LOCUS       NM_153534               4211 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus adenylate cyclase 2 (Adcy2), mRNA.
ACCESSION   NM_153534
VERSION     NM_153534.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4211)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4211)
  AUTHORS   Li,G., Chen,L., Jiang,Z. and Yau,K.W.
  TITLE     Coexistence within one cell of microvillous and ciliary
            phototransductions across M1- through M6-IpRGCs
  JOURNAL   Proc Natl Acad Sci U S A 120 (52), e2315282120 (2023)
   PUBMED   38109525
REFERENCE   3  (bases 1 to 4211)
  AUTHORS   Hu,L., Xie,X., Xue,H., Wang,T., Panayi,A.C., Lin,Z., Xiong,Y.,
            Cao,F., Yan,C., Chen,L., Cheng,P., Zha,K., Sun,Y., Liu,G., Yu,C.,
            Hu,Y., Tao,R., Zhou,W., Mi,B. and Liu,G.
  TITLE     MiR-1224-5p modulates osteogenesis by coordinating
            osteoblast/osteoclast differentiation via the Rap1 signaling target
            ADCY2
  JOURNAL   Exp Mol Med 54 (7), 961-972 (2022)
   PUBMED   35831436
  REMARK    GeneRIF: MiR-1224-5p modulates osteogenesis by coordinating
            osteoblast/osteoclast differentiation via the Rap1 signaling target
            ADCY2.
REFERENCE   4  (bases 1 to 4211)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4211)
  AUTHORS   Haller,M., Mo,Q., Imamoto,A. and Lamb,D.J.
  TITLE     Murine model indicates 22q11.2 signaling adaptor CRKL is a
            dosage-sensitive regulator of genitourinary development
  JOURNAL   Proc Natl Acad Sci U S A 114 (19), 4981-4986 (2017)
   PUBMED   28439006
REFERENCE   6  (bases 1 to 4211)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 4211)
  AUTHORS   Meneray,M.A. and Lallier,T.E.
  TITLE     Differential expression of adenylyl cyclase mRNAs in lacrimal
            glands of NZB/NZW and NOD pre-autoimmune mice
  JOURNAL   Adv Exp Med Biol 506 (Pt A), 41-49 (2002)
   PUBMED   12613887
REFERENCE   8  (bases 1 to 4211)
  AUTHORS   Baker,L.P., Nielsen,M.D., Impey,S., Hacker,B.M., Poser,S.W.,
            Chan,M.Y. and Storm,D.R.
  TITLE     Regulation and immunohistochemical localization of
            betagamma-stimulated adenylyl cyclases in mouse hippocampus
  JOURNAL   J Neurosci 19 (1), 180-192 (1999)
   PUBMED   9870949
REFERENCE   9  (bases 1 to 4211)
  AUTHORS   Suzuki,Y., Shen,T., Poyard,M., Best-Belpomme,M., Hanoune,J. and
            Defer,N.
  TITLE     Expression of adenylyl cyclase mRNAs in the denervated and in the
            developing mouse skeletal muscle
  JOURNAL   Am J Physiol 274 (6), C1674-C1685 (1998)
   PUBMED   9611134
REFERENCE   10 (bases 1 to 4211)
  AUTHORS   Edelhoff,S., Villacres,E.C., Storm,D.R. and Disteche,C.M.
  TITLE     Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in
            mouse
  JOURNAL   Mamm Genome 6 (2), 111-113 (1995)
   PUBMED   7766992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132312.1, AI322582.1 and BY623048.1.
            
            On Jan 26, 2007 this sequence version replaced NM_153534.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132312.1, BC037107.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3416              AK132312.1         2-3417
            3417-3420           AI322582.1         741-744
            3421-4192           AK132312.1         3422-4193
            4193-4211           BY623048.1         389-407
FEATURES             Location/Qualifiers
     source          1..4211
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 35.55 cM"
     gene            1..4211
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /note="adenylate cyclase 2"
                     /db_xref="GeneID:210044"
                     /db_xref="MGI:MGI:99676"
     exon            1..468
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..3534
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /EC_number="4.6.1.1"
                     /note="adenylyl cyclase 2; ATP pyrophosphate-lyase 2;
                     adenylate cyclase type II"
                     /codon_start=1
                     /product="adenylate cyclase type 2"
                     /protein_id="NP_705762.2"
                     /db_xref="CCDS:CCDS36721.1"
                     /db_xref="GeneID:210044"
                     /db_xref="MGI:MGI:99676"
                     /translation="MWQEAMRRRRYLRDRAEAAAAAAAGGGEGLQRSRDWLYESYYCM
                     SQQHPLIVFLLLIVMGACLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCI
                     ESVFKKLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMR
                     DAIIASVLTSSSHTIVLSVYLSATPGAKEHLFWQILANVIIFICGNLAGAYHKHLMEL
                     ALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM
                     ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENE
                     CMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHS
                     GNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDG
                     EIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAA
                     KPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAID
                     GINAQKQWLKSEDIQRISLFFYNKNIEKEYRATALPAFKYYVTCACLIFLCIFIVQIL
                     VLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASASLLWLLKSSGIIANRPWP
                     RISLTIVTTAIILTMAVFNMFFLSNSEETTLPTANASNANVSVPDNQTAILHARNLFF
                     LPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNIILLHTHAHVLDAYSQVLFQ
                     RPGIWKDLKTMGSVSLSIFFITLLVLGRQSEYYCRLDFLWKNKFKKEREEIETMENLN
                     RVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGL
                     ECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHAQEPERQYM
                     HIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVN
                     VASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSL
                     SQSNLAS"
     exon            469..666
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            667..828
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            829..978
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1127
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1239
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1367
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1526
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1659
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1836
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1880
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1961
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2031
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2129
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2214
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2352
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2472
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2642
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2727
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2886
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3033
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3141
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3256
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3381
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..4211
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3832..3837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /note="hexamer: AATAAA"
     polyA_site      3855
                     /gene="Adcy2"
                     /gene_synonym="mKIAA1060"
                     /note="major polyA site"
ORIGIN      
        1 gccctcgcga gcggtggtgg cggcggcggc gcccgggagc tgccctgagg ccgcccccgg
       61 cccccgcccg cgcgtcagcg cgcccagccc ggggctccga gctccgcccg cgcccgaggc
      121 ccctgagcac agctccgggc gggcagccgg cgggtcgcga agcgcggggg cggcaggcgg
      181 taggtgacca cagagcggcg ctgcccgggc agggcgcgca cagcgggcgc cccgcgagcc
      241 gccccgatgt ggcaggaggc gatgcggcgg cgccgctacc tgcgggaccg cgccgaggcg
      301 gcggcagcag cggcggcggg cggcggcgag gggctgcagc ggtcccggga ctggctctac
      361 gagtcctact actgcatgag ccagcagcac cctctcatcg tcttcctgct gctcatcgtc
      421 atgggcgcct gcctcgccct gctcgccgtc ttcttcgcgc tcgggctgga ggtagaagac
      481 catgtggcat ttttaataac cgttcccact gccctggcca tcttcttcgc catattcatt
      541 cttgtctgca ttgagtctgt gttcaagaag cttctccgag tgttctcgct ggtgatctgg
      601 atatgtctgg ttgccatggg atacctgttc atgtgctttg gagggaccgt gtctgcctgg
      661 gaccaggtgt cattcttcct cttcatcatc ttcgtggtgt acaccatgct tcccttcaac
      721 atgagggatg ccatcatcgc cagcgtcctc acctcttcat ctcatacgat agtgctgagt
      781 gtctacctgt ctgcaacacc aggggccaag gagcacctgt tctggcagat actggccaac
      841 gtgatcattt tcatctgtgg gaacttggcg ggagcttacc ataagcacct catggaactt
      901 gccctgcagc aaacctatcg ggacacatgt aattgcatca agtcccggat caagctggaa
      961 tttgaaaaac ggcagcagga acgacttctg ctttccctgc tgcctgctca cattgccatg
     1021 gaaatgaagg ctgaaatcat tcaaaggcta cagggaccca aagcaggaca gatggaaaac
     1081 acgaacaact tccacaacct gtatgtcaag cgacacacca acgtgagcat attatatgct
     1141 gacattgttg gcttcacccg ccttgcaagc gattgctccc ctggtgaact ggtccacatg
     1201 ctgaatgaac tctttgggaa gtttgatcaa attgcaaagg agaatgagtg catgagaatt
     1261 aaaattttag gagactgcta ttactgtgtt tccgggctcc cgatatctct ccctaaccat
     1321 gccaagaact gtgtgaaaat gggactggat atgtgcgaag ccataaagaa agtgagggat
     1381 gctactgggg tcgatatcaa catgcgcgtg ggagtgcatt ctgggaacgt tctctgtggt
     1441 gtgattggtc tccagaagtg gcagtatgac gtgtggtctc atgatgttac tttggccaac
     1501 cacatggaag ctggaggagt ccctggacgt gttcacattt cctcagtcac tctggagcac
     1561 ttgaatgggg cttataaagt ggaggaagga gacggtgaga taagagaccc atatttaaag
     1621 cagcatttgg tgaaaaccta ctttgtaatc aaccccaagg gagaaagacg gagtcctcag
     1681 catctcttca gacctcgaca cactctggat ggagccaaga tgagagcatc tgtccgcatg
     1741 acccggtact tggagtcctg gggagcagcc aagccatttg cacatctgca ccacagagat
     1801 agcatgacca cagagaatgg gaagattagc accacggatg tgccaatggg tcaacataat
     1861 tttcaaaatc gcaccttaag aactaagtca cagaagaagc gattcgaaga agaactgaat
     1921 gaaaggatga tccaagcaat tgacgggatc aacgcacaaa agcaatggct caagtcagaa
     1981 gacattcaaa gaatctccct gtttttctat aacaaaaata tagaaaaaga atatcgagcc
     2041 actgcactgc cagcattcaa gtactacgtg acctgtgcct gcctcatctt cctctgtatc
     2101 ttcattgtac agattcttgt actgccaaaa acgtccatcc ttggcttctc ctttggagct
     2161 gcatttctct ccctcatctt catcctcttt gtctgcttcg ctggacagct tttgcaatgc
     2221 agcaaaaagg cctctgcctc tctcttgtgg cttttgaaat catcaggcat catagccaac
     2281 cgcccatggc cacggatctc cctcacgatc gtcaccacag ctatcatact aaccatggct
     2341 gtgtttaaca tgtttttcct gagcaactct gaggagacaa cccttccgac tgccaatgca
     2401 tctaatgcaa acgtttctgt cccagacaac cagacagcaa ttcttcatgc acgaaacttg
     2461 tttttcctcc cgtacttcat atacagctgc attctgggtt tgatctcctg ctccgttttc
     2521 ctgagggtga actacgagtt gaaaatgtta atcatgatgg tggcactcgt gggctacaac
     2581 atcattctgc tccacaccca tgcccatgtc ctggatgcat acagccaggt cctgtttcag
     2641 agaccaggca tttggaaaga cctgaagacc atgggctctg tgtccctctc tatattcttc
     2701 atcacgctgc tcgttctggg tagacagagt gaatattact gtaggttaga cttcttgtgg
     2761 aagaacaagt tcaaaaaaga gcgggaggag atcgaaacca tggagaacct aaaccgagtg
     2821 ctgctggaga acgtgctacc tgcacacgtg gctgaacact tcctggccag gagcctgaaa
     2881 aacgaggagt tgtaccacca gtcctacgat tgtgtctgtg tcatgtttgc ctccattccg
     2941 gacttcaagg aattctacac ggagtcagat gtgaacaagg aaggcttgga atgcctccgg
     3001 ctcctgaatg agatcatcgc tgactttgat gatctgcttt ccaagccgaa gttcagtggc
     3061 gttgaaaaga tcaagaccat tggtagcaca tacatggcag ccacgggtct gagtgctgta
     3121 cccagtcagg agcacgccca ggaacccgag cgtcaataca tgcacatagg caccatggtg
     3181 gagtttgcat acgccctggt ggggaaactg gatgccatca ataagcactc cttcaacgac
     3241 ttcaaacttc gagtgggtat caaccatgga cctgtaatag ctggcgtcat aggggctcag
     3301 aagccacaat atgacatctg gggcaacact gtcaacgtcg ctagtaggat ggacagcacc
     3361 ggagtcctgg acaaaataca ggtgactgag gagacaagcc tcatcctgca gacgcttggc
     3421 tacacgtgta catgtcgagg tatcatcaac gtgaagggga aaggggacct gaagacgtac
     3481 tttgtaaaca ccgagatgtc acggtccctt tctcagagca acttggcttc ctgagaagct
     3541 gtctcttcct gacaagaagc gtgtgcttgc aggaaggtac cacgcacttt ctgactgcag
     3601 cccttcccct tcgtcttgat tacgtacgtg ctctgtccca ccctctggag cccttgcaga
     3661 ctagttcctg tgacccagtg gcatactgtt tggtgtctgc gtgtgcccag attgtcctgc
     3721 cacttgcact gtgcttgctc ctaagcagaa ggagaaggaa ccgtgtcctg gaaggagagc
     3781 attggaagaa gtgatggagg aagaggtgaa gtgaacacac attcttaagg caataaaact
     3841 ggggggtgta tattatcttc tggtgcatgt tcttctctgg aaaatacggt agctcgtaac
     3901 cgcatcccta gtctgatact caaacccaca gtatttgtga ataagctgat cccgtcactc
     3961 aacatggagt ctgtgctcac ccacccgtgt gtctcattgc cagtggtcat ccgcgggcct
     4021 cagctgagac tcgcggcttt tgtcaccttg ctgtgttgtc ttgtggcagc agcacgttgc
     4081 catccattac cagaattagt cctcacagcc taggaccggt tttgtaccaa actcgtctga
     4141 tgttttgatg ccatttgtct tttgtaaggt taattcatta aaagttttac gtactttggt
     4201 gtctagtgcc c
//
