LOCUS       NM_001037724            5969 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus adenylate cyclase 7 (Adcy7), transcript variant 3,
            mRNA.
ACCESSION   NM_001037724
VERSION     NM_001037724.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5969)
  AUTHORS   Li,G., Chen,L., Jiang,Z. and Yau,K.W.
  TITLE     Coexistence within one cell of microvillous and ciliary
            phototransductions across M1- through M6-IpRGCs
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2315282120 (2023)
   PUBMED   38109525
REFERENCE   2  (bases 1 to 5969)
  AUTHORS   Hu,Y., Hill,R.A. and Yoshimura,M.
  TITLE     Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia
  JOURNAL   Int J Mol Sci 24 (1), 347 (2022)
   PUBMED   36613790
  REMARK    GeneRIF: Role of Adenylyl Cyclase Type 7 in Functions of BV-2
            Microglia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5969)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5969)
  AUTHORS   McClelland,K.S., Bell,K., Larney,C., Harley,V.R., Sinclair,A.H.,
            Oshlack,A., Koopman,P. and Bowles,J.
  TITLE     Purification and Transcriptomic Analysis of Mouse Fetal Leydig
            Cells Reveals Candidate Genes for Specification of Gonadal
            Steroidogenic Cells
  JOURNAL   Biol Reprod 92 (6), 145 (2015)
   PUBMED   25855264
REFERENCE   5  (bases 1 to 5969)
  AUTHORS   Jiang,L.I., Wang,J.E. and Sternweis,P.C.
  TITLE     Regions on adenylyl cyclase VII required for selective regulation
            by the G13 pathway
  JOURNAL   Mol Pharmacol 83 (3), 587-593 (2013)
   PUBMED   23229509
REFERENCE   6  (bases 1 to 5969)
  AUTHORS   Kirstein,S.L., Davidson,K.L., Ehringer,M.A., Sikela,J.M.,
            Erwin,V.G. and Tabakoff,B.
  TITLE     Quantitative trait loci affecting initial sensitivity and acute
            functional tolerance to ethanol-induced ataxia and brain cAMP
            signaling in BXD recombinant inbred mice
  JOURNAL   J Pharmacol Exp Ther 302 (3), 1238-1245 (2002)
   PUBMED   12183685
REFERENCE   7  (bases 1 to 5969)
  AUTHORS   Suzuki,Y., Shen,T., Poyard,M., Best-Belpomme,M., Hanoune,J. and
            Defer,N.
  TITLE     Expression of adenylyl cyclase mRNAs in the denervated and in the
            developing mouse skeletal muscle
  JOURNAL   Am J Physiol 274 (6), C1674-C1685 (1998)
   PUBMED   9611134
REFERENCE   8  (bases 1 to 5969)
  AUTHORS   Doyle,J., Ren,X., Lennon,G. and Stubbs,L.
  TITLE     Mutations in the Cacnl1a4 calcium channel gene are associated with
            seizures, cerebellar degeneration, and ataxia in tottering and
            leaner mutant mice
  JOURNAL   Mamm Genome 8 (2), 113-120 (1997)
   PUBMED   9060410
REFERENCE   9  (bases 1 to 5969)
  AUTHORS   Doyle,J., Hellevuo,K. and Stubbs,L.
  TITLE     The gene encoding adenylyl cyclase VII is located in central mouse
            chromosome 8
  JOURNAL   Mamm Genome 7 (4), 320-321 (1996)
   PUBMED   8661708
REFERENCE   10 (bases 1 to 5969)
  AUTHORS   Watson,P.A., Krupinski,J., Kempinski,A.M. and Frankenfield,C.D.
  TITLE     Molecular cloning and characterization of the type VII isoform of
            mammalian adenylyl cyclase expressed widely in mouse tissues and in
            S49 mouse lymphoma cells
  JOURNAL   J Biol Chem 269 (46), 28893-28898 (1994)
   PUBMED   7961850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205086.1, AK155831.1, AK138911.1 and BB761797.1.
            
            On Oct 6, 2007 this sequence version replaced NM_001037724.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154652.1, AK155831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY205086.1         3-32
            31-1332             AK155831.1         2-1303
            1333-3810           AK138911.1         1317-3794
            3811-5966           AK138911.1         3796-5951
            5967-5969           BB761797.1         463-465
FEATURES             Location/Qualifiers
     source          1..5969
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 43.06 cM"
     gene            1..5969
                     /gene="Adcy7"
                     /note="adenylate cyclase 7"
                     /db_xref="GeneID:11513"
                     /db_xref="MGI:MGI:102891"
     exon            1..59
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            60..167
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            168..275
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            276..696
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..3825
                     /gene="Adcy7"
                     /EC_number="4.6.1.1"
                     /note="adenylyl cyclase type VII; adenylyl cyclase 7; ATP
                     pyrophosphate-lyase 7; adenylate cyclase type VII"
                     /codon_start=1
                     /product="adenylate cyclase type 7"
                     /protein_id="NP_001032813.1"
                     /db_xref="CCDS:CCDS22509.1"
                     /db_xref="GeneID:11513"
                     /db_xref="MGI:MGI:102891"
                     /translation="MPAKGRYFLNEGDEGPDQAALYEKYRLTSLHGPLLLLLLLVAAA
                     TCIALISIAFSHEDLRRHQVVLGTAFLMLTLFVALYVLVYVECLVQRWLRALALLTWA
                     CLMVLGSVLMWDSLENEAHAWEQVPFFLFVVFVVYALLPLSRRAAIVAGVTSTVSHLL
                     VFGAVTRAFQTSMSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCI
                     QIRRKLRVEKRQQENLLLSVLPAHISMGMKLAIIERLKEGGDRHYMPDNNFHSLYVKR
                     HQNVSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYC
                     VSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDISMRVGIHSGNVLCGVIGLRKW
                     QYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIR
                     TYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESV
                     SSSETPISNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSK
                     SDDFHTFGPIFLEKGFEREYRLVPIPRARYDFACASLVFVCILLVHLLVMPRMATLGV
                     SFGLVACLLGLVLSFCFATEFSRCFPSRSTLQAISESVETQPLVRLVLVVLTVGSLLT
                     VAIINMPLTLNPGPEQPGDNKTSPLAAQNRVGTPCELLPYYTCSCILGFIACSVFLRM
                     SLELKAMLLTVALVAYLLLFNLSPCWHVSGNSTETNGTQRTRLLLSDAQSMPSHTLAP
                     GARETAPSPSYLERDLKIMVNFYLILFYATLILLSRQIDYYCRLDCLWKKKFKKEHEE
                     FETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVPDFKVFYTEC
                     DVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSAPSGHENQD
                     LERKHVHIGVLVEFSMALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDI
                     WGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGELRTYFVCT
                     DTAKFQGLGLN"
     exon            697..900
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1068
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1218
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1367
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1479
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1607
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1766
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1899
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2091
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2126
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2207
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2280
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2378
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2463
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2589
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2688
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2864
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3030
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3186
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3333
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3438
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3553
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3678
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..5969
                     /gene="Adcy7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5950..5955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy7"
                     /note="hexamer: ATTAAA"
     polyA_site      5968
                     /gene="Adcy7"
                     /note="major polyA site"
ORIGIN      
        1 gtcaaaaccc acagccacca ggaagaccca agaagttgcc gagagagttt tgggctgggg
       61 gaagaagatg tctctacctg gaagctccca ggagacagct gtggagccca cgagagccac
      121 agggccttga cctcatctct tcccaccatc caagagggca aagtcagggg ctttaaacgg
      181 gagaggagag acgactcagc actcctcgtg ataaggccct gtggatgtgt ggctagcttg
      241 ctctgtcctg tgcgtcaagg aatgcaggtg caaagagctg aggacctgga agtttctgtc
      301 agctcctcct agacaccctg aagacaccag tgaacagaac ccagtggctg gagcaggtgt
      361 cacatgctca tggagccacg ggctctaggt gcctctgtcc agtcctgcct gataccctca
      421 gaaagggaag aagcctagac cacacactaa agcgtcagct gacagatgta tctcagaccg
      481 tggggctcct gagcaggctg ctggaccagg ccactgggga agaggatgcc agccaagggg
      541 cgctacttcc taaatgaggg tgatgaaggc cccgaccagg cagcgctcta tgagaagtac
      601 cggctcacca gcttgcacgg gccactgctg ctcttgctcc tcctggtggc cgcggccacc
      661 tgcattgcgc tcatcagcat cgccttcagt catgaggatc tccgcagaca ccaggttgtc
      721 ctgggcactg cgttcctcat gctgacgctg tttgtggctc tctatgtgct ggtgtatgtc
      781 gagtgcctgg tgcagcggtg gctgcgggcc ttggcgctac tcacctgggc ttgcctcatg
      841 gtactaggct ccgtgctgat gtgggactct ttggagaatg aagcccatgc gtgggagcag
      901 gtgcctttct tcctgtttgt cgtctttgtg gtgtatgcac tactgcctct cagcaggagg
      961 gcagccatcg tggcaggcgt gacctccacg gtctcccatc tcctggtgtt tggagctgtg
     1021 acaagagcct tccagacgtc catgtctagc actcaactgg ggctgcagct cctggccaat
     1081 gccgttatcc tcctgggtgg gaacttcacg ggtgccttcc acaagcacca gctgcaggac
     1141 gcgtccaggg atctctttat ctacaccgtc aaatgcatcc agatccgtcg gaagcttcgt
     1201 gtggagaagc gccagcagga gaacctgctt ctgtcagtgc tcccagcaca catctccatg
     1261 ggtatgaagc tggccatcat tgagcgcctc aaagagggtg gtgaccgaca ctacatgccc
     1321 gacaacaact ttcacagcct ctatgtcaag cggcaccaga atgtcagcat cttgtatgca
     1381 gacatcgtgg gcttcacgag gctggccagc gactgctctc ccaaggagct ggtggtggtg
     1441 ctcaacgagc tgtttgggaa gtttgaccag attgctaagg ccaatgagtg catgcggatc
     1501 aagatcctgg gtgactgtta ctactgcgtg tcaggcctgc ccgtgtcgct gcccacacat
     1561 gcccgcaact gtgtgaagat gggtctggac atctgcgagg ccattaagca ggtgcgtgag
     1621 gccacgggcg tggacatcag catgcgtgtg ggcattcact ccgggaatgt gctatgtggg
     1681 gtcatcgggc tccgtaagtg gcagtatgat gtgtggtccc atgatgtgtc cctggccaac
     1741 aggatggagg cagctggagt ccctggccgg gtgcacatca cagaggcaac attgaatcac
     1801 ctggacaagg catatgaggt ggaggatggg catggggagc agcgagaccc ctatctgaaa
     1861 gagatgaaca tccgaaccta cctggtgatc gatccccgga gccagcagcc acccccaccc
     1921 agccaccacc tctccaagcc caagggggac gcaactctga agatgcgggc ttcagtgcgt
     1981 gtaacccgct atctggagtc ttggggggca gcaaggccct ttgcacacct caaccaccgg
     2041 gagagtgtga gcagcagtga gacccccatc tccaatggac ggaggcagaa ggccattcct
     2101 ctgcgtcgac accgtgcccc tgataggagt gcatctccca aggggcgctt ggaagatgac
     2161 tgtgatgacg agatgctgtc agccattgag ggtctcagct ccaccaggcc ctgctgctcc
     2221 aagtctgatg acttccacac ctttggtccc atcttcttgg agaagggctt tgagcgtgag
     2281 taccgcctgg tgcccatccc ccgggctcgc tacgacttcg cctgtgccag ccttgtcttc
     2341 gtctgcatcc tgcttgtcca ccttctagtg atgcccagga tggcaactct gggtgtgtcc
     2401 tttgggttgg tggcctgcct gctggggctg gttctgagtt tctgctttgc tactgagttc
     2461 tcgaggtgct ttccatcccg aagtacactc caggccatct cggagagcgt ggagacgcag
     2521 cccctggtca ggcttgtcct ggttgtgctg actgttggca gcctactgac tgtcgccatc
     2581 attaacatgc cactgacgct taacccaggc ccagagcagc ctggagacaa caagacaagc
     2641 ccactggctg cacagaacag agttgggacc ccatgtgagc tcctcccgta ctacacctgc
     2701 agctgcatcc tgggcttcat tgcatgctct gttttcctgc ggatgagcct agagctgaag
     2761 gccatgctgc tgacagtggc cttggtggcc tacctgctgc tcttcaacct ctccccatgc
     2821 tggcacgtct caggcaacag cactgagacc aacgggacac aaaggacacg gctgctcctg
     2881 tctgatgcac aaagcatgcc cagccacacc cttgctccgg gggctcggga gactgcccct
     2941 tctcccagtt atttagagag agacctgaag atcatggtta acttctacct gatcctgttc
     3001 tatgccaccc tcatcttgct gtctagacag attgactact actgccgctt ggactgtctg
     3061 tggaagaaga agttcaaaaa ggagcacgag gagtttgaaa caatggagaa tgtgaaccgc
     3121 ctcctcctgg agaatgtgct gccggcgcac gtggctgccc acttcattgg ggacaaggca
     3181 gcagaggatt ggtaccatca atcttatgac tgtgtctgtg tcatgtttgc atccgttccg
     3241 gacttcaaag tgttctacac tgagtgtgat gtcaacaaag aaggactgga gtgccttcga
     3301 ctgctgaatg agataattgc tgattttgac gagctcctgc tgaagcccaa gtttagtggt
     3361 gtggagaaga tcaagaccat tggcagcacc tacatggcgg cagcagggct cagtgccccc
     3421 tcaggacatg agaaccagga cctggagcgg aagcacgtgc acatcggagt cttggtagaa
     3481 tttagcatgg ccctgatgag caagctggat gggatcaaca ggcactcctt caactccttc
     3541 cgcctccgag tcggcataaa ccacgggcct gtgattgctg gagtgattgg agcacgcaag
     3601 cctcagtatg acatctgggg aaacacagtc aatgttgcca gccgcatgga gagcaccgga
     3661 gagcttggga aaatccaggt taccgaagag acatgcacta tcctccaggg actcggatat
     3721 tcgtgtgaat gccgtgggct gatcaacgtc aaaggcaaag gggaactgcg gacttacttt
     3781 gtatgtacag acactgccaa gtttcaaggg ctggggctaa actgaggtgg ctggtggtca
     3841 gcctccttcc ccgagggagc caagaatgta gccccatgtc tgttgcagtg gcttctttgg
     3901 acttgcacta caggatggct ttgacctgtg catcagattc tgtttgaagc agctactgcg
     3961 ttgtacacag aggctctgtg cttcagcctc tacagttcca aattagctag accactggtc
     4021 tactacaggc tgtgttcatt tccagggtgc tggggaagag acttcagtgc atgaccaaga
     4081 tagacatcca ccttggtggc cagtgaacag cattcacagg agacaaaagc tctactggct
     4141 acaggaggct cagccaggct gactagcatg ggttgctgct tgccttcctc ccatcaaatc
     4201 taccatggga tgttattctc tcaattaggc attctggtaa atggagttga aaactgtgta
     4261 tattggtggg tagtctcaaa acagcagaga aaatgtctga tctacacttg tcactttttt
     4321 ccatctctgg cttatgtttg aaacggacat gtcataaaca gagttttagc tttaccactg
     4381 actcttagat gctagacaaa gatctccacc tttctagtgt attttctctt gttaaccaca
     4441 gactacaagt aaataggtct gctgtctagt gtccgtttat aggatcagat tggctgcagg
     4501 gacagagttc taaggaatgg ggctcatagc agcagcaaag ctttgaattt gcaatcaagc
     4561 attttttgat gcaaatcttt tgggacaagg ctcaggaagt ttaaagtcta gaaatgaggt
     4621 atgatgtttc agtttttctg tgtgcacttt atttattttg gagtcagggt cagcctagct
     4681 tggtctcaaa cttctaacct cctgtttcgg tctccggaga gtttcaatta cagatgtgca
     4741 cgactatctc cagctgtttc tgtgggaaag cctgtgtaga caggcttgga caactttgta
     4801 gcacttgcct tttctccagt cttctgagct gactgcagag cttcaagaac aatccacttg
     4861 gcaggaacat gtgttcagga ctctggcctg tgaactgagc ccctcaacaa atgccaaatt
     4921 gttcttatgc aaatgagtca aggcaaaagc cagcttcgtg agatgggtgt cttactgtgc
     4981 ttagctccag agcattccga gagatgacca aacaccccac tcctttttgg aaatgacttc
     5041 actgccacag aacgcactac atcatggtct tcttagctag cagtcaccaa ggaacctcca
     5101 gagtctacaa atgatataag tgccgcagac agggtgctaa ccagcaggtt tacccgggac
     5161 tttagtccaa ggctgagtag tcagggacgc agaggggaga gataggaact gtttgcttgt
     5221 gctgtctcct gtggagtttc atcagcccag gaaagaaagg ctgattttag tttgcacaaa
     5281 ggaatctagt agtggccagg gcttcccagc aaggcatctc tggggagtta gtaaagctcc
     5341 tggtgatgcc cgcaatgccg tgcagacaga gagcaggaca gagcttcctt ccctgaggct
     5401 gacacatttc tactcttcca acagccaagt tacctttccc ctccaagcaa cagaaatctt
     5461 agcttgagtt taaaagtaat tggctgccat tcatgcattg tttcttttca actgaagcac
     5521 tgtgcctgga gtattttaag ttattgttca ggtcctaaga gtgtaactga cagaaaacat
     5581 cacttgggac tcatgcatac atacttggtt tctactttcc aagtaatttc tttacaagtg
     5641 tcttgttttt tcacaggaac tttttttttt aaacccttct gtgggtcaag gattcgtttc
     5701 aggatctcta ctaaggcggc cttctctgac tacagacagt aatacaccgt cttctgactt
     5761 aaagacactt cctgacaaag tgattgttac tgtgtacttc atagatgaca ggtcaatgct
     5821 ccgagtgggt acaagcaaat aactatggtt tgttctgtat gtttaatatt tatagacatt
     5881 tgcttcagtg ttctgttcca ttttcataaa tcatcagtgc ctggctcctt tttatatgtt
     5941 caaccaacaa ttaaaacatc tgaatgtcc
//
