LOCUS       NM_001410664            4352 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus adenosine deaminase, RNA-specific (Adar), transcript
            variant 11, mRNA.
ACCESSION   NM_001410664
VERSION     NM_001410664.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Zerad,L., Gacem,N., Gayda,F., Day,L., Sinigaglia,K., Richard,L.,
            Parisot,M., Cagnard,N., Mathis,S., Bole-Feysot,C., O'Connell,M.A.,
            Pingault,V., Dambroise,E., Keegan,L.P., Vallat,J.M. and
            Bondurand,N.
  TITLE     Overexpression of Egr1 Transcription Regulator Contributes to
            Schwann Cell Differentiation Defects in Neural Crest-Specific Adar1
            Knockout Mice
  JOURNAL   Cells 13 (23), 1952 (2024)
   PUBMED   39682701
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Cai,D. and Chen,S.Y.
  TITLE     ADAR1 Is Essential for Smooth Muscle Homeostasis and Vascular
            Integrity
  JOURNAL   Cells 13 (15), 1257 (2024)
   PUBMED   39120288
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Gan,W.L., Ren,X., Ng,V.H.E., Ng,L., Song,Y., Tano,V., Han,J.,
            An,O., Xie,J., Ng,B.Y.L., Tay,D.J.T., Tang,S.J., Shen,H., Khare,S.,
            Chong,K.H.C., Young,D.Y., Wu,B., DasGupta,R. and Chen,L.
  TITLE     Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates
            ADAR1-mediated immunity in the liver
  JOURNAL   Cell Rep 43 (7), 114400 (2024)
   PUBMED   38935501
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   Licht,K. and Jantsch,M.F.
  TITLE     The Other Face of an Editor: ADAR1 Functions in Editing-Independent
            Ways
  JOURNAL   Bioessays 39 (11) (2017)
   PUBMED   28960389
  REMARK    GeneRIF: ADAR1 functions other than RNA editing are reviewed.
            Review article
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Walkley,C.R. and Li,J.B.
  TITLE     Rewriting the transcriptome: adenosine-to-inosine RNA editing by
            ADARs
  JOURNAL   Genome Biol 18 (1), 205 (2017)
   PUBMED   29084589
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Keegan,L., Khan,A., Vukic,D. and O'Connell,M.
  TITLE     ADAR RNA editing below the backbone
  JOURNAL   RNA 23 (9), 1317-1328 (2017)
   PUBMED   28559490
  REMARK    Review article
REFERENCE   7  (bases 1 to 4352)
  AUTHORS   Wang,Q., Li,X., Qi,R. and Billiar,T.
  TITLE     RNA Editing, ADAR1, and the Innate Immune Response
  JOURNAL   Genes (Basel) 8 (1), 41 (2017)
   PUBMED   28106799
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4352)
  AUTHORS   Schwartz,T., Behlke,J., Lowenhaupt,K., Heinemann,U. and Rich,A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
REFERENCE   9  (bases 1 to 4352)
  AUTHORS   Wang,Q., Khillan,J., Gadue,P. and Nishikura,K.
  TITLE     Requirement of the RNA editing deaminase ADAR1 gene for embryonic
            erythropoiesis
  JOURNAL   Science 290 (5497), 1765-1768 (2000)
   PUBMED   11099415
REFERENCE   10 (bases 1 to 4352)
  AUTHORS   Weier,H.U., George,C.X., Lersch,R.A., Breitweser,S., Cheng,J.F. and
            Samuel,C.E.
  TITLE     Assignment of the RNA-specific adenosine deaminase gene (Adar) to
            mouse chromosome 3F2 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 214-215 (2000)
   PUBMED   10965125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166364.2 and AC102392.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF291875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC166364.2         14320-14401         c
            83-266              AC166364.2         6985-7168           c
            267-415             AC166364.2         5840-5988           c
            416-554             AC166364.2         5187-5325           c
            555-739             AC166364.2         4880-5064           c
            740-887             AC102392.8         179441-179588       c
            888-1059            AC102392.8         178973-179144       c
            1060-1153           AC102392.8         178306-178399       c
            1154-1276           AC102392.8         177670-177792       c
            1277-1410           AC102392.8         177293-177426       c
            1411-1593           AC102392.8         175145-175327       c
            1594-1706           AC102392.8         174616-174728       c
            1707-1834           AC102392.8         174209-174336       c
            1835-4352           AC102392.8         171518-174035       c
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.19 cM"
     gene            1..4352
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /note="adenosine deaminase, RNA-specific"
                     /db_xref="GeneID:56417"
                     /db_xref="MGI:MGI:1889575"
     exon            1..82
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            83..266
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2081
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /EC_number="3.5.4.37"
                     /note="isoform 9 is encoded by transcript variant 11;
                     double-stranded RNA-specific adenosine deaminase;
                     RNA-specific adenosine deaminase p150 form; RNA-specific
                     adenosine deaminase p110 form; RNA adenosine deaminase 1"
                     /codon_start=1
                     /product="double-stranded RNA-specific adenosine deaminase
                     isoform 9"
                     /protein_id="NP_001397593.1"
                     /db_xref="GeneID:56417"
                     /db_xref="MGI:MGI:1889575"
                     /translation="MAILLREAKAKDSGQPEDLSHCPMEEDSEKPAEAQAPSSSATSL
                     FSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPPVSAPSKKV
                     AKQMAAEEAMKALQEEAASSADDQSGGANTDSLDESMAPNKIRRIGELVRYLNTNPVG
                     GLLEYARSHGFAAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADA
                     ALRVLIGESEKAEQLGFAELPLSGSTFHDQIAMLSHRCFNALTNSFQPSLLGRKILAA
                     IIMKRDPEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSELMK
                     YNHHTAKNSIFELARGGEKLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAVESTESR
                     HYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNV
                     LGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRVTRDGKAFEDGLRYPFIVNH
                     PKVGRVSVYDSKRQSGKTKETSVNWCMADGYDLEILDGTRGTVDGPGKELSRVSKKNI
                     FLQFKKLCSFRARRDLLQLSYGEAKKAARDYDLAKNYFKKSLRDMGYGNWISKPQEEK
                     NFYLCPVPND"
     exon            267..415
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            416..554
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            555..739
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            740..887
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1059
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1153
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1276
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1410
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1593
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1706
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1834
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..4352
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /note="hexamer: ATTAAA"
     polyA_site      2312
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
     regulatory      4332..4337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /note="hexamer: AATAAA"
     polyA_site      4352
                     /gene="Adar"
                     /gene_synonym="Adar1; Adar1p110; Adar1p150; DRADA;
                     mZaADAR"
                     /note="major polyA site"
ORIGIN      
        1 gaactctggg gagccagcca tcttacggcc acaggtgcgg gccttgccgg cactatgtct
       61 caagggttca ggggacccac agatttaaat tccaggttgt catcaatggg cgggaatttc
      121 ccccagctga ggctggcagc aagaaagtag ccaagcagga cgcagcagtg aaagccatgg
      181 cgattctgct tcgggaagcc aaagccaaag acagtggtca accagaagac ttgtcccact
      241 gtcccatgga agaagactcg gagaaaccag cagaggctca ggcccccagc tcctcagcaa
      301 catccttgtt ctctgggaag agcccagtta ctacactgct tgagtgcatg cacaaactag
      361 ggaactcctg tgaattccgt ctcctgtcca aagaaggccc tgctcatgac cccaagttcc
      421 agtactgtgt agcagtagga gcccagacct tcccccctgt gagcgccccc agcaagaagg
      481 tagcaaagca gatggccgca gaggaagcca tgaaggcgct gcaggaggag gcagccagtt
      541 cagcggatga ccagtctgga ggtgcgaaca cagactcact tgatgaatct atggctccca
      601 acaagatcag gaggattggt gagctcgtca ggtacctgaa caccaacccc gtaggcggct
      661 tgttggagta cgcccgatct catggctttg ctgctgagtt caagctcatt gaccagtctg
      721 gacctcctca cgaacccaag tttgtttacc aagcaaaagt tgggggccgc tggtttccag
      781 ccgtgtgtgc acacagcaag aaacagggca agcaggatgc agcggatgca gccctccggg
      841 tcttgatcgg ggagagcgag aaggcagagc agttgggttt cgcagagctt cctctctctg
      901 gcagcacctt ccacgaccag atagctatgc tgagccacag gtgcttcaat gctctgacca
      961 acagtttcca gccctccctg ctcggccgca agatcctggc tgccattatt atgaaaagag
     1021 atccagagga catgggtgtt gtcgtgagtt tggggacagg caatcgctgt gtgaaagggg
     1081 actctctcag cctgaaggga gagacggtca atgactgcca tgccgaaatc atctcccgga
     1141 ggggcttcat caggtttctc tacagtgaac tgatgaagta caaccaccac actgccaaga
     1201 acagcatatt tgagcttgcc aggggaggag agaagctgca gataaagaag acggtttctt
     1261 ttcatctcta catcagcacg gcgccatgtg gagatggggc cctctttgac aaatcctgca
     1321 gtgaccgtgc cgtggaaagc acagagtccc gccattaccc tgtctttgaa aatcccaagc
     1381 aaggcaagct tcgcaccaag gtggagaatg gggaaggcac aattcctgtg gagtccagtg
     1441 atattgtacc cacgtgggat ggcatccgcc ttggggaaag actccgtacc atgtcctgta
     1501 gtgacaaaat cctacgctgg aatgtgctgg gcctgcaagg ggcgttgttg acgcacttcc
     1561 tacagcctgt gtacctgaaa tctgtaacct taggttacct tttcagccaa gggcatctga
     1621 cccgtgctat ttgctgccgc gtgaccagag atgggaaagc atttgaggat ggactacgct
     1681 atccctttat tgtcaaccac cccaaggtcg gccgagtcag tgtttatgat tccaaaagac
     1741 agtccggaaa gaccaaggaa acaagcgtca actggtgcat ggctgatggc tatgacctag
     1801 agatcctgga tggcaccaga ggcactgtgg atggaccagg gaaagagttg tctcgggtgt
     1861 ccaagaagaa tattttcctt cagtttaaga agctctgctc cttccgagcc cgcagagatt
     1921 tactgcagct ctcttatggt gaagccaaga aagctgcccg tgactatgac ttagccaaga
     1981 actacttcaa gaaaagcctg cgagacatgg gctatgggaa ttggatcagc aaaccccagg
     2041 aggaaaagaa cttttacctc tgtccagtac ccaatgactg atagtggggc gcgtttctcc
     2101 tggggtcaga gggcggtcat ggcattcctc atcacaccgg gccagaggat aggagctttt
     2161 tttacccact cccccctttt ttaatggtag aaccataata gatggtacca agaactgctt
     2221 tctttgggat ttcaaggtgg ggtccagcca agtccccacc tcccttttct caagggaaga
     2281 ggccaagatt aaaggaaatg gaaatgctac cattccatat gtagcacaga cagttcttgg
     2341 tcacatggag cccaggcccc tcgggcttcg ttttgcggag gtttttttca tctccttttc
     2401 ctttgctgca ctggcctctt gtgggtttga ttccatccca tcagttctct gtaaatgatg
     2461 tcaggggcca gtgatgtcac ctgcagatgc gcaggcaggc ccctgctctg tcatccttcc
     2521 ctcctaggat gccttcctgt gatgaggttt ctccttcccc accccagagg atagaggtga
     2581 acataaagga ttggtgaaat gtttacaagg gcaggagttg acaaccgtgg tcagggattg
     2641 tcgaacaaca ggaatgtggt aaactgtggt tgggacaggc aagccctacc cagtaacagg
     2701 ccgtgctggc ccaccaagga acttcccttc ctgggcagca gggaagttga gaatcggcca
     2761 gtgggaccga ggaaggtacc caaaccaagc acgtcccagt aggggtccac aagcactaac
     2821 tagagtgcac cagcattcca tggaatgtcg ctatgcctcc atctgcccct ccatgagcac
     2881 tcccagaagc tggccctggg cacgtgtggt gttggcccca ggccccagct gtttgtgaaa
     2941 agcagagggt gagcatagtg ggcagagcag ctttgcccag acggcaaagg taaaggcaga
     3001 gcatcctgcc ggtgcactgg gattcttctg gtctcagcag aagtgacaaa gccctgcata
     3061 gaattaatgt ttctaaaagg ccagaggcat tgattctgaa ctgcatcaaa gactggagat
     3121 gcaaatatta cttctccatt agtaaatgta ctttcattct atcagatggc ttcagaagct
     3181 gggtcacgga cagggcacag ggccctggaa tctctgccct gctcctttga ggatcttcat
     3241 ttacatacaa gtgttgtagg tggcagggca ggctggcctc ccactctggg atgggcttct
     3301 ttgactcctc cccctctgac agtgacttgt gggtatgtgg gagcctctgt agaatctggt
     3361 tctagcatca gatcaaccag ccagaccctg ctccattctg cccctctagg accaagccca
     3421 cctctttcct ctgaatggtg tggctccatc tggagacagc tggccagtgt gttcaacagt
     3481 ttcctgcacc cccttgctta accctcagag ctgcctggtt cccccaccct ctggcccact
     3541 gccaacagca aacatcacat tcgtacttca agtctaatgg ctactgcctc ctcaatctat
     3601 gaacagatct ggccaacaca agaacctgtg tcttcacaat acactgggga tgtctttgca
     3661 cagccaaatc atcctatgaa actccagcgt ctgtggaagt gagaaagcag caccatgctt
     3721 gtggtgtcgg ctggaggcgt gtcaccctcc ggcaactgca tctgaagcag agcccttgtg
     3781 gtttccaggc ctggacaggg agctcttccc ctggggtcta aaggacagag atgtctctcc
     3841 ctttgattcc tttggtccct ctggtcctcc ctgggtattc acacataccc caatcctgtc
     3901 tagacaacga gtggttctgg gtttctgcag atggaagaga gcaaggtgtc cctgagttct
     3961 gtggacttga cccccgcatc ccaccctgac cctgcctcca gtcccgctgg ccgagggcag
     4021 agcctcctcc cactgtgctt ccttcacgtt tactttaaga agcagggcct ccctccacac
     4081 cgtctcttaa tactttctgt agttgatttg tctgaaccgt ggctgtcttg cattccttga
     4141 ataatcatgt gtaagaattg tcaatgcttg aaactatttc ctgtactcaa gttgaaggga
     4201 ctttgttggc cttggggttt tagcagtgac tccaagagca gagtggggaa gcacccaggc
     4261 atagccttgg cgctgtgatg gatgcagtcc ctccctctgt ccctttacaa gtgacagtat
     4321 acattcctaa aaataaaaac actgaagcat ca
//
