LOCUS       NM_029981               3626 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus ADAMTS-like 2 (Adamtsl2), mRNA.
ACCESSION   NM_029981 XM_130065
VERSION     NM_029981.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Iwanaga,Y., Tsuji,K., Nishimura,A., Tateishi,K., Kakiuchi,M. and
            Tsuji,T.
  TITLE     A nonsense mutation in mouse Adamtsl2 causes uterine hypoplasia and
            an irregular estrous cycle
  JOURNAL   Mamm Genome 34 (4), 559-571 (2023)
   PUBMED   37656189
  REMARK    GeneRIF: A nonsense mutation in mouse Adamtsl2 causes uterine
            hypoplasia and an irregular estrous cycle.
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Taye,N., Singh,M., Baldock,C. and Hubmacher,D.
  TITLE     Secreted ADAMTS-like 2 promotes myoblast differentiation by
            potentiating WNT signaling
  JOURNAL   Matrix Biol 120, 24-42 (2023)
   PUBMED   37187448
  REMARK    GeneRIF: Secreted ADAMTS-like 2 promotes myoblast differentiation
            by potentiating WNT signaling.
REFERENCE   3  (bases 1 to 3626)
  AUTHORS   Rypdal,K.B., Erusappan,P.M., Melleby,A.O., Seifert,D.E.,
            Palmero,S., Strand,M.E., Tonnessen,T., Dahl,C.P., Almaas,V.,
            Hubmacher,D., Apte,S.S., Christensen,G. and Lunde,I.G.
  TITLE     The extracellular matrix glycoprotein ADAMTSL2 is increased in
            heart failure and inhibits TGFbeta signalling in cardiac
            fibroblasts
  JOURNAL   Sci Rep 11 (1), 19757 (2021)
   PUBMED   34611183
  REMARK    GeneRIF: The extracellular matrix glycoprotein ADAMTSL2 is
            increased in heart failure and inhibits TGFbeta signalling in
            cardiac fibroblasts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3626)
  AUTHORS   Zhang,A., Berardinelli,S.J., Leonhard-Melief,C., Vasudevan,D.,
            Liu,T.W., Taibi,A., Giannone,S., Apte,S.S., Holdener,B.C. and
            Haltiwanger,R.S.
  TITLE     O-Fucosylation of ADAMTSL2 is required for secretion and is
            impacted by geleophysic dysplasia-causing mutations
  JOURNAL   J Biol Chem 295 (46), 15742-15753 (2020)
   PUBMED   32913123
  REMARK    GeneRIF: O-Fucosylation of ADAMTSL2 is required for secretion and
            is impacted by geleophysic dysplasia-causing mutations.
REFERENCE   5  (bases 1 to 3626)
  AUTHORS   Hubmacher,D., Taye,N., Balic,Z., Thacker,S., Adams,S.M., Birk,D.E.,
            Schweitzer,R. and Apte,S.S.
  TITLE     Limb- and tendon-specific Adamtsl2 deletion identifies a role for
            ADAMTSL2 in tendon growth in a mouse model for geleophysic
            dysplasia
  JOURNAL   Matrix Biol 82, 38-53 (2019)
   PUBMED   30738849
REFERENCE   6  (bases 1 to 3626)
  AUTHORS   Jensen,L.D., Hot,B., Ramskold,D., Germano,R.F.V., Yokota,C.,
            Giatrellis,S., Lauschke,V.M., Hubmacher,D., Li,M.X., Hupe,M.,
            Arnold,T.D., Sandberg,R., Frisen,J., Trusohamn,M., Martowicz,A.,
            Wisniewska-Kruk,J., Nyqvist,D., Adams,R.H., Apte,S.S.,
            Vanhollebeke,B., Stenman,J.M. and Kele,J.
  TITLE     Disruption of the Extracellular Matrix Progressively Impairs
            Central Nervous System Vascular Maturation Downstream of
            beta-Catenin Signaling
  JOURNAL   Arterioscler Thromb Vasc Biol 39 (7), 1432-1447 (2019)
   PUBMED   31242033
REFERENCE   7  (bases 1 to 3626)
  AUTHORS   Delhon,L., Mahaut,C., Goudin,N., Gaudas,E., Piquand,K., Le Goff,W.,
            Cormier-Daire,V. and Le Goff,C.
  TITLE     Impairment of chondrogenesis and microfibrillar network in Adamtsl2
            deficiency
  JOURNAL   FASEB J 33 (2), 2707-2718 (2019)
   PUBMED   30303737
  REMARK    GeneRIF: Adamtsl2 deficiency is associated with Impairment of
            chondrogenesis and microfibrillar network.
REFERENCE   8  (bases 1 to 3626)
  AUTHORS   Aviram,R., Zaffryar-Eilot,S., Hubmacher,D., Grunwald,H., Maki,J.M.,
            Myllyharju,J., Apte,S.S. and Hasson,P.
  TITLE     Interactions between lysyl oxidases and ADAMTS proteins suggest a
            novel crosstalk between two extracellular matrix families
  JOURNAL   Matrix Biol 75-76, 114-125 (2019)
   PUBMED   29758265
REFERENCE   9  (bases 1 to 3626)
  AUTHORS   Hubmacher,D., Wang,L.W., Mecham,R.P., Reinhardt,D.P. and Apte,S.S.
  TITLE     Adamtsl2 deletion results in bronchial fibrillin microfibril
            accumulation and bronchial epithelial dysplasia--a novel mouse
            model providing insights into geleophysic dysplasia
  JOURNAL   Dis Model Mech 8 (5), 487-499 (2015)
   PUBMED   25762570
  REMARK    GeneRIF: the bronchial epithelial dysplasia accompanying
            microfibril dysregulation in Adamtsl2(-/-) mice cannot be reversed
            by TGFbeta neutralization, and thus might be mediated by other
            mechanisms.
REFERENCE   10 (bases 1 to 3626)
  AUTHORS   Koo,B.H., Le Goff,C., Jungers,K.A., Vasanji,A., O'Flaherty,J.,
            Weyman,C.M. and Apte,S.S.
  TITLE     ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely
            expressed during mouse embryogenesis and is regulated during
            skeletal myogenesis
  JOURNAL   Matrix Biol 26 (6), 431-441 (2007)
   PUBMED   17509843
  REMARK    GeneRIF: Data suggest that induction of Adamtsl2 mRNA is an
            integral feature of myogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845266.2, AB096928.1 and AI844377.1.
            
            On Apr 26, 2018 this sequence version replaced NM_029981.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156991.1, BC128568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL845266.2         100245-100246
            3-3244              AB096928.1         1-3242
            3245-3626           AI844377.1         1-382               c
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.22 cM"
     gene            1..3626
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /note="ADAMTS-like 2"
                     /db_xref="GeneID:77794"
                     /db_xref="MGI:MGI:1925044"
     exon            1..195
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            196..286
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3070
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /note="ADAMTS-like protein 2; TSP1-repeats-containing
                     protein 1; TSP1-repeat-containing protein 1"
                     /codon_start=1
                     /product="ADAMTS-like protein 2 precursor"
                     /protein_id="NP_084257.1"
                     /db_xref="CCDS:CCDS15824.1"
                     /db_xref="GeneID:77794"
                     /db_xref="MGI:MGI:1925044"
                     /translation="MDGRRQHPHWAWSLLAVAVVAGGAAPTEASDNSPTSNSLEGGAD
                     TTAYWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGTGNRTCVGTSKRYQLCRV
                     QECPPDGRSFREEQCVSFNSRVYDGRAYQWKPLYPDDYVHISSKPCDLHCSTVDGQRQ
                     LTVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGVCQGDGSSCTHVTG
                     NYRKGNNHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGFYFFNGNYKVDSPKN
                     FNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTLLQSP
                     HMHHLPPVYYSFSEAASQSTESTERQELDSARLLGFMQHNGSLYRQTSSERLGLNSQL
                     FQPPAPEVELGPSRGQESNEVCKQASGGVCEGPPRGKGFQDHNATGRAFSADKDDREI
                     SAHFTSHELLSANTISDQLLGTGSESEEFSLNETMNSIFAQGAPRSSPAESLYVDYEE
                     NEGPAAYLINGSYLELSSDRINTSSEAPFPNTSASPPNLAGNRTHKARTRPKARKQGV
                     SPADMYRWKLSSHEPCSATCTTGVMSTYAMCVRYDGVEVDDSYCDALTRPEPVHEFCA
                     GRECQPRWETSSWSECSRTCGEGHQFRIVRCWKMLSPGFDSSVYSDLCEATEAVRPEE
                     RKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPSTKPVGEKNCTG
                     PPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQTETKPLAIHPCGDK
                     NCPAHWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQIRSGPECGLARKPPEESTCF
                     ERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP
                     TEPPDDSCQDQPGTNCALAIKVNLCGHWYYSKACCRSCRPPHS"
     exon            287..429
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..505
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..608
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..754
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..878
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            879..959
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1135
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1493
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1863
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1961
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2088
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2302
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2458
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2629
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2806
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2951
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3612
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3584..3589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /note="hexamer: AATAAA"
     polyA_site      3607
                     /gene="Adamtsl2"
                     /gene_synonym="A930008K15Rik; tcp-1"
                     /note="major polyA site"
ORIGIN      
        1 actgggctga gagcccctcc tgggaacccc ctcccttgaa tgctctttga agtgggagag
       61 ggaggcagct ggggaagcag gaccagagac aggcagagcc cgcacatctc tgcactcacc
      121 ttcctgcacc gtgcacctgg cagtagctct cacccttttc tctaaaagga ggacaacctg
      181 ctgaccctgg gtgaggatgg atggcagacg gcagcatcca cactgggctt ggtccttgct
      241 ggctgtagca gttgtggctg ggggtgcggc acctacggag gcttccgaca acagccccac
      301 atccaacagc ctagagggag gtgctgacac cactgcctac tggtgggggg agtggaccaa
      361 gtggacagca tgttcccgca gttgtggggg cggggtgaca tcccaggagc gccactgcct
      421 tcaacagagg aggaagtctg ttccaggcac agggaacagg acctgtgtgg gcacgtccaa
      481 acggtaccag ctctgcagag tgcaggagtg tccaccggat gggaggagct tccgtgaaga
      541 gcagtgtgtc tccttcaact cccgtgtgta tgacggccgg gcgtaccagt ggaagcccct
      601 ttacccggat gactacgtgc acatctccag taagccatgc gacctacact gcagcaccgt
      661 ggacggccaa cggcagctca cggtgccggc ccgagacggc acttcctgca agctcaccga
      721 cctgagaggg gtttgcgtgt ctggaaaatg tgagcccatt ggctgtgatg gagtactctt
      781 ctccacccac acgctggaca agtgtggtgt ctgccagggg gacgggagca gctgcaccca
      841 cgtgacaggc aactaccgaa agggcaacaa tcatcttggt tactccttgg tgacccatat
      901 tccagctggt gcccgggata tccagattgt ggagaggaag aagtcagcag atgtgctggc
      961 ccttgcagat gaagctggtt tctacttctt caatggcaac tacaaagtgg acagccccaa
     1021 gaacttcaac attgctggca cagtggtcaa gtaccgacgg cccatggatg tctatgagac
     1081 tggcatcgag tatatagtgg cacaggggcc caccaaccag ggcctgaatg tcatggtgtg
     1141 gaaccagaac ggcaaaagcc cctctatcac cttcgagtac accttgctgc agtcacctca
     1201 catgcaccac ctgccgcctg tctattacag cttctctgag gcagcctccc agagcacaga
     1261 gagcaccgag cggcaggagc tggacagtgc caggctgctg ggcttcatgc agcacaatgg
     1321 ctcactctac cgccagacct cctcagagag gctgggcctg aacagccagc tgtttcagcc
     1381 tccagcccct gaggtggagc taggtccaag cagaggccag gagtccaacg aggtgtgcaa
     1441 gcaagccagc ggtggggtct gtgagggacc tcccaggggc aagggtttcc aagaccacaa
     1501 tgccactggg agagctttct ccgcggacaa ggatgaccgg gagatcagtg cccatttcac
     1561 ctcccacgag cttctctcag ccaacaccat ctccgaccag ctcttgggca caggctctga
     1621 atcagaagag ttctcactca atgagaccat gaatagcatc tttgcccagg gtgctcccag
     1681 aagctcccca gctgagagcc tctatgtgga ttatgaggag aatgaggggc ctgctgccta
     1741 cttgatcaat gggtcttacc tggagctgag cagtgacagg atcaacacct cctctgaggc
     1801 cccattcccc aacaccagtg ccagcccccc caacttggct gggaacagga ctcacaaggc
     1861 aaggaccaga cccaaggcac gcaagcaagg tgtgagccca gctgacatgt accggtggaa
     1921 gctctcatcc catgagccct gcagtgccac atgcaccaca ggagtcatgt ccacctatgc
     1981 catgtgtgtt cgctatgatg gtgttgaagt ggatgacagc tactgcgatg ccctcacccg
     2041 tcctgagcct gtccacgaat tctgcgctgg gagggagtgc cagcccaggt gggagaccag
     2101 cagctggagt gagtgctcac gtacctgtgg tgagggccat cagttccgca tcgtgcgctg
     2161 ctggaagatg ctgtcccctg gatttgacag ctccgtgtac agtgacctct gtgaagccac
     2221 ggaggctgtc cggccggagg aacgcaagac atgccgcaac ccagcctgcg gaccacagtg
     2281 ggagatgtct gagtggtcag agtgcactgc caagtgtgga gagcgcagtg tagtgaccag
     2341 agacatccgc tgttccgagg acgagaaact gtgtgacccc agcaccaagc ctgtgggaga
     2401 gaagaactgc actgggcctc cctgtgaccg ccagtggact gtctcggact ggggaccgtg
     2461 cagtgggagc tgtggacagg gccgcactat caggcatgtg tactgtaaga ccagcgatgg
     2521 acgggtagtt cccgagtctc agtgccagac agagacaaag cctctggcta tccacccctg
     2581 tggggacaag aactgcccag cacactggct ggctcaagac tgggaaaggt gcaataccac
     2641 ctgtgggcgt ggtgtgaaaa agcggttagt tctctgcatg gagctggcca acggaaagcc
     2701 tcagatccgc agtggccctg aatgcgggtt agccaggaag ccccctgagg agagcacgtg
     2761 cttcgagagg ccttgcttca agtggtacac cagcccctgg tcagagtgca ccaaaacatg
     2821 tggggtaggt gtgaggatgc gagacgtgaa gtgttaccag ggaaccgaca ttgtccgtgg
     2881 atgtgaccca ctggtgaagc ctgttggccg acaggcttgt gacttgcagc catgccccac
     2941 agagccccca gatgacagct gccaggacca gccaggcacc aactgtgcac tggcaatcaa
     3001 agtgaacctc tgtggccact ggtattacag caaagcctgc tgtcgctcct gcaggccccc
     3061 ccattcctag ctgctgctgc tgcagcccct gagatataag cacgctatcc tggggcttcc
     3121 ttggacaccc actctgcagg ggatgctgaa ctgtgaagat gtgacacagg gcacaactga
     3181 caagaaggga cttctcagat ggagccaccc tgctgcggaa gctgcacatg cactcccagg
     3241 atcctgtgtc tgtgcccatc ccagagggct cagagtccag aagccagagg aagcagtacc
     3301 tgcccatttc tcagactcaa ctctgatgtg acagaaccct ctcaaggtga cctgcaggtg
     3361 ccacaggaag gacagagtct cgtttctttg gctgtcttgg gtaaggagaa gccttgggtc
     3421 agctgaggag gccaggctgc cctgtctctg gaagtactga aggtacccct tcctatggca
     3481 ttagtgccac tgtcccctcc cagagttcct gtgctagatg ggagggacgg cccgtgttcc
     3541 tgggtgtctc tgccagcctc ctcactactt actggtgcat gttaataaag tggctgtatt
     3601 tatgggagca taaaaaaaaa aaaaaa
//
