LOCUS       NM_173029               5209 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus adenylate cyclase 10 (Adcy10), transcript variant 1,
            mRNA.
ACCESSION   NM_173029
VERSION     NM_173029.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5209)
  AUTHORS   You,J., Reilly,M.D., Eljalby,M., Bareja,R., Yusupova,M., Vyas,N.S.,
            Bang,J., Ding,W., Desman,G., Miller,L.S., Elemento,O.,
            Granstein,R.D. and Zippin,J.H.
  TITLE     Soluble adenylyl cyclase contributes to imiquimod-mediated
            inflammation and is a potential therapeutic target in psoriasis
  JOURNAL   Exp Dermatol 32 (7), 1051-1062 (2023)
   PUBMED   37039485
  REMARK    GeneRIF: Soluble adenylyl cyclase contributes to imiquimod-mediated
            inflammation and is a potential therapeutic target in psoriasis.
REFERENCE   2  (bases 1 to 5209)
  AUTHORS   Wiggins,S.V., Schreiner,R., Ferreira,J., Marmorstein,A.D.,
            Levin,L.R. and Buck,J.
  TITLE     Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is
            Independent of Soluble Adenylyl Cyclase
  JOURNAL   J Ocul Pharmacol Ther 39 (5), 317-323 (2023)
   PUBMED   37097314
REFERENCE   3  (bases 1 to 5209)
  AUTHORS   Ritagliati,C., Ayoub,S., Balbach,M., Buck,J. and Levin,L.R.
  TITLE     In vivo characterization of sAC null sperm
  JOURNAL   Front Cell Dev Biol 11, 1134051 (2023)
   PUBMED   37152282
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5209)
  AUTHORS   Ferreira,J.J., Lybaert,P., Puga-Molina,L.C. and Santi,C.M.
  TITLE     Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper
            Channels in Human and Mouse Sperm
  JOURNAL   Front Cell Dev Biol 9, 733653 (2021)
   PUBMED   34650979
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5209)
  AUTHORS   Nguyen,T.M.D., Filliatreau,L., Klett,D., Hai,N.V., Duong,N.T. and
            Combarnous,Y.
  TITLE     Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on the
            LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line
  JOURNAL   Int J Mol Sci 22 (9), 4641 (2021)
   PUBMED   33924969
  REMARK    GeneRIF: Effect of Soluble Adenylyl Cyclase (ADCY10) Inhibitors on
            the LH-Stimulated cAMP Synthesis in Mltc-1 Leydig Cell Line.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5209)
  AUTHORS   Hess,K.C., Jones,B.H., Marquez,B., Chen,Y., Ord,T.S.,
            Kamenetsky,M., Miyamoto,C., Zippin,J.H., Kopf,G.S., Suarez,S.S.,
            Levin,L.R., Williams,C.J., Buck,J. and Moss,S.B.
  TITLE     The 'soluble' adenylyl cyclase in sperm mediates multiple signaling
            events required for fertilization
  JOURNAL   Dev Cell 9 (2), 249-259 (2005)
   PUBMED   16054031
REFERENCE   7  (bases 1 to 5209)
  AUTHORS   Esposito,G., Jaiswal,B.S., Xie,F., Krajnc-Franken,M.A.,
            Robben,T.J., Strik,A.M., Kuil,C., Philipsen,R.L., van Duin,M.,
            Conti,M. and Gossen,J.A.
  TITLE     Mice deficient for soluble adenylyl cyclase are infertile because
            of a severe sperm-motility defect
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 2993-2998 (2004)
   PUBMED   14976244
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5180. Jaiswal
            Byjay S [corrected to Jaiswal Bijay S]]
REFERENCE   8  (bases 1 to 5209)
  AUTHORS   Unterwald,E.M., Ivkovic,S., Cuntapay,M., Stroppolo,A., Guinea,B.
            and Ehrlich,M.E.
  TITLE     Prenatal exposure to cocaine decreases adenylyl cyclase activity in
            embryonic mouse striatum
  JOURNAL   Brain Res Dev Brain Res 147 (1-2), 67-75 (2003)
   PUBMED   14741752
REFERENCE   9  (bases 1 to 5209)
  AUTHORS   Jaiswal,B.S. and Conti,M.
  TITLE     Identification and functional analysis of splice variants of the
            germ cell soluble adenylyl cyclase
  JOURNAL   J Biol Chem 276 (34), 31698-31708 (2001)
   PUBMED   11423534
REFERENCE   10 (bases 1 to 5209)
  AUTHORS   Sinclair,M.L., Wang,X.Y., Mattia,M., Conti,M., Buck,J.,
            Wolgemuth,D.J. and Levin,L.R.
  TITLE     Specific expression of soluble adenylyl cyclase in male germ cells
  JOURNAL   Mol Reprod Dev 56 (1), 6-11 (2000)
   PUBMED   10737962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029849.1 and BC138448.1.
            
            On Apr 25, 2009 this sequence version replaced NM_173029.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029849.1, BC138448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1124              AK029849.1         3-1126
            1125-2069           BC138448.1         1006-1950
            2070-3237           AK029849.1         2072-3239
            3238-5059           BC138448.1         3119-4940
            5060-5209           AK029849.1         5062-5211
FEATURES             Location/Qualifiers
     source          1..5209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.83 cM"
     gene            1..5209
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /note="adenylate cyclase 10"
                     /db_xref="GeneID:271639"
                     /db_xref="MGI:MGI:2660854"
     exon            1..153
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            154..361
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..5058
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /EC_number="4.6.1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testicular soluble adenylyl cyclase; adenylate cyclase
                     type 10; germ cell soluble adenylyl cyclase"
                     /codon_start=1
                     /product="adenylate cyclase type 10 isoform 1"
                     /protein_id="NP_766617.2"
                     /db_xref="CCDS:CCDS35756.1"
                     /db_xref="GeneID:271639"
                     /db_xref="MGI:MGI:2660854"
                     /translation="MSARRQELQDRAIVKIAAHLPDLIVYGDFSPERPSVKCFDGVLM
                     FVDISGFTAMTEKFSTAMYMDRGAEQLVEILNYYISAIVEKVLIFGGDILKFAGDALL
                     ALWKVERKQLKNIITVVIKCSLEIHGLFEAKEAEEGLDIRVKIGLAAGHITMLVFGDE
                     TRNYFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFL
                     KPPPTFNFDEFFTKCMGFMDYYPSGDHKNFLRLACMLESDPELELSLQKYVMEIILKQ
                     IDDKQLRGYLSELRPVTIVFVNLMFKEQDKVEVIGSAIQAACVHITSVLKVFRGQINK
                     VFMFDKGCSFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVHKIRTVSIGVASGIVF
                     CGIVGHTVRHEYTVIGQKVNIAARMMMYYPGIVSCDSVTYDGSNLPAYFFKELPKKVM
                     KGVADPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRVREIDYFMSTMKDFLMTNC
                     SRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILMANVL
                     GLDTCKHYKERQTNLQNRVKTLLDEKFHCLLNDIFHVQFPVSREMSRMSKIRKQKQLE
                     ALFMKILAQTVREERIIFIIDEAQFVDGTSWAFIEKLIRSMPIFIVMSLAPFSEVPCA
                     AANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIPRELDSYLVEGSCGIPYYCEE
                     LLKNLDHHRVLLFQQAETEQKTNVTWNNMFKHSVRPTDDMQLFTSISEGQKEVCYLVS
                     GVRLNNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKM
                     MIKALATLVESNVFNCFRSSKDLQLALKQNVPTFEVHYRSLALKLKEGLTYGEEEELR
                     EMEGEVVECRILRFCRPIMQKTAYELWLKDQKKVLHLKCARFLEESAHRCNHCRNVDF
                     IPYHHFIVDIRLNTLDMDTVKRMVTSQGFKIDEEEAIFSKSELPRKYKFPENLSITEI
                     REKILHFFDNVILKMKSSPNDIIPLESCQCKELLQIVILPLAQHFVALEENNKALYYF
                     LELASAYLILGDNYNAYMYLGEGERLLKSLTNEDSWSQTFEYATFYSLKAEVCFNMGQ
                     MVLAKKMLRKALKLLNRMFPCNLLTLTFQMHVEKNRLSHFMNQHTQEGSVPGKKLAQL
                     YLQASCFSLLWRIYSLNFFFHYKYYGHLAAMMEMNTSLETQNDFQIIKAYLDFSLYHH
                     LAGYQGVWFKYEILVMEQLLNLPLKGEAIEIMAYTADTLGHIKFLMGHLDLAIELGSR
                     AHRMWSLLRNPNKYQMVLCRLSKPLFLKSRYKHLVQVLGWLWDLSVTEEDIFSKAFFY
                     FVCLDIMLYSGFIYRTFEECLEFIHHNEDNRILKFQSGLLLGLYSCIAVWYARLQEWD
                     NFNKFSDRAKHLVTRRTPTVLYYEGISRYMEGQVLHLQKQIEEQAENAQDSGVEILKA
                     LETLVAQNTTGPVFYPRLYHLMAYVCILMGDGHSCDFFLNTALELSETHGNLLEKCWL
                     SMSKEWWYSASELTGDQWLQTVLSLPSWDKIVSGKGGQRKRSWSWFCPPNFSMVSWSQ
                     PQCA"
     exon            362..466
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            467..505
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            506..649
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            650..855
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            856..952
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1041
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1233
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1352
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1429
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1619
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1675
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1832
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2025
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2112
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2387
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2524
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2650
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2929
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3220
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3290
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3522
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3630
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3806
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3960
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..4165
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4262
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4263..4378
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..4496
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..4692
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4693..4881
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4882..4974
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
     exon            4975..5209
                     /gene="Adcy10"
                     /gene_synonym="4930431D04Rik; 4931412F17; sAC; Sacy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaactgtca tttgatgggt caggtatgga cagacatggc acttctgctg tcttcagaat
       61 aataacacca gacccctttc ctgttctctg cattcctgaa agatctagtc cctaatctag
      121 gctcgagctt ctccacagtc ttggagaaca gagaagacct acttggggag acagtttcct
      181 ggtgctgaaa aatcctgacc attgtccttg aacatgagtg cgcgaaggca ggaattacaa
      241 gacagggcaa tcgtcaagat agctgctcac ttaccagacc tcatcgtcta cggagatttc
      301 tctccggaac ggccgtcagt aaaatgtttt gatggagttc tgatgtttgt tgatatttca
      361 ggttttactg caatgactga gaagttcagc acggccatgt acatggaccg aggagccgaa
      421 cagctcgtgg agatcctcaa ctactacata agtgccatag tggagaaagt gctgattttt
      481 ggaggagaca tcctaaaatt tgcaggtgat gccttgctgg ccctgtggaa agtggaacga
      541 aagcaactga agaacatcat cacggtggtg attaagtgca gcctggagat ccatggcttg
      601 tttgaagcca aggaggctga agaaggcctg gacattcgag ttaagatagg gctggctgct
      661 ggccacatca ccatgttggt ctttggggat gaaacacgga actacttcct ggtgattggc
      721 caggcggtgg atgatgtccg ccttgctcag aacatggctc agatgaacga cgttattttg
      781 tcaccaaact gctggcagct ctgtgatcgg agcatgattg aaattgagag gattccagat
      841 cagagagcag ttaaggttag cttcttaaaa ccacccccaa cctttaattt tgacgagttt
      901 ttcacaaaat gtatgggctt catggattat tatccttctg gtgaccacaa aaacttccta
      961 aggcttgcct gcatgctgga gtctgatcct gaactcgagc tgtctctaca aaagtacgtg
     1021 atggaaatca ttttgaagca gatcgatgac aagcagctgc ggggctattt atctgagctt
     1081 cgccctgtga caattgtgtt tgtgaacttg atgtttaaag agcaagacaa agtagaagtc
     1141 ataggctcag ccatccaagc tgcctgtgta cacatcactt ctgtcttgaa ggtcttccga
     1201 ggccagatca ataaggtctt catgtttgat aagggctgct ccttcctctg tgtcttcggc
     1261 ttccctgggg aaaaggctcc cgatgagatc actcatgcgc tggaaagtgc cgtggatata
     1321 tttgacttct gctcccaggt ccacaaaatc cgtactgtct ccatcggtgt tgccagtggg
     1381 attgtcttct gtgggatcgt tggacacact gtgagacatg agtacacagt catcggtcag
     1441 aaggtcaaca ttgctgccag gatgatgatg tactacccgg gcatcgtgag ctgcgactct
     1501 gtcacctacg atggcagcaa cctaccagcc tactttttta aggagcttcc gaagaaagtt
     1561 atgaaaggag ttgcagatcc tggacccgtg tatcagtgtt tgggcctcaa tgagaaagtc
     1621 atgtttggta tggcatatct catctgcaac agatatgagg gctacccttt gctgggacgt
     1681 gttagggaga tcgactattt catgtctact atgaaggact ttttgatgac gaactgcagc
     1741 cgagttctaa tgtatgaagg attaccagga tatggaaaaa gccaggtact catggaaatc
     1801 gaatatctgg cctctcagca tgagaaccac agggctgttg ctattgcact gactaagatc
     1861 agcttccatc aaaattttta tactatccag atactcatgg ctaatgtact aggtctggac
     1921 acttgtaaac attacaaaga acgacagacc aatcttcaaa atagagtcaa gacgctgttg
     1981 gatgagaagt tccactgtct tcttaatgac atcttccatg ttcagttccc tgtttcccgg
     2041 gagatgtcca ggatgagcaa gataagaaag cagaagcaac tggaagccct gtttatgaag
     2101 atcttggcgc aaacagtgag agaagaaagg attattttca tcatcgatga ggcccagttt
     2161 gtggatggaa cctcctgggc cttcatagag aagctcatcc gctctatgcc catcttcatc
     2221 gttatgtccc tggctccttt ctctgaagtt ccctgtgcag ctgccaatgc cataatgaag
     2281 aaccggaaca ccacctacat cacgcttggt accatgcagc ctcaggaaat ccgggacaag
     2341 gtctgtgttg accttagtgt aagcagcatc cccagagagc tcgactcgta cctggtagag
     2401 ggaagctgcg ggattccgta ttactgtgaa gaattgctga aaaacctcga ccaccacaga
     2461 gttctccttt ttcaacaagc agagactgag caaaagacaa acgtgacctg gaataacatg
     2521 ttcaagcact ctgttaggcc aacagatgac atgcaacttt tcacttccat atctgagggg
     2581 cagaaagaag tctgttacct tgtgagtggt gtcaggctga ataatttgtc acctccagca
     2641 tcgctaaaag agatatctct ggtccagctg gacagcatga gcctttccca tcagatgctg
     2701 gtgagatgcg ctgccatcat tggcctaacc ttcaccacgg agctgctgtt tgagattctc
     2761 ccctgctgga acatgaagat gatgatcaag gccctggcca ccctagtgga atcaaatgtt
     2821 ttcaattgct tccggagtag caaagatctt caactagcct taaaacaaaa tgtgccaaca
     2881 tttgaggttc attatcgctc tttggccctg aagctcaagg aagggttaac ttacggcgaa
     2941 gaggaggagc tccgtgagat ggaaggagag gtggttgagt gccggatcct tcggttctgc
     3001 agacccataa tgcagaagac agcctacgaa ctgtggctca aggaccagaa gaaagtcttg
     3061 catctgaaat gtgcccgctt tttggaagaa agtgcccatc ggtgcaacca ctgcagaaac
     3121 gtagacttca ttccctacca ccatttcata gtggacattc gactcaacac tttggatatg
     3181 gacactgtca agaggatggt gacatcccaa ggatttaaaa ttgacgaaga ggaagccatc
     3241 ttttctaagt cagagctccc taggaaatac aagttccccg agaatctcag catcacagaa
     3301 ataagggaaa aaatcttgca tttctttgac aatgtcatcc taaagatgaa atcgtctcca
     3361 aatgacatca tccctctgga atcctgccag tgtaaggaac tgctccagat tgtcatcctg
     3421 cctctggccc aacatttcgt agccttagaa gaaaacaaca aagccttgta ctacttccta
     3481 gaactggcat ctgcctacct catcctggga gacaactata atgcgtacat gtatttgggc
     3541 gagggagaaa ggctgctgaa atctctgacg aatgaagatt cttggagtca gacctttgaa
     3601 tatgctacct tttatagtct caaggctgag gtctgtttta acatggggca gatggtcctc
     3661 gccaagaaga tgctgaggaa ggcgctgaag ctgctcaaca gaatgtttcc ctgcaatctg
     3721 ctcaccctga ctttccaaat gcatgtggag aaaaacagac tctcccactt catgaaccag
     3781 catacccagg agggctcggt gccagggaag aaactggcac aactttacct gcaagcttcc
     3841 tgcttctcct tgctgtggag gatctacagc ttgaacttct ttttccacta caagtattac
     3901 ggtcatctgg ccgcgatgat ggaaatgaac acttccctgg aaactcaaaa tgacttccag
     3961 atcatcaagg cttacctgga cttttccctg taccaccacc tcgctggcta ccagggcgtg
     4021 tggttcaaat atgaaatact ggtcatggag cagctcctga acctccccct gaaaggcgag
     4081 gccattgaga tcatggcgta tacagccgac acactgggcc acatcaagtt cttaatgggt
     4141 catctggact tggccattga gttaggctct cgagcccaca ggatgtggtc acttcttcgg
     4201 aatcccaaca aataccagat ggttctctgc agactgagta aacctctttt cttgaaaagc
     4261 agatataaac atttggtcca ggtgctggga tggttgtggg acctttctgt aacagaagag
     4321 gacatcttca gcaaggcatt tttctatttc gtctgcttgg acatcatgct ttattctggc
     4381 ttcatttaca gaacatttga agaatgcttg gaattcatac accacaatga agacaacaga
     4441 atcctcaagt tccagagcgg actcctcctg ggactttact cctgcatcgc tgtctggtat
     4501 gccagacttc aagagtggga caactttaac aaattttccg acagagctaa gcatctcgtg
     4561 acacgaagaa ccccgacagt tctttactac gaagggatct ctaggtacat ggaagggcaa
     4621 gtcctccact tgcagaagca aatagaagaa caggccgaga acgctcagga cagtggggtg
     4681 gagatactca aggccttgga gacccttgtg gctcaaaata ccaccggccc cgtcttctac
     4741 ccgaggctct accatctgat ggcctatgtc tgcatactaa tgggagacgg gcacagctgt
     4801 gacttcttcc tgaacacagc cttggagctt tctgagacac atgggaattt gctggagaaa
     4861 tgttggctaa gcatgagcaa ggaatggtgg tactcagcct ccgagttaac aggagatcaa
     4921 tggcttcaga cagtcttgag tcttccatca tgggataaaa ttgtatcagg caagggaggt
     4981 cagaggaaac gttcgtggag ttggttctgt ccccccaact tttcaatggt ttcctggagt
     5041 caacctcagt gtgcatgacg gcttggagct gcacaggatt gcaaatgtca agcctctgtc
     5101 gaggtctgaa gcagcaagat tagaaagaat aaagttgtct gtgccagctt ccggagccat
     5161 ggtggtgccc cacaggcacc tcacatctgt acaaataaaa gctttaagt
//
