LOCUS       NM_001361604            3530 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus adenylate cyclase 4 (Adcy4), transcript variant 2,
            mRNA.
ACCESSION   NM_001361604 XM_006518323
VERSION     NM_001361604.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3530)
  AUTHORS   Li,G., Chen,L., Jiang,Z. and Yau,K.W.
  TITLE     Coexistence within one cell of microvillous and ciliary
            phototransductions across M1- through M6-IpRGCs
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2315282120 (2023)
   PUBMED   38109525
REFERENCE   2  (bases 1 to 3530)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 3530)
  AUTHORS   Chen,K., Wang,S. and Sun,Z.
  TITLE     In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene
            Protects against Klotho Deficiency-induced Heart Failure
  JOURNAL   Transl Res 244, 101-113 (2022)
   PUBMED   35114419
  REMARK    GeneRIF: In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4
            Gene Protects against Klotho Deficiency-induced Heart Failure.
REFERENCE   4  (bases 1 to 3530)
  AUTHORS   Estrada,S.M., Thagard,A.S., Dehart,M.J., Damicis,J.R.,
            Dornisch,E.M., Ippolito,D.L., Burd,I., Napolitano,P.G. and
            Ieronimakis,N.
  TITLE     The orphan nuclear receptor Nr4a1 mediates perinatal
            neuroinflammation in a murine model of preterm labor
  JOURNAL   Cell Death Dis 11 (1), 11 (2020)
   PUBMED   31907354
  REMARK    Erratum:[Cell Death Dis. 2020 Jun 30;11(6):495. doi:
            10.1038/s41419-020-2682-y.. PMID: 32606386]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3530)
  AUTHORS   Kittikulsuth,W., Stuart,D. and Kohan,D.E.
  TITLE     Adenylyl cyclase 4 does not regulate collecting duct water and
            sodium handling
  JOURNAL   Physiol Rep 2 (3), e00277 (2014)
   PUBMED   24760529
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3530)
  AUTHORS   Meneray,M.A. and Lallier,T.E.
  TITLE     Differential expression of adenylyl cyclase mRNAs in lacrimal
            glands of NZB/NZW and NOD pre-autoimmune mice
  JOURNAL   Adv Exp Med Biol 506 (Pt A), 41-49 (2002)
   PUBMED   12613887
REFERENCE   7  (bases 1 to 3530)
  AUTHORS   Baker,L.P., Nielsen,M.D., Impey,S., Hacker,B.M., Poser,S.W.,
            Chan,M.Y. and Storm,D.R.
  TITLE     Regulation and immunohistochemical localization of
            betagamma-stimulated adenylyl cyclases in mouse hippocampus
  JOURNAL   J Neurosci 19 (1), 180-192 (1999)
   PUBMED   9870949
REFERENCE   8  (bases 1 to 3530)
  AUTHORS   Suzuki,Y., Shen,T., Poyard,M., Best-Belpomme,M., Hanoune,J. and
            Defer,N.
  TITLE     Expression of adenylyl cyclase mRNAs in the denervated and in the
            developing mouse skeletal muscle
  JOURNAL   Am J Physiol 274 (6), C1674-C1685 (1998)
   PUBMED   9611134
REFERENCE   9  (bases 1 to 3530)
  AUTHORS   Edelhoff,S., Villacres,E.C., Storm,D.R. and Disteche,C.M.
  TITLE     Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in
            mouse
  JOURNAL   Mamm Genome 6 (2), 111-113 (1995)
   PUBMED   7766992
REFERENCE   10 (bases 1 to 3530)
  AUTHORS   Gao,B.N. and Gilman,A.G.
  TITLE     Cloning and expression of a widely distributed (type IV) adenylyl
            cyclase
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10178-10182 (1991)
   PUBMED   1946437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY346402.1, AK141767.1 and AC098877.3.
            
            On Mar 29, 2018 this sequence version replaced XM_006518323.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141767.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BY346402.1         1-30
            31-1392             AK141767.1         1-1362
            1393-1393           AC098877.3         94493-94493         c
            1394-3530           AK141767.1         1364-3500
FEATURES             Location/Qualifiers
     source          1..3530
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..3530
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /note="adenylate cyclase 4"
                     /db_xref="GeneID:104110"
                     /db_xref="MGI:MGI:99674"
     exon            1..181
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            182..372
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3447
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /EC_number="4.6.1.1"
                     /note="adenylyl cyclase 4; ATP pyrophosphate-lyase 4;
                     adenylate cyclase type IV"
                     /codon_start=1
                     /product="adenylate cyclase type 4"
                     /protein_id="NP_001348533.1"
                     /db_xref="CCDS:CCDS27130.1"
                     /db_xref="GeneID:104110"
                     /db_xref="MGI:MGI:99674"
                     /translation="MARLFSPRPPPSEDLFYETYYSLSQQYPLLILLLVIVLCALVAL
                     PAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQQLQRWTRPLSGLIWVALLA
                     LGYGFLFTGGVVSAWDQVSFFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYL
                     GWQPESQRALLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLHSRRRLDT
                     EKKHQEHLLLSILPAYLAREMKAEIMARLQAGQRSRPENTNNFHSLYVKRHQGVSVLY
                     ADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSL
                     PDHAINCVRMGLDMCRAIRKLRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHD
                     VTLANHMEAGGVPGRVHITGATLALLAGAYAVERADTEHRDPYLRELGEPTYLVIDPR
                     AEEEDEKGTAKGLLSSLEGHTMRPSLLMTRYLESWGAAKPFAHLSHLDSPVSTSTPLP
                     EKAFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNLLTLYFRE
                     KEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRPPALIITYSITFLLFFLLL
                     FVCFSEHLTKCVQKGPKMLHWLPALSVLVATRPGFRVALGTATILLVFTMAIASLLFL
                     PVSSDCLFLASNVSSVTFNASWEMPGSLPLISIPLISIPYSMHCCVLGFLSCSLFLHM
                     SFELKLLLLLLWLVASCSLFLHSHAWLSDCLIARLYQSPSDSRPGVLKEPKLMGAIYF
                     FIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQF
                     IGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDEL
                     LSKPKFSGVEKIKTIGSTYMAATGLNATSGQDTQQDSERSCSHLGTMVEFAVALGSKL
                     GVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQV
                     TEETARALQSLGYTCYSRGSIKVKGKGELCTYFLNTDLTRTGSPSAS"
     exon            373..570
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            571..732
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            733..882
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1031
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1143
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1271
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1430
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1563
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1737
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1772
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1859
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1929
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2027
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2112
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2250
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2376
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2561
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2646
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2805
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2952
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3060
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3175
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3300
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3530
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3478..3483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
                     /note="hexamer: AATAAA"
     polyA_site      3502
                     /gene="Adcy4"
                     /gene_synonym="mKIAA4004"
ORIGIN      
        1 gagggaagtg ccagtcgccc ggcaggccct gagccactag caaagcagcg aaggtgagta
       61 gtagccatcc cacccaggtt ccctcctgga gcctagcttt gctgagagaa cttctggagc
      121 ttgacccaaa gcggtgagtc tgcggcacct tcttctcagc tccagccagg acactagcac
      181 gggcaggggc tccgggctgg ggcggggaag accatggccc gcctcttcag tccccggcct
      241 cctcccagcg aagatctctt ctacgaaact tactacagcc tgagccaaca gtacccactg
      301 ctgatactgc ttttggtcat tgtgctctgc gcgctggtgg cactgcccgc cgtcgcctgg
      361 gccagcggca gggagctgac ctcagaccca agcttcctga caactgtgct gtgtgctttg
      421 ggtggcttct ctctgctatt ggggcttgct tcccgggagc agcaactgca gcgatggaca
      481 cgacctcttt ctggtctcat atgggttgca ttactggctc tgggctatgg atttctgttc
      541 actgggggtg tggtgagcgc ctgggaccag gtgtcttttt tcctcttcat catcttcacc
      601 gtgtacgcca tgctgccctt gggcatgcgg gatgctgctg ctgcgggagt catctcatcc
      661 ctctcgcacc tgctggtcct tggactgtat cttgggtggc agcctgagtc acagagagct
      721 ctgctaccac agttggcagc aaacgcggta ttgttcctgt gtgggaacgt ggtgggagcg
      781 taccacaagg ccctgatgga gcgagcattg cgggccacgt tccgggaggc tcttagctct
      841 ctgcactcac gccggaggct ggacactgag aaaaagcacc aggagcacct cctcttgtct
      901 atccttcctg cctacctggc ccgagagatg aaagcagaga tcatggcccg gctgcaggct
      961 ggacagcgct cacggccaga gaacacaaac aactttcaca gcctgtatgt caagaggcac
     1021 caaggagtga gtgtgctgta tgctgacatc gtgggcttca cgcggctggc cagcgagtgt
     1081 tccccgaagg agctggtgct catgctgaat gagctctttg gcaagttcga ccaaattgcc
     1141 aaggagcacg aatgcatgcg gatcaagatc ctgggagact gttactactg tgtctccggg
     1201 ctgcccctct cgctgcctga ccacgctatc aattgtgtgc gcatggggct ggacatgtgc
     1261 cgggccatca ggaaacttcg ggtagccacc ggtgtggata tcaacatgcg tgtgggcgtg
     1321 cactcgggca gcgttctctg tggagtcatt gggctacaga agtggcagta tgatgtctgg
     1381 tcccatgatg tcacattggc caaccatatg gaagcaggcg gtgtaccagg acgagtgcac
     1441 atcacagggg ccacgctggc cctgctagca ggagcttatg ctgtggagag ggcagacacg
     1501 gaacaccgag acccatacct tcgggagcta ggagaaccta catacctggt cattgatcct
     1561 cgggctgagg aggaagacga gaagggcacc gcaaaaggat tgctgtcttc tctggagggg
     1621 cacacgatgc gtccgtcact actgatgact cgctatctgg agtcttgggg tgcagccaag
     1681 cctttcgccc acctaagcca ccttgacagt cccgtgtcca cctccactcc actcccggag
     1741 aaagccttca gcccccagtg gagcctggac cggagtcgca ccccccgggg actagatgat
     1801 gaactggaca ctggtgatgc taagttcttc caggtcatcg aacaactcaa ctctcagaaa
     1861 cagtggaagc agtcgaagga cttcaacctc ctgacgctgt acttcagaga gaaggagatg
     1921 gagaaacagt atcggctctc tgcactcccc gccttcaaat actacgcagc ctgcaccttc
     1981 ctggtttttc tgtccaactt cactatccaa atgctggtga caaccaggcc cccagctctg
     2041 atcatcacct acagcatcac cttccttctc ttctttctcc tcctcttcgt ctgcttctca
     2101 gagcacctga cgaagtgtgt ccagaaaggt cccaagatgt tgcactggct gcctgcactg
     2161 tctgtcctgg tggccacacg gccaggattt cgagtagccc tgggtacggc caccatcctc
     2221 ctggtattca ctatggccat cgccagcctg ctcttcttac cagtgtcatc agactgcctt
     2281 ttcctggctt ccaatgtgtc atctgtgact ttcaatgctt cctgggagat gccaggatcc
     2341 ctgcccctca tcagcatccc cctcatcagc atcccatact ccatgcattg ctgcgtgttg
     2401 ggtttcctct cctgctccct ttttctgcac atgagcttcg aactgaagct gctcctactt
     2461 ctgctgtggc tggtggcatc ttgttcccta tttctgcatt cccacgcctg gctgtctgac
     2521 tgcctcattg cccgccttta tcaaagccct tcggactcca gaccaggggt actgaaggaa
     2581 cccaagctga tgggagcgat ctacttcttc atcttcttct tcacactcct ggtcctggct
     2641 cggcagaatg agtattactg ccgcctggac ttcctgtgga aaaagaaact gaggcaggag
     2701 cgagaggaga ctgagacaat ggagaacctg acccggctcc tcctggagaa tgtactccct
     2761 gcacacgtgg ccccccagtt catcggccag aaccggcgca atgaggacct ctaccaccag
     2821 tcgtacgaat gcgtttgtgt cctcttcgcg tcggtcccag actttaagga attctactct
     2881 gaatccaaca tcaaccacga ggggctggag tgcctgcggc tgctcaatga gatcattgct
     2941 gactttgatg agctgctctc caagccaaag ttcagtggag tagagaagat caaaactatt
     3001 ggcagtacct acatggcggc cacaggctta aatgccacct ctggacagga tactcagcag
     3061 gattctgaga gaagctgcag tcatctgggc accatggtgg aatttgcagt ggccctgggg
     3121 tctaagctgg gagtcatcaa caagcactcg ttcaataact tccgcctgcg tgtggggttg
     3181 aaccacggac cagtagtagc aggggtgatt ggggcgcaga agccacagta cgacatctgg
     3241 gggaacacag tgaatgtggc cagccgaatg gagagcacag gcgttctcgg caagatccaa
     3301 gtgactgagg agacagcgcg ggccctgcag tccctgggtt acacgtgcta tagcagaggc
     3361 agcatcaagg tcaaaggcaa aggggaactc tgtacctact tcctgaacac agacctgacg
     3421 cggaccggat ctccctcagc atcctaggca cctgagctcc cctcttcgaa gatcctcaat
     3481 aaaatgtctc cgagcatctg tagcctccgg atgcagcacc gtttcctccc
//
