LOCUS       NM_001289530            5628 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus adenosine deaminase, RNA-specific, B2 (Adarb2),
            transcript variant 2, mRNA.
ACCESSION   NM_001289530 XM_006516512
VERSION     NM_001289530.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5628)
  AUTHORS   Li,Z., Zhu,J. and Wang,Y.
  TITLE     ADAR3 alleviated inflammation and pyroptosis of neuropathic pain by
            targeting NLRP3 in chronic constriction injury mice
  JOURNAL   Gene 805, 145909 (2021)
   PUBMED   34419568
  REMARK    GeneRIF: ADAR3 alleviated inflammation and pyroptosis of
            neuropathic pain by targeting NLRP3 in chronic constriction injury
            mice.
            Erratum:[Gene. 2022 Feb 5;810:146107. doi:
            10.1016/j.gene.2021.146107.. PMID: 34872782]
REFERENCE   3  (bases 1 to 5628)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5628)
  AUTHORS   Mladenova,D., Barry,G., Konen,L.M., Pineda,S.S., Guennewig,B.,
            Avesson,L., Zinn,R., Schonrock,N., Bitar,M., Jonkhout,N.,
            Crumlish,L., Kaczorowski,D.C., Gong,A., Pinese,M., Franco,G.R.,
            Walkley,C.R., Vissel,B. and Mattick,J.S.
  TITLE     Adar3 Is Involved in Learning and Memory in Mice
  JOURNAL   Front Neurosci 12, 243 (2018)
   PUBMED   29719497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5628)
  AUTHORS   Heraud-Farlow,J.E., Chalk,A.M., Linder,S.E., Li,Q., Taylor,S.,
            White,J.M., Pang,L., Liddicoat,B.J., Gupte,A., Li,J.B. and
            Walkley,C.R.
  TITLE     Protein recoding by ADAR1-mediated RNA editing is not essential for
            normal development and homeostasis
  JOURNAL   Genome Biol 18 (1), 166 (2017)
   PUBMED   28874170
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5628)
  AUTHORS   Nicod,J., Davies,R.W., Cai,N., Hassett,C., Goodstadt,L.,
            Cosgrove,C., Yee,B.K., Lionikaite,V., McIntyre,R.E., Remme,C.A.,
            Lodder,E.M., Gregory,J.S., Hough,T., Joynson,R., Phelps,H.,
            Nell,B., Rowe,C., Wood,J., Walling,A., Bopp,N., Bhomra,A.,
            Hernandez-Pliego,P., Callebert,J., Aspden,R.M., Talbot,N.P.,
            Robbins,P.A., Harrison,M., Fray,M., Launay,J.M., Pinto,Y.M.,
            Blizard,D.A., Bezzina,C.R., Adams,D.J., Franken,P., Weaver,T.,
            Wells,S., Brown,S.D., Potter,P.K., Klenerman,P., Lionikas,A.,
            Mott,R. and Flint,J.
  TITLE     Genome-wide association of multiple complex traits in outbred mice
            by ultra-low-coverage sequencing
  JOURNAL   Nat Genet 48 (8), 912-918 (2016)
   PUBMED   27376238
REFERENCE   7  (bases 1 to 5628)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   8  (bases 1 to 5628)
  AUTHORS   Garcia-Lopez,J., Hourcade Jde,D. and Del Mazo,J.
  TITLE     Reprogramming of microRNAs by adenosine-to-inosine editing and the
            selective elimination of edited microRNA precursors in mouse
            oocytes and preimplantation embryos
  JOURNAL   Nucleic Acids Res 41 (10), 5483-5493 (2013)
   PUBMED   23571754
REFERENCE   9  (bases 1 to 5628)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5628)
  AUTHORS   Slavov,D., Clark,M. and Gardiner,K.
  TITLE     Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes
            from mammals, pufferfish and zebrafish
  JOURNAL   Gene 250 (1-2), 41-51 (2000)
   PUBMED   10854777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134964.1 and AK046083.1.
            
            On Jan 23, 2014 this sequence version replaced XM_006516512.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, compared to variant 1, which results in a
            frameshift and a protein (isoform 2) with a shorter and distinct
            C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046083.1, SRR7345562.2376192.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AK134964.1         3-427
            426-2487            AK046083.1         370-2431
            2488-5628           AK134964.1         2495-5635
FEATURES             Location/Qualifiers
     source          1..5628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.48 cM"
     gene            1..5628
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="adenosine deaminase, RNA-specific, B2"
                     /db_xref="GeneID:94191"
                     /db_xref="MGI:MGI:2151118"
     exon            1..455
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..2461
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     adenosine deaminase 3, RNA dependent; double-stranded
                     RNA-specific editase B2; RNA-editing enzyme 2; RNA-editing
                     deaminase 2; dsRNA adenosine deaminase B2; RNA dependent
                     adenosine deaminase 3"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase B2 isoform
                     2"
                     /protein_id="NP_001276459.1"
                     /db_xref="CCDS:CCDS70428.1"
                     /db_xref="GeneID:94191"
                     /db_xref="MGI:MGI:2151118"
                     /translation="MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLA
                     PFKYLSPGTTNTEDEDNLSTSSAEVKENRNVSNLGTRPLPPGDWARGSTPSVKRKRPL
                     EEGNGGHFCKLQLIWKKLSWSVTPKNALVQLHELKPGLQYRMVSQTGPVHAPVFAVAV
                     EVNGLTFEGTGPTKKKAKMRAAEMALKSFVQFPNAFQAHLAMGSSTSPCTDFTSDQAD
                     FPDTLFKEFEPSSKNEDFPGCHPVDTEFLSSAYRRGRLLYHTLDLMGQALPDRSRLAP
                     GALGERNPVVVLNELRSGLRYVCLSETAEKPRVKSFVMAVCVDGRTFEGSGRSKKLAK
                     GQAAQAALQALFDIRLPGHIPSRSKSNLLPQDFADSVSQLVTQKFRELTVGLTSVYAR
                     HKTLAGIVMTKGLDTKQAQVIVLSSGTKCISGEHISDQGLVVNDCHAEIVARRAFLHF
                     LYSQLELHLSKHQEDPERSIFIRLKEGGYRLRENILFHLYVSTSPCGDARVNSPYEIT
                     TDLNSSKHIVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGILLGEQLITMSCTDKIA
                     SWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHLARVMSHRMEGIGQLPASYRQNRP
                     LLSGVSHAEARQPGKSPHFSANWVVGSADLEIINATTGKRSCGGSSRLCKHVFSAWWA
                     RLHAKHTDPQPWRHTIHVL"
     exon            456..542
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..1450
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1565
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1734
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1886
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2055
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2237
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2411
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..5628
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4170..4175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="hexamer: AATAAA"
     polyA_site      4192
                     /gene="Adarb2"
                     /gene_synonym="Adar3; RED2"
                     /note="major polyA site"
ORIGIN      
        1 aaagtggatg gtgccaaaca actcgcagag gcgcaaaagt agcagctctg cttctggagc
       61 ccagacgaag aggagagagc tccagggcgc tcaggacgcg cgggagaatc tttcccagag
      121 ctttcagcct aaggaagggt tcagctttcc agcgtgcacc cgaggcttcc agctcatccg
      181 gaaccaaggg acgggcaatt atagagaagg tgcttgctga ggagaccagt cctaaaaagt
      241 gagcctgaga cttgatttgc aaaaccagaa acactcccga ctgcggccgc agcagcaaga
      301 ctaagaaagg tgaaattgct gaaggaccag ctcctctctg ggtctcccaa ctggcatggc
      361 atctgtcctg gggagtggca gagggtctgg agggctaagc agtcaactca aatgcaagtc
      421 caagaggagg aggaggagga ggtccaagag gaaagacaaa gtcagcatac tgtcaacctt
      481 ccttgctcct ttcaagtacc taagtcctgg caccacaaac acagaggatg aagataacct
      541 aagtaccagc agtgctgaag tgaaggaaaa ccgaaatgtg agcaacctgg ggaccaggcc
      601 cctgccccct ggagactggg ccagaggcag cacacccagc gttaaaagga aaaggccgct
      661 ggaggaagga aatgggggac atttctgcaa actccagctg atctggaaga agctctcctg
      721 gtctgtgaca cccaagaatg cgctggtcca gctgcatgag ctgaagcctg gtctgcagta
      781 ccgaatggtg tcacagacgg gcccggtgca cgccccagtt ttcgcagtgg ctgtagaagt
      841 gaacggcctc acatttgaag gcacggggcc cactaagaag aaggccaaga tgcgggcagc
      901 agaaatggcc ctgaagtcct ttgtgcagtt ccccaatgcc ttccaggccc acctggccat
      961 gggcagtagt accagcccgt gcactgactt cacctctgac caggctgact tcccagacac
     1021 gttgttcaag gagtttgaac catcctcaaa aaacgaagac ttcccaggct gtcatcccgt
     1081 tgatactgag tttctgtcct ctgcctatcg gcgaggacgg ctactctacc acaccctgga
     1141 cctcatgggc caggctctgc ctgacaggtc caggctggct ccgggagcct tgggtgagag
     1201 gaaccctgta gtggtactga atgagttacg ctcaggtctt cggtatgtgt gcctctccga
     1261 gacagccgag aagccccgag tcaagagctt tgtcatggct gtgtgcgtgg atgggaggac
     1321 gttcgaaggc tctggacgca gcaagaagct ggccaagggc caagcagcac aagctgcctt
     1381 gcaggccctc ttcgatatcc ggctgcctgg tcacataccc agcaggagta aaagcaacct
     1441 cttgccacag gattttgcag actctgtgtc ccagctggtc acacagaagt tccgtgaact
     1501 gacagtcggc ctgacatctg tgtatgcccg ccacaaaaca ctggcaggaa tcgtcatgac
     1561 caaaggcttg gacaccaaac aagcgcaggt catcgttctg tcctctggga ccaagtgtat
     1621 cagcggtgag cacatcagtg accaggggct ggttgtcaac gactgtcatg ctgagatcgt
     1681 ggcgaggcgg gcatttcttc acttcctcta ctctcagctg gagctgcact tgagcaagca
     1741 tcaagaggac cccgagagat caatattcat acgtttaaag gaaggaggtt acaggctgcg
     1801 agaaaacatc ctcttccatc tctacgtgag cacatccccc tgtggagatg ccagagtcaa
     1861 ctctccatat gaaatcacca cagacttgaa cagcagcaaa cacatcgtca ggaagttccg
     1921 agggcacctg cgcaccaaga ttgagtctgg ggaaggaaca gtccctgtgc ggggccccag
     1981 tgcagtccag acgtgggatg gcatcctatt gggggagcag ctaatcacca tgtcctgcac
     2041 agacaagatt gccagctgga atgtgctggg actacaaggc gctctcctct gtcacttcat
     2101 cgagcctgtg tacctccaca gcatcattgt gggcagcctg caccacacgg gccatcttgc
     2161 acgggtcatg agccacagga tggagggaat cggccagctg cctgcctcat accgacaaaa
     2221 caggcctctc cttagtggcg tgagtcacgc agaggcccgg cagccaggaa agtctcccca
     2281 cttcagtgcc aactgggtcg tgggcagcgc cgacctggag atcattaatg ccaccactgg
     2341 gaagaggagc tgtgggggct catcccggct ctgcaaacac gtgttttctg cttggtgggc
     2401 acggctgcat gctaagcaca cggatcccca gccatggaga cacaccatcc atgtactgtg
     2461 aggccaagca gggggctcac acctaccagt ctgttaaaca gcagctcttc aaggcctttc
     2521 agaaagccgg tcttggcacc tgggtgagaa aaccaccgga gcaagatcag tttctactaa
     2581 gtctctaagt cactaggctc cttcgctatt ggaccagagg gagatgcctg gagaggatga
     2641 agccgtatga tggtgtggtg tgtccatcag ttcttgacct ttgttctcct tcactgttca
     2701 ggaacatgtg gctccatgtg tggatgagag actaggtttg agtttgggtc gggctgcttc
     2761 tccctgggct gttagttcca agaaccccat ccaccatagc tagagagaga agctttgttg
     2821 tgtcagcccc atcccttact gggtatcaaa aggaaattct ctgttcaggc aagggagtcc
     2881 agaggcagga ctgaaaggta gtactaaagc gtagcttcat gcatcttcct ttggacctcc
     2941 cctcccttct cttccaaggg cctctctagt ggtgtgatca agtctcacca gcacaagttt
     3001 atatgacatt tcaagataag ccacaggtga acaggaaagc caggggctcc ccaactccaa
     3061 agaacccaac aggaatgctg tattgttctc attattcatt cagacctttc caacttcttt
     3121 caagaagaac ttgagacaga cactgtcaaa gagcagccaa agtgaaagct atacttatga
     3181 cacaaaggga tagttaccta agacaggaaa gagtcataat tgatgagcta agaaaactgt
     3241 tattaaactg cccaatgata gtatgttgca aacaaaccca agcctttcca cttgatgaca
     3301 acctctccat tgcttttata gataatgata gccacagaag tgacaactgt agggtgatta
     3361 accactaccc aataatctct ctactaggta tgagtaatga aactgagttt tagatcaaat
     3421 tctaaatttt aagcaatttt ttattagaaa gaaatcacac acacacacac acacacacac
     3481 acacacacct cagtgcaatc tttcggtttg aggagctgca tgctctctgt cattttaggt
     3541 cccttgatca tcatgtcgca tgaataaaat aataataacc acaaagataa tgatgacttg
     3601 ccatagctga caaaattaaa gggacagaat catgccactt ttagaacgga cattagagtt
     3661 catcggtaga catatatttc tttaatattt agcctacatc atcatctcta agaggaaaac
     3721 aaaatacagg caagaggagg catgttgcca accaatgttt cttgaattaa ttgtctttaa
     3781 acacttggag ctcatttcta acattcatca agctagttaa catgcgtcta atcttttcta
     3841 ttgaacccca tgtgacgggc tggagagatg gctcagcagt taggagcttt gctgcttcta
     3901 tagaggactc tggttgagtt cccagcttcc acacggcagc ttacagccat ccataactcc
     3961 agccccagca gctccacaca tccatgcagt gcacctacat aaatgtgggc aaattatcat
     4021 agacataaag ttaaaataaa taaatccttt ttaatcccat ctgagatgca ttacggattt
     4081 ctgtttcatt ttgttttgtt tttaaagaat aggaggaacc atgtttagaa tatgggagtc
     4141 ttgattagaa ttctagtgca tcatccccca ataaaattca accattacat catgatgctt
     4201 ttattctatc ttatattgca gatgtcacaa gaatttggta aacatgaaat acattcaatt
     4261 gtagctattc aataaaaaga aaagtggaga tattaattcc ttggatttaa tatgagatca
     4321 catcactaaa gtcctttgag aaaagaatat gaacaccatt gtaggaatgt gttcaagata
     4381 aactttcaaa gacatgcaaa tgtttctgca aatgagtgat tcatatcata aatattgagg
     4441 aaaatgtaat cttaactcaa ggtaaaggct aagatcaaaa tgccaactta cagtgatctc
     4501 tgataacttg atatatcact agggggaggc ttagaaacac aagaaacctt gagagctgaa
     4561 tatggcttag ctgtaatcct tcaacggtta ggcacagtta cttcctagct gaactctagg
     4621 acctgccctc aaatcatttg tattctgagc tattgaatgg agagcacaca gcacatcaga
     4681 gcagtgagct ccaaacagag ttattggtta taaaaataat tggcattaac ttcagggtct
     4741 taaacaagat ggaaggaggc agagtggggt acctttcaga tattctcaga gaataccatc
     4801 actttggcct atgcaagagt cagagaaagc agtggctacc cagcaccatc atggacataa
     4861 gttccaggga tagatttatg actcatggtg tctacagtac tgtttctcca gaaacaaccc
     4921 aaactttcct aagagactag gggatcaaat ttgtttatag aggtaaaaga attctttaat
     4981 gctacaagac aatttttaaa aactaaagat aattttctcc ttctgaaaga aggattcatt
     5041 ccacccctga gcactagcat agagatttgc ttgtttattc taatcacatg tatatgtgtg
     5101 tgattgtgta tgggtatgtt catgtgtgtg caggtgcctg caggaggctg aagagggtgt
     5161 cagagctgct gaagtgagag tcttacgcag ttgtgagata ccctgtgtgg gtgccaggaa
     5221 gccaaatggg ttctctggaa gatgctttta accactgagt taactctcca gccctgagaa
     5281 tcacttgtta aataaacaaa agattcctat ataggagagc taggggatcc acatttgttt
     5341 gtagaggtaa aagaattctt taatgctaca agacaatttt aagaaactac agcttgtcca
     5401 aagagacatc atgggaaatg ctttttttca atagttgact gtcttgcaag atacctgtca
     5461 gggtgaatgt aaaataaagg agatgggagg aaggaggcag agggtccctg aatctcttca
     5521 atgaaaagag acttactaaa attatctaag tgaaccctgc cacgtgctta gaagcagagg
     5581 tcaggaaaag acaatcttcc aagaagcagg aaaacacaaa gaggtact
//
