LOCUS       NM_144899               3938 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ADAMTS-like 4 (Adamtsl4), transcript variant 2, mRNA.
ACCESSION   NM_144899
VERSION     NM_144899.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3938)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3938)
  AUTHORS   Collin,G.B., Hubmacher,D., Charette,J.R., Hicks,W.L., Stone,L.,
            Yu,M., Naggert,J.K., Krebs,M.P., Peachey,N.S., Apte,S.S. and
            Nishina,P.M.
  TITLE     Disruption of murine Adamtsl4 results in zonular fiber detachment
            from the lens and in retinal pigment epithelium dedifferentiation
  JOURNAL   Hum Mol Genet 24 (24), 6958-6974 (2015)
   PUBMED   26405179
  REMARK    GeneRIF: the first ADAMTSL4 mouse model, tvrm267, bearing a
            nonsense mutation in Adamtsl4
REFERENCE   3  (bases 1 to 3938)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 3938)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 3938)
  AUTHORS   Hubmacher,D. and Apte,S.S.
  TITLE     Genetic and functional linkage between ADAMTS superfamily proteins
            and fibrillin-1: a novel mechanism influencing microfibril assembly
            and function
  JOURNAL   Cell Mol Life Sci 68 (19), 3137-3148 (2011)
   PUBMED   21858451
  REMARK    Review article
REFERENCE   6  (bases 1 to 3938)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
  REMARK    GeneRIF: O-fucose modification of thrombospondin type 1 repeats was
            essential for modulation of growth factor signaling during
            gastrulation.
REFERENCE   7  (bases 1 to 3938)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   8  (bases 1 to 3938)
  AUTHORS   Buchner,D.A. and Meisler,M.H.
  TITLE     TSRC1, a widely expressed gene containing seven thrombospondin type
            I repeats
  JOURNAL   Gene 307, 23-30 (2003)
   PUBMED   12706885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093317.22, BY204619.1,
            AY158701.1 and AI595354.1.
            
            On Sep 6, 2014 this sequence version replaced NM_144899.2.
            
            Summary: The protein encoded by this gene is a member of the ADAMTS
            superfamily of secreted proteins, which contain a metalloprotease
            domain at the N-terminus and a C-terminal ancillary domain.
            ADAMTS-like proteins lack protease activity and resemble the
            ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been
            implicated in regulation of the extracellular matrix. The encoded
            protein contains 7 thrombospondin type 1 repeats, a conserved
            extracellular domain. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158701.1, BC117925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC093317.22        183548-183569
            23-59               BY204619.1         2-38
            60-3297             AY158701.1         1-3238
            3298-3298           AC093317.22        194645-194645
            3299-3915           AY158701.1         3240-3856
            3916-3938           AI595354.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..3938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..3938
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="ADAMTS-like 4"
                     /db_xref="GeneID:229595"
                     /db_xref="MGI:MGI:2389008"
     exon            1..97
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..195
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..3286
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="thrombospondin repeat containing 1; ADAMTS-like
                     protein 4; thrombospondin repeat protein 1; thrombospondin
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="ADAMTS-like protein 4 precursor"
                     /protein_id="NP_659148.2"
                     /db_xref="CCDS:CCDS17618.1"
                     /db_xref="GeneID:229595"
                     /db_xref="MGI:MGI:2389008"
                     /translation="MESWLGRLWLCMMLLLPLPQPCQDQELFGPSHQLPSEEGQVPEG
                     LWGPWGRWASCSQPCGVGVQRRSRTCELHPALPLPPRPPRHPEAHRPRGQGSRPQTPR
                     DPQSLYRPQPRGRGGPLRAPASQVGREETQEPQGAQRFRVRDPIKPGMFGYGRVPFAL
                     PLHRSRRHPHRPGQPKNSSTGEGMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRS
                     GTAQTEVLPRTSSAPSYTGTPAPTSSFGDSRSFQGSLGPRMPPSPGSWSSPQGAERRH
                     PPPFSPVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSPLWSIFAPSIPAPNCSGESEQ
                     MRACSQEPCPPEQPDPRALQCAAFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFR
                     FYVRHTEKVQDGTLCQPGSLDICVAGRCLSPGCDGVLGSGRRPDGCGVCGGDGSTCRL
                     VSGNLTDRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDP
                     PGSYTAIGTVFQYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEDNPGVFYQYVISSP
                     PAVLESPSTKPPALQPQPEMLRGEPLLPSAPRPVRAPGTLQRQVRIPQVPPPTRVRTA
                     MGSSAGYWKQVGHSECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASPEPC
                     HGPPCPPYWEAGEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQ
                     PCQLHLCGHWEISSPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSRE
                     ACDMGPCTTAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLR
                     SRPPDMRACSLGPCERTWRWFTGPWSECSSECGSGTQHRDIICVSKLGAEFNVTSPSN
                     CSHLPRPPALQPCQGQACEDKWFSTLWSPCSRSCQGGMQTREVQCLSGNQTLSSRCPP
                     HLRPSRKRPCNSQPCNQRPDDQCKDSSPHCPLVVQARLCVYPYYTTTCCRSCAHVLEQ
                     SQLEPA"
     exon            196..253
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..591
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1198
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1301
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1438
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1643
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1816
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1928
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2114
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2244
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2449
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2626
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2824
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3004
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3149
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3918
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3896..3901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="hexamer: ATTAAA"
     polyA_site      3918
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtggggc ggagcctgcc gcgggcggcg ctgtcctggg gctccgggcc gcggtggcca
       61 ctaccagagg cagctggaga gagcgggcgc agagaagagc accctccaag ccccgatgcc
      121 agagtagcca ccctgtcccc tgctccccag cccaggggca gtcacaggaa gagcaatgga
      181 atcttggctg ggcaggctct ggctgtgtat gatgctgctc ctgcctctcc ctcagccctg
      241 ccaggatcag gagctgtttg gaccttctca tcagctgcca tcagaggagg gccaggtccc
      301 tgaaggcctc tggggacctt ggggtcgatg ggcttcctgc tcccagccct gtggggtggg
      361 ggtgcagcgc aggagccgaa catgtgaact gcacccagcc ctacccctcc ctccccgacc
      421 cccaagacat ccagaagccc accggccccg gggccagggc tccagacccc agactccacg
      481 ggatccccag tctctgtata ggccacagcc tcggggaagg ggtggccctc ttcgagctcc
      541 tgcttctcaa gtggggagag aggaaaccca ggagcctcaa ggggcccaga ggttccgggt
      601 tcgagacccc atcaagccag ggatgttcgg ttatgggaga gtgccttttg ccttgcctct
      661 gcaccggagc cgcaggcatc ctcacagacc cgggcaaccc aagaactctt ctacagggga
      721 agggatggtt ccatctcagc ctccaagcac agagctggcc tctgaaaagc acggccctca
      781 catgcagccc cctgaacccc gttctcactc agctgaaact ccaaggtctg gaactgctca
      841 gacagaagtg ctccccagaa ctagttctgc tccttcctac acagggaccc ctgcacctac
      901 ctcctctttt ggagacagta ggtctttcca gggatccctt gggccacgaa tgccaccttc
      961 cccgggaagt tggagcagtc cccagggagc agagcgacga cacccacctc ctttctctcc
     1021 tgtcccccgg agccagcaga gcaggaggca ctggagacct ccaggtcctc acaggtcccc
     1081 agatggctgg ctgcccctga caagagactc cagcccactc tggagcatct ttgctcccag
     1141 tatccctgct ccaaactgtt ctggggaaag tgaacagatg cgagcctgca gccaggagcc
     1201 ttgcccccct gagcagccag accccagggc cctacagtgt gccgcctttg actcccagga
     1261 attcatgggc cagctgtacc agtgggagcc cttcaccgaa gttcagggct cccagcgctg
     1321 tgaactgaac tgccgccccc gtggcttccg attctatgtc cgacacactg aaaaggtgca
     1381 ggatggaacc ctgtgtcagc ctggatccct agacatctgt gtggctggac gctgcctgag
     1441 ccctggctgt gatggggtcc ttggctctgg caggcgtccg gatggctgcg gagtctgcgg
     1501 gggtgatggt tctacctgcc gcctggtttc gggaaatctc actgaccgag ggggcccctt
     1561 gggctatcag aagatcctgt ggatccctgc cggggcctcc caccttcaca tttcccagtt
     1621 gcgacccagt tccaattacc tcgcactccg agggcctggg ggccgctcca ttatcaatgg
     1681 gaactgggct gtggatcctc cagggtccta tacagccatt gggactgtct tccagtataa
     1741 ccgtcctcca cgggaagaag gcaaggggga gagtctgtca gcagaaggcc ctaccactca
     1801 gcctgtggac gtctatatga tctttcaaga ggacaaccca ggtgtttttt atcagtatgt
     1861 catctcttcc cctcctgcag tcctagagag tccttccaca aagcctccag cccttcagcc
     1921 tcagcctgag atgctgaggg gggagcccct actcccctca gccccccgcc cagtccgggc
     1981 accaggcacc ctccaacgtc aggtgcggat tccccaagtg cctcctccga ctcgtgtcag
     2041 gacagccatg gggtcttctg ctggatactg gaaacaagtg gggcactctg agtgttcagc
     2101 atcctgtggc aaaggtgttt ggcaccccat tttcctctgc atttcccgtg agtcaggaga
     2161 ggagttggat gaacagagct gtgctgtggg ggccagaccc ccagcttccc ctgaaccctg
     2221 ccatggaccc ccgtgtcctc catactggga ggctggcgag tggacatcct gcagccgatc
     2281 ctgtggccct ggcacccagc accgccagct actctgcaga caggaattcg gaggtggtgg
     2341 ctcctcggta cctccagagc gctgtggaca tctcccccgg cccaacatca cccagccttg
     2401 tcagctgcac ctctgtggcc actgggagat tagctccccc tggagccagt gctctgtgcg
     2461 ctgtggtcgt ggtcagagga gccggcaagt tcggtgtgtt ggcagtaatg gtgatgaggt
     2521 ggacaagcag gagtgtgctt cagggccccc gccgcccccc agcagagagg cctgtgacat
     2581 gggcccctgc accacagcct ggttctacag tgactggagt tccaagtgct cagccgagtg
     2641 cgggacagga atccagagac gcgctgtggt ctgccttagg agtggggaga cccttcaggg
     2701 agacccggaa gcaggaagca ctgagcaggg ctgccctctc agaagccgcc ctcccgatat
     2761 gcgtgcctgc agtttagggc cctgtgagag gacatggcgc tggttcacag gcccctggag
     2821 tgagtgttcc tcggagtgtg ggtctggcac acaacacaga gacattatct gtgtgtccaa
     2881 gctgggggcc gagttcaatg tgacttctcc cagcaactgt tcccacctac ccaggccgcc
     2941 tgccctgcag ccctgtcagg ggcaggcctg tgaggacaaa tggttctcca ctctctggag
     3001 tccgtgttct cgatcctgcc agggaggcat gcagacgagg gaagtccagt gcctgagtgg
     3061 caaccagact ctcagctccc gatgccctcc tcacctgaga ccttccagga agcggccctg
     3121 caacagccaa ccctgcaacc agcgaccaga tgaccaatgc aaggacagct ctccacactg
     3181 ccccctggtg gtacaggccc ggctctgcgt ctacccctac tacacaacta cctgctgccg
     3241 ctcttgtgcc catgtcctgg agcagtccca gctggaaccg gcttgaaacg ggtcccagag
     3301 accctgcctt cgtggttttc ttgtgccacc cactgactag cccgctctgt accctctggc
     3361 ttttcacctg gtctcagcct tgccagaggg atcctccagg gtgagagacc tacagtgtga
     3421 tagctcaaga agtgtacctg acctgcctgg gggtctgtcc tgtgtatgtt tatcacttcc
     3481 acaaaagcag cttgagaaag aataggaagt gggcggtgcc tgtatccctc atgcttttct
     3541 gggctgggga gaaaggggga gagagcaagg ttatatttcc acactaatct gagctacata
     3601 gtgtgtgtcc cccagaagtt ccaggtctgt gccccaatcc tcgtctccac atcttctaaa
     3661 ttaccctgtt gttcccatcc ctgccttatc tagtctctgt attcctacct ccctcattag
     3721 caggggcagg gatcagccac tgctacccta ccttactggg gaaggaccac acctctccag
     3781 ggcagggacc acttgtgtcg agggtgaaaa agagaaacgt cagcataaga catcctagcc
     3841 ccagtcgcca cttcacactg aaaatgatgc ccaccccaga agtaatttat tttttattaa
     3901 agttggtttt gacataaaaa aaaaaaaaaa aaaaaaaa
//
