LOCUS       NM_001277297            2205 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aarF domain containing kinase 1 (Adck1), transcript
            variant 2, mRNA.
ACCESSION   NM_001277297
VERSION     NM_001277297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Rizzo,P., Tinello,C., Pearlstein,R.A. and Taniuchi,H.
  TITLE     Antibody immunodiversity: a study on the marked specificity
            difference between two anti-yeast iso-1 cytochrome c monoclonal
            antibodies whose epitopes are closely related
  JOURNAL   J Protein Chem 18 (5), 523-532 (1999)
   PUBMED   10524770
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY242507.1, AK011310.1, AK050868.1 and BB042684.1.
            
            Transcript Variant: This variant (2), as well as variants 1 and 3,
            encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011310.1, SRR11927937.4149801.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY242507.1         5-44
            41-1592             AK011310.1         1-1552
            1593-2195           AK050868.1         1683-2285
            2196-2205           BB042684.1         292-301
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 42.55 cM"
     gene            1..2205
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /note="aarF domain containing kinase 1"
                     /db_xref="GeneID:72113"
                     /db_xref="MGI:MGI:1919363"
     exon            1..82
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            83..228
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1671
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /note="isoform a is encoded by transcript variant 2; aarF
                     domain-containing protein kinase 1"
                     /codon_start=1
                     /product="aarF domain-containing protein kinase 1 isoform
                     a"
                     /protein_id="NP_001264226.1"
                     /db_xref="CCDS:CCDS26087.1"
                     /db_xref="GeneID:72113"
                     /db_xref="MGI:MGI:1919363"
                     /translation="MARKALKLASWTSVALAASGVYLYSNNYLDPNDFGAVRVGRAVA
                     TTAVISYDYLTSLRSVPYGSEEYLQRRSQVHLRSARRLFELCCANRGTFIKVGQHLGA
                     LDYLLPEEYTSTLKVLHSQAPQSSMQEVRQVIREDLGKEIHDLFLSFDDTPLGAASLA
                     QVHKAVLHDGRTVAVKVQHPKVQAQSSKDILLMEVLVLAVKQLFPDFEFMWLVDEAKK
                     NLPLELDFLNEGRNAEKVAHMLRHFDFLKVPQIHWELSTKRVLLMEFVEGGQVNDRAY
                     MEKNQIDVNEISCHLGKMYSEMIFVNGFVHCDPHPGNVLVRKRPDTGKAEIVLLDHGL
                     YQVLTEEFRLDYCHLWQSLIWTDMDGLKQYSQRLGAADLYPLFACMLTARSWDSVKQG
                     IGQAPVSATEDSEIRNNAACYLPEISQLLNHVPRQMLLILKTNDLLRSIETTLGTRSS
                     ASSFLNMSRCCIRALAEHKKRDAGSFFRRTQISFSEAFSLWQINLHELLLRVRALRLA
                     CWVSALLGWLTRAPHRM"
     exon            229..312
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            313..516
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..675
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..834
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..951
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1101
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1299
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1493
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..2205
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2179..2184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2205
                     /gene="Adck1"
                     /gene_synonym="2610005A10Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttctgtaggc gctctggtgg cgaaagcact gtttcctgga atttgggttc cgggctgcgc
       61 ggcgcagctt ccctaccctc tgggtctgga gacatggcca gaaaggctct caagcttgct
      121 tcatggacca gcgtggctct tgctgcctcc ggtgtctacc tctacagtaa caactacttg
      181 gaccctaatg actttggcgc tgtcagggtg ggcagagctg ttgctacgac agctgtcatc
      241 agctatgact acctcacctc cctgaggagt gtcccatatg gctctgagga gtatttgcag
      301 cgtcgatccc aggtgcacct ccgctctgcc aggcgtctct ttgagctctg ctgtgccaac
      361 cggggcactt tcatcaaggt gggccagcac ctgggggcgc tggactacct gctgccagaa
      421 gagtacacca gcacactgaa ggtgttgcac agtcaagccc cacagagcag catgcaagag
      481 gtccggcagg tcatccgaga agacctgggc aaggagatcc acgatttgtt cctgagcttc
      541 gatgacaccc ctcttggggc agcctccctg gcccaggtcc acaaggcggt gttgcatgat
      601 ggtcggacag tggcagttaa ggtccagcac ccgaaggttc aggctcaaag ctctaaggac
      661 attctcctga tggaggtgct tgtcctggcc gtgaagcaac ttttcccaga ttttgaattc
      721 atgtggctgg tggatgaagc gaagaagaac ctgcctctcg agttggactt cctgaatgaa
      781 gggaggaacg ctgagaaagt ggcccacatg ctcaggcact ttgacttcct aaaggttccc
      841 cagatccact gggagctgtc taccaagagg gtgctcctga tggaatttgt agagggaggt
      901 caagtcaacg acagggccta catggagaag aaccagatcg atgtgaatga gatctcctgc
      961 cacctgggca agatgtacag tgagatgatc tttgtcaatg gcttcgtgca ctgtgacccc
     1021 cacccaggca acgtactggt acggaagcgt cctgacacgg gcaaggctga gattgtcctc
     1081 ttagaccatg ggctttacca ggtgctcacg gaggagttcc gcctggacta ctgccatctg
     1141 tggcagtctc tgatctggac tgacatggac gggctgaaac agtacagcca gcgcctggga
     1201 gctgcagacc tctacccact gtttgcctgt atgctgacag cccggtcctg ggactcagtc
     1261 aaacagggca ttgggcaagc tccagtctct gctactgagg actcagagat tcgcaataat
     1321 gcagcctgct acctgcctga gatcagccag ctccttaacc atgtgcctcg ccagatgctg
     1381 ctcatcctga agactaatga tctactccgt agcattgaga ccaccctggg cacgcgctcc
     1441 agtgccagtt ccttcctcaa catgtctcgg tgttgtatca gggcgctggc tgaacacaag
     1501 aagagggatg ccggctcttt cttcagaagg actcagatat ctttcagtga ggcctttagc
     1561 ctgtggcaga tcaaccttca tgaacttctg cttcgagtga gggccttgag gctagcttgc
     1621 tgggtctcag ctctcctggg ctggctgact cgggctccac acagaatgtg atggtctttc
     1681 cctgcccctt cgtagtgtct ttccacacct cattccttcc ttcacgctgg gacgacccac
     1741 tgacccatgg ctgcctaggg ttggctgtgg tcccagagtg gtcatccatg gcaccctcat
     1801 gctctgccat tggagcccct gccttggggt ggccttgtct tgaggtcctg gaatgtcctg
     1861 gagagtgaga tgggataaag caacctctct cccatctcct gtgtgtgcca ttgacttggt
     1921 catccctact tttatgagga ctgtgagaat ggaccaacca cctgtgtcac aggggcgtgt
     1981 ttaacttgta gggaataagt agaaactcag aacctgcaga gaacagactt tatatttttg
     2041 ctgtatcact cccaaagttg tctcgcctca gtgaggaaga ctgcatctga gagggaacga
     2101 tgcaactgtg ggctcatgct gtcatggtga caccttcagt gttatatgta ttgtatatat
     2161 tgtttattgt aataaaccaa taaacagttt caaggttgca gggac
//
