LOCUS       NM_001285435            2976 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ADAMTS-like 5 (Adamtsl5), transcript variant 1, mRNA.
ACCESSION   NM_001285435
VERSION     NM_001285435.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2976)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2976)
  AUTHORS   Bader,H.L., Wang,L.W., Ho,J.C., Tran,T., Holden,P., Fitzgerald,J.,
            Atit,R.P., Reinhardt,D.P. and Apte,S.S.
  TITLE     A disintegrin-like and metalloprotease domain containing
            thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel
            fibrillin-1-, fibrillin-2-, and heparin-binding member of the
            ADAMTS superfamily containing a netrin-like module
  JOURNAL   Matrix Biol 31 (7-8), 398-411 (2012)
   PUBMED   23010571
REFERENCE   4  (bases 1 to 2976)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   5  (bases 1 to 2976)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152062.6.
            
            On Feb 1, 2022 this sequence version replaced NM_001285435.1.
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.5164269.1,
                                           SRR13422603.415150.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC152062.6         88707-88763
            58-126              AC152062.6         89494-89562
            127-317             AC152062.6         91416-91606
            318-409             AC152062.6         91706-91797
            410-470             AC152062.6         92016-92076
            471-579             AC152062.6         92178-92286
            580-707             AC152062.6         93393-93520
            708-819             AC152062.6         94099-94210
            820-906             AC152062.6         94726-94812
            907-1070            AC152062.6         94897-95060
            1071-1269           AC152062.6         95178-95376
            1270-1341           AC152062.6         95459-95530
            1342-2976           AC152062.6         95663-97297
FEATURES             Location/Qualifiers
     source          1..2976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2976
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /note="ADAMTS-like 5"
                     /db_xref="GeneID:66548"
                     /db_xref="MGI:MGI:1913798"
     exon            1..57
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            58..126
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            127..317
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1643
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /note="thrombospondin, type I domain containing 6"
                     /codon_start=1
                     /product="ADAMTS-like protein 5"
                     /protein_id="NP_001272364.1"
                     /db_xref="CCDS:CCDS48628.1"
                     /db_xref="GeneID:66548"
                     /db_xref="MGI:MGI:1913798"
                     /translation="MAIHPDPALHCLLVTLCSLKPRLFPLLPFLLWTLLSCDLRGAAQ
                     GPGEWTPWGSWSRCSSSCGRGVSVRRRQCVRLPGEELCWGDSHEYRVCQLPDCPPGTT
                     PFRDLQCSLYNGHPVLDTQKTYQWVPFHGAPNVCDLNCLAEGHAFYHSFGRVLDGTPC
                     TPGTQGLCVAGRCLSAGCDGILGSGTLEDRCGLCGGANDSCLFVQRVFRDAGAFAGFW
                     NVTLIPEGARHIRVAQRSHNHLALVTRGGHYVLNGDGVLSPPGTYEAAGTRVVYTRSA
                     GPEETLQATGPTSQELLLQVLLREPNPGVHFEFWLPRERYGPFQAQVQALGWPLRQPQ
                     PREVEPQPAETPVVPEAIPARVASLPPDPCGPCPDSRGRAHRLLHYCGSDFVFQARVL
                     GRHRQAQETRYEVRVLLIYKSRTPLRTREYVWAPGHCPCPPLAPHREYLLAARRLVSP
                     DGTQDRLLLPHAGYARLWSPAEDSRVRLAARRCPV"
     exon            318..409
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            410..470
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            471..579
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            580..707
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            708..819
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            820..906
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1070
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1269
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1341
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..2976
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /note="hexamer: ATTAAA"
     polyA_site      1862
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /note="major polyA site"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /note="hexamer: AATAAA"
     polyA_site      2976
                     /gene="Adamtsl5"
                     /gene_synonym="2010109H09Rik; Thsd6"
                     /note="major polyA site"
ORIGIN      
        1 agtccccggg gcgtcccggg gaaacttgga cgtattgcct tgggctctca gcagatgatc
       61 ctctaggcac cgcagcccgc agctctggca gatgagacca tgacccacgt gttggcagga
      121 ggccagagac aagaggaccc agagaggttt ggctaccatc gaacacacag ccagccaggg
      181 ctgagatggc aattcaccct gaccctgctc ttcactgcct cttggtaacc ctgtgctccc
      241 tcaaaccccg cctcttcccg cttcttccgt tcttgctgtg gactctcctg agctgtgatt
      301 tgaggggtgc tgcccagggt ccgggagagt ggacgccctg ggggtcttgg agcaggtgtt
      361 ccagctcttg tggtcggggc gtctcagtgc gcagacgcca atgtgtccga cttcccggag
      421 aggaactttg ttggggcgac agccatgaat accgggtgtg ccagctgccg gactgccctc
      481 cagggaccac accattccga gacctgcagt gttctctcta caatggccac cctgtcctgg
      541 acacccagaa aacctaccag tgggtgccct tccacggggc gcccaatgtg tgtgacctca
      601 actgcctagc tgaaggccac gccttctacc acagctttgg ccgcgtgctg gatggcaccc
      661 cctgcacccc gggtacccag ggtctctgcg tggcaggccg ctgtctgagc gcaggctgtg
      721 acgggatact gggctccggc accctcgagg accgctgcgg cctctgtggt ggcgctaacg
      781 actcttgcct gttcgtgcag cgcgtgttcc gcgacgccgg tgccttcgcc ggcttctgga
      841 atgtgacttt gatccccgag ggcgccaggc acatccgcgt agcacagcgc agccacaacc
      901 acctggcgct ggttacccgc ggcgggcact acgtgctcaa cggtgatggg gtgctcagcc
      961 cgcctggcac ctacgaggct gcgggcaccc gagtggttta cacccggagt gcgggcccag
     1021 aggagactct gcaggcgacc ggccccacct cccaggagct gctgttacag gtgctgctgc
     1081 gggagcccaa cccaggcgta cacttcgagt tctggctgcc ccgggagcgc tatggcccct
     1141 ttcaggctca ggtgcaggcc ctgggctggc ccttgcgaca gcctcagcct cgggaggtgg
     1201 agccacagcc tgcagagact cctgtagtcc ccgaggccat ccctgcccgt gttgcatccc
     1261 tgccaccaga cccctgcggg ccatgccccg acagccgtgg tcgcgcacac cggcttcttc
     1321 actactgtgg cagcgacttt gtgttccagg cccgtgtgct gggccgccac cgccaggccc
     1381 aggagacccg ctacgaagtg cgggtcttgc tcatctacaa aagccgcacg cctctgcgta
     1441 ctcgagaata tgtatgggca ccaggccact gtccgtgccc accactggcc ccacaccgag
     1501 aatacctgtt ggctgccagg cgactcgtaa gccctgatgg cacgcaggat cggctactgc
     1561 tgcctcacgc tggctatgct cgactctgga gtcccgcgga ggacagcaga gttcggctgg
     1621 ctgcccggcg ctgtccagtc taaacccctg gaggttggat cctcagcagg gctcctgttc
     1681 tggcgtccca tgactcagga aaacctccca cctggaagct catatatttt aaccagggtc
     1741 tccctgactg gcctggaact ctgtgtagac caggctaacc ttgaagttat ggtaatccac
     1801 ctgcctctgt ctctgcagtg agtgctggga ttaaaggtgc actccatatc tgagaacttt
     1861 aaggagcttc aagatcctgg gctacttttc cgcgaaacaa ctttctgttc atctcttttc
     1921 aagttactat ttaattttta caagaacgtg gaaaaagaac aaatccctcg cccctcactt
     1981 cctgagctat agggactcca ggacacccta gaagagtggc aggcattgtg cacagacaca
     2041 cccccattcc catcttttcc taatctgccc ggacacccag tacagactag cacaggaagt
     2101 acgagaggtt tgggcacaca caggaaccga tgtgcctcct cctcagtcct ctaggctatg
     2161 ggttcatttc cgctgtatat catgggtgtc tgtcctacag tcgctcagca aatcatcccc
     2221 agtggggtgt tccttaaggc tatcccttct gagtcctgaa tctgtcacgt ggtctaacca
     2281 gttgccccac ccttctgcct cacatctgct tctgcttcac acccttctca catctgctag
     2341 ctctgtctgt gaaccactta gctctccaat gactatttac tgaataccga ctgtatgtga
     2401 aagacccagc gagtcctggg gagatgccgt gctgtgccgg gataagcagg ggtcactctg
     2461 tctaacgggc tttcgaaggt agtcccccca aactccacac aatgtaggtc cgttctacag
     2521 ggatttgtgg attccttgcg ccccctggtg gctggacatg gattcccagt ttgggagatg
     2581 gcctacaagt tggcctgcgg cagcaagcag gcttcaggaa cctcacacaa ctacaatggc
     2641 tggccaatgt gacacaagag accaggacag agtcatccct gacagggtcc ctgtgctgag
     2701 cctgatgcac ccggcaggaa gagtagcaga aacatggcag aaaggcacac gatgctggtc
     2761 gcactatggt gaggctgttg ggctccccta agcctggagc tgtcccatga ggcccggaca
     2821 tgttaagatt caatctgaag gggaaataaa aaaccacgag aagacagctg ctgccccagg
     2881 cctgtgatcc cagcacttgg gagcagaagc aggaggacca tcacaagttc agggaaattt
     2941 aaggctgccc gtttcaaaat aaaaggaagg cctgag
//
