LOCUS       NM_009622              12315 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus adenylate cyclase 1 (Adcy1), mRNA.
ACCESSION   NM_009622 XM_483980
VERSION     NM_009622.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12315)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 12315)
  AUTHORS   Shi,W., Chen,Q.Y., Ma,Y., Wan,J., Li,X.H. and Zhuo,M.
  TITLE     Selective enhancement of fear extinction by inhibiting neuronal
            adenylyl cyclase 1 (AC1) in aged mice
  JOURNAL   Mol Brain 17 (1), 11 (2024)
   PUBMED   38389098
  REMARK    GeneRIF: Selective enhancement of fear extinction by inhibiting
            neuronal adenylyl cyclase 1 (AC1) in aged mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12315)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12315)
  AUTHORS   Zhang,M. and Wang,H.
  TITLE     Ca2+-stimulated ADCY1 and ADCY8 regulate distinct aspects of
            synaptic and cognitive flexibility
  JOURNAL   Front Cell Neurosci 17, 1215255 (2023)
   PUBMED   37465213
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12315)
  AUTHORS   Ren,L., Thai,P.N., Gopireddy,R.R., Timofeyev,V., Ledford,H.A.,
            Woltz,R.L., Park,S., Puglisi,J.L., Moreno,C.M., Santana,L.F.,
            Conti,A.C., Kotlikoff,M.I., Xiang,Y.K., Yarov-Yarovoy,V.,
            Zaccolo,M., Zhang,X.D., Yamoah,E.N., Navedo,M.F. and
            Chiamvimonvat,N.
  TITLE     Adenylyl cyclase isoform 1 contributes to sinoatrial node
            automaticity via functional microdomains
  JOURNAL   JCI Insight 7 (22), e162602 (2022)
   PUBMED   36509290
  REMARK    GeneRIF: Adenylyl cyclase isoform 1 contributes to sinoatrial node
            automaticity via functional microdomains.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12315)
  AUTHORS   Villacres,E.C., Wong,S.T., Chavkin,C. and Storm,D.R.
  TITLE     Type I adenylyl cyclase mutant mice have impaired mossy fiber
            long-term potentiation
  JOURNAL   J Neurosci 18 (9), 3186-3194 (1998)
   PUBMED   9547227
REFERENCE   7  (bases 1 to 12315)
  AUTHORS   Welker,E., Armstrong-James,M., Bronchti,G., Ourednik,W.,
            Gheorghita-Baechler,F., Dubois,R., Guernsey,D.L., Van der Loos,H.
            and Neumann,P.E.
  TITLE     Altered sensory processing in the somatosensory cortex of the mouse
            mutant barrelless
  JOURNAL   Science 271 (5257), 1864-1867 (1996)
   PUBMED   8596955
REFERENCE   8  (bases 1 to 12315)
  AUTHORS   Villacres,E.C., Wu,Z., Hua,W., Nielsen,M.D., Watters,J.J., Yan,C.,
            Beavo,J. and Storm,D.R.
  TITLE     Developmentally expressed Ca(2+)-sensitive adenylyl cyclase
            activity is disrupted in the brains of type I adenylyl cyclase
            mutant mice
  JOURNAL   J Biol Chem 270 (24), 14352-14357 (1995)
   PUBMED   7782295
REFERENCE   9  (bases 1 to 12315)
  AUTHORS   Edelhoff,S., Villacres,E.C., Storm,D.R. and Disteche,C.M.
  TITLE     Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in
            mouse
  JOURNAL   Mamm Genome 6 (2), 111-113 (1995)
   PUBMED   7766992
REFERENCE   10 (bases 1 to 12315)
  AUTHORS   Wu,Z.L., Thomas,S.A., Villacres,E.C., Xia,Z., Simmons,M.L.,
            Chavkin,C., Palmiter,R.D. and Storm,D.R.
  TITLE     Altered behavior and long-term potentiation in type I adenylyl
            cyclase mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (1), 220-224 (1995)
   PUBMED   7816821
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669838.22.
            
            On Jul 6, 2018 this sequence version replaced NM_009622.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF053980.1, SRR1660815.134107.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-803               AL669838.22        55322-56124
            804-953             AL669838.22        70777-70926
            954-1072            AL669838.22        92459-92577
            1073-1184           AL669838.22        100890-101001
            1185-1312           AL669838.22        122165-122292
            1313-1471           AL669838.22        129162-129320
            1472-1613           AL669838.22        130176-130317
            1614-1769           AL669838.22        130923-131078
            1770-1964           AL669838.22        136567-136761
            1965-2062           AL669838.22        136930-137027
            2063-2147           AL669838.22        138398-138482
            2148-2237           AL669838.22        141391-141480
            2238-2491           AL669838.22        141851-142104
            2492-2618           AL669838.22        142666-142792
            2619-2735           AL669838.22        152095-152211
            2736-2882           AL669838.22        153168-153314
            2883-2981           AL669838.22        153741-153839
            2982-3096           AL669838.22        157301-157415
            3097-3221           AL669838.22        158953-159077
            3222-12315          AL669838.22        161302-170395
FEATURES             Location/Qualifiers
     source          1..12315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.72 cM"
     gene            1..12315
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /note="adenylate cyclase 1"
                     /db_xref="GeneID:432530"
                     /db_xref="MGI:MGI:99677"
     exon            1..803
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..3524
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /EC_number="4.6.1.1"
                     /note="barrelless; adenylyl cyclase 1; adenylate cyclase
                     type I; ATP pyrophosphate-lyase 1;
                     Ca(2+)/calmodulin-activated adenylyl cyclase"
                     /codon_start=1
                     /product="adenylate cyclase type 1"
                     /protein_id="NP_033752.1"
                     /db_xref="CCDS:CCDS24426.1"
                     /db_xref="GeneID:432530"
                     /db_xref="MGI:MGI:99677"
                     /translation="MAGAPRGQGGGGGAGEPGGAERAAGPGGRRGFRACGEEFACPEL
                     EALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFL
                     ALFVVTNVRSLQVSQLQQVGQLALFFSLTFALLCCPFALGGPARSSAGGAMGSTVAEQ
                     GVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANAL
                     LFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAM
                     EMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKF
                     DELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDL
                     NMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGD
                     YEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLV
                     QLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNR
                     YISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGL
                     IYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLI
                     YSVAQGCVVGCLPWAWSSQSNSSLVVLAAGGRRTVLPALPCESAHHALLCCLVGTLPL
                     AIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLA
                     LHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNM
                     DLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKD
                     LEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLCTLADFAIDMFDVLDEINYQSYNDF
                     VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLKRC
                     SYQFVCRGKVSVKGKGEMLTYFLEGRTDGNSSHGRTFRLERRMCPYGRGGGQARRPPL
                     CPAAGPPVRPGLPPAPTSQYLSSTAAGKEA"
     exon            804..953
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1072
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1184
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1312
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1471
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1613
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1769
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1964
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2062
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2147
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2237
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2491
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2618
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2735
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2882
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2981
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3096
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3221
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..12315
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6656..6661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /note="hexamer: GATAAA"
     regulatory      6681..6686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /note="hexamer: GATAAA"
     polyA_site      6688
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /note="major polyA site"
     polyA_site      6705
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
     regulatory      12288..12293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
                     /note="hexamer: AATAAA"
     polyA_site      12293
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
     polyA_site      12315
                     /gene="Adcy1"
                     /gene_synonym="AC1; brl; D11Bwg1392e; I-AC"
ORIGIN      
        1 gcgctcgggg cgcgcgcgct gggcagccgg cgccccaact ccgcccgccc cgcgccccgg
       61 cgcctcgccg cccgccgccc gcccgccccg gggccgccgg ccggcgcccc ggcgccccgg
      121 gccggcgagg ggcgcgcccg tggccgcggc cgctgcatgg cgctgagatg gcgggggcgc
      181 cgcgcggcca aggcggcggc ggaggcgcgg gcgagcccgg gggcgcagag cgggcggccg
      241 ggccgggcgg ccggcgtggg ttccgggcgt gtggcgagga gttcgcgtgc cccgagctgg
      301 aggcgctgtt ccgcggctac acgttgcggc tggagcaggc ggccacgctg aaagcgctgg
      361 ctgtgctcag cctactggcg ggcgccctgg cgctggctga gctgctgggc gcaccggggc
      421 cagcgccggg cctcgccaag gggtcgcacc cagtgcactg catccttttc ctggcgctgt
      481 tcgtggtcac caatgtccga tccctgcagg tgtcccagct gcagcaggtc ggtcagctgg
      541 cgctgttctt cagcctcacc ttcgcgctac tctgctgccc cttcgcgctg ggcggccccg
      601 cgaggagctc tgcaggaggc gcaatgggct cgacggtcgc cgagcagggg gtttggcaac
      661 tccttttggt caccttcgtg tcctatgcct tgctgcccgt gcgcagccta ctggccatcg
      721 gcttcgggct ggtggtggct gcctcgcact tactggtcac agccgccttg gtccctgcca
      781 agcgcccacg tctctggagg acgctcggtg ccaatgccct gctcttcttt ggtgtgaaca
      841 tgtatggcgt cttcgtgcgg atcttgacag agcgctccca gaggaaggcc ttcctgcagg
      901 ctcgaaactg cattgaggac cggctgcggc tggaggatga gaatgagaag caggaacggt
      961 tgctcatgag cctcttgccc cggaatgtcg ccatggagat gaaggaagac ttcctgaagc
     1021 cccctgagag gatttttcac aagatttaca tccagaggca tgacaatgtg agcatcctgt
     1081 ttgcagacat cgtgggtttc acaggtctgg cgtcccagtg cacagcccag gagctggtga
     1141 aactgctcaa tgaactcttt ggcaagttcg atgagttagc cacggaaaac cactgtcgcc
     1201 gaatcaagat ccttggtgac tgctactact gtgtgtctgg cctcacccag cctaagacgg
     1261 atcacgccca ctgctgtgtg gagatgggac ttgacatgat cgataccatc acatccgtgg
     1321 ctgaggctac tgaagtagac ctgaacatgc gtgtgggcct acacaccggc agggtcctct
     1381 gtggtgtcct gggcctacga aagtggcagt atgatgtatg gtccaatgac gtgaccctgg
     1441 ccaatgtcat ggaggctgct ggcttaccag ggaaggtcca catcacaaag acgaccctcg
     1501 cgtgcttgaa cggggactac gaggtggagc caggtcatgg ccatgagagg aacacctttc
     1561 tgagaactca caacattgag accttcttta ttgtgccatc ccatcggagg aagatattcc
     1621 caggcttgat tctctcggat atcaaaccag ccaagaggat gaagttcaag actgtgtgct
     1681 atctgctggt gcagctcatg cactgccgga aaatgttcaa ggctgagatc cccttctcca
     1741 acgtgatgac ctgcgaggat gacgacaagc ggagggcatt gagaacagcc tcggagaagc
     1801 tcagaaaccg ttcgtctttc tctactaatg tggtctacac cactccgggt acacgcgtca
     1861 acaggtacat cagccgcctt ctcgaagccc gccagacaga gctggagatg gccgatctga
     1921 acttctttac tctgaagtac aaacatgtcg aacgagaaca aaaataccac cagcttcagg
     1981 acgagtactt caccagcgcc gttgtcctcg ccctcatcct ggctgcctta tttgggctta
     2041 tctaccttct ggtaatccca cagagtgtgg ctgtcctgct gctgctggta ttttccatct
     2101 gcttcttggt ggcctgtacc ctgtacctgc acatcacgcg ggtccagtgt tttccagggt
     2161 gcctgacgat ccagatccgc accgccttgt gtgtgttcat agtggtctta atctactcgg
     2221 tagctcaagg ctgtgtggtg ggctgcctgc cctgggcctg gagctctcag tctaacagtt
     2281 ccctagtggt cctcgcagct ggtggccggc gcactgtgct gcctgccctg ccctgtgagt
     2341 ctgcacacca tgccctgctc tgctgcctgg tgggcaccct cccactagcc atattcctgc
     2401 gggtgtcctc cttgccaaag atgatcctgc tgtctgggct gactacttcc tacatccttg
     2461 tcctggagct cagtggatac accaaggttg ggggcggtgc cctctctggg cgcagctatg
     2521 agccaatcat ggctatcctg ctgttctcat gcacgctggc cctgcacgcc aggcaagtgg
     2581 atgtcagact acggctggac tacctctggg cagcacaggc ggaggaggaa cgggatgaca
     2641 tggagagagt caagctggac aacaagagga tcctcttcaa tctcctgcca gctcacgtcg
     2701 cacagcactt cctcatgtcc aatccccgga acatggacct ctactaccag tcctactccc
     2761 aggtgggcgt catgtttgcc tccatcccca acttcaatga cttctacata gaactggatg
     2821 gcaacaacat gggtgttgag tgtctgcggc tcctcaacga gatcattgcc gactttgatg
     2881 agctcatgga caaggacttc tataaggacc tggagaagat taagaccatt gggagcactt
     2941 acatggctgc cgtggggctg gcgcccacag caggaaccag ggctaagaag tccatctcct
     3001 cccacctatg cacactggca gacttcgcca tcgacatgtt tgatgttctg gatgaaatca
     3061 actaccagtc ctacaacgac tttgttctcc gagttggcat caacgttggc cccgtggttg
     3121 ctggagtgat cggtgctcgc aggccccagt acgacatctg gggaaacaca gtcaatgtgg
     3181 ccagtcggat ggatagcact ggggtccagg gacgaattca ggtgactgag gaagtccacc
     3241 ggctgctgaa gaggtgctca taccagtttg tgtgcagagg caaagtcagc gtgaagggca
     3301 agggagagat gctaacgtac tttctagaag gcaggactga tggaaacagt tcccacggca
     3361 ggacctttcg cttggaacga aggatgtgtc cttatgggag aggcggaggc caggccagac
     3421 ggcccccact gtgtcccgcg gctggacccc cagtcagacc agggctccct ccagccccca
     3481 ctagccagta cctgtcatcc acagcagcag ggaaggaagc ctagtggagc ccatgggcca
     3541 ctggagatgc atgcaaggca agaatgctcc agggtgtcac aagccaccat ggctctagcc
     3601 aggaccagac agaggagcca agtggctggg ctggaggaga agcattgtct gagtgtggcc
     3661 tgaggccaat gggaaatgtg cccaagccac cccttggggc acactgagct ctgtctcttc
     3721 ctaatgacct ggttatgcct ggctagtgtt gccataggtg gcgggacctt gggagtatct
     3781 tccatggtca cagcaaaagc tatggaggtc aagctggcag aggagcccac catgactgag
     3841 ccccaagtca actggcttat gggtggctcc agccctggta agccctggct tatgggtggc
     3901 tctagccctg gtaggtcctg gcttatgggt ggctccagcc ctggtaagcc ctggcttatg
     3961 gatggctcta gccctggtag gtcctggctt atgggtaact ccaagcctgg gtagcagttt
     4021 caagtatgag tgccagactg ggaagttggc cccgctgggc agggccatga cagttgagct
     4081 gttcatacca tgggcacagc aaagagctgg tcaggtcttg gtcagggcag tatgggaaga
     4141 attgaaaaga cacctcttac tgcatgaaga gcggggttgc tggctttccc caagagtagg
     4201 ctcttgctaa cagccagagg caggtcttct ggaattctcg ggaggcccta cagccccact
     4261 tctgatctcc tggcccgtac attctcttcc aacccctcct ggctgctggc ttctgactgc
     4321 tgcgacagtg ggccctcctc ttcctgtgcc atggctgcac attcagagag gaggggtgtg
     4381 tgctgtcttc tctgtggtgt cttggacgct gtaagtctaa caagaatcaa gccttcgttt
     4441 atgctaagag cgattgaccc actataccca cgagtgctct ccttgctgga agacatcctc
     4501 tccttggcct aaccagctct cctcttggtg gtttcagagt cggcacagtg tgcattcctg
     4561 agtctaggtg tggtgtccct gctccagggt gatgggaaag agtggccctg ttgactgaca
     4621 cctgggacct cccacctgtg tgtcccagta actgcaactg tgaggaaatc ccgttagggt
     4681 acaggattct ggaggagttg gtaggaagca actggctgga aatagcggga tgaagcctgg
     4741 cttttgaaga tactcagttt caatacagga agggaggcag cttgaagcag ggcaggtggg
     4801 cataagccct gcctgatctt gtctgtggag gcccatttcc tcacggctcc ccaagagctt
     4861 gcccccttcc aagggtccta tcttcttaga atagggcaga gcaaagccta gttttccccg
     4921 gcagggtgca tatgtggtgt tctggattca gctctggttc aagtgtgtgg ctttgttggt
     4981 gcctgggtaa ttttccaggt cagccagcgc ccgttcctgg gacactcagc tgagtctaga
     5041 ctcaggttac ctgtgggtag gaagaaaact ttcagcaagg gagagctgga ggctgcatgc
     5101 caagtctcca agtctttgag gctgcacctc aggtgcccta gggccgggtg gggcagctgt
     5161 gaagattgca cattctctgt ggccagggat ggagcttgtg ggtggtggta agggtatcat
     5221 ctagcacctt ctgcagagga actctgaccc atgcccaccc tgctttgttg cctttctgat
     5281 gatatcaggt agcacggcct gggcattgtc ggctgccttt ctgtcagccc actgtggcta
     5341 gaacccagag ccagggccag actgacttca gcactccact gcagccttca gggttggaga
     5401 gcaggtagct tcatcgtcct ccggtggtca tgtctggttc ctgaggcgtg gtattttgtt
     5461 gtaacagtgt tgggggagaa tgctggctcc cagagagttg agggcagcag gacaggcttt
     5521 tggtttctcc catggccctg aagaccatct taagattgca cttataagaa agattcaggt
     5581 tgttggggcg ctctgagaag gggcagattc ctctgagcca gaacctaggt aggcatgcga
     5641 gcactctttc tttgtggctc ctgcctcctg cccgtcccca ggtgttccta tccttgggac
     5701 aaatggcttt tcctcatggg gctcttttgc actaggaatt tctcacctcg tctgtctgtc
     5761 ttgcagtcag ctcagccagg agcacccaga gcaagtgagt atatggtgac tttggctgag
     5821 ggctgtggca ctgtccctgg ccttccaggc cactgaggag ggtagagaac ctctcacaca
     5881 gcctggagtt cctcagagtg gcttctaggc acccagaact agtgcctctc tggctgatca
     5941 gatgagggac agaagagtgg ttctcaaaga tgcccacatg acagccccag gtcctgtgtg
     6001 tcctttgcca cagtggagga ccttgacaag gggacttagg gtaggtaggc ctgaaggatt
     6061 gagaaaggat tgagaaagtc tacaccaatg ggtttagtgt ggacacaggg cccctcagaa
     6121 gtggacagaa agatgcccag gactgagtct ctgttgctga cctgaagatg aggacatgaa
     6181 atacattgaa gagacttagg aggacagcac agctccagcc agcaaagaag ccaggatgtc
     6241 acgcacgccc ataaccacaa ggagctgaaa ctggccaaag cctgagtata cagcaggcag
     6301 accatcagag ccatgaggga ggaggccagc cagtggcccc tggatctgac ctatatgacg
     6361 ctgagcagag ccagcctagg tcgataacac tgcaatcacg catgcgtgtg tcaaaccgag
     6421 gccacatggg tgcatgggca gagccaccca aggtgtggtc agagtgagag aaagcaacct
     6481 ttaggatgac actgccttct ctgggcacag gactgttctg aagcagacca cacaggagcc
     6541 ttggctgggt ctcttcttca ggggcgacat ctccatcatc agcaattcca aacccgccta
     6601 cttcctgtga ggtcaggaac cacacgtgca gccataatgt accttggggt ttggtgataa
     6661 acaaccttct ttttacttgt gataaaaatg tattatattg ccttatttat ttttaatctt
     6721 gtacaatatt catgtacaaa tgttagagcc atttaggtag gattctctcc aaattattta
     6781 ttttaagatg ctctgtaaat agtgcaccag ttacaggtgc ttgatcactt gtaccaaaaa
     6841 tgaggaaaag cctggtaccc acttcagccc ctcttgtaat gccgtggccc ttgggaaatg
     6901 accctgttgt gttcccttcc cgcccctagc atgcctcccg tgcctgacac catagaatag
     6961 aacacagccc cagaatgctt ccaaatgctt ccatgggctg tgccatcctg ggacagtcca
     7021 ctcctggggt gtccatacct acaggtgtat gtccccccca cacacagcaa tccagttgtt
     7081 tctcagactc caaagccacc agggcttccg gaccccttct gtcatagaag caataaccat
     7141 aacctaatac tgtagagaca agtctggccc aagcagattg ctattccaga aactacctgt
     7201 gcatgtgaga ttgctataaa ggactgacat ccaagtcccc catccctccc agaaggccta
     7261 gctctagctt cttggttcct acagccagga ttggtacaca cacaccccgc cctccaagat
     7321 atagctgagc ggactgagcc agccaccagt cctgggcccc actattgtca ctaaggaata
     7381 aaggtgaggg cagccttccg atccttatat ctatacctat ccttgaatcg tgatgtttta
     7441 tgtgactgag ggtcgtgatg gtttgtttca gtgttgcaac attgaaaggt acttgtggca
     7501 tattccaggt ggcacatctg gtgggaaaag ggcacccccg agggtatatc aggaaagagc
     7561 tagaaagggc tgactgagga ttcaggctgt gggcttggct ggcagatatg agcggcttcc
     7621 agagagctca cattgtattt acacgtgagc tgaaggactc ttgtaccact gtgctaacag
     7681 caacccgctg agactgtgca aatgacttgc tttaacgggg tgagtaagag ggaaacagtt
     7741 tggactgtgg aataggggaa gagttcactc aagtctccca gccaccctca gcaggtaagt
     7801 tctaggactc tccaagtccc agggatcttt tacagcctgt gcagaacttc tgtcagtgga
     7861 cgtttggagg catggttgta tagagcaagc atctaccctt cacgtaatag tggcagggaa
     7921 agaacactgc tacatacact gcacacccgt cagcaccatg ctgcagaagg gatgctgata
     7981 ttttacattc ttacatggct gtacatatgt agccaccaga aactgacttg ctcgtgcttt
     8041 ttaatggctt caacttgcaa agggtgtgct tggcttgata aaattaataa agagcaagga
     8101 tggcagcttg gatattatgt gggtctttga agcatcttgc ttctctagct gtgattggct
     8161 ttgaatgttt ctatagcagg cttgaaccaa tagctcattt ctatttacaa ctataggctt
     8221 ggcaggaggt tgatggttaa aagtgtgtat gcatatgcac ttgcacacat acacatgtac
     8281 acacacacaa ttttcatagg gaatatgaga gttggtttgt aatcctgacc ccttaggctg
     8341 ggggttagag gagctgcttg gagatgtcct tggactcaga gttcagaagg caaaattgag
     8401 cctccctcag ctggcctggg gaaagaacct ctcaggcgaa agaggtctca atccaggaac
     8461 tgaggcacct agataactat cttatacata aatcattccg agctctttga caccagagag
     8521 aaaacgtgtt gatatgttca cagcagacac gatgaatgtg gttgaaatgg atgctgtttg
     8581 acccaaagca actcctgtac ctacatagtc aaccagtgcc acatggacca agaccaatgt
     8641 ggatccagag gcacagacct agagccagga gccttcctag gggacggcag aaggtgtgtg
     8701 gcctggccag aggattcact cctgaagtgt agggtgggca cagtacggaa gggcaagggc
     8761 atattcagga aggctcctgc tgctcactgg taggagaatt ctggagagtg tcatctcaca
     8821 tatagagttg gatgacctgg ggtggcctgg tcctgatgct ggctgatgac tgctgcacga
     8881 ggggttcttc ctagctagag gccatctgtg atgctctgtg ggctggaggc aaggaggatg
     8941 tggtaggttc tagtggctgt tacacaaggt ctggcacacc gtgagcacaa cttcacacag
     9001 acacactgag tcatgcaagg caggtgtcga caccctgcag agtctgcctc acctccaaga
     9061 attcagaggg cacttttgga tggatatggg aacccttgtt tattccttgt gagcacaggt
     9121 ccaataatag gagatgagat ctgtcactct gtggttcatt ccataaatgc ttcagatcca
     9181 acttcaagtg ccacattctg tcactaaaca attatccaat caacacatca ttatctaatg
     9241 actaagacat ttgggttttt aaggtttctg accagtttaa tccattctgt tccacacata
     9301 ccagatctgt tcagtagctt ataaaacaaa aattactcca ctagaggctg tgcttaattc
     9361 aaatcaatgt gtgttcctgc gcatgtgtgt gtgcatgtgg gtagacatgt gcatgcatgt
     9421 ctaataagac ataaaattat tctccctggg gttaagatta ctcactgaag aaaaataaat
     9481 acatttgaat atagtgagct gtcacttggg acacttgata tcctataagc tgaggcagca
     9541 cacaccatcc ccttccctcg ctccagggag ggagggggat gggcacatcc ctgagccact
     9601 cagcctacta ctaagtctct tttgcaaaaa gaccgatata atagcatcat tctggtctgg
     9661 gtgcataaag agaccctgtt gctcctgtct ctcttgtctt gttggactga gagtttgggt
     9721 gtatgttgac tattgtgcag agtaggtggt aactccacat gccgggtggg tgtccatcca
     9781 aactctgagg agggaacaaa atgacatcaa cctcaggtac atgagccctt ccctgccctc
     9841 catgttctag gagctgacgt ggaggccaca cctttcatct ggcgtgtcag ctgttgcctg
     9901 tctgggttat ccagtgggaa gaacaaggct caggaggcta tcttgggttg tgtttcctaa
     9961 gtagctggaa aaagaaagtc ttaaaattca gaaaattaac caccatcatg ccacatcctc
    10021 ggtcctgcca agtgctggtc atttaaaatt ctaacgaatt ttcttcagca tgttgctagg
    10081 cctgctcagt ccacactcac acaaggaagg tcaatcatta ccgccccatt agcaaacacc
    10141 tttaggggcc tttggtatgg gggtaaattg atcaaacatt cattcctagt acttccattt
    10201 agttttgcaa ttccagggcc ccttctgtgg gctccttgtt catgggaagg aagtggtttg
    10261 ctaatactca atacacattg tcctgagaat gtgaggcaga gagggagggg ccagacctca
    10321 actgctcatc tgatcaggcc aagctgcgcg ttttctgttg cagttaaggt ctctgctaag
    10381 ccaggtgaaa tctgtaagaa ctaggctgct gttgatgcta tcgtctatac aacagtgctt
    10441 acccagtgtg gtgcagggca cctcatggac gcgggtctct tgtgggcaag agttgcttga
    10501 agcccacatt tggagcatgt ggccaagtgc tgtttggttc tgtatttctt ggcttcttgt
    10561 tgctaaattg gagccgtttg attcttttcc gatcagctgc attcctccaa ggttagagac
    10621 accattccga gcaagaaatt agaaccccgg cttcagcctt atagtgccct tgatagtctc
    10681 aaaggttttg aaatacaaac tgacattgtg tctagtggca tcttcttaaa tcaatttttt
    10741 tctgaaaggc ctgacatcga atagggacag agctatgaca ttcctgtaga gcccaagcca
    10801 cactgcccag ccagcctggc tccagttaca gctcttacat tcaatgctct catgcttcca
    10861 gcaggcaggc acagcaatga gggtgccttc ccagggactt ccctgggggg ttagagagag
    10921 ttctccagga gtgcatagaa agcaaggaag gggcaatggt gcatggcaga aagcatggct
    10981 gcctctccca tgttacagga gccccatacg ctttccaggc actggttcct gccgatgcca
    11041 gactacatcc acttcagatg tattggtttc caaacatttc cagccatttg ctgagaatta
    11101 gcatttcaac ggacatgcta tctgagactg actccagaaa tctcttagac ttcataaact
    11161 tgtaggattg cctgcaagaa catttgcagg ccacttagat ctgtctgggg tggtcccccc
    11221 tgctccatgg cacagcattg ggaagtgggc ctgacagcag ccagaaactt gtttctcacc
    11281 tcccaccagc aacctccact cagccccaga ccccaggcac atgaagcaca agtctcaggg
    11341 gaccgttccc atgctgtggg gagcccaagg aagcccccag catctcttgc atacaccact
    11401 ggcagtgtgg gcacaactgg ccaccaggag cacacatgcc tggggaagag gggcctgctc
    11461 tgttgccttc atccctgtta aaattgagta tatgcaagcc atttgcacta cggaattgca
    11521 tgccttgaaa ttccttactg tgtgcacctt agtttgaatt tgacgttatg tagcatgcac
    11581 aaaagaatgg atgggcttgg gcttgttccc aagtcacctc taccgctcat tgggagcaca
    11641 gtgctgccct cagccaatcc caggttccgt ggagcccgtg tggctccagc acttactgtg
    11701 cagtggctcc ctttcccacc gtgctccctt tcccaccgtg cccacttaag ctgatggctc
    11761 actaatttgc acaaatggaa ttgttatgat cacgtcttag cagtatcttg atttaaagta
    11821 agcccaaagc ccacttctgg agttccttac ttaaaaaaaa aaaaaagaaa agaaaaaaaa
    11881 aaggcatgtg taagcacctg tgtcctgtgt ttatcaagaa agctttgagt cccttagtgg
    11941 gatagagggt gcatggacaa agggggcatt ttatcccaca cgatacactt accagatgtg
    12001 tctgtagcta tgagaactcg atgattatat tcacaataac tcaatatcac tgggtaacct
    12061 ctcacaatag atttgtataa tcaatacggg tctattttta tgtcaactct gtagagcacc
    12121 ttccagtctt tttcaagatt gttaaatcga gatgagtaat tgaataattt gtcctatttt
    12181 tatttaaaaa gtgaatgaac tgaaatgtta atgtgaatgt acatttctta actgcaactt
    12241 ttctactgag tgtttgcact atactctctg gggtcttatt taacaaaaat aaaggagaaa
    12301 aattgcttga ctaaa
//
