LOCUS       NM_001024837            6602 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus adenosine deaminase, RNA-specific, B1 (Adarb1),
            transcript variant 2, mRNA.
ACCESSION   NM_001024837
VERSION     NM_001024837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6602)
  AUTHORS   Omata,Y., Haraguchi,M., Yoshinaga,S., Ogino,T., Okawa,M.,
            Tsuruta,A., Koyanagi,S. and Ohdo,S.
  TITLE     RNA editing enzyme ADAR2 regulates P-glycoprotein expression in
            murine breast cancer cells through the circRNA-miRNA pathway
  JOURNAL   Biochem Biophys Res Commun 726, 150289 (2024)
   PUBMED   38917633
  REMARK    GeneRIF: RNA editing enzyme ADAR2 regulates P-glycoprotein
            expression in murine breast cancer cells through the circRNA-miRNA
            pathway.
REFERENCE   2  (bases 1 to 6602)
  AUTHORS   Kung,M.L., Yang,T.H., Lin,C.C., Ho,J.Y., Hung,T.C., Chang,C.H.,
            Huang,K.W., Chen,C.C. and Chen,Y.W.
  TITLE     ADAR2 deficiency ameliorates non-alcoholic fatty liver disease and
            muscle atrophy through modulating serum amyloid A1
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (3), 949-962 (2024)
   PUBMED   38533529
  REMARK    GeneRIF: ADAR2 deficiency ameliorates non-alcoholic fatty liver
            disease and muscle atrophy through modulating serum amyloid A1.
REFERENCE   3  (bases 1 to 6602)
  AUTHORS   Kung,M.L., Cheng,S.M., Wang,Y.H., Cheng,K.P., Li,Y.L., Hsiao,Y.T.,
            Tan,B.C. and Chen,Y.W.
  TITLE     Deficiency of ADAR2 ameliorates metabolic-associated fatty liver
            disease via AMPK signaling pathways in obese mice
  JOURNAL   Commun Biol 7 (1), 594 (2024)
   PUBMED   38760406
  REMARK    GeneRIF: Deficiency of ADAR2 ameliorates metabolic-associated fatty
            liver disease via AMPK signaling pathways in obese mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6602)
  AUTHORS   Lebedeva,M., Kubistova,A., Spisska,V., Filipovska,E., Pacesova,D.,
            Svobodova,I., Kuchtiak,V., Balik,A. and Bendova,Z.
  TITLE     The disruption of circadian rhythmicity of gene expression in the
            hippocampus and associated structures in Gria2R/R mice; a
            comparison with C57BL/6J and Adar2-/- mice strains
  JOURNAL   Brain Res 1826, 148739 (2024)
   PUBMED   38157956
  REMARK    GeneRIF: The disruption of circadian rhythmicity of gene expression
            in the hippocampus and associated structures in Gria2[R/R] mice; a
            comparison with C57BL/6J and Adar2[-/-] mice strains.
REFERENCE   5  (bases 1 to 6602)
  AUTHORS   Feng,Y., Sansam,C.L., Singh,M. and Emeson,R.B.
  TITLE     Altered RNA editing in mice lacking ADAR2 autoregulation
  JOURNAL   Mol Cell Biol 26 (2), 480-488 (2006)
   PUBMED   16382140
  REMARK    GeneRIF: ADAR2 autoediting is a key regulator of ADAR2 protein
            expression and activity in vivo.
REFERENCE   6  (bases 1 to 6602)
  AUTHORS   Slavov,D. and Gardiner,K.
  TITLE     Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2
            genes and transcripts: conservation and diversity in editing site
            sequence and alternative splicing patterns
  JOURNAL   Gene 299 (1-2), 83-94 (2002)
   PUBMED   12459255
REFERENCE   7  (bases 1 to 6602)
  AUTHORS   Wiltshire,T., Pletcher,M., Cole,S.E., Villanueva,M., Birren,B.,
            Lehoczky,J., Dewar,K. and Reeves,R.H.
  TITLE     Perfect conserved linkage across the entire mouse chromosome 10
            region homologous to human chromosome 21
  JOURNAL   Genome Res 9 (12), 1214-1222 (1999)
   PUBMED   10613844
REFERENCE   8  (bases 1 to 6602)
  AUTHORS   Cole,S.E., Wiltshire,T., Rue,E.E., Morrow,D., Hieter,P., Brahe,C.,
            Fisher,E.M., Katsanis,N. and Reeves,R.H.
  TITLE     High-resolution comparative physical mapping of mouse chromosome 10
            in the region of homology with human chromosome 21
  JOURNAL   Mamm Genome 10 (3), 229-234 (1999)
   PUBMED   10051316
REFERENCE   9  (bases 1 to 6602)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 6602)
  AUTHORS   Mittaz,L., Scott,H.S., Rossier,C., Seeburg,P.H., Higuchi,M. and
            Antonarakis,S.E.
  TITLE     Cloning of a human RNA editing deaminase (ADARB1) of glutamate
            receptors that maps to chromosome 21q22.3
  JOURNAL   Genomics 41 (2), 210-217 (1997)
   PUBMED   9143496
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB622419.1, AF403107.2,
            BC040200.1 and BC030049.1.
            
            On Nov 30, 2007 this sequence version replaced NM_001024837.1.
            
            Summary: This gene encodes a double-stranded-RNA-specific adenosine
            deaminase that is involved in editing pre-mRNAs by site-specific
            conversion of adenosine (A) to inosine (I). Substrates for this
            enzyme include ionotropic glutamate receptors (GluR2-6) and
            serotonin receptor (5HT2C). Studies in rodents have shown that this
            protein can modify its own pre-mRNA by A->I editing to create a
            novel acceptor splice site, alternative splicing to which results
            in down regulation of its protein expression. Additional splicing
            events result in transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate, in-frame
            donor splice site at one of the internal coding exons, compared to
            transcript variant 1. This results in a longer isoform (2)
            containing a 10 aa segment that is missing in isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF403107.2, AK141777.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            undergoes RNA editing  :: PMID: 16382140, 12459255
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BB622419.1         1-79
            80-3053             AF403107.2         32-3005
            3054-6580           BC040200.1         1609-5135
            6581-6602           BC030049.1         2158-2179
FEATURES             Location/Qualifiers
     source          1..6602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..6602
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /note="adenosine deaminase, RNA-specific, B1"
                     /db_xref="GeneID:110532"
                     /db_xref="MGI:MGI:891999"
     exon            1..179
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..348
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            349..423
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     CDS             396..2531
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /EC_number="3.5.4.37"
                     /note="isoform 2 is encoded by transcript variant 2;
                     double-stranded RNA-specific editase 1; dsRNA adenosine
                     deaminase; RNA-editing deaminase 1; RNA-editing enzyme 1"
                     /codon_start=1
                     /product="double-stranded RNA-specific editase 1 isoform
                     2"
                     /protein_id="NP_001020008.1"
                     /db_xref="CCDS:CCDS35948.1"
                     /db_xref="GeneID:110532"
                     /db_xref="MGI:MGI:891999"
                     /translation="MDIEDEENMSSSSTDIKENRNLDNMPPKDSSTPGPGEGIPLSNG
                     GGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTG
                     PVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLS
                     VNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLT
                     QPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEG
                     SGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGK
                     FSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALND
                     CHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSP
                     CGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNAS
                     IQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHL
                     SRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDATIEVINA
                     TTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAREYQAAK
                     ARLFTAFIKAGLGAWVEKPTEQDQFSFTP"
     exon            424..1358
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1473
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1642
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1821
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1990
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2172
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2351
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..6586
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6560..6565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /note="hexamer: AATAAA"
     polyA_site      6586
                     /gene="Adarb1"
                     /gene_synonym="1700057H01Rik; Adar2; D10Bwg0447e; Red1"
                     /note="major polyA site"
ORIGIN      
        1 gagggggcgg agccgccggc gccgaggcta gaggcagagg ctgaggcagc ggctgaggct
       61 gaggtggctg aggctgaggc ggcggcgagg ggctcctagc tggggccgcg gggctagccg
      121 aggccgccgc agcgcccaga gccagacgcc ggcagcccgc gggcgcagcg tgagcggaga
      181 gtgaagtgtg tcaggctgga catggagagc ccaaggtgtg gctaaaggaa gctcgtcagc
      241 ccagtgcatc acgcttgcta ttttagtgct gcggagcaat gagctcactt tgcttgccct
      301 gaaggagttt tgcctcagga tttgagacaa aaactaaaca aattcaagac aaaagaggtc
      361 tccgccagtc aagaagccct caaaagtgtt ttaccatgga tatagaagat gaagagaata
      421 tgagttccag cagcactgat attaaagaaa accgcaatct ggacaacatg ccccccaagg
      481 acagcagcac acctgggcct ggcgagggta ttccgctctc caacgggggt ggtggtagca
      541 ccagcaggaa gcggcccctg gaggagggca gcaatggtca ctccaagtac cgcctgaaga
      601 agcgaaggaa aacaccaggg cctgttctgc ccaagaacgc cctgatgcag ctgaacgaga
      661 tcaaacctgg cttacagtac atgctgctgt cccagacagg acccgtgcat gcacctctgt
      721 ttgtcatgtc tgtggaggta aacgggcagg tttttgaggg ctctggccct acaaagaaaa
      781 aggcaaaact ccatgctgct gagaaggccc tgaggtcttt tgtccagttt cccaacgcct
      841 ccgaggccca cctagccatg ggaaggaccc tctctgtgaa cacagacttc acgtctgacc
      901 aggctgactt ccctgacaca ctcttcaatg gcttcgagac tccagacaag tcagagccac
      961 ccttctacgt aggctccaac ggggatgact cgttcagctc aagtggagat gtcagcctat
     1021 cggcctcccc agtgcctgcc agccttaccc agcctcctct gcccatccca ccaccattcc
     1081 cacccccaag tgggaagaat cccgtgatga tcttgaatga gctacgccca gggctgaagt
     1141 atgacttcct ctctgagagt ggggagagcc acgccaagag cttcgtcatg tccgtggtgg
     1201 tagatggcca gttctttgag ggctcaggaa gaaacaagaa gcttgccaag gcccgggctg
     1261 cacagtctgc cttggctact gtcttcaatt tgcacttgga ccaaacacca tctcgccagc
     1321 ctgtcctcag tgagggtctt cagttgcatt tgccacaggt attggcagat gctgtctccc
     1381 gcctggtcct gggtaagttc agtgacctga cagacaactt ttcctcccct catgcacgaa
     1441 ggaaagtgct ctctggagta gtgatgacca caggtacaga tgtcaaagat gccaaggtga
     1501 taagtgtttc gacagggacg aagtgtatca acggtgaata catgagtgac cgtggcctcg
     1561 cactcaatga ctgccacgca gagataatct cccgaaggtc cctgctcagg tttctttatg
     1621 cacagctcga gctttattta aataacaaag aagaccagaa aaagtccata tttcagaagt
     1681 cagagcgggg tgggttccgg ctgaaggata ccgtgcagtt ccacctgtac atcagcacct
     1741 cgccctgcgg agacgccaga atattctctc cccacgagcc cgtgctagag ggtatgacgc
     1801 cagactctca ccagctgaca gaaccagcag atagacatcc gaatcgcaaa gcaaggggac
     1861 agctacggac gaaaatagag tctggcgagg ggacaatccc tgtgcgctca aatgccagca
     1921 tccagacctg ggacggggtg ctgcaggggg aacggctgct caccatgtcc tgcagtgaca
     1981 agatagcacg ctggaacgtg gtgggcatcc aggggtccct gctcagcatt ttcgtggaac
     2041 ccatctactt ctccagcatc atcttgggca gcctgtacca cggggaccac ctctccaggg
     2101 ccatgtacca gcggatctcc aacatagagg acctgccacc gctctacact ctcaacaagc
     2161 ccctgctcag cggcatcagc aatgcagagg cacggcagcc agggaaggca cccaacttca
     2221 gtgtcaactg gacagtgggt gacgccacca ttgaggtcat caatgccaca acagggaagg
     2281 atgagcttgg ccgcccatcc cgcctgtgta agcacgcgct gtactgtcgc tggatgcgtg
     2341 tacacggcaa ggttcccccc cacctgctgc gcaccaagat cactaagcct accacatacc
     2401 acgagtccaa gctggcagcg agggagtacc aggctgccaa ggcccgtctg ttcactgcct
     2461 tcatcaaggc ggggctgggc gcctgggtgg agaagcccac agagcaggac cagttctcct
     2521 tcactccctg agccaggcgg gtgtcgagca cagagtgcga gactgtgatg ccgaactgtc
     2581 ccccagagcc ttgcatctga actgggacag gtgtgcacct ctgggacggc atggggagtc
     2641 tgggggaacc actggacatc aagcatcatc ctcagcggct ctcaccccaa aagggcagcg
     2701 tggggatgtg tagggtgccg ggcacctcac ttctgagtag ggatcgggta cacagtgggg
     2761 gtgcatgggg gcacaggggc ccatcaccac ccctcgccac acatttcccc tcttgagcta
     2821 cccagtgacc gctttatatc tcagtttaca ttagacattg agttctactg agtagggctt
     2881 cctcaagtat aggaaaatag aaattacttt gtgtgagatt cttgaataaa taatttattc
     2941 agagctagga atgagattta taaaataaga agtaattatg tcaggtcact tttatgccac
     3001 attattttaa ttgcaaaaat taaaaataaa agtgtttcta tgtgaaagag cacgagaata
     3061 tagaggtagg aagtagaaga gagccaccac gcgcacatct gtgtgtggct cctctccgta
     3121 ggtccttcac acttaggttc tcacagtagg ttttaacagc tctcctgggg tggccccagc
     3181 atgatacggt gtgaccttgg cacacaactg gccctgcatc tgggatgctg tgtcctagag
     3241 tcacgaccta ggctctgctg ccccagctgc ctctagaatc ttccatgctc ctggttaggc
     3301 tcaaatcatg gaaaacccta tttgcttcta agtcactgaa ggtcaaatcc atttatagcc
     3361 tgtcccagct ggccatcatg tgggggttct aaccatatag gttttgtgac ctagaggcac
     3421 tcagtagggc tgctacacac tcagagcaca gccttccttc tgcccctccc ttgggatctg
     3481 gtgggtggga accactgacc gctcagaaga gcttcagagg atgggaagag ttgtaggcag
     3541 gtaccattct tggagcgtgc catgtaaggc atattactaa ggtatccttc cagagaaatt
     3601 aaccattcag gttgaagctg gtgtgacagt atgagcctgg aacgctgcag accagacatt
     3661 ggtgtctcga caggcaggcc tgggtgctcc tggcatcttg gggctgaccc ccaagatgct
     3721 actcagcacc ctctctgcac agggtggacc cctggacctc ctgtgctcag acttgcccca
     3781 ggtgccttgt cacttccact caggattagg gaggagtaga gggaggaggg ggaggagggg
     3841 ctgtgactgt catcccagtg tgccagcctg gtccagcagg gtcgctctga agagagagct
     3901 tcagggccga gagcagagcg ggcgcagact catccctcag cacacgtctg ccacggctgc
     3961 atccggggct ctgacagcca tgtggctctg agctgttcgc ccaggtgtcc acgcccttga
     4021 cacactgaga aagaaacagg gcaagagcat agccactgta ggttccacca gattcccagc
     4081 agacctcaag aggccgtgtg tcattgctta agtgagatcc acttgtgtct ccatgtccag
     4141 agctctgtca tgtccttgtg ggtgtctccc atggttcttg tcctgtgggg cttgatcttc
     4201 gaggcatgaa ggtcctacca gaactcccta gtgacacgtg ctatctcgga tctcctcagt
     4261 tcaccacctg tccccctgaa agggaggcct cccaggcagg attgtgggcc ctgcgtgctg
     4321 tggcagggcc aactttgggt gaaacgcact ggggttcctt agagaaacgg tctcatttta
     4381 tcacagtacc atgccttccc cacaggctcc tgcactttct agaaagaaaa acacacacga
     4441 tggtgtgttc tttctcttgc ttttaaattg tattttttcc agtggagatg ggaagataga
     4501 tttagtttgt ttgctgtttt taagtacgtt ttggttataa agtgtagcaa aaatcccata
     4561 tacactaaaa accatgcact acatctggct ttccatgtca gataacaagg gtgcccaacc
     4621 aggaagtgaa ggttacatgc agagagcatc tgaaaccaca ggagctggtc ctgcttagac
     4681 ttgacctagg cccagaaagg agggagagtc aggaagtacc ctgtgtcgag gaggcagcac
     4741 ggggcatgcg ccaccttgcc ctgcacccag gatatagtag ctcaaacagc ccgtctgtga
     4801 cctgagaaaa aggaagcaaa tactgattga agacactaag ctctttgagc ctcttcccag
     4861 aggtccccat gacggtagct catgcccagg acctaaatgt cacagactca gcagaaagct
     4921 tgacataaga ccctgatgga aatgtcctgg atacttcagc aggtacggga gcttcagccg
     4981 ggcgtggtgg cgcacgcctt taatcccagc acttgggagg cagaggcagg cagatttctg
     5041 agttcgaggc cagccagggc tacacagaga aaccctgtct cgaaaagaac aggagcttct
     5101 ctgccctgta tacttagcta gaacagaagt attagttcca caaagcagta tctctcagga
     5161 ttatttgggc ccagcatcag cggggctgta gctaaacaaa aggaaggcat catcgccagg
     5221 agtcgtggga gggctgtcat gtttctacag agcagagact ctccacgtag atggaggcag
     5281 ggtgagtgtg gtgtccatgc cgttagccct gatccctaac ggtatcaggt aagtagcacc
     5341 tcccctagca agggacacca aagaacaact ttgaatctga atctgagtct ttcagcattc
     5401 tgactatttt gaagtttggt tttgtttttt gtttttttaa taattaaaca tatatttgta
     5461 agtgtgcagg ccatcgtttc ataaggcatt gctctctgtt tattttaccc cccaccccac
     5521 cccaccccca gctcctcttg cctccagact gtacatgctg cttggttttt taatctttac
     5581 tttcagacag gtgcaccaaa ggtgggcagc caccagagag aggatcagga atgtggggtg
     5641 agctgcaccg caccctgggc caagatagat gcacagtgca ggggcagctt gtcattccca
     5701 aaacacttta ctccagaaat gtcagctctc cccgtcagtg actttgctcc agaaagagaa
     5761 agaaagtgag ctgaaatcca aacctgtaag ttctcgaaat tagggaacct ccccccttga
     5821 tcccttgata ctgtcagccc cagactacat cgtgagaagg gcagagtgtg tgcgttcagt
     5881 gtgtacagct tgtgtgtgtc ctgtcctggc atatctgtca tgtgacagtc tccccagggc
     5941 tgaggggtac tcacccactc tgcagctgcg gactgctcca caccggggct acggggttca
     6001 tgagatatta gggaatggga attgggaagc ctctgacccg ccagggacca tgagggagtt
     6061 agtcccgccg tctgaccagt catggccggc tcctcagtgc acttcccgtc tagttcctgg
     6121 ggaaatggtc acgtctctgt ggtagtgcct gtactttctg tttgccgttt gaacgacaag
     6181 tgcccagcct cagaagcact taactgtagc cacagcagga gctgatggtg cataagggac
     6241 tggtgggcca ttcttctgaa tggaacacag taggttaaaa gcacagtttg tggaatgtta
     6301 atgggataag cccctaaaag ctgttagctt ttccaggctt tgagttatat acttttaatt
     6361 tgattttaga gtttggacac tttacatgaa tgtaactcag ccaagaaacg tgttgctaag
     6421 atacaatcct cagtgttctc tgtatgtata tttctgtata taccacatgt tacagcctgc
     6481 atgagcttcc tcacaccaag cccagccggc actgagcatg agatgctgtt acatgtagac
     6541 aaaggactga gatgttctca ataaagacta agacgtttca ctatgaaaaa aaaaaaaaaa
     6601 aa
//
