LOCUS       NM_130895               6572 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus adenosine deaminase, RNA-specific, B1 (Adarb1),
            transcript variant 1, mRNA.
ACCESSION   NM_130895
VERSION     NM_130895.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6572)
  AUTHORS   Omata,Y., Haraguchi,M., Yoshinaga,S., Ogino,T., Okawa,M.,
            Tsuruta,A., Koyanagi,S. and Ohdo,S.
  TITLE     RNA editing enzyme ADAR2 regulates P-glycoprotein expression in
            murine breast cancer cells through the circRNA-miRNA pathway
  JOURNAL   Biochem Biophys Res Commun 726, 150289 (2024)
   PUBMED   38917633
  REMARK    GeneRIF: RNA editing enzyme ADAR2 regulates P-glycoprotein
            expression in murine breast cancer cells through the circRNA-miRNA
            pathway.
REFERENCE   2  (bases 1 to 6572)
  AUTHORS   Kung,M.L., Yang,T.H., Lin,C.C., Ho,J.Y., Hung,T.C., Chang,C.H.,
            Huang,K.W., Chen,C.C. and Chen,Y.W.
  TITLE     ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and
            muscle atrophy through modulating serum amyloid A1
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (3), 949-962 (2024)
   PUBMED   38533529
  REMARK    GeneRIF: ADAR2 deficiency ameliorates non-alcoholic fatty liver
            disease and muscle atrophy through modulating serum amyloid A1.
REFERENCE   3  (bases 1 to 6572)
  AUTHORS   Kung,M.L., Cheng,S.M., Wang,Y.H., Cheng,K.P., Li,Y.L., Hsiao,Y.T.,
            Tan,B.C. and Chen,Y.W.
  TITLE     Deficiency of ADAR2 ameliorates metabolic-associated fatty liver
            disease via AMPK signaling pathways in obese mice
  JOURNAL   Commun Biol 7 (1), 594 (2024)
   PUBMED   38760406
  REMARK    GeneRIF: Deficiency of ADAR2 ameliorates metabolic-associated fatty
            liver disease via AMPK signaling pathways in obese mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6572)
  AUTHORS   Lebedeva,M., Kubistova,A., Spisska,V., Filipovska,E., Pacesova,D.,
            Svobodova,I., Kuchtiak,V., Balik,A. and Bendova,Z.
  TITLE     The disruption of circadian rhythmicity of gene expression in the
            hippocampus and associated structures in Gria2R/R mice; a
            comparison with C57BL/6J and Adar2-/- mice strains
  JOURNAL   Brain Res 1826, 148739 (2024)
   PUBMED   38157956
  REMARK    GeneRIF: The disruption of circadian rhythmicity of gene expression
            in the hippocampus and associated structures in Gria2[R/R] mice; a
            comparison with C57BL/6J and Adar2[-/-] mice strains.
REFERENCE   5  (bases 1 to 6572)
  AUTHORS   Feng,Y., Sansam,C.L., Singh,M. and Emeson,R.B.
  TITLE     Altered RNA editing in mice lacking ADAR2 autoregulation
  JOURNAL   Mol Cell Biol 26 (2), 480-488 (2006)
   PUBMED   16382140
  REMARK    GeneRIF: ADAR2 autoediting is a key regulator of ADAR2 protein
            expression and activity in vivo.
REFERENCE   6  (bases 1 to 6572)
  AUTHORS   Slavov,D. and Gardiner,K.
  TITLE     Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2
            genes and transcripts: conservation and diversity in editing site
            sequence and alternative splicing patterns
  JOURNAL   Gene 299 (1-2), 83-94 (2002)
   PUBMED   12459255
REFERENCE   7  (bases 1 to 6572)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   8  (bases 1 to 6572)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
REFERENCE   9  (bases 1 to 6572)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 6572)
  AUTHORS   Mittaz,L., Scott,H.S., Rossier,C., Seeburg,P.H., Higuchi,M. and
            Antonarakis,S.E.
  TITLE     Cloning of a human RNA editing deaminase (ADARB1) of glutamate
            receptors that maps to chromosome 21q22.3
  JOURNAL   Genomics 41 (2), 210-217 (1997)
   PUBMED   9143496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB622419.1, AF403107.2,
            AF291049.1, BC040200.1 and BC030049.1.
            
            On Nov 30, 2007 this sequence version replaced NM_130895.2.
            
            Summary: This gene encodes a double-stranded-RNA-specific adenosine
            deaminase that is involved in editing pre-mRNAs by site-specific
            conversion of adenosine (A) to inosine (I). Substrates for this
            enzyme include ionotropic glutamate receptors (GluR2-6) and
            serotonin receptor (5HT2C). Studies in rodents have shown that this
            protein can modify its own pre-mRNA by A->I editing to create a
            novel acceptor splice site, alternative splicing to which results
            in down regulation of its protein expression. Additional splicing
            events result in transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF403106.2, SRR1660817.174490.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            undergoes RNA editing :: PMID: 16382140, 12459255
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BB622419.1         1-79
            80-589              AF403107.2         32-541
            590-2039            AF291049.1         425-1874
            2040-6550           BC040200.1         625-5135
            6551-6572           BC030049.1         2158-2179
FEATURES             Location/Qualifiers
     source          1..6572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..6572
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /note="adenosine deaminase, RNA-specific, B1"
                     /db_xref="GeneID:110532"
                     /db_xref="MGI:MGI:891999"
     exon            1..179
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..348
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..423
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..2501
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /EC_number="3.5.4.37"
                     /note="isoform 1 is encoded by transcript variant 1;
                     double-stranded RNA-specific editase 1; dsRNA adenosine
                     deaminase; RNA-editing deaminase 1; RNA-editing enzyme 1"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase 1 isoform
                     1"
                     /protein_id="NP_570965.2"
                     /db_xref="CCDS:CCDS35949.1"
                     /db_xref="GeneID:110532"
                     /db_xref="MGI:MGI:891999"
                     /translation="MDIEDEENMSSSSTDIKENRNLDNMPPKDSSTPGPGEGIPLSNG
                     GGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTG
                     PVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLS
                     VNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLT
                     QPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEG
                     SGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGK
                     FSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALND
                     CHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSP
                     CGDARIFSPHEPVLEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQG
                     ERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISN
                     IEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDATIEVINATTGKDELGRP
                     SRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAREYQAAKARLFTAFIKA
                     GLGAWVEKPTEQDQFSFTP"
     exon            424..1358
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1473
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1642
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1791
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1960
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2142
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2321
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..6556
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6530..6535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /note="hexamer: AATAAA"
     polyA_site      6556
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /note="major polyA site"
ORIGIN      
        1 gagggggcgg agccgccggc gccgaggcta gaggcagagg ctgaggcagc ggctgaggct
       61 gaggtggctg aggctgaggc ggcggcgagg ggctcctagc tggggccgcg gggctagccg
      121 aggccgccgc agcgcccaga gccagacgcc ggcagcccgc gggcgcagcg tgagcggaga
      181 gtgaagtgtg tcaggctgga catggagagc ccaaggtgtg gctaaaggaa gctcgtcagc
      241 ccagtgcatc acgcttgcta ttttagtgct gcggagcaat gagctcactt tgcttgccct
      301 gaaggagttt tgcctcagga tttgagacaa aaactaaaca aattcaagac aaaagaggtc
      361 tccgccagtc aagaagccct caaaagtgtt ttaccatgga tatagaagat gaagagaata
      421 tgagttccag cagcactgat attaaagaaa accgcaatct ggacaacatg ccccccaagg
      481 acagcagcac acctgggcct ggcgagggta ttccgctctc caacgggggt ggtggtagca
      541 ccagcaggaa gcggcccctg gaggagggca gcaatggtca ctccaagtac cgcctgaaga
      601 agcgaaggaa aacaccaggg cctgttctgc ccaagaacgc cctgatgcag ctgaacgaga
      661 tcaaacctgg cttacagtac atgctgctgt cccagacagg acccgtgcat gcacctctgt
      721 ttgtcatgtc tgtggaggta aacgggcagg tttttgaggg ctctggccct acaaagaaaa
      781 aggcaaaact ccatgctgct gagaaggccc tgaggtcttt tgtccagttt cccaacgcct
      841 ccgaggccca cctagccatg ggaaggaccc tctctgtgaa cacagacttc acgtctgacc
      901 aggctgactt ccctgacaca ctcttcaatg gcttcgagac tccagacaag tcagagccac
      961 ccttctacgt aggctccaac ggggatgact cgttcagctc aagtggagat gtcagcctat
     1021 cggcctcccc agtgcctgcc agccttaccc agcctcctct gcccatccca ccaccattcc
     1081 cacccccaag tgggaagaat cccgtgatga tcttgaatga gctacgccca gggctgaagt
     1141 atgacttcct ctctgagagt ggggagagcc acgccaagag cttcgtcatg tccgtggtgg
     1201 tagatggcca gttctttgag ggctcaggaa gaaacaagaa gcttgccaag gcccgggctg
     1261 cacagtctgc cttggctact gtcttcaatt tgcacttgga ccaaacacca tctcgccagc
     1321 ctgtcctcag tgagggtctt cagttgcatt tgccacaggt attggcagat gctgtctccc
     1381 gcctggtcct gggtaagttc agtgacctga cagacaactt ttcctcccct catgcacgaa
     1441 ggaaagtgct ctctggagta gtgatgacca caggtacaga tgtcaaagat gccaaggtga
     1501 taagtgtttc gacagggacg aagtgtatca acggtgaata catgagtgac cgtggcctcg
     1561 cactcaatga ctgccacgca gagataatct cccgaaggtc cctgctcagg tttctttatg
     1621 cacagctcga gctttattta aataacaaag aagaccagaa aaagtccata tttcagaagt
     1681 cagagcgggg tgggttccgg ctgaaggata ccgtgcagtt ccacctgtac atcagcacct
     1741 cgccctgcgg agacgccaga atattctctc cccacgagcc cgtgctagag gaaccagcag
     1801 atagacatcc gaatcgcaaa gcaaggggac agctacggac gaaaatagag tctggcgagg
     1861 ggacaatccc tgtgcgctca aatgccagca tccagacctg ggacggggtg ctgcaggggg
     1921 aacggctgct caccatgtcc tgcagtgaca agatagcacg ctggaacgtg gtgggcatcc
     1981 aggggtccct gctcagcatt ttcgtggaac ccatctactt ctccagcatc atcttgggca
     2041 gcctgtacca cggggaccac ctctccaggg ccatgtacca gcggatctcc aacatagagg
     2101 acctgccacc gctctacact ctcaacaagc ccctgctcag cggcatcagc aatgcagagg
     2161 cacggcagcc agggaaggca cccaacttca gtgtcaactg gacagtgggt gacgccacca
     2221 ttgaggtcat caatgccaca acagggaagg atgagcttgg ccgcccatcc cgcctgtgta
     2281 agcacgcgct gtactgtcgc tggatgcgtg tacacggcaa ggttcccccc cacctgctgc
     2341 gcaccaagat cactaagcct accacatacc acgagtccaa gctggcagcg agggagtacc
     2401 aggctgccaa ggcccgtctg ttcactgcct tcatcaaggc ggggctgggc gcctgggtgg
     2461 agaagcccac agagcaggac cagttctcct tcactccctg agccaggcgg gtgtcgagca
     2521 cagagtgcga gactgtgatg ccgaactgtc ccccagagcc ttgcatctga actgggacag
     2581 gtgtgcacct ctgggacggc atggggagtc tgggggaacc actggacatc aagcatcatc
     2641 ctcagcggct ctcaccccaa aagggcagcg tggggatgtg tagggtgccg ggcacctcac
     2701 ttctgagtag ggatcgggta cacagtgggg gtgcatgggg gcacaggggc ccatcaccac
     2761 ccctcgccac acatttcccc tcttgagcta cccagtgacc gctttatatc tcagtttaca
     2821 ttagacattg agttctactg agtagggctt cctcaagtat aggaaaatag aaattacttt
     2881 gtgtgagatt cttgaataaa taatttattc agagctagga atgagattta taaaataaga
     2941 agtaattatg tcaggtcact tttatgccac attattttaa ttgcaaaaat taaaaataaa
     3001 agtgtttcta tgtgaaagag cacgagaata tagaggtagg aagtagaaga gagccaccac
     3061 gcgcacatct gtgtgtggct cctctccgta ggtccttcac acttaggttc tcacagtagg
     3121 ttttaacagc tctcctgggg tggccccagc atgatacggt gtgaccttgg cacacaactg
     3181 gccctgcatc tgggatgctg tgtcctagag tcacgaccta ggctctgctg ccccagctgc
     3241 ctctagaatc ttccatgctc ctggttaggc tcaaatcatg gaaaacccta tttgcttcta
     3301 agtcactgaa ggtcaaatcc atttatagcc tgtcccagct ggccatcatg tgggggttct
     3361 aaccatatag gttttgtgac ctagaggcac tcagtagggc tgctacacac tcagagcaca
     3421 gccttccttc tgcccctccc ttgggatctg gtgggtggga accactgacc gctcagaaga
     3481 gcttcagagg atgggaagag ttgtaggcag gtaccattct tggagcgtgc catgtaaggc
     3541 atattactaa ggtatccttc cagagaaatt aaccattcag gttgaagctg gtgtgacagt
     3601 atgagcctgg aacgctgcag accagacatt ggtgtctcga caggcaggcc tgggtgctcc
     3661 tggcatcttg gggctgaccc ccaagatgct actcagcacc ctctctgcac agggtggacc
     3721 cctggacctc ctgtgctcag acttgcccca ggtgccttgt cacttccact caggattagg
     3781 gaggagtaga gggaggaggg ggaggagggg ctgtgactgt catcccagtg tgccagcctg
     3841 gtccagcagg gtcgctctga agagagagct tcagggccga gagcagagcg ggcgcagact
     3901 catccctcag cacacgtctg ccacggctgc atccggggct ctgacagcca tgtggctctg
     3961 agctgttcgc ccaggtgtcc acgcccttga cacactgaga aagaaacagg gcaagagcat
     4021 agccactgta ggttccacca gattcccagc agacctcaag aggccgtgtg tcattgctta
     4081 agtgagatcc acttgtgtct ccatgtccag agctctgtca tgtccttgtg ggtgtctccc
     4141 atggttcttg tcctgtgggg cttgatcttc gaggcatgaa ggtcctacca gaactcccta
     4201 gtgacacgtg ctatctcgga tctcctcagt tcaccacctg tccccctgaa agggaggcct
     4261 cccaggcagg attgtgggcc ctgcgtgctg tggcagggcc aactttgggt gaaacgcact
     4321 ggggttcctt agagaaacgg tctcatttta tcacagtacc atgccttccc cacaggctcc
     4381 tgcactttct agaaagaaaa acacacacga tggtgtgttc tttctcttgc ttttaaattg
     4441 tattttttcc agtggagatg ggaagataga tttagtttgt ttgctgtttt taagtacgtt
     4501 ttggttataa agtgtagcaa aaatcccata tacactaaaa accatgcact acatctggct
     4561 ttccatgtca gataacaagg gtgcccaacc aggaagtgaa ggttacatgc agagagcatc
     4621 tgaaaccaca ggagctggtc ctgcttagac ttgacctagg cccagaaagg agggagagtc
     4681 aggaagtacc ctgtgtcgag gaggcagcac ggggcatgcg ccaccttgcc ctgcacccag
     4741 gatatagtag ctcaaacagc ccgtctgtga cctgagaaaa aggaagcaaa tactgattga
     4801 agacactaag ctctttgagc ctcttcccag aggtccccat gacggtagct catgcccagg
     4861 acctaaatgt cacagactca gcagaaagct tgacataaga ccctgatgga aatgtcctgg
     4921 atacttcagc aggtacggga gcttcagccg ggcgtggtgg cgcacgcctt taatcccagc
     4981 acttgggagg cagaggcagg cagatttctg agttcgaggc cagccagggc tacacagaga
     5041 aaccctgtct cgaaaagaac aggagcttct ctgccctgta tacttagcta gaacagaagt
     5101 attagttcca caaagcagta tctctcagga ttatttgggc ccagcatcag cggggctgta
     5161 gctaaacaaa aggaaggcat catcgccagg agtcgtggga gggctgtcat gtttctacag
     5221 agcagagact ctccacgtag atggaggcag ggtgagtgtg gtgtccatgc cgttagccct
     5281 gatccctaac ggtatcaggt aagtagcacc tcccctagca agggacacca aagaacaact
     5341 ttgaatctga atctgagtct ttcagcattc tgactatttt gaagtttggt tttgtttttt
     5401 gtttttttaa taattaaaca tatatttgta agtgtgcagg ccatcgtttc ataaggcatt
     5461 gctctctgtt tattttaccc cccaccccac cccaccccca gctcctcttg cctccagact
     5521 gtacatgctg cttggttttt taatctttac tttcagacag gtgcaccaaa ggtgggcagc
     5581 caccagagag aggatcagga atgtggggtg agctgcaccg caccctgggc caagatagat
     5641 gcacagtgca ggggcagctt gtcattccca aaacacttta ctccagaaat gtcagctctc
     5701 cccgtcagtg actttgctcc agaaagagaa agaaagtgag ctgaaatcca aacctgtaag
     5761 ttctcgaaat tagggaacct ccccccttga tcccttgata ctgtcagccc cagactacat
     5821 cgtgagaagg gcagagtgtg tgcgttcagt gtgtacagct tgtgtgtgtc ctgtcctggc
     5881 atatctgtca tgtgacagtc tccccagggc tgaggggtac tcacccactc tgcagctgcg
     5941 gactgctcca caccggggct acggggttca tgagatatta gggaatggga attgggaagc
     6001 ctctgacccg ccagggacca tgagggagtt agtcccgccg tctgaccagt catggccggc
     6061 tcctcagtgc acttcccgtc tagttcctgg ggaaatggtc acgtctctgt ggtagtgcct
     6121 gtactttctg tttgccgttt gaacgacaag tgcccagcct cagaagcact taactgtagc
     6181 cacagcagga gctgatggtg cataagggac tggtgggcca ttcttctgaa tggaacacag
     6241 taggttaaaa gcacagtttg tggaatgtta atgggataag cccctaaaag ctgttagctt
     6301 ttccaggctt tgagttatat acttttaatt tgattttaga gtttggacac tttacatgaa
     6361 tgtaactcag ccaagaaacg tgttgctaag atacaatcct cagtgttctc tgtatgtata
     6421 tttctgtata taccacatgt tacagcctgc atgagcttcc tcacaccaag cccagccggc
     6481 actgagcatg agatgctgtt acatgtagac aaaggactga gatgttctca ataaagacta
     6541 agacgtttca ctatgaaaaa aaaaaaaaaa aa
//
