LOCUS       NM_172133               1611 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus ArfGAP with dual PH domains 2 (Adap2), mRNA.
ACCESSION   NM_172133
VERSION     NM_172133.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1611)
  AUTHORS   Venturin,M., Carra,S., Gaudenzi,G., Brunelli,S., Gallo,G.R.,
            Moncini,S., Cotelli,F. and Riva,P.
  TITLE     ADAP2 in heart development: a candidate gene for the occurrence of
            cardiovascular malformations in NF1 microdeletion syndrome
  JOURNAL   J Med Genet 51 (7), 436-443 (2014)
   PUBMED   24711647
  REMARK    GeneRIF: ADAP2 has a role in heart development, and might be a
            reliable candidate gene for the occurrence of cardiovascular
            malformations in patients with NF1 microdeletion.
REFERENCE   2  (bases 1 to 1611)
  AUTHORS   Venturin,M., Bentivegna,A., Moroni,R., Larizza,L. and Riva,P.
  TITLE     Evidence by expression analysis of candidate genes for congenital
            heart defects in the NF1 microdeletion interval
  JOURNAL   Ann Hum Genet 69 (Pt 5), 508-516 (2005)
   PUBMED   16138909
REFERENCE   3  (bases 1 to 1611)
  AUTHORS   Jenne,D.E., Tinschert,S., Dorschner,M.O., Hameister,H., Stephens,K.
            and Kehrer-Sawatzki,H.
  TITLE     Complete physical map and gene content of the human NF1 tumor
            suppressor region in human and mouse
  JOURNAL   Genes Chromosomes Cancer 37 (2), 111-120 (2003)
   PUBMED   12696059
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC027165.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027165.1, AK050398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1611
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 47.56 cM"
     gene            1..1611
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /note="ArfGAP with dual PH domains 2"
                     /db_xref="GeneID:216991"
                     /db_xref="MGI:MGI:2663075"
     exon            1..148
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1200
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /note="centaurin, alpha 2; cnt-a2"
                     /codon_start=1
                     /product="arf-GAP with dual PH domain-containing protein
                     2"
                     /protein_id="NP_742145.1"
                     /db_xref="CCDS:CCDS25128.1"
                     /db_xref="GeneID:216991"
                     /db_xref="MGI:MGI:2663075"
                     /translation="MGDRERNKKRLLELLQAAGTGNGHCADCGAADPDWASYKLGIFI
                     CLHCSGVHRNFPDISKVKSVRLDFWDDSMVEFMTHHGNLNVKAKFEARVPAFYYVPQA
                     NDCLVLKEQWIRAKYERQEFTAIDKAVSHPGNREGFLWKRGRDNAQFLRRRFVLLSRE
                     GLLKYYTKEEGKAPKAVISIKDLNATFQTEKIGHPHGLQITYRKEGHTRNLFVYHDSG
                     KEIVDWFNALRAARLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKR
                     WFALDPQERRLLYYKNPLDAFELGQVFLGSNEQGYEVWEDLPKGIRGNRWKAGLTVIT
                     PERKFIFTCPTEKEQREWLESLRGVLSSPLSPLHLLTTSAETGCGLG"
     exon            149..279
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..371
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            372..451
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..564
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..711
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..795
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..858
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..936
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1165
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1597
                     /gene="Adap2"
                     /gene_synonym="Centa2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggaagca cagaggtggc agggttgagc cccgctgaga cctctgggcc ggccatgggc
       61 gaccgcgagc gcaacaagaa gcggctgctg gagctgctgc aggctgcggg caccggcaac
      121 gggcactgcg ccgactgcgg ggcagcggat cctgattggg cctcttacaa gctggggatt
      181 ttcatctgtc tccactgctc tggcgtccac cgcaacttcc cagacatcag caaagttaaa
      241 tccgtgagac tggacttctg ggacgacagt atggtggagt tcatgactca ccatgggaac
      301 ctcaacgtga aagccaagtt tgaagcaaga gtcccagctt tctactatgt ccctcaggcc
      361 aacgactgcc tggtcttaaa ggaacaatgg attcgagcta agtatgaaag acaggagttt
      421 acggctattg acaaagctgt ctcacatcca ggtaaccgag aagggttcct gtggaagcga
      481 ggacgggaca acgcacagtt cctgagaagg cggtttgtcc ttctgtcgag ggaaggcctc
      541 ctgaagtact acaccaagga ggagggtaaa gccccaaagg ctgtcatcag catcaaggac
      601 ttaaacgcca ccttccagac agagaagata ggacatcccc acgggctgca gatcacctac
      661 aggaaagagg gccacaccag gaacctgttt gtttatcatg acagtgggaa ggagatagtg
      721 gattggttca atgctctccg tgcagcccgc ctgcaatacc tgaaattggc ctttcctgat
      781 ctcccagagt ctgagctcgt gcctctcatc accaggaact acctcaaaca aggcttcatg
      841 gagaagactg gtccaaagca tagagaaccc ttcaagaaaa gatggtttgc cttggatccg
      901 caggaacgga ggctgctcta ttataagaac cccctggatg cttttgagct gggccaggtt
      961 tttctgggaa gcaatgagca gggatatgaa gtatgggaag atctgcccaa gggcatccga
     1021 gggaaccgct ggaaggctgg acttaccgtc atcactccgg agcggaaatt catcttcacc
     1081 tgccccactg aaaaggaaca gcgagaatgg ctagagagtc tgcggggcgt cttgtccagt
     1141 cccttgtcac ccctccacct cctcaccaca tcagcagaga ctggctgtgg cctggggtga
     1201 cccatctcgg aggatctggc tggctactgt gcatctgaag ttctggagaa gtgttcacct
     1261 cagccctagt tgtccagaag gaagccctga ggccagcagc tgccccacta gtgaactcca
     1321 gggtgtggtt gatcctacga ctccccgtgc tccttccagc aaactctcct cagtcttgag
     1381 gagctggtat ggagaagaat tcagctctcc aagcttagaa gtcctgaagg gttcctcata
     1441 actgcaccaa gagctggcca tggtgacgca tgccaggcaa gaggcgaggg tgccatgagc
     1501 ccagtgacaa cctggactac actgggggtt cagttcagcc tgagttacat agcaagacct
     1561 tgtctcagaa acaaacaaac aaacaaacca aaaaccaaaa aaaaaaaaaa a
//
