LOCUS       NM_172723               2418 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ArfGAP with dual PH domains 1 (Adap1), mRNA.
ACCESSION   NM_172723
VERSION     NM_172723.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2418)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2418)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2418)
  AUTHORS   Szatmari,E.M., Moran,C., Cohen,S., Jacob,A., Parra-Bueno,P.,
            Kamasawa,N., Guerrero-Given,D., Klein,M., Stackman,R. Jr. and
            Yasuda,R.
  TITLE     ADAP1/Centaurin-alpha1 Negatively Regulates Dendritic Spine
            Function and Memory Formation in the Hippocampus
  JOURNAL   eNeuro 8 (1) (2021)
   PUBMED   33139322
  REMARK    GeneRIF: ADAP1/Centaurin-alpha1 Negatively Regulates Dendritic
            Spine Function and Memory Formation in the Hippocampus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2418)
  AUTHORS   Van Duzer,A., Taniguchi,S., Elhance,A., Tsujikawa,T. and
            Oshimori,N.
  TITLE     ADAP1 promotes invasive squamous cell carcinoma progression and
            predicts patient survival
  JOURNAL   Life Sci Alliance 2 (6), e201900582 (2019)
   PUBMED   31792062
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2418)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY740716.1, CX242691.1 and BC079634.1.
            
            On May 30, 2007 this sequence version replaced NM_172723.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.526664.1,
                                           SRR17784647.478489.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BY740716.1         159-268
            111-206             CX242691.1         111-206
            207-2418            BC079634.1         1-2212
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 78.27 cM"
     gene            1..2418
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /note="ArfGAP with dual PH domains 1"
                     /db_xref="GeneID:231821"
                     /db_xref="MGI:MGI:2442201"
     exon            1..184
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1227
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /note="centaurin, alpha 1"
                     /codon_start=1
                     /product="arf-GAP with dual PH domain-containing protein
                     1"
                     /protein_id="NP_766311.2"
                     /db_xref="CCDS:CCDS19806.2"
                     /db_xref="GeneID:231821"
                     /db_xref="MGI:MGI:2442201"
                     /translation="MAGERRRALLELLTRPGNTRCADCGAPDPDWASYTLGVFICLSC
                     SGIHRNIPQVSKVKSVRLDAWDEAQVEFMASHGNEAARATFESKVPPFYYRPTFSDCQ
                     LLREQWIRAKYERQEFVHVEKQEPYSTGYREGLLWKRGRDNGQFLSRKFVLTEREGAL
                     KYFNKNDAKEPKAVMKIEHLNATFQPAKMGHPHGLQVTYLKDNSTRNIFIYHEDGKEI
                     VDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFT
                     MDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLEGLPLSTQGHHWPHGITIVTPDRKF
                     LFTCETESDQREWIAAFQKVVDRPMLPQEYAVEAHFKHKP"
     exon            185..315
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            316..407
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            408..490
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            491..603
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            604..750
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            751..834
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            835..897
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            898..969
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1198
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2399
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2375..2380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /note="hexamer: AATAAA"
     polyA_site      2392
                     /gene="Adap1"
                     /gene_synonym="4930431P11Rik; Centa1; GC1L; p42IP4"
                     /note="major polyA site"
ORIGIN      
        1 cgcgggctga gcggtggcga tggcgcaagg cgggcggcgg gcgcgcggcg cggggcccta
       61 gcggggcggg cgtgctcggg acggcgcggt ggccgcgcag ccatggccgg ggagcggcgc
      121 cgggcgctgc tggagctact gacgcggccg gggaacacgc gctgcgctga ctgcggagcc
      181 ccggatcctg actgggcgtc ctacaccctg ggtgtgttca tctgtttgag ctgctctggg
      241 atccaccgga acatccccca ggtcagcaag gtgaagtcag tccgtctgga tgcctgggat
      301 gaggcccaag ttgagttcat ggcatctcat gggaacgagg ctgccagagc cacatttgag
      361 tccaaagtac cgcccttcta ctaccggccc acgttctccg actgccaact cctacgtgag
      421 cagtggatcc gtgccaagta tgagaggcaa gaattcgttc atgtggagaa gcaggaacca
      481 tactctacag gctaccgtga gggccttctc tggaagcgtg ggcgggacaa cggacagttc
      541 ttaagccgga agtttgtgct gacagaacga gagggtgccc tgaaatactt caacaaaaac
      601 gatgccaagg agcctaaggc cgtcatgaag attgagcacc tgaatgcgac cttccagcca
      661 gccaagatgg gccaccccca cggcctgcag gtcacctact tgaaggacaa cagcacccgc
      721 aacatcttta tctaccatga agacggcaag gagatcgtgg actggttcaa tgcactgcga
      781 gcagcccgat tccactacct gcaggtggct ttcccaggag ccagtgatgc agatctggtg
      841 cccaagctct ctaggaacta cctgaaggaa ggctacatgg agaagacagg gcccaagcag
      901 acagaaggct tccggaagcg ttggttcacc atggatgacc gaaggctcat gtacttcaaa
      961 gaccccctgg acgcctttgc ccgaggggaa gtcttcattg gcagcaagga aagcggttac
     1021 acggtcctgg agggcctccc actgtccacc cagggtcacc actggcctca tggcataacc
     1081 attgtcaccc ctgaccgcaa attcctgttc acgtgtgaga cggagtcaga ccagagggag
     1141 tggattgcgg ccttccagaa ggtggtggac aggcccatgc tgcctcagga gtacgcagtg
     1201 gaagcccact tcaagcataa accctaagga agaaagcccg gaggccccag gattctacgc
     1261 tcatgtggct ggacaggcgc actggacatt aggggagtcc atcctccagg cccacaccct
     1321 gttccttgtg tggcccaggc atggccaggt ggggctcagg caagcccatt ggatagacag
     1381 tttttcagaa cctcattaaa gttgaaggca gacttggttt tgggcctcac ctgaccctgg
     1441 ccctgtcacg atgctcccag ccacgcccag ctgacccatc cactctcctg ctgctggaag
     1501 ccctgcctcc caactttgag caggacccta ctaactcttc tggcctgagg ggatcttggc
     1561 ctcaggacag gacttggtgc tgggctgctg tggacagcca tggacagcca tggacagcca
     1621 tggatagctg tggcagcggg ctggcctggc tgctggggac tcactctggg atgtgccgca
     1681 tgcctcccct ttcctccccc cacctcaaca agtatttatt gagcacctgc tgtgtgtcag
     1741 tcagggatca agggtcaggg gtcagctctt tttcccctag ggctgaccca gctggggtat
     1801 tgggggtcag gtatttttcc aagagaactt tgtgcacagg ccctgagtcc acctgtttgg
     1861 ggcccccagt ctccttggga cagctggctg gggcaaccgg gaggaaacct agtctgcagg
     1921 gtgctgtgca tggagcccag tagtggcttc cttgggagcc agggagcgcc ccaccccatc
     1981 tgcttttggg cgtcggtgcc cagctcggtg ctgtccctgc tttgtaaccc atgccctctg
     2041 gccctgacct tacagtcttt gagcccttga tgaatgagag cccaagccaa gaggcggcca
     2101 tgggcaggag tggctgcccc cagccctgat tgctgctggc aggccagtag ttaaagctac
     2161 ctgtatttat ctccctgctg ccctctggcc accccaacag atgggctccc ttctatggga
     2221 tccccaaagg gcaggtcctg gccgctggac agctggggag cattgatggg ggaacgcatc
     2281 tgtgaatgac ctgggccctc atcaaagctg caccccaggg aatgggggag gggtccttag
     2341 ttgggcttct gctgccctgt gtcatgtccc ctggaataaa gtgtggctct ggcgttgtca
     2401 aaaaaaaaaa aaaaaaaa
//
