LOCUS       NM_025748               1453 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus adenosine deaminase, tRNA-specific 2 (Adat2), mRNA.
ACCESSION   NM_025748
VERSION     NM_025748.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1453)
  AUTHORS   Ramos-Morales,E., Bayam,E., Del-Pozo-Rodriguez,J.,
            Salinas-Giege,T., Marek,M., Tilly,P., Wolff,P., Troesch,E.,
            Ennifar,E., Drouard,L., Godin,J.D. and Romier,C.
  TITLE     The structure of the mouse ADAT2/ADAT3 complex reveals the
            molecular basis for mammalian tRNA wobble adenosine-to-inosine
            deamination
  JOURNAL   Nucleic Acids Res 49 (11), 6529-6548 (2021)
   PUBMED   34057470
  REMARK    GeneRIF: The structure of the mouse ADAT2/ADAT3 complex reveals the
            molecular basis for mammalian tRNA wobble adenosine-to-inosine
            deamination.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016938.1, AK021291.1 and AC153979.3.
            
            On Nov 16, 2007 this sequence version replaced NM_025748.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016938.1, BY716618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               AK016938.1         15-573
            560-1127            AK021291.1         248-815
            1128-1453           AC153979.3         91880-92205
FEATURES             Location/Qualifiers
     source          1..1453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 4.94 cM"
     gene            1..1453
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /note="adenosine deaminase, tRNA-specific 2"
                     /db_xref="GeneID:66757"
                     /db_xref="MGI:MGI:1914007"
     exon            1..455
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             360..935
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /EC_number="3.5.4.33"
                     /note="deaminase domain containing 1; adenosine deaminase,
                     tRNA-specific 2, TAD2 homolog; deaminase domain-containing
                     protein 1; tRNA-specific adenosine-34 deaminase subunit
                     ADAT2"
                     /codon_start=1
                     /product="tRNA-specific adenosine deaminase 2"
                     /protein_id="NP_080024.3"
                     /db_xref="CCDS:CCDS35847.1"
                     /db_xref="GeneID:66757"
                     /db_xref="MGI:MGI:1914007"
                     /translation="MEEKVESTTTPDGPCVVSVQETEKWMEEAMRMAKEALENIEVPV
                     GCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCHQHGQSPSTVFEHTVLYV
                     TVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRA
                     EEAVELLKTFYKQENPNAPKSKVRKKDCQKS"
     exon            456..560
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..711
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..818
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..891
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1453
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /note="hexamer: AACAAA"
     polyA_site      1112
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
                     /note="major polyA site"
     polyA_site      1134
                     /gene="Adat2"
                     /gene_synonym="4933426M09Rik; Deadc1"
ORIGIN      
        1 cccgtgttgt gtgggttgcc taggggagag gggctggctc accgtgtctt ccgtccacct
       61 ggcctggacc tccggcagca gcgcggtggc ggcgctaggt gctctccaga aaccacagac
      121 gtttctctga gcagaggttg tggcttaagc ggaggaaggg ggcgtggact agagcggagc
      181 agcgacgctt tcggtccccc agccgccgct tactgatccg ggacgcctgg gtccgtccgc
      241 aaatagctcc cgggtgcctc gtcttttccc gtcctcctgg aagcaaggtc cgctcccgcc
      301 gcgttccgct gtcctctctt ctctcgtccc tcggcccgga gtctctgagc ggcggaggta
      361 tggaggagaa ggtggagtcc accactactc cagacggccc gtgcgtggtg tccgtacagg
      421 agacggaaaa gtggatggag gaggcgatgc gaatggccaa agaagctttg gaaaatattg
      481 aagttcctgt tggctgcctt atggtctata acaatgaagt tgtggggaag ggaagaaatg
      541 aagtgaatca gacaaaaaac gctactcggc atgctgaaat ggtggccatt gatcaggtcc
      601 tagactggtg tcatcagcat ggacagagcc cttccactgt attcgagcac accgtgttgt
      661 acgtcactgt ggagccgtgc atcatgtgtg ctgccgccct gcgccttatg aaaatcccgc
      721 tggtcgtcta tggctgtcag aacgaacggt ttggtggttg cggttccgtc ctaaacattg
      781 cctctgctga cctacccaat actggaagac cgtttcagtg catccctggg taccgagctg
      841 aggaggctgt ggagctccta aagaccttct acaaacagga gaacccaaat gcgccaaaat
      901 caaaagttcg gaaaaaggat tgtcagaaat cctgattctg taatgatcaa cgtctagtac
      961 agtttggaga cctggacaga attcctgacc gagagccgct gacgtcgctg gtcacgttta
     1021 tatgttatta ctgtgtgtaa aaatggtgtc gctcgtcatt tgctctgtta aaggaacaaa
     1081 ttagcccttt taaaaatgtc tggcaatgta aacaaccgtg agctcttcca ccaagctgaa
     1141 agactatttc caggaagggg cgggattaag gttgaggtcc cagagatccg caagcagcgc
     1201 cgcccttcac ccacagcctc agttagctct ggcttaatga agctttttgt ggctgtgaag
     1261 agggccaagt ggtgaaatgc ttgccatgca accatgagga ttgggtcccc atcagtgcca
     1321 ggtgggtggt ttggtggcct gcctgtgatt ccagtgcttg gaaaacagag atgggcttcc
     1381 gagatcccaa agcaagctct ggggtcaaat gagagatatt gcctcgataa ttcatgtgaa
     1441 gagagatcta gga
//
