LOCUS       NM_013906               4613 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus ADAM metallopeptidase with thrombospondin type 1 motif
            8 (Adamts8), transcript variant 1, mRNA.
ACCESSION   NM_013906 XM_914563
VERSION     NM_013906.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4613)
  AUTHORS   Feng,W., Bais,A., He,H., Rios,C., Jiang,S., Xu,J., Chang,C.,
            Kostka,D. and Li,G.
  TITLE     Single-cell transcriptomic analysis identifies murine heart
            molecular features at embryonic and neonatal stages
  JOURNAL   Nat Commun 13 (1), 7960 (2022)
   PUBMED   36575170
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4613)
  AUTHORS   Omura,J., Satoh,K., Kikuchi,N., Satoh,T., Kurosawa,R., Nogi,M.,
            Ohtsuki,T., Al-Mamun,M.E., Siddique,M.A.H., Yaoita,N., Sunamura,S.,
            Miyata,S., Hoshikawa,Y., Okada,Y. and Shimokawa,H.
  TITLE     ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension
            and Right Ventricular Failure: A Possible Novel Therapeutic Target
  JOURNAL   Circ Res 125 (10), 884-906 (2019)
   PUBMED   31556812
  REMARK    GeneRIF: ADAMTS8 deletion reduced pulmonary artery smooth muscle
            cell proliferation with AMPK up-regulation.
REFERENCE   3  (bases 1 to 4613)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   4  (bases 1 to 4613)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   5  (bases 1 to 4613)
  AUTHORS   Rossier,J., Bernard,A., Cabungcal,J.H., Perrenoud,Q., Savoye,A.,
            Gallopin,T., Hawrylycz,M., Cuenod,M., Do,K., Urban,A. and Lein,E.S.
  TITLE     Cortical fast-spiking parvalbumin interneurons enwrapped in the
            perineuronal net express the metallopeptidases Adamts8, Adamts15
            and Neprilysin
  JOURNAL   Mol Psychiatry 20 (2), 154-161 (2015)
   PUBMED   25510509
  REMARK    GeneRIF: This study demonstrated that Cortical fast-spiking
            parvalbumin interneurons enwrapped in the perineuronal net express
            the metallopeptidases Adamts8 in mice.
REFERENCE   6  (bases 1 to 4613)
  AUTHORS   Stankunas,K., Hang,C.T., Tsun,Z.Y., Chen,H., Lee,N.V., Wu,J.I.,
            Shang,C., Bayle,J.H., Shou,W., Iruela-Arispe,M.L. and Chang,C.P.
  TITLE     Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment
            for myocardial morphogenesis
  JOURNAL   Dev Cell 14 (2), 298-311 (2008)
   PUBMED   18267097
REFERENCE   7  (bases 1 to 4613)
  AUTHORS   Wagsater,D., Bjork,H., Zhu,C., Bjorkegren,J., Valen,G., Hamsten,A.
            and Eriksson,P.
  TITLE     ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in
            macrophage-rich areas of human atherosclerotic plaques
  JOURNAL   Atherosclerosis 196 (2), 514-522 (2008)
   PUBMED   17606262
  REMARK    GeneRIF: ADAMTS-4 expression was upregulated during the development
            of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
REFERENCE   8  (bases 1 to 4613)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   9  (bases 1 to 4613)
  AUTHORS   Georgiadis,K.E., Hirohata,S., Seldin,M.F. and Apte,S.S.
  TITLE     ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on
            mouse chromosome 9 and human chromosome 11
  JOURNAL   Genomics 62 (2), 312-315 (1999)
   PUBMED   10610729
REFERENCE   10 (bases 1 to 4613)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
            Lombardo,M. and Iruela-Arispe,M.L.
  TITLE     METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
            new family of proteins with angio-inhibitory activity
  JOURNAL   J Biol Chem 274 (33), 23349-23357 (1999)
   PUBMED   10438512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT025653.7 and AK043875.1.
            
            On May 13, 2016 this sequence version replaced NM_013906.2.
            
            Summary: This gene encodes a member of 'a disintegrin and
            metalloproteinase with thrombospondin motifs' (ADAMTS) family of
            multi-domain matrix-associated metalloendopeptidases that have
            diverse roles in tissue morphogenesis and pathophysiological
            remodeling, in inflammation and in vascular biology. This gene is
            expressed in mouse lung, heart and macrophage-rich areas of
            atherosclerotic plaques. The encoded preproprotein undergoes
            proteolytic processing to generate an active, zinc-dependent
            aggrecanase enzyme. This gene is located adjacent to a related
            ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF175282.1, SRR6116558.193540.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-896               CT025653.7         80142-81037
            897-1127            AK043875.1         3-233
            1128-1280           AK043875.1         235-387
            1281-1416           CT025653.7         90175-90310
            1417-3335           AK043875.1         388-2306
            3336-3336           CT025653.7         100141-100141
            3337-3842           AK043875.1         2307-2812
            3843-3843           CT025653.7         100648-100648
            3844-4613           AK043875.1         2814-3583
FEATURES             Location/Qualifiers
     source          1..4613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 16.49 cM"
     gene            1..4613
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif 8"
                     /db_xref="GeneID:30806"
                     /db_xref="MGI:MGI:1353468"
     exon            1..1040
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2993
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; a disintegrin and metalloproteinase with
                     thrombospondin motifs 8; a disintegrin-like and
                     metalloprotease (reprolysin type) with thrombospondin type
                     1 motif, 8; a disintegrin-like and metallopeptidase
                     (reprolysin type) with thrombospondin type 1 motif, 8"
                     /codon_start=1
                     /product="A disintegrin and metalloproteinase with
                     thrombospondin motifs 8 isoform 1 preproprotein"
                     /protein_id="NP_038934.2"
                     /db_xref="CCDS:CCDS22946.1"
                     /db_xref="GeneID:30806"
                     /db_xref="MGI:MGI:1353468"
                     /translation="MLRDPTTTGWPPLLLLLLQLPPPPLVCGAPAGPGTGAQASELVV
                     PTRLPGSASELAFHLSAFGQGFVLRLAPDASFLAPEFKIERLGGSSAAAGGEPGLRGC
                     FFSGTVNGERESLAAMSLCRGLSGSFLLAGEEFTIQPQGAGDSLDQPHRLQRWGPGQR
                     REDPGLAAAEVFPLPQGLEWEVEMGNGQGQERSDNEEDRKQDKEGLLKETEDSRKVPP
                     PFGSKTRSKRFVSEARFVETLLVADASMAAFYGTDLQNHILTVMSMAARIYKHPSIRN
                     SVNLVVVKVLIVEEEGWGPEVSDNGGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTR
                     QNFCGKGEQCDTLGMADVGTICDPDKSCSVIKDEGLQAAYTLAHELGHVLSMPHDDSK
                     PCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPL
                     PTGLPGHSTLYELDQQCKQIFGPDFRHCPNTSVEDICVQLWCRHRDSDEPICHTKNGS
                     LLWADGTPCGPGHLCLDGSCVLKEDVENPKAVVDGDWGPWRPWGQCSRTCGGGIQFSN
                     RECDNPMPQNGGRFCLGERVKYQSCNTEECPPNGKSFREQQCEKYNAYNHTDLDGNFL
                     QWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPDTLSICVRGQCVKAGC
                     DHVVNSPKKLDKCGVCGGKGTACRKISGSFTPFSYGYNDIVTIPAGATNIDVKQRSHP
                     GVRNDGSYLALKTANGQYLLNGNLAISAIEQDILVKGTILKYSGSMATLERLQSFQAL
                     PEPLTVQLLTVSGEVFPPKVRYTFFVPNDMDFSVQNSKERATTNIIQSLPSAEWVLGD
                     WSECPSTCRGSWQRRTVECRDPSGQASDTCDEALKPEDAKPCGSQPCPL"
     exon            1041..1280
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1416
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1584
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1889
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2073
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2246
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2422
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..4613
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3609..3614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /note="hexamer: ACTAAA"
     polyA_site      3631
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /note="major polyA site"
     regulatory      4297..4302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
                     /note="hexamer: AATAAA"
     polyA_site      4318
                     /gene="Adamts8"
                     /gene_synonym="METH-2; METH2"
ORIGIN      
        1 ggcgactgca cgggacgccg cggaggacgc gcgctcgcgg cccggggcgc cagctgctcg
       61 agttctgcta ggttggctgg cgcaggagga gcgggctgcg cgatccagag gggccgccag
      121 gggaccgccg cgcctgctgc cgctagccga gtcggcctcc ccatccgatt gatcattttt
      181 cctggacaga gcggcccggc cgcctcgggc caccagcacc tgcccgcgcg cggcgatctt
      241 cttccctctc ccgcgctccg cagcactctg cccccatgct ccgcgacccc accaccaccg
      301 ggtggccgcc cctcctgctg ctgctattgc agctgccgcc gccgccactc gtctgcggcg
      361 ccccggcggg gccgggaacc ggggcgcagg cctcggagct agtggtgccc acgcggttgc
      421 ccggcagcgc gagcgagctc gccttccacc tgtccgcctt cggccagggc ttcgtgctgc
      481 gcctggcgcc tgacgccagc ttcctggcgc cggaattcaa gatcgagcgc ctcgggggct
      541 cgagcgcggc ggccgggggc gagccgggac tgcgtggctg cttcttctct ggcacagtga
      601 atggagaacg ggagtcgctg gcggcgatga gcctgtgtcg cgggctgagc ggctcgttct
      661 tgctggcagg cgaggagttc accatccagc cacagggcgc tggggactcc ctggaccagc
      721 ctcatcgcct gcagcgctgg gggccgggac agcgccgcga agaccccggg ctcgctgccg
      781 ccgaagtttt ccccctccct caaggactgg agtgggaggt ggagatgggt aatgggcagg
      841 gacaggagag aagtgacaac gaagaggaca ggaagcagga caaggagggg ttgctcaaag
      901 agacagaaga ctcccgcaaa gtgccaccac ccttcggatc caaaactaga agcaagaggt
      961 ttgtgtccga ggctcgcttc gtggaaacac ttctggtggc tgatgcgtcc atggctgcct
     1021 tctatgggac cgacctgcag aaccacatcc tcacggtgat gtcaatggca gcccgaatct
     1081 acaagcaccc gagcatcagg aactccgtca accttgtggt ggtgaaagtg ctaatagtgg
     1141 aagaggaagg atggggcccg gaggtgtcgg acaacggggg gctcacactg cgcaacttct
     1201 gcagctggca acggcgtttc aacaagccca gtgaccgcca cccggagcac tatgacactg
     1261 ccatcttgtt caccagacag aacttctgtg ggaagggaga gcagtgtgac accctgggga
     1321 tggcagacgt tggcaccatc tgtgaccccg acaagagctg ctcagtgatc aaggatgagg
     1381 gactgcaggc agcctacacc ctggcccatg agctagggca cgttctcagc atgccccatg
     1441 atgattctaa gccctgtgtg agattgtttg ggcccatggg caagtaccac atgatggcgc
     1501 cattcttcat ccacgtgaac aagacgctgc cctggtctcc ctgcagtgct gtctacctca
     1561 cagagctcct ggatgatggt cacggagatt gtcttctgga tgcccccacc tcggttctgc
     1621 ccctccccac aggcctcccg ggccacagca ccctctacga gctggaccag cagtgcaagc
     1681 agatctttgg gcctgatttc cgacactgcc ccaacacctc tgtggaggac atctgtgtcc
     1741 agctctggtg ccgtcatcgg gatagtgatg agcccatttg ccacacaaag aatggtagcc
     1801 tgctctgggc tgatggtaca ccctgtggcc ctgggcacct gtgcctggat ggtagctgtg
     1861 tactcaagga ggatgtggag aatcccaagg ctgtggtaga tggagactgg ggtccctgga
     1921 gaccctgggg acaatgttct cgcacctgtg gtggagggat acaattctcg aaccgtgaat
     1981 gtgataatcc aatgcctcag aatggaggaa gattttgcct gggtgaaaga gtcaagtacc
     2041 aatcatgcaa cacagaggaa tgtccaccaa acggaaaaag cttccgggag cagcagtgtg
     2101 agaaatataa tgcctacaac cacactgacc tggatgggaa tttcctgcag tgggtcccca
     2161 agtattcagg agtgtccccc cgagaccgat gcaagctgtt ttgcagagcc cgtgggagga
     2221 gtgagttcaa agtgtttgaa gctaaggtga tcgatggcac tctgtgtgga ccggatactc
     2281 tgtccatctg cgtccggggg caatgtgtta aggctggctg tgaccatgtg gtgaactcac
     2341 ctaagaagct ggacaaatgt ggggtgtgtg ggggcaaagg cactgcctgt aggaagatct
     2401 ccggttcttt cacccccttc agttatggct acaatgacat tgtcaccatc ccagctggtg
     2461 ccacaaacat tgatgtgaaa cagcggagtc acccaggggt caggaacgac ggcagctacc
     2521 tggcgctgaa gacagccaat gggcagtacc tgctcaatgg taacctggcc atctctgcca
     2581 tagagcaaga catcttggtg aaggggacca tcctgaagta cagtggctcc atggctaccc
     2641 tggagcggct gcagagcttc caggccctgc ctgagcctct tacagtacag ctcctgactg
     2701 tgtctggtga ggtcttccct ccaaaagtca gatatacctt ctttgtcccc aatgacatgg
     2761 acttcagcgt gcagaatagc aaggaaagag caaccaccaa catcattcag tcactgccct
     2821 ctgcggagtg ggttctggga gactggtctg aatgtccgag cacgtgcaga ggtagctggc
     2881 agcggcggac tgtggaatgc agggacccct caggtcaggc ctctgacacc tgtgatgagg
     2941 ctctgaaacc tgaggatgcc aagccctgtg gaagccagcc gtgtcccctc tgatcccctt
     3001 ggtggaaatc tcttaggctt atggatttgg gctactggtg taacagacaa aggtcccctc
     3061 caaggtgata ctacatatca agatggcacg gccctttcag gccttctatt actacaaccc
     3121 cttgggtact acctaattca taaggaagag agaagagggt ataagggtaa cagattgtaa
     3181 agttgactgt ctggtggact ggaccttgct tatgaccaag aagtcgggat aggttaaaag
     3241 gtagaagtgc acttattgat ccaaatggga gatttcagag ccagtctctt tgcaaaggac
     3301 tagcaaagct aaatgaaaaa gaagaatttt ttttttctat ttggtttccc caataatcaa
     3361 tctacctcac agcggggaaa aatcagtata caagaggtat aaggccaggt gttggcagtg
     3421 aacgccaaag caagctccat aggtatctcc aagctatctt cagaaatgtc cgtggctgtt
     3481 ttcagtatta aaatctgttg tctaaaaggg cagcagtgtc catcacaggg ttatagaaag
     3541 ccacttttct caggctgcca cctgctgggg cggacccatt tcaagtattt atgcaaatat
     3601 gtctccgaac taaagtgtga tcttacacca atgaaattgt ctagtctggt tcattacttc
     3661 cttggaagag acccagcctc caaagacaag ggttaaacat agcttacctg gagtactcac
     3721 agggcagctg ctattttctc tgggtatctt caactttcag taagaaagtt ctaaaaggcc
     3781 tgctaaatcc agctcatgca agtagctgtt catccgtgtg atgtacatca atgtggttct
     3841 caaaccccag agccttgtaa agggctcagt ccagcgcaat ggctgagcag gccgtggatc
     3901 tacattccca acagccgcca ggtgctatga aggttgaggt tctagagact gcatcccaag
     3961 atccccacat ttgagaaaat tccaatctgt aggttacgct cttcattact ctgggatccc
     4021 tcagttttca ctgatgttcg ttatgttttc tgattttgag aggggatctc atggagtcca
     4081 ggctaacctc aaactctcga tgtagtcaag ggcggtcttg aacttctgac cctcctatct
     4141 ccacctccca agcgctgaca ttgcagctat ggaccaccaa acctgtttgt ttgttttgga
     4201 ggcagggact tgttattcgg gagaaatagt attgctctac tcagcaagct gcactatcag
     4261 ccctcttatg tgctgacctg ctcatttaag tcaaaaaata aagcctttta ggatcccaga
     4321 atccccctcc ttttgcctag ggaccaccac tctagagaca tccattcctg ctcaacacct
     4381 gacccccatc acatttcatc cctctcttga aaccctcata ctccagcttc ccagtgggtg
     4441 ctattaacct ggaacagtcc ctacctatta cccactggaa ctctccccga gagcctctaa
     4501 aatcctgtct tcctacctct tctctctcaa agttcagaag agctccctgg ctcagtcttc
     4561 catataagga attcagtcct tggtcacaaa tggatgagat gaaatggata ttt
//
