_xref="MGI:MGI:1341110"
                     /translation="MELSDVHCLSGSEELYTIQPTPPAGDDGSGSRPQRLLWQTAVRH
                     ITEQRFIHGHRGGGGGGVSRKASNPAGSGPNHHAPQLSSDSVLPLYSLGPGERAHNTG
                     GTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFK
                     SRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFT
                     GIEVVICALVVVRKDNTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTL
                     FATYSMLPLPLTWAILAGLGTSLLQVTLQVLIPRLAVFSINQVLAQVVLFMCMNTAGI
                     FISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVE
                     DEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHE
                     HHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGI
                     HSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEG
                     HGKERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEGSWSPE
                     LPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLR
                     REHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMT
                     IQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGA
                     VLNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLK
                     LAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHG
                     QQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELY
                     SQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEK
                     IKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIG
                     ISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFD
                     YRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQ
                     RQKQLLNENSNSGIIKSHYNRRTLLTPSGPEPGAQAEGTDKSDLP"
     exon            2146..2295
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2426
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2538
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2666
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2825
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..3096
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3294
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3395
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3597
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3687
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3860
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..3939
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            3940..4098
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4245
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4246..4338
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4339..4453
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..5039
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5010..5015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /note="hexamer: AATAAA"
     polyA_site      5039
                     /gene="Adcy8"
                     /gene_synonym="AC8"
                     /note="major polyA site"
ORIGIN      
        1 attcctccca ggctccggtc ccgctgcgcg gttccgagcg cccaagtagc cccgcgcttc
       61 cctggatccg gaggcgtctc atcgacttcc actcggcctg gagcctcttc tcgctcaaac
      121 ctttcgcctg ccgcctcacc cgccaaggct cgtttctcag gctcaggaat ccgctcctgt
      181 ggcttctctt cgaactcagc tgttggcttt attacccttc ccacttgtgc tttcctcaca
      241 ccccctgggg tctggcaggc ccaatggact ccaaagagcg aagtgaaggg aatgggaatt
      301 gtgtgctgcg acccatcaga atcgctacta gcagcggtga cttagtcctg tagcggaggc
      361 tgggaccctg gggctagcag cgccacgatc ttccttgagg aatgcatcag tccagaaccc
      421 gcgctgccag tatttgctct ggaagtggcc acaatgagga aggaaccgaa gagagagctt
      481 cattcagcac acctccaaat taactgtttg gtgacttgtt agtgctaagg ctaccacctt
      541 tctcctgccc tcccgcgggg cgccctgccg cctcaccatc acccacacct cctgcctcat
      601 cgcgcccgcc tccagctccg ccccggctcc ccatgccggc gcaatggagt tatccgaagg
      661 gcgatgattg ccgccacagc tgctaactta gcacccatcc tagccatcgg ttacccttgg
      721 ccagcctttc tgcagccgcc gagacgtggg cgtccagagt ccagtgccgc agccaggacc
      781 cgcccgacgc gcagcagaag cgcggcgccc aggcgcctct tggagaagga agactgcgcc
      841 aagacgctga gcttagagac agccaggggg ctggagcgca gaaagggaca gcgtggctca
      901 gagcgctgag gatttcgcgg acaaacagcc accactttca ctgcgtatcc aagctgagct
      961 gattggcggg aaggtggctt gccagtacac aggggtccgc tgcattctac caggaacacc
     1021 ttgctcctgg gctcactatg acttgacctg tgggggccct gctcagggct cctgcagtcg
     1081 aacagcttag gaaagaaggg atcgctgcca agcggccttt gggtctttag gaacccctat
     1141 caccaactga cacaaccagt gtctgtgcct ccctccccgc ggacccaagc catggagctc
     1201 tcggatgtgc actgccttag tggcagcgag gaactctaca ccatccaacc gacgcccccg
     1261 gccggcgacg acgggagcgg ctctcggccg cagcggctgc tgtggcagac ggcggtgcgg
     1321 cacatcacgg agcagcgctt catccacggg caccgaggcg gcggcggcgg cggggtctcc
     1381 cgcaaagcct cgaaccctgc gggcagtgga cccaatcacc acgcgccgca gctgtctagc
     1441 gactcggtgc tgcctctcta ttctctgggc cccggagagc gagcgcacaa caccggtggc
     1501 accaaagtct ttccggaacg cagcgggagc ggcagtgcca gtggcagcgg gggcgggggc
     1561 gacttgggct tcctacacct tgactgtgcc ccaagtaact cggatttctt cctcaatgga
     1621 ggatacagct accgaggggt catttttcca accctacgca actccttcaa gtctcgggat
     1681 ctggagcgcc tctaccaacg ctatttcctg ggccagaggc gcaaatcgga ggtagtgatg
     1741 aacgtgttgg atgtactaac caaactcacc cttttagtcc tgcacttgag cctggcctcg
     1801 gctccaatgg accctctcaa gggcatcctg ctaggctttt tcactggcat cgaggtggtg
     1861 atctgcgccc tcgtggtggt caggaaggac aacacctccc acacttacct gcaatacagc
     1921 ggcgtggtca cttgggtggc tatgaccacc cagattctgg cagcaggcct gggctatggg
     1981 cttctgggcg acggcatagg ctacgtgctt tttacactct tcgccaccta cagcatgctt
     2041 cccctgcctc tcacctgggc catcttggcc ggcctgggca catctttgct gcaagtcacc
     2101 cttcaagtac tcatacccag gctagcggtc ttttccatca accaggtcct ggcccaggtg
     2161 gtgctattca tgtgtatgaa tacagcagga atcttcatca gttacctttc agaccgtgcc
     2221 cagcgccagg ccttcctgga gacccggagg tgtgtggagg ccaggctccg cttggagaca
     2281 gagaaccaaa gacaggagcg gcttgtgctg tctgtgctcc ccaggtttgt cgtcctggaa
     2341 atgatcaacg acatgaccaa tgtggaggat gagcacctgc agcatcagtt ccaccgcatc
     2401 tacatccatc gctatgagaa cgtcagtatt ctttttgcag atgtcaaagg atttaccaac
     2461 ctctctacga ccttgtctgc tcaggagctg gtcaggatgc tcaacgaact ctttgccaga
     2521 ttcgaccggc tggcccatga gcatcactgt cttcgcatta aaatcctggg ggactgctac
     2581 tactgtgtgt ctggactgcc tgagccccgc cgggaccacg ctcattgctg tgttgaaatg
     2641 ggcctcagca tgatcaaaac tatcaggttt gtgagatcca gaacgaagca cgatgttgac
     2701 atgcgaattg gaatccattc aggttctgtg ctatgtggtg tgttgggcct gaggaaatgg
     2761 cagtttgatg tctggtcttg ggatgtggac atagcaaaca agcttgagtc tggaggaatc
     2821 cctgggagga ttcacatttc taaagccacc ctggattgcc tcaatggtga ctataacgtg
     2881 gaagagggtc acgggaaaga gaggaacgaa ttcttgagga agcataacat agagacctat
     2941 ttgattaagc agcctgagga gagtttgctc tgcttgcctg aagacatcgt taaggagtcg
     3001 gtgagctgct ctgacaggag aaacagtgga gcaacattca cagaaggatc gtggagccca
     3061 gagctgcctt tcgacaacat cgtgggcaaa cagaatactc tggctgccct aacaagaaat
     3121 tcaataaatc tgcttccaaa ccatctcgca caagctttgc atgtccagtc tgggcctgag
     3181 gaaattaaca agagaataga gcataccatc gacttgcgga gtggcgataa gttgagaaga
     3241 gagcatatca agccattctc actgatgttt aaagactcca gcctggagca caagtattct
     3301 caaatgaggg atgaagtatt caagtcaaac ttggtctgtg catttatcgt tcttctgttt
     3361 atcactgcaa ttcaaagttt gcttccttct tcaaggctga tgcctatgac tatccagttc
     3421 tccatcctga tcatgctgca ctctgccctg gtcctcatca ccacagcaga agactataag
     3481 tgtctgcccc tcatcctccg aaaaacctgc tgttggatta atgagaccta tctggcccgc
     3541 aacgtcatca tcttcgcttc catcttaatt aacttcctgg gagctgtcct aaatattctg
     3601 tggtgtgatt ttgacaagtc gatacccttg aagaacctga ctttcaattc ctcagctgtg
     3661 tttacagata tctgctccta cccagagtac tttgtcttca ctggggtgtt ggccatggtg
     3721 acctgtgctg tgtttctacg gcttaactct gtcctgaagc tggcagtgct actcatcatg
     3781 atcgccatct acgccctgct cacagagacc atctacgcag gtctctttct gagttatgac
     3841 aacctgaacc acagtggaga agatttcctg gggaccaagg aagcatcact gctgctgatg
     3901 gccatgttcc ttcttgctgt gttctaccat ggacaacagc tggagtacac agcccgcctg
     3961 gatttcctgt ggcgcgtaca ggccaaagag gagatcaacg agatgaagga actgagggaa
     4021 cacaacgaga acatgctgcg caatatctta cccagccatg tggcccgcca cttcctggag
     4081 aaagacagag acaatgagga gctgtattct caatcctacg atgctgttgg agtgatgttc
     4141 gcctccatcc ctgggttcgc agacttctac tctcagacag aaatgaacaa ccagggagta
     4201 gaatgtctgc gcttgctgaa tgagatcatt gctgactttg atgagctgct cggggaggac
     4261 cggtttcagg acattgagaa gattaagacc attggtagta catacatggc tgtctcagga
     4321 ctgtccccag agaaacagca atgtgaagat aaatggggac atttgtgtgc cctggctgac
     4381 ttctctcttg ctctgactga aagcatacaa gagatcaaca agcattcatt caacaatttt
     4441 gaactccgaa tcggcatcag ccatggctca gtggtggcag gtgtaattgg agctaagaaa
     4501 ccacagtatg acatttgggg gaaaactgtg aacttggcaa gccgaatgga cagcacggga
     4561 gtaagtggcc ggatccaagt tcctgaggag acctacctta tcctgaagga ccagggcttt
     4621 gcctttgact accgtgggga gatatatgtg aagggcatca gtgaacaaga agggaaaatc
     4681 aaaacatact ttctcctggg acgagtccaa cccaacccat tcatcttacc cccaaggaga
     4741 cttcccgggc aatactctct ggctgcggtt gtccttggcc ttgtccagtc tctcaacagg
     4801 caaaggcaga agcaacttct caacgagaac agcaattcgg gcatcatcaa gagccattac
     4861 aaccggcgga ctttgctaac gccaagtggg ccagagcctg gagcacaagc tgaaggcact
     4921 gacaaatccg atttgccata aaagcatttt ctttgtgttt ctttctcgtt ttttttttgt
     4981 atttctttta tatataaaat aaatatacta ataaaaaggt ttaatttttt ttagaacaaa
     5041 aaaaaaaaaa aaaaaaaaaa aaaa
//
