LOCUS       NM_052977               5633 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adenosine deaminase, RNA-specific, B2 (Adarb2),
            transcript variant 1, mRNA.
ACCESSION   NM_052977
VERSION     NM_052977.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5633)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5633)
  AUTHORS   Li,Z., Zhu,J. and Wang,Y.
  TITLE     ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by
            targeting NLRP3 in chronic constriction injury mice
  JOURNAL   Gene 805, 145909 (2021)
   PUBMED   34419568
  REMARK    GeneRIF: ADAR3 alleviated inflammation and pyroptosis of
            neuropathic pain by targeting NLRP3 in chronic constriction injury
            mice.
            Erratum:[Gene. 2022 Feb 5;810:146107. doi:
            10.1016/j.gene.2021.146107.. PMID: 34872782]
REFERENCE   3  (bases 1 to 5633)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5633)
  AUTHORS   Mladenova,D., Barry,G., Konen,L.M., Pineda,S.S., Guennewig,B.,
            Avesson,L., Zinn,R., Schonrock,N., Bitar,M., Jonkhout,N.,
            Crumlish,L., Kaczorowski,D.C., Gong,A., Pinese,M., Franco,G.R.,
            Walkley,C.R., Vissel,B. and Mattick,J.S.
  TITLE     Adar3 Is Involved in Learning and Memory in Mice
  JOURNAL   Front Neurosci 12, 243 (2018)
   PUBMED   29719497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5633)
  AUTHORS   Heraud-Farlow,J.E., Chalk,A.M., Linder,S.E., Li,Q., Taylor,S.,
            White,J.M., Pang,L., Liddicoat,B.J., Gupte,A., Li,J.B. and
            Walkley,C.R.
  TITLE     Protein recoding by ADAR1-mediated RNA editing is not essential for
            normal development and homeostasis
  JOURNAL   Genome Biol 18 (1), 166 (2017)
   PUBMED   28874170
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5633)
  AUTHORS   Nicod,J., Davies,R.W., Cai,N., Hassett,C., Goodstadt,L.,
            Cosgrove,C., Yee,B.K., Lionikaite,V., McIntyre,R.E., Remme,C.A.,
            Lodder,E.M., Gregory,J.S., Hough,T., Joynson,R., Phelps,H.,
            Nell,B., Rowe,C., Wood,J., Walling,A., Bopp,N., Bhomra,A.,
            Hernandez-Pliego,P., Callebert,J., Aspden,R.M., Talbot,N.P.,
            Robbins,P.A., Harrison,M., Fray,M., Launay,J.M., Pinto,Y.M.,
            Blizard,D.A., Bezzina,C.R., Adams,D.J., Franken,P., Weaver,T.,
            Wells,S., Brown,S.D., Potter,P.K., Klenerman,P., Lionikas,A.,
            Mott,R. and Flint,J.
  TITLE     Genome-wide association of multiple complex traits in outbred mice
            by ultra-low-coverage sequencing
  JOURNAL   Nat Genet 48 (8), 912-918 (2016)
   PUBMED   27376238
REFERENCE   7  (bases 1 to 5633)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 5633)
  AUTHORS   Garcia-Lopez,J., Hourcade Jde,D. and Del Mazo,J.
  TITLE     Reprogramming of microRNAs by adenosine-to-inosine editing and the
            selective elimination of edited microRNA precursors in mouse
            oocytes and preimplantation embryos
  JOURNAL   Nucleic Acids Res 41 (10), 5483-5493 (2013)
   PUBMED   23571754
REFERENCE   9  (bases 1 to 5633)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5633)
  AUTHORS   Slavov,D., Clark,M. and Gardiner,K.
  TITLE     Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes
            from mammals, pufferfish and zebrafish
  JOURNAL   Gene 250 (1-2), 41-51 (2000)
   PUBMED   10854777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134964.1 and AK139079.1.
            
            On Jan 23, 2014 this sequence version replaced NM_052977.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134964.1, AK139079.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK134964.1         3-45
            44-5499             AK139079.1         2-5457
            5500-5633           AK134964.1         5502-5635
FEATURES             Location/Qualifiers
     source          1..5633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.48 cM"
     gene            1..5633
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="adenosine deaminase, RNA-specific, B2"
                     /db_xref="GeneID:94191"
                     /db_xref="MGI:MGI:2151118"
     exon            1..455
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..2593
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenosine deaminase 3, RNA dependent; double-stranded
                     RNA-specific editase B2; RNA-editing enzyme 2; RNA-editing
                     deaminase 2; dsRNA adenosine deaminase B2; RNA dependent
                     adenosine deaminase 3"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase B2 isoform
                     1"
                     /protein_id="NP_443209.2"
                     /db_xref="CCDS:CCDS26231.1"
                     /db_xref="GeneID:94191"
                     /db_xref="MGI:MGI:2151118"
                     /translation="MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLA
                     PFKYLSPGTTNTEDEDNLSTSSAEVKENRNVSNLGTRPLPPGDWARGSTPSVKRKRPL
                     EEGNGGHFCKLQLIWKKLSWSVTPKNALVQLHELKPGLQYRMVSQTGPVHAPVFAVAV
                     EVNGLTFEGTGPTKKKAKMRAAEMALKSFVQFPNAFQAHLAMGSSTSPCTDFTSDQAD
                     FPDTLFKEFEPSSKNEDFPGCHPVDTEFLSSAYRRGRLLYHTLDLMGQALPDRSRLAP
                     GALGERNPVVVLNELRSGLRYVCLSETAEKPRVKSFVMAVCVDGRTFEGSGRSKKLAK
                     GQAAQAALQALFDIRLPGHIPSRSKSNLLPQDFADSVSQLVTQKFRELTVGLTSVYAR
                     HKTLAGIVMTKGLDTKQAQVIVLSSGTKCISGEHISDQGLVVNDCHAEIVARRAFLHF
                     LYSQLELHLSKHQEDPERSIFIRLKEGGYRLRENILFHLYVSTSPCGDARVNSPYEIT
                     TDLNSSKHIVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGILLGEQLITMSCTDKIA
                     SWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHLARVMSHRMEGIGQLPASYRQNRP
                     LLSGVSHAEARQPGKSPHFSANWVVGSADLEIINATTGKRSCGGSSRLCKHVFSAWWA
                     RLHGRLSTRIPSHGDTPSMYCEAKQGAHTYQSVKQQLFKAFQKAGLGTWVRKPPEQDQ
                     FLLSL"
     exon            456..542
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..1450
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1565
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1734
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1886
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2055
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2237
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2416
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..5633
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4175..4180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="hexamer: AATAAA"
     polyA_site      4197
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="major polyA site"
ORIGIN      
        1 aaagtggatg gtgccaaaca actcgcagag gcgcaaaagt agcagctctg cttctggagc
       61 ccagacgaag aggagagagc tccagggcgc tcaggacgcg cgggagaatc tttcccagag
      121 ctttcagcct aaggaagggt tcagctttcc agcgtgcacc cgaggcttcc agctcatccg
      181 gaaccaaggg acgggcaatt atagagaagg tgcttgctga ggagaccagt cctaaaaagt
      241 gagcctgaga cttgatttgc aaaaccagaa acactcccga ctgcggccgc agcagcaaga
      301 ctaagaaagg tgaaattgct gaaggaccag ctcctctctg ggtctcccaa ctggcatggc
      361 atctgtcctg gggagtggca gagggtctgg agggctaagc agtcaactca aatgcaagtc
      421 caagaggagg aggaggagga ggtccaagag gaaagacaaa gtcagcatac tgtcaacctt
      481 ccttgctcct ttcaagtacc taagtcctgg caccacaaac acagaggatg aagataacct
      541 aagtaccagc agtgctgaag tgaaggaaaa ccgaaatgtg agcaacctgg ggaccaggcc
      601 cctgccccct ggagactggg ccagaggcag cacacccagc gttaaaagga aaaggccgct
      661 ggaggaagga aatgggggac atttctgcaa actccagctg atctggaaga agctctcctg
      721 gtctgtgaca cccaagaatg cgctggtcca gctgcatgag ctgaagcctg gtctgcagta
      781 ccgaatggtg tcacagacgg gcccggtgca cgccccagtt ttcgcagtgg ctgtagaagt
      841 gaacggcctc acatttgaag gcacggggcc cactaagaag aaggccaaga tgcgggcagc
      901 agaaatggcc ctgaagtcct ttgtgcagtt ccccaatgcc ttccaggccc acctggccat
      961 gggcagtagt accagcccgt gcactgactt cacctctgac caggctgact tcccagacac
     1021 gttgttcaag gagtttgaac catcctcaaa aaacgaagac ttcccaggct gtcatcccgt
     1081 tgatactgag tttctgtcct ctgcctatcg gcgaggacgg ctactctacc acaccctgga
     1141 cctcatgggc caggctctgc ctgacaggtc caggctggct ccgggagcct tgggtgagag
     1201 gaaccctgta gtggtactga atgagttacg ctcaggtctt cggtatgtgt gcctctccga
     1261 gacagccgag aagccccgag tcaagagctt tgtcatggct gtgtgcgtgg atgggaggac
     1321 gttcgaaggc tctggacgca gcaagaagct ggccaagggc caagcagcac aagctgcctt
     1381 gcaggccctc ttcgatatcc ggctgcctgg tcacataccc agcaggagta aaagcaacct
     1441 cttgccacag gattttgcag actctgtgtc ccagctggtc acacagaagt tccgtgaact
     1501 gacagtcggc ctgacatctg tgtatgcccg ccacaaaaca ctggcaggaa tcgtcatgac
     1561 caaaggcttg gacaccaaac aagcgcaggt catcgttctg tcctctggga ccaagtgtat
     1621 cagcggtgag cacatcagtg accaggggct ggttgtcaac gactgtcatg ctgagatcgt
     1681 ggcgaggcgg gcatttcttc acttcctcta ctctcagctg gagctgcact tgagcaagca
     1741 tcaagaggac cccgagagat caatattcat acgtttaaag gaaggaggtt acaggctgcg
     1801 agaaaacatc ctcttccatc tctacgtgag cacatccccc tgtggagatg ccagagtcaa
     1861 ctctccatat gaaatcacca cagacttgaa cagcagcaaa cacatcgtca ggaagttccg
     1921 agggcacctg cgcaccaaga ttgagtctgg ggaaggaaca gtccctgtgc ggggccccag
     1981 tgcagtccag acgtgggatg gcatcctatt gggggagcag ctaatcacca tgtcctgcac
     2041 agacaagatt gccagctgga atgtgctggg actacaaggc gctctcctct gtcacttcat
     2101 cgagcctgtg tacctccaca gcatcattgt gggcagcctg caccacacgg gccatcttgc
     2161 acgggtcatg agccacagga tggagggaat cggccagctg cctgcctcat accgacaaaa
     2221 caggcctctc cttagtggcg tgagtcacgc agaggcccgg cagccaggaa agtctcccca
     2281 cttcagtgcc aactgggtcg tgggcagcgc cgacctggag atcattaatg ccaccactgg
     2341 gaagaggagc tgtgggggct catcccggct ctgcaaacac gtgttttctg cttggtgggc
     2401 acggctgcat ggtaggctaa gcacacggat ccccagccat ggagacacac catccatgta
     2461 ctgtgaggcc aagcaggggg ctcacaccta ccagtctgtt aaacagcagc tcttcaaggc
     2521 ctttcagaaa gccggtcttg gcacctgggt gagaaaacca ccggagcaag atcagtttct
     2581 actaagtctc taagtcacta ggctccttcg ctattggacc agagggagat gcctggagag
     2641 gatgaagccg tatgatggtg tggtgtgtcc atcagttctt gacctttgtt ctccttcact
     2701 gttcaggaac atgtggctcc atgtgtggat gagagactag gtttgagttt gggtcgggct
     2761 gcttctccct gggctgttag ttccaagaac cccatccacc atagctagag agagaagctt
     2821 tgttgtgtca gccccatccc ttactgggta tcaaaaggaa attctctgtt caggcaaggg
     2881 agtccagagg caggactgaa aggtagtact aaagcgtagc ttcatgcatc ttcctttgga
     2941 cctcccctcc cttctcttcc aagggcctct ctagtggtgt gatcaagtct caccagcaca
     3001 agtttatatg acatttcaag ataagccaca ggtgaacagg aaagccaggg gctccccaac
     3061 tccaaagaac ccaacaggaa tgctgtattg ttctcattat tcattcagac ctttccaact
     3121 tctttcaaga agaacttgag acagacactg tcaaagagca gccaaagtga aagctatact
     3181 tatgacacaa agggatagtt acctaagaca ggaaagagtc ataattgatg agctaagaaa
     3241 actgttatta aactgcccaa tgatagtatg ttgcaaacaa acccaagcct ttccacttga
     3301 tgacaacctc tccattgctt ttatagataa tgatagccac agaagtgaca actgtagggt
     3361 gattaaccac tacccaataa tctctctact aggtatgagt aatgaaactg agttttagat
     3421 caaattctaa attttaagca attttttatt agaaagaaat cacacacaca cacacacaca
     3481 cacacacaca cacctcagtg caatctttcg gtttgaggag ctgcatgctc tctgtcattt
     3541 taggtccctt gatcatcatg tcgcatgaat aaaataataa taaccacaaa gataatgatg
     3601 acttgccata gctgacaaaa ttaaagggac agaatcatgc cacttttaga acggacatta
     3661 gagttcatcg gtagacatat atttctttaa tatttagcct acatcatcat ctctaagagg
     3721 aaaacaaaat acaggcaaga ggaggcatgt tgccaaccaa tgtttcttga attaattgtc
     3781 tttaaacact tggagctcat ttctaacatt catcaagcta gttaacatgc gtctaatctt
     3841 ttctattgaa ccccatgtga cgggctggag agatggctca gcagttagga gctttgctgc
     3901 ttctatagag gactctggtt gagttcccag cttccacacg gcagcttaca gccatccata
     3961 actccagccc cagcagctcc acacatccat gcagtgcacc tacataaatg tgggcaaatt
     4021 atcatagaca taaagttaaa ataaataaat cctttttaat cccatctgag atgcattacg
     4081 gatttctgtt tcattttgtt ttgtttttaa agaataggag gaaccatgtt tagaatatgg
     4141 gagtcttgat tagaattcta gtgcatcatc ccccaataaa attcaaccat tacatcatga
     4201 tgcttttatt ctatcttata ttgcagatgt cacaagaatt tggtaaacat gaaatacatt
     4261 caattgtagc tattcaataa aaagaaaagt ggagatatta attccttgga tttaatatga
     4321 gatcacatca ctaaagtcct ttgagaaaag aatatgaaca ccattgtagg aatgtgttca
     4381 agataaactt tcaaagacat gcaaatgttt ctgcaaatga gtgattcata tcataaatat
     4441 tgaggaaaat gtaatcttaa ctcaaggtaa aggctaagat caaaatgcca acttacagtg
     4501 atctctgata acttgatata tcactagggg gaggcttaga aacacaagaa accttgagag
     4561 ctgaatatgg cttagctgta atccttcaac ggttaggcac agttacttcc tagctgaact
     4621 ctaggacctg ccctcaaatc atttgtattc tgagctattg aatggagagc acacagcaca
     4681 tcagagcagt gagctccaaa cagagttatt ggttataaaa ataattggca ttaacttcag
     4741 ggtcttaaac aagatggaag gaggcagagt ggggtacctt tcagatattc tcagagaata
     4801 ccatcacttt ggcctatgca agagtcagag aaagcagtgg ctacccagca ccatcatgga
     4861 cataagttcc agggatagat ttatgactca tggtgtctac agtactgttt ctccagaaac
     4921 aacccaaact ttcctaagag actaggggat caaatttgtt tatagaggta aaagaattct
     4981 ttaatgctac aagacaattt ttaaaaacta aagataattt tctccttctg aaagaaggat
     5041 tcattccacc cctgagcact agcatagaga tttgcttgtt tattctaatc acatgtatat
     5101 gtgtgtgatt gtgtatgggt atgttcatgt gtgtgcaggt gcctgcagga ggctgaagag
     5161 ggtgtcagag ctgctgaagt gagagtctta cgcagttgtg agataccctg tgtgggtgcc
     5221 aggaagccaa atgggttctc tggaagatgc ttttaaccac tgagttaact ctccagccct
     5281 gagaatcact tgttaaataa acaaaagatt cctatatagg agagctaggg gatccacatt
     5341 tgtttgtaga ggtaaaagaa ttctttaatg ctacaagaca attttaagaa actacagctt
     5401 gtccaaagag acatcatggg aaatgctttt tttcaatagt tgactgtctt gcaagatacc
     5461 tgtcagggtg aatgtaaaat aaaggagatg ggaggaagga ggcagagggt ccctgaatct
     5521 cttcaatgaa aagagactta ctaaaattat ctaagtgaac cctgccacgt gcttagaagc
     5581 agaggtcagg aaaagacaat cttccaagaa gcaggaaaac acaaagaggt act
//
