LOCUS       NM_001301705            4056 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ADAMTS-like 4 (Adamtsl4), transcript variant 1, mRNA.
ACCESSION   NM_001301705 XM_006501367
VERSION     NM_001301705.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4056)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4056)
  AUTHORS   Collin,G.B., Hubmacher,D., Charette,J.R., Hicks,W.L., Stone,L.,
            Yu,M., Naggert,J.K., Krebs,M.P., Peachey,N.S., Apte,S.S. and
            Nishina,P.M.
  TITLE     Disruption of murine Adamtsl4 results in zonular fiber detachment
            from the lens and in retinal pigment epithelium dedifferentiation
  JOURNAL   Hum Mol Genet 24 (24), 6958-6974 (2015)
   PUBMED   26405179
  REMARK    GeneRIF: the first ADAMTSL4 mouse model, tvrm267, bearing a
            nonsense mutation in Adamtsl4
REFERENCE   3  (bases 1 to 4056)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   4  (bases 1 to 4056)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4056)
  AUTHORS   Hubmacher,D. and Apte,S.S.
  TITLE     Genetic and functional linkage between ADAMTS superfamily proteins
            and fibrillin-1: a novel mechanism influencing microfibril assembly
            and function
  JOURNAL   Cell Mol Life Sci 68 (19), 3137-3148 (2011)
   PUBMED   21858451
  REMARK    Review article
REFERENCE   6  (bases 1 to 4056)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
  REMARK    GeneRIF: O-fucose modification of thrombospondin type 1 repeats was
            essential for modulation of growth factor signaling during
            gastrulation.
REFERENCE   7  (bases 1 to 4056)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   8  (bases 1 to 4056)
  AUTHORS   Buchner,D.A. and Meisler,M.H.
  TITLE     TSRC1, a widely expressed gene containing seven thrombospondin type
            I repeats
  JOURNAL   Gene 307, 23-30 (2003)
   PUBMED   12706885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093317.22, BY204619.1,
            AY158701.1, BY196249.1 and AI595354.1.
            
            On Sep 6, 2014 this sequence version replaced XM_006501367.1.
            
            Summary: The protein encoded by this gene is a member of the ADAMTS
            superfamily of secreted proteins, which contain a metalloprotease
            domain at the N-terminus and a C-terminal ancillary domain.
            ADAMTS-like proteins lack protease activity and resemble the
            ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been
            implicated in regulation of the extracellular matrix. The encoded
            protein contains 7 thrombospondin type 1 repeats, a conserved
            extracellular domain. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155481.1, SRR17784647.491117.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC093317.22        183548-183569
            23-59               BY204619.1         2-38
            60-97               AY158701.1         1-38
            98-215              BY196249.1         61-178
            216-3415            AY158701.1         39-3238
            3416-3416           AC093317.22        194645-194645
            3417-4033           AY158701.1         3240-3856
            4034-4056           AI595354.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..4056
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..4056
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="ADAMTS-like 4"
                     /db_xref="GeneID:229595"
                     /db_xref="MGI:MGI:2389008"
     exon            1..97
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            98..313
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..3404
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="thrombospondin repeat containing 1; ADAMTS-like
                     protein 4; thrombospondin repeat protein 1; thrombospondin
                     repeat-containing protein 1"
                     /codon_start=1
                     /product="ADAMTS-like protein 4 precursor"
                     /protein_id="NP_001288634.1"
                     /db_xref="CCDS:CCDS17618.1"
                     /db_xref="GeneID:229595"
                     /db_xref="MGI:MGI:2389008"
                     /translation="MESWLGRLWLCMMLLLPLPQPCQDQELFGPSHQLPSEEGQVPEG
                     LWGPWGRWASCSQPCGVGVQRRSRTCELHPALPLPPRPPRHPEAHRPRGQGSRPQTPR
                     DPQSLYRPQPRGRGGPLRAPASQVGREETQEPQGAQRFRVRDPIKPGMFGYGRVPFAL
                     PLHRSRRHPHRPGQPKNSSTGEGMVPSQPPSTELASEKHGPHMQPPEPRSHSAETPRS
                     GTAQTEVLPRTSSAPSYTGTPAPTSSFGDSRSFQGSLGPRMPPSPGSWSSPQGAERRH
                     PPPFSPVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSPLWSIFAPSIPAPNCSGESEQ
                     MRACSQEPCPPEQPDPRALQCAAFDSQEFMGQLYQWEPFTEVQGSQRCELNCRPRGFR
                     FYVRHTEKVQDGTLCQPGSLDICVAGRCLSPGCDGVLGSGRRPDGCGVCGGDGSTCRL
                     VSGNLTDRGGPLGYQKILWIPAGASHLHISQLRPSSNYLALRGPGGRSIINGNWAVDP
                     PGSYTAIGTVFQYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEDNPGVFYQYVISSP
                     PAVLESPSTKPPALQPQPEMLRGEPLLPSAPRPVRAPGTLQRQVRIPQVPPPTRVRTA
                     MGSSAGYWKQVGHSECSASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASPEPC
                     HGPPCPPYWEAGEWTSCSRSCGPGTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQ
                     PCQLHLCGHWEISSPWSQCSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSRE
                     ACDMGPCTTAWFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLR
                     SRPPDMRACSLGPCERTWRWFTGPWSECSSECGSGTQHRDIICVSKLGAEFNVTSPSN
                     CSHLPRPPALQPCQGQACEDKWFSTLWSPCSRSCQGGMQTREVQCLSGNQTLSSRCPP
                     HLRPSRKRPCNSQPCNQRPDDQCKDSSPHCPLVVQARLCVYPYYTTTCCRSCAHVLEQ
                     SQLEPA"
     exon            314..371
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..709
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..1316
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1419
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1556
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1761
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1934
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2046
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2232
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2362
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2567
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2744
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2942
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3122
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3267
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..4036
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="hexamer: ATTAAA"
     polyA_site      4036
                     /gene="Adamtsl4"
                     /gene_synonym="ADAMTSL-4; Tsrc1"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtggggc ggagcctgcc gcgggcggcg ctgtcctggg gctccgggcc gcggtggcca
       61 ctaccagagg cagctggaga gagcgggcgc agagaaggtc ctaaaggggt ggaccattcc
      121 tcccccaccc ctccaggctg ttggtgttgt gctgagacag cccttcagtc cccccagata
      181 gctggagggg taacgccatg ctcctccctc ctcagagcac cctccaagcc ccgatgccag
      241 agtagccacc ctgtcccctg ctccccagcc caggggcagt cacaggaaga gcaatggaat
      301 cttggctggg caggctctgg ctgtgtatga tgctgctcct gcctctccct cagccctgcc
      361 aggatcagga gctgtttgga ccttctcatc agctgccatc agaggagggc caggtccctg
      421 aaggcctctg gggaccttgg ggtcgatggg cttcctgctc ccagccctgt ggggtggggg
      481 tgcagcgcag gagccgaaca tgtgaactgc acccagccct acccctccct ccccgacccc
      541 caagacatcc agaagcccac cggccccggg gccagggctc cagaccccag actccacggg
      601 atccccagtc tctgtatagg ccacagcctc ggggaagggg tggccctctt cgagctcctg
      661 cttctcaagt ggggagagag gaaacccagg agcctcaagg ggcccagagg ttccgggttc
      721 gagaccccat caagccaggg atgttcggtt atgggagagt gccttttgcc ttgcctctgc
      781 accggagccg caggcatcct cacagacccg ggcaacccaa gaactcttct acaggggaag
      841 ggatggttcc atctcagcct ccaagcacag agctggcctc tgaaaagcac ggccctcaca
      901 tgcagccccc tgaaccccgt tctcactcag ctgaaactcc aaggtctgga actgctcaga
      961 cagaagtgct ccccagaact agttctgctc cttcctacac agggacccct gcacctacct
     1021 cctcttttgg agacagtagg tctttccagg gatcccttgg gccacgaatg ccaccttccc
     1081 cgggaagttg gagcagtccc cagggagcag agcgacgaca cccacctcct ttctctcctg
     1141 tcccccggag ccagcagagc aggaggcact ggagacctcc aggtcctcac aggtccccag
     1201 atggctggct gcccctgaca agagactcca gcccactctg gagcatcttt gctcccagta
     1261 tccctgctcc aaactgttct ggggaaagtg aacagatgcg agcctgcagc caggagcctt
     1321 gcccccctga gcagccagac cccagggccc tacagtgtgc cgcctttgac tcccaggaat
     1381 tcatgggcca gctgtaccag tgggagccct tcaccgaagt tcagggctcc cagcgctgtg
     1441 aactgaactg ccgcccccgt ggcttccgat tctatgtccg acacactgaa aaggtgcagg
     1501 atggaaccct gtgtcagcct ggatccctag acatctgtgt ggctggacgc tgcctgagcc
     1561 ctggctgtga tggggtcctt ggctctggca ggcgtccgga tggctgcgga gtctgcgggg
     1621 gtgatggttc tacctgccgc ctggtttcgg gaaatctcac tgaccgaggg ggccccttgg
     1681 gctatcagaa gatcctgtgg atccctgccg gggcctccca ccttcacatt tcccagttgc
     1741 gacccagttc caattacctc gcactccgag ggcctggggg ccgctccatt atcaatggga
     1801 actgggctgt ggatcctcca gggtcctata cagccattgg gactgtcttc cagtataacc
     1861 gtcctccacg ggaagaaggc aagggggaga gtctgtcagc agaaggccct accactcagc
     1921 ctgtggacgt ctatatgatc tttcaagagg acaacccagg tgttttttat cagtatgtca
     1981 tctcttcccc tcctgcagtc ctagagagtc cttccacaaa gcctccagcc cttcagcctc
     2041 agcctgagat gctgaggggg gagcccctac tcccctcagc cccccgccca gtccgggcac
     2101 caggcaccct ccaacgtcag gtgcggattc cccaagtgcc tcctccgact cgtgtcagga
     2161 cagccatggg gtcttctgct ggatactgga aacaagtggg gcactctgag tgttcagcat
     2221 cctgtggcaa aggtgtttgg caccccattt tcctctgcat ttcccgtgag tcaggagagg
     2281 agttggatga acagagctgt gctgtggggg ccagaccccc agcttcccct gaaccctgcc
     2341 atggaccccc gtgtcctcca tactgggagg ctggcgagtg gacatcctgc agccgatcct
     2401 gtggccctgg cacccagcac cgccagctac tctgcagaca ggaattcgga ggtggtggct
     2461 cctcggtacc tccagagcgc tgtggacatc tcccccggcc caacatcacc cagccttgtc
     2521 agctgcacct ctgtggccac tgggagatta gctccccctg gagccagtgc tctgtgcgct
     2581 gtggtcgtgg tcagaggagc cggcaagttc ggtgtgttgg cagtaatggt gatgaggtgg
     2641 acaagcagga gtgtgcttca gggcccccgc cgccccccag cagagaggcc tgtgacatgg
     2701 gcccctgcac cacagcctgg ttctacagtg actggagttc caagtgctca gccgagtgcg
     2761 ggacaggaat ccagagacgc gctgtggtct gccttaggag tggggagacc cttcagggag
     2821 acccggaagc aggaagcact gagcagggct gccctctcag aagccgccct cccgatatgc
     2881 gtgcctgcag tttagggccc tgtgagagga catggcgctg gttcacaggc ccctggagtg
     2941 agtgttcctc ggagtgtggg tctggcacac aacacagaga cattatctgt gtgtccaagc
     3001 tgggggccga gttcaatgtg acttctccca gcaactgttc ccacctaccc aggccgcctg
     3061 ccctgcagcc ctgtcagggg caggcctgtg aggacaaatg gttctccact ctctggagtc
     3121 cgtgttctcg atcctgccag ggaggcatgc agacgaggga agtccagtgc ctgagtggca
     3181 accagactct cagctcccga tgccctcctc acctgagacc ttccaggaag cggccctgca
     3241 acagccaacc ctgcaaccag cgaccagatg accaatgcaa ggacagctct ccacactgcc
     3301 ccctggtggt acaggcccgg ctctgcgtct acccctacta cacaactacc tgctgccgct
     3361 cttgtgccca tgtcctggag cagtcccagc tggaaccggc ttgaaacggg tcccagagac
     3421 cctgccttcg tggttttctt gtgccaccca ctgactagcc cgctctgtac cctctggctt
     3481 ttcacctggt ctcagccttg ccagagggat cctccagggt gagagaccta cagtgtgata
     3541 gctcaagaag tgtacctgac ctgcctgggg gtctgtcctg tgtatgttta tcacttccac
     3601 aaaagcagct tgagaaagaa taggaagtgg gcggtgcctg tatccctcat gcttttctgg
     3661 gctggggaga aagggggaga gagcaaggtt atatttccac actaatctga gctacatagt
     3721 gtgtgtcccc cagaagttcc aggtctgtgc cccaatcctc gtctccacat cttctaaatt
     3781 accctgttgt tcccatccct gccttatcta gtctctgtat tcctacctcc ctcattagca
     3841 ggggcaggga tcagccactg ctaccctacc ttactgggga aggaccacac ctctccaggg
     3901 cagggaccac ttgtgtcgag ggtgaaaaag agaaacgtca gcataagaca tcctagcccc
     3961 agtcgccact tcacactgaa aatgatgccc accccagaag taatttattt tttattaaag
     4021 ttggttttga cataaaaaaa aaaaaaaaaa aaaaaa
//
