LOCUS       NM_001012765            7004 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus adenylate cyclase 5 (Adcy5), transcript variant 1,
            mRNA.
ACCESSION   NM_001012765 XM_156060 XM_358801
VERSION     NM_001012765.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7004)
  AUTHORS   Yang,Q., Abdulla,A., Farooq,M., Ishikawa,Y. and Liu,S.J.
  TITLE     Emotional stress increases GluA2 expression and potentiates fear
            memory via adenylyl cyclase 5
  JOURNAL   Cell Rep 44 (1), 115180 (2025)
   PUBMED   39786995
REFERENCE   2  (bases 1 to 7004)
  AUTHORS   Liao,Y. and Muntean,B.S.
  TITLE     KCTD1 regulation of Adenylyl cyclase type 5 adjusts striatal cAMP
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 121 (43), e2406686121 (2024)
   PUBMED   39413138
  REMARK    GeneRIF: KCTD1 regulation of Adenylyl cyclase type 5 adjusts
            striatal cAMP signaling.
REFERENCE   3  (bases 1 to 7004)
  AUTHORS   Hernandez,M., Zhang,Y., Filippelli,G.M. and Boehm,S.L. 2nd.
  TITLE     Early-life low-level lead exposure alters anxiety-like behavior,
            voluntary alcohol consumption and AC5 protein content in adult male
            and female C57BL/6 J mice
  JOURNAL   Neurotoxicol Teratol 95, 107149 (2023)
   PUBMED   36539102
  REMARK    GeneRIF: Early-life low-level lead exposure alters anxiety-like
            behavior, voluntary alcohol consumption and AC5 protein content in
            adult male and female C57BL/6 J mice.
REFERENCE   4  (bases 1 to 7004)
  AUTHORS   Dommel,S., Hoffmann,A., Berger,C., Kern,M., Kloting,N., Kannt,A.
            and Bluher,M.
  TITLE     Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on
            Systemic Insulin Sensitivity and Adipose Tissue
  JOURNAL   Int J Mol Sci 22 (9), 4353 (2021)
   PUBMED   33919448
  REMARK    GeneRIF: Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5)
            Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7004)
  AUTHORS   Prada,M.P., Syed,A.U., Reddy,G.R., Martin-Aragon Baudel,M.,
            Flores-Tamez,V.A., Sasse,K.C., Ward,S.M., Sirish,P.,
            Chiamvimonvat,N., Bartels,P., Dickson,E.J., Hell,J.W., Scott,J.D.,
            Santana,L.F., Xiang,Y.K., Navedo,M.F. and Nieves-Cintron,M.
  TITLE     AKAP5 complex facilitates purinergic modulation of vascular L-type
            Ca2+ channel CaV1.2
  JOURNAL   Nat Commun 11 (1), 5303 (2020)
   PUBMED   33082339
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7004)
  AUTHORS   Lavine,N., Ethier,N., Oak,J.N., Pei,L., Liu,F., Trieu,P.,
            Rebois,R.V., Bouvier,M., Hebert,T.E. and Van Tol,H.H.
  TITLE     G protein-coupled receptors form stable complexes with inwardly
            rectifying potassium channels and adenylyl cyclase
  JOURNAL   J Biol Chem 277 (48), 46010-46019 (2002)
   PUBMED   12297500
REFERENCE   7  (bases 1 to 7004)
  AUTHORS   Lee,K.W., Hong,J.H., Choi,I.Y., Che,Y., Lee,J.K., Yang,S.D.,
            Song,C.W., Kang,H.S., Lee,J.H., Noh,J.S., Shin,H.S. and Han,P.L.
  TITLE     Impaired D2 dopamine receptor function in mice lacking type 5
            adenylyl cyclase
  JOURNAL   J Neurosci 22 (18), 7931-7940 (2002)
   PUBMED   12223546
REFERENCE   8  (bases 1 to 7004)
  AUTHORS   Suzuki,Y., Shen,T., Poyard,M., Best-Belpomme,M., Hanoune,J. and
            Defer,N.
  TITLE     Expression of adenylyl cyclase mRNAs in the denervated and in the
            developing mouse skeletal muscle
  JOURNAL   Am J Physiol 274 (6), C1674-C1685 (1998)
   PUBMED   9611134
REFERENCE   9  (bases 1 to 7004)
  AUTHORS   Edelhoff,S., Villacres,E.C., Storm,D.R. and Disteche,C.M.
  TITLE     Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in
            mouse
  JOURNAL   Mamm Genome 6 (2), 111-113 (1995)
   PUBMED   7766992
REFERENCE   10 (bases 1 to 7004)
  AUTHORS   Premont,R.T., Chen,J., Ma,H.W., Ponnapalli,M. and Iyengar,R.
  TITLE     Two members of a widely expressed subfamily of hormone-stimulated
            adenylyl cyclases
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9809-9813 (1992)
   PUBMED   1409703
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171205.1.
            
            On Feb 24, 2023 this sequence version replaced NM_001012765.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147649.1, AK147590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2355              AC171205.1         149256-151610       c
            2356-2505           AC171205.1         57541-57690         c
            2506-2627           AC171205.1         53229-53350         c
            2628-2739           AC171205.1         39200-39311         c
            2740-2867           AC171205.1         37408-37535         c
            2868-3026           AC171205.1         35495-35653         c
            3027-3168           AC171205.1         34271-34412         c
            3169-3309           AC171205.1         31926-32066         c
            3310-3332           AC171205.1         27974-27996         c
            3333-3477           AC171205.1         27151-27295         c
            3478-3575           AC171205.1         26055-26152         c
            3576-3663           AC171205.1         22882-22969         c
            3664-3780           AC171205.1         16870-16986         c
            3781-3945           AC171205.1         16300-16464         c
            3946-4121           AC171205.1         14814-14989         c
            4122-4151           AC171205.1         13444-13473         c
            4152-4284           AC171205.1         12397-12529         c
            4285-4548           AC171205.1         7881-8144           c
            4549-4753           AC171205.1         6834-7038           c
            4754-4878           AC171205.1         4100-4224           c
            4879-7004           AC171205.1         753-2878            c
FEATURES             Location/Qualifiers
     source          1..7004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 24.71 cM"
     gene            1..7004
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /note="adenylate cyclase 5"
                     /db_xref="GeneID:224129"
                     /db_xref="MGI:MGI:99673"
     exon            1..2355
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     CDS             1219..5007
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate cyclase type 5; adenylyl cyclase 5; adenylate
                     cyclase type V; ATP pyrophosphate-lyase 5"
                     /codon_start=1
                     /product="adenylate cyclase type 5 isoform 1"
                     /protein_id="NP_001012783.3"
                     /db_xref="CCDS:CCDS37322.1"
                     /db_xref="GeneID:224129"
                     /db_xref="MGI:MGI:99673"
                     /translation="MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPH
                     APGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLAGGFGFSFRSKS
                     AWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVELG
                     LEERRGKGRAAEELEPGTGIVEDGDGSEDGGSSVASGSGTGAVLSLGACCLALLQIFR
                     SKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLA
                     AAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTV
                     FFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCTNI
                     VGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADIN
                     AKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE
                     NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGI
                     HSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG
                     CGGDRNAYLKEHSIETFLILSCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFY
                     NHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRK
                     FLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCF
                     LLLALVVFVSVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFM
                     CNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFTYS
                     VLLSLLACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSN
                     NGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEM
                     EELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVEL
                     EANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGK
                     THIKAIADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTV
                     NVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
                     "
     exon            2356..2505
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2627
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2739
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2867
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3026
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3168
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3309
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3332
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3477
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3575
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3576..3663
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3780
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3781..3945
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4121
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4151
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4284
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            4285..4548
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            4549..4753
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            4754..4878
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..7004
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5633..5638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /note="hexamer: AATAAA"
     polyA_site      5647
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /note="major polyA site"
     regulatory      6983..6988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /note="hexamer: ATTAAA"
     polyA_site      7004
                     /gene="Adcy5"
                     /gene_synonym="Ac5"
                     /note="major polyA site"
ORIGIN      
        1 gagaagggag gagcggcgcg agcggccgga gcggcgcagg gcccgaggcg tgcatggcgc
       61 gcccggagcc gggctccctc gggcccctcg ggagcgcccc cggggcgccg cggctcttcg
      121 gccggccctt atcggccggc tgctgttgag ccgcagccct ccatcgctgg atgccgtggt
      181 ccccgggaga agcccgcctg cgttggggca gaacggcggc ggcgctgcgc cggattccgc
      241 cctccgcgta gtggttctgc gctcggctac ggtgggccag ccgccggcaa cgaggaaccc
      301 agggcttgcg gagctagcga ctcaaccctc gggacctgcc ggaacgggcc ggcctgctgg
      361 gtctggggga caggaggaga cgagagggga agggccgcac cgcaggagcc ggtcctcgcc
      421 cccgccccct gcgcgggcac gccggaggct ctgttcgcct ttcgcggggg ccacgctccc
      481 actcgcgcct ccggaggtgg gggatgcggg cgacggcccc cccgggctcc aggaccctcc
      541 tccccggggc tccggagctc ttgctccgcc cgccgccccc tcccccgtcc tctccacccc
      601 ccatcccacc tccccacccc tcgtaagaaa ataatgctgg caggagcctg cacctcccag
      661 tcgctcccag tgcgctgcga gcaaagggca cccgctgcgt ctccgtgccg ggacccctgc
      721 cgagccgccc tcgccgccac cttgctggga gagtcgctgc tctcggctta ggcaaaagcc
      781 acgagcgccg cgcccgggaa ctgccagctt cggagaggcg ccgcccgcaa ggacacctct
      841 ccgtcccgcc tgctcctcaa ctcccagcct gagctcgacg cgagccagga gtccggacat
      901 ctctgcgtcc ggcgcagcag tcagagctgt ccccactgcc accgctcgga gccaactccg
      961 tctcggacct gggactctgg actctaattc gtagctactt ctcacctcgg ggctgcgctg
     1021 tctccccgct agccttcccg ttgtcctcca ccgctcagga cgggggtgcc acgatgtccc
     1081 gctgctgcgc agggccccgg gcctccctcg acgtgtgacc ctagcctggt ccccctgctt
     1141 ggctgtccgc cctctccttg gagacccccg gcccggcccc cgggggaaga ggaagaagac
     1201 gacgaggccg agggggggat gtccggctcc aaaagcgtga gccccccggg ctacgctgca
     1261 cagacagcgg cgtcgccagc gccccgggga ggcccggagc atcgcgccgc ttggggagaa
     1321 gccgattccc gcgccaatgg ctacccccac gcccccgggg gatcaacccg cggctccacc
     1381 aagagatctg ggggagcggt gaccccacaa cagcagcagc gcctggccag ccgttggcgc
     1441 ggtggcgatg acgacgaaga ccctccacta agcggtgatg accctctggc tgggggcttc
     1501 ggcttcagct tccgctctaa gtccgcctgg caggagcgcg gtggcgacga cggcggtcgc
     1561 ggcagcaggc ggcagcggcg gggcgcggct ggagggggca gcacccgggc gccccctgcg
     1621 ggcggcagcg gcagttcggc ggcggccgca gcggccgcag gtggcacaga ggtgcgcccc
     1681 cgctcggtgg agctgggcct ggaggagcgt cgaggaaaag gccgagcggc cgaggagctg
     1741 gagcccggga ctggcatcgt cgaggatgga gacgggtcgg aggatggagg cagttctgtg
     1801 gcgtcaggct ctgggaccgg cgcggtgctg tcgttgggcg cctgctgcct ggccttgctg
     1861 cagatattcc gctctaagaa gttcccgtcg gacaaactgg agcgtctgta ccagcgctac
     1921 ttcttccgcc tgaaccagag cagtctcacc atgctcatgg ccgtgctggt gcttgtgtgc
     1981 ctggtcatgc tggctttcca cgcggcgcgc cccccgctcc agatagccta cctggccgtg
     2041 ttggcagctg ctgtgggcgt gatccttatc atggccgtgc tctgcaaccg tgcagcgttc
     2101 caccaggacc acatgggcct ggcctgctat gcgctcattg cagtggtgct ggccgtccag
     2161 gtagtgggcc tgttgctgcc acagccacgc agcgcctccg agggcatctg gtggaccgtg
     2221 ttcttcatct ataccatcta caccctgctg cctgtgcgca tgagggctgc ggtgctcagc
     2281 ggggtgcttc tgtcggctct ccacttggcc atctctctgc acaccaactc ccaggaccag
     2341 tttctgctga aacagcttgt ctccaatgtc ctcatcttct cctgcaccaa cattgtgggt
     2401 gtgtgcactc actacccagc tgaggtctcc cagagacagg ccttccagga gacccgggag
     2461 tgtatccagg ctcggctcca ttcccagcgg gagaaccagc aacaggagcg tctcctgctg
     2521 tctgtccttc cccgtcatgt tgccatggag atgaaagcag acatcaacgc caagcaggag
     2581 gatatgatgt tccacaagat ctacatccag aagcatgaca atgtgagcat cctgtttgct
     2641 gacatcgagg gcttcaccag cctggcttcc cagtgtactg cccaagaact ggtcatgacc
     2701 ctcaatgagc tcttcgcccg ctttgacaag ttggctgcgg agaatcactg tttacggatt
     2761 aagatcctcg gggattgtta ctactgcgtc tcggggctgc ctgaagccag agccgaccat
     2821 gcccactgct gcgtggagat gggaatggac atgatcgagg ccatctcgtt ggtccgggag
     2881 gtgacagggg tgaacgtgaa catgcgcgtg ggaattcaca gcgggagagt acactgcggt
     2941 gtccttggtc tcagaaagtg gcaattcgac gtgtggtcta acgatgtcac tctggccaac
     3001 cacatggaag ctggtggcaa ggcgggccgc atccacatca ccaaggccac actcaactac
     3061 ctgaatgggg actatgaggt ggaaccaggc tgtggtggcg atcgcaatgc ctacctcaag
     3121 gagcacagca ttgagacctt cctcatcctg agctgtaccc agaagcggaa agaagagaag
     3181 gccatgatcg ccaagatgaa ccgccagaga accaactcca tcggacacaa tccgcctcac
     3241 tggggagccg agcgcccctt ctacaaccac ttgggcggca accaggtgtc aaaggagatg
     3301 aagaggatgg gctttgagga ccccaaggac aagaatgccc aggaaagtgc gaacccagag
     3361 gatgaagtgg acgagtttct gggtcgggcc atcgatgcca ggagcatcga cagactgcga
     3421 tctgaacacg tccgcaagtt cctcctgacc ttcagggagc ccgacttaga gaagaagtac
     3481 tccaagcagg tggatgaccg atttggtgcc tatgtggcct gcgcctcgct tgttttcctc
     3541 ttcatctgct ttgtccagat caccattgtg ccccactccc tgttcatgct gagtttctac
     3601 ctgtcgtgtt tcctgctgct ggccttggtg gtgtttgtgt ctgtgatcta tgcctgtgtg
     3661 aagcttttcc ccactcccct gcagacactc tccaggaaga tagtgcgatc caagaagaac
     3721 agcaccctgg tcggggtatt caccatcacc ctggtgttcc tctcggcttt tgtcaacatg
     3781 ttcatgtgca actctaagaa cctggtgggc tgcctggcag aggagcacaa catcacggtg
     3841 aaccaggtca acgcatgtca tgtgatggag tcggccttca actacagcct gggcgacgag
     3901 cagggcttct gtggcagccc ccagcccaac tgcaacttcc cagagtactt cacctacagc
     3961 gtgctgctca gcctgctggc ctgctccgtg ttcctgcaga tcagctgcat tggaaagctg
     4021 gtgctcatgc tggccattga gttcatctat gtgctcatcg tggaggtgcc cggcgtcaca
     4081 ctcttcgaca acgctgacct tctggtcacc gccaatgcca tagacttcag caacaacggg
     4141 acctcccagt gccctgagca tgcaaccaag gtggcgctga aggtggtgac gcccatcatc
     4201 atctctgtct tcgtgctggc tctgtatctg catgcccagc aggtggagtc cactgctcgc
     4261 cttgacttcc tctggaaact gcaggccaca gaagagaagg aggagatgga ggagctgcag
     4321 gcctacaatc ggcgcctgct gcacaacatt ctgcccaagg acgtggctgc ccacttcctg
     4381 gcccgggaac ggcgcaatga cgagctgtac taccaatcgt gcgagtgtgt ggctgtcatg
     4441 tttgcctcca ttgccaactt ctccgaattc tatgtagagc tagaggccaa caatgagggc
     4501 gtcgagtgcc tacggctgct caatgagatc atcgcagact tcgatgagat catcagtgag
     4561 gatcggttca ggcagctgga aaagatcaag accataggca gcacctacat ggctgcctct
     4621 ggcctcaacg actccaccta tgacaaggca ggcaagaccc acatcaaggc tattgcagac
     4681 ttcgctatga agctgatgga ccaaatgaag tacatcaatg agcactcctt caacaacttc
     4741 cagatgaaga ttgggctcaa cattggacct gtagtggctg gagtcattgg ggctcgcaag
     4801 cctcagtatg acatctgggg caatacagtg aatgtggcca gccgtatgga cagcactggg
     4861 gtgcctgacc gcatccaggt tactacagat atgtaccagg tgctggccgc caacacatac
     4921 cagctggagt gccggggtgt ggtcaaggtc aagggcaagg gtgagatgat gacttacttc
     4981 ctcaatggag ggcctcccct cagttagcag ataccagcca gcggtgccag catcctggcc
     5041 tccagaggat tggaacagct tttgtgcacc atgggcagat agggcctgtg ctccaggctc
     5101 acagctgtgc tggtaaaatt cccactttga ctcagaagca acttctgcct ttgctggtgg
     5161 gcatggcttt tggcctaggc ccagggtgcc agcgtcctgc aagcaccgag ctgaccaaag
     5221 atgtttcccc ttggcagaag actctgctag actcgagttg aaccttgagt tttctgacaa
     5281 gtgctgctgc cgcatggtgg aggtgctacc ggagccttca ttggtggtgc agcatggcac
     5341 atggtggctg gcctgagggg aggccttggc catgatgggg tggtaggcaa gctcaaagct
     5401 ggcctggggg tgtccatgga actcaagggt ctgcttttcc actgtggaga ggtcactccc
     5461 cctcacaacg tttgggggac aggaactggg agacgtgtgg cctgtgccat cctctcccca
     5521 cacctccacg cacagagaca atgccctgta agggaaacag gactgttgac aagggaggca
     5581 agaggacacc aggcaaggag cagtggctct gagcaaaaga aaatatttat taaataaaac
     5641 aaaacaagtt ttctctgccc gtctttagac tatgctagtt gtatgcgtgt tataagacac
     5701 acaagcaaaa cgaggatgcc actggggaag ggaggtggga accccaactt gtctttttgt
     5761 attttttatt ttgtattatt gaaaccttgg agatctaaca aatataccaa attctatatt
     5821 ttgtaaattc tattaggaag cagctgtgcc cagcagtgca cttctgctcc tctgtactgt
     5881 acgtgtgtgt gtgtgtgtgt gtactggtgt acgtgtgtgt tcccctcatt tcagacttct
     5941 aggcacagcc agagcagggt tgtgtgttgt tttggggtac cacactagcc cctctttcga
     6001 actccacctt acacacatcc catttcccaa gtaagtgaat gccaacagga caagaaggcc
     6061 aaggcactgc tcctgtccca ggaggtctga gcatcctgca ctcactagcg ctgctcttcc
     6121 actcgtctca gagacgctgc acggtcccct ccctcacaga ggccggtcct acaggttcct
     6181 ggagctcaat agtggccagg gctggaggaa gcccaggctc tacaacctcc tcagttggct
     6241 caggtgcggg gggctgtctt ggaaagggtc cctgtgacct ggggatgcaa tctatccatc
     6301 ctgggtttag ggaaagggta tagccctgcc ttccaccccc agacacaggt aagattttgt
     6361 ctggttttgg tgggagggga cacttaaatg ccctgaggag aaaatagttt ttgtactttc
     6421 caagaacctt tgaggaatga ccttctctac cacagataaa cttgaacagc acccttactg
     6481 tctgcccaga tctcctcatt gcttctcagg gtgcagttat tctcccctct agcacgagag
     6541 taaaagtgag gtggcagcca ggtgccagct caatgttacc ctgatgtcct tcaccagccc
     6601 caagaaacaa agtccggacc ccagactgct gcccctgcct ctgttctgtg ctctgccgct
     6661 tcccgagttc tgcactgccc tcacctctgt ttgggggctg cttctctcgc accgttctca
     6721 agtccccagc cctccacatg tcctgccaac accagtgggt ttctgtttag cttccaacca
     6781 gagtacagtg tgtgtgctga gtttatactg tgtttcccca tggaggctcc tccccactcc
     6841 agcagtgact ggtgacagcg tgcagtgcca gctcttcctt ccctctaagg ggtgtgtgca
     6901 ctctttttat tcctgctctt gcaaaaatga tacgattatg atttcccatg gaaattgaaa
     6961 agtctattta aataatttaa ctattaaaaa cactttcact ggta
//
