LOCUS       NM_178873               3539 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus aarF domain containing kinase 2 (Adck2), mRNA.
ACCESSION   NM_178873
VERSION     NM_178873.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3539)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3539)
  AUTHORS   Vazquez-Fonseca,L., Schaefer,J., Navas-Enamorado,I.,
            Santos-Ocana,C., Hernandez-Camacho,J.D., Guerra,I., Cascajo,M.V.,
            Sanchez-Cuesta,A., Horvath,Z., Siendones,E., Jou,C., Casado,M.,
            Gutierrez,P., Brea-Calvo,G., Lopez-Lluch,G.,
            Fernandez-Ayala,D.J.M., Cortes-Rodriguez,A.B.,
            Rodriguez-Aguilera,J.C., Matte,C., Ribes,A., Prieto-Soler,S.Y.,
            Dominguez-Del-Toro,E., Francesco,A.D., Aon,M.A., Bernier,M.,
            Salviati,L., Artuch,R., Cabo,R., Jackson,S. and Navas,P.
  TITLE     ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and
            Causes Myopathy Associated with CoQ Deficiency
  JOURNAL   J Clin Med 8 (9), 1374 (2019)
   PUBMED   31480808
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3539)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 3539)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK028568.1.
            
            On Apr 5, 2007 this sequence version replaced NM_178873.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028568.1, AK161225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3539              AK028568.1         2-3540
FEATURES             Location/Qualifiers
     source          1..3539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.39 cM"
     gene            1..3539
                     /gene="Adck2"
                     /note="aarF domain containing kinase 2"
                     /db_xref="GeneID:57869"
                     /db_xref="MGI:MGI:1889336"
     exon            1..1331
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..2279
                     /gene="Adck2"
                     /codon_start=1
                     /product="uncharacterized aarF domain-containing protein
                     kinase 2"
                     /protein_id="NP_849204.1"
                     /db_xref="CCDS:CCDS20024.1"
                     /db_xref="GeneID:57869"
                     /db_xref="MGI:MGI:1889336"
                     /translation="MVTPWRLSVRVCLSHLRCFEFRKELGHSRPLGCSRNARLCWFLL
                     GTLPKLISAHGSVGEGAPGSLCQRKTHWSDLAENGLVEKVAQEGPLARVLLCLRLGLR
                     AGVLLAKFFPLLFLYPLTYLAPGLSTLWLHLLFKATETSGPTYIKLGQWASTRRDLFS
                     EAFCTQFSKLHVQVTPHPWARTEYLLQQAFGEDWGSLLFFETREPVGSGCVAQVYKAF
                     ASISLLEEDRIWRLGELSAPGTRAVVMQREPFMKDRKPSENLADEAFLEKLLLPKADL
                     GGSEVGVSQAPWHLPKSDHLIPVAVKVLHPGLLSQVSMDLLLMKIGSKALGLLPGVKW
                     LSLPEIVEEFEKLMVQQTDLRYEAQNLEHFQHNFQDMASVKFPTPLRPLITRDILVET
                     YEESVPVSSYQQAGIPTDLKRKIAQLGINMLLKMIFVDNFVHGDLHPGNILVQGADGV
                     SPSLEMQQQQVNVCDTLVATIAPALCPLRLVLLDAGIVAKLQASDLRNFRAVFQAVVM
                     GQGHRVAELMLHHAQANECKDVERFKAEMATLVTQARKNIVTLEKLHVSSLLSSVFKL
                     LMTHKVKLESNFASIVVAIMVLEGLGRSLDPTLDILEAAKPFLFKGPASFL"
     exon            1332..1478
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1607
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1703
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1955
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2084
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2138
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..3539
                     /gene="Adck2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2500..2505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adck2"
                     /note="hexamer: AATACA"
     polyA_site      2545
                     /gene="Adck2"
                     /note="major polyA site"
ORIGIN      
        1 ggaagctggg agcagcgctg gcccggacgc ttagtgctct ctctctctgc ctggttgtca
       61 ctgcccgctc tgtgcaggtc ccgagccatc ggctcggcat ctccgccgcc ccccgggagc
      121 ctggcccgtg agcccgccgg agcgcgcctc tcaggtcttc ccgcggccct ctgaggcttc
      181 gtcgttctct ctaggccgcg ggtccgcatc tccgtccctg gcgctcggcg actccctgca
      241 ctctgagctc tggcgctgga cagcttgtca cccgtggtcc ccggctcagg tccccgttat
      301 ccctcccctc ctgggctgcg ctagggggcg cggtccgact catccccgct tcggcacgga
      361 gcgtctccac aatggcttcc ctttaggtag agaacaagca gtctaggcca aggggtctag
      421 agaggatggt gaccccctgg cgtttgtctg tcagggtctg cttgtcacac ttaagatgct
      481 ttgagttcag aaaggaactt gggcattcca gacccctggg atgctctcgc aatgccagac
      541 tatgttggtt tctgctaggt actttgccca aattaatctc agcccatggc agtgttggag
      601 agggggcgcc tggcagcttg tgccagagaa agactcactg gagtgacctg gcggaaaatg
      661 gactagtgga gaaggtggcc caagaagggc ctctggcccg cgtcttactg tgtctccgcc
      721 tagggctccg cgctggtgtg ctcttggcga aattcttccc cctcctcttc ttgtaccctc
      781 tcacctactt ggcccctggc ctctccaccc tctggctcca tctgcttttc aaagctacag
      841 agacctcagg cccaacatat atcaaattgg gccaatgggc cagcacccgg cgcgacctct
      901 tttcagaggc tttctgtacc cagttctcca agctgcatgt ccaggtgacc ccccaccctt
      961 gggcaaggac ggaatactta ctccagcagg catttgggga ggattggggc agcctcctct
     1021 ttttcgagac ccgggaacct gtaggttcag gttgtgtggc ccaagtgtac aaagcgttcg
     1081 ctagtatttc cttgttggag gaagacagga tctggagact tggggagctc tctgccccag
     1141 gaaccagggc cgtggtgatg cagagagagc cctttatgaa agaccggaag ccttcagaaa
     1201 accttgccga cgaagcattt ctagaaaaac tgcttcttcc taaagctgac cttggtgggt
     1261 cagaagtggg tgtgtctcag gctccctggc atctgcctaa gtcagatcac ctcatcccag
     1321 tggcagtgaa agtattacac ccaggcttgc tctctcaggt gtccatggat ttactgctga
     1381 tgaagattgg cagcaaagcc ctggggcttt tacctggagt caaatggctt agcttgcctg
     1441 agatcgtgga ggaattcgag aagctcatgg tccaacagac agacctgcgc tatgaagctc
     1501 agaatctaga gcactttcag cacaacttcc aggacatggc atctgtgaaa tttcccaccc
     1561 cactgcgccc cctcatcact agggatattc tggtggaaac gtatgaagag agtgttccag
     1621 tgtccagcta ccagcaggca ggaattccca ccgatctgaa gaggaagatt gcacagctgg
     1681 ggatcaacat gcttttgaag atgatatttg tggataactt tgtacacgga gatctacacc
     1741 ctggaaacat cctggtccag ggtgctgatg gagtgtcccc aagcctggag atgcaacagc
     1801 agcaggtgaa tgtctgtgac acactggtgg ctaccatagc gcctgccctg tgcccactgc
     1861 gcctggtgtt gttggatgct ggcattgtgg caaaactgca ggcttctgac ctgaggaatt
     1921 tccgggcagt tttccaggct gtagtgatgg gacagggcca tcgagtggct gagctcatgc
     1981 tgcatcatgc ccaggccaat gagtgcaagg atgtggaaag gttcaaggct gagatggcta
     2041 cactggtgac ccaggccagg aagaacatcg tcacactgga aaagcttcat gtttccagcc
     2101 tcctatccag tgtctttaag ctactgatga cccataaggt aaagctggag agcaacttcg
     2161 cctccattgt ggttgccatc atggtgctgg aggggctcgg ccgctcactg gaccccacgc
     2221 tggacatcct agaggcagca aaacccttcc tcttcaaagg gccagcatca ttcctgtgac
     2281 agtggcagtg tgcacacagt gaaggcagat cctcagggtc tgccctttgg cagctaagac
     2341 acctaaaact ggatgtgtgg cagagtcacc accgctttcc cagcgagcca gcttcagggt
     2401 ctgcttaaaa accgggttat tttagggcat aaagggaggg acgctggaac tggtgccagg
     2461 ggcactattt caggaaaaat ggtctgtaaa agacgacaaa atacatttac ttattttgtt
     2521 tttctgtttt cttcttctta aaaaaggtgt gtgttgcatc ttgtctgcct gcctgcctgc
     2581 ctgtatctat gtgtatgtag atacctactg aaggccaggt gagaccattg tgtcctttgg
     2641 agttataggc agttgtgaat gctgggaaat gaatttaggt cctctcaaga gcagcagagt
     2701 gctactaacc actgagctat ctcttcaacc cttccttggt ccctccctcc ctccgtccct
     2761 tccttccttt ttaaattgca tgtacttgtg taggaggagg ggctgtggca atcagaacca
     2821 cagggatttc tagggattgg actcaggact taagcctggc atcgaatgcc ttcagttcag
     2881 ccatcctgct gcctgttttt cttttttctt aaccctcaca ctctttggtc ctctttgctg
     2941 gtggttctta cccttagact taggttagaa aatgccataa aatcctgtag accacaattt
     3001 ccaatttttt ttttgaaaat tatgtatgca gttaggcagt ggtgtcacac acctttaatc
     3061 tcagtgcttg agaggcaaag gcaggcagat ctttgggttt gaggccaact aagtctacag
     3121 ggtgagttcc aggacagcct ggaccacaca gagaaaccct gtcttgaaaa accaaaagaa
     3181 aaaaaaagtc tagatttgac aaaaagttga aagccagttt aagttttata tgggcactgt
     3241 caatactaga gaaattttga aagcacaatt ggcaatttaa tgggttcaag ttatcttgac
     3301 aatttttaat atttgctaat ttcttcctga atttattttt cagtgttaaa ataatgaggc
     3361 tggtggtata gctccacagt ggaggcttag tccaccaggt ctgcggctcc aggtttaatc
     3421 ctcagcacca cctaccccat cagtgactgc tgtagagcca acgacttcct ctctttgttg
     3481 gtggggaggg gatgcagcaa gtctttagga aataaagtaa acatcatttc tcttttctc
//
